Biological variation of asymmetric dimethylarginine and related arginine metabolites and analytical performance goals for their measurement in human plasma

European Journal of Clinical Investigation

Volumn 37, Issue 5, 2007, Pages 364-371

  Blackwell, S ^a   O'Reilly, D St J ^a   Talwar, D ^a  

^a GLASGOW ROYAL INFIRMARY   (United Kingdom)

Author keywords

ADMA; Analytical performance goals; Biological variation; Reference change value; Reference interval

Indexed keywords

ARGININE; HOMOARGININE; N(G),N(G) DIMETHYLARGININE;

ADULT; AGED; AMINO ACID ANALYSIS; AMINO ACID BLOOD LEVEL; ANALYTICAL ERROR; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; MALE; NORMAL HUMAN; PRIORITY JOURNAL; REFERENCE VALUE;

ADULT; ARGININE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DATA INTERPRETATION, STATISTICAL; FEMALE; HUMANS; MALE; MIDDLE AGED; REFERENCE STANDARDS; REPRODUCIBILITY OF RESULTS;

EID: 34247500396     PISSN: 00142972     EISSN: 13652362     Source Type: Journal    
DOI: 10.1111/j.1365-2362.2007.01798.x     Document Type: Article

References (30)

1. Cooke JP. Asymmetrical dimethylarginine, the Über Marker? Circulation 2004 109 : 1813 9.
2. Vallance P, Leone A, Calver A, Collier J, Moncada S. Accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure. Lancet 1992 339 : 572 5.
3. Cooke JP. The pivotal role of nitric oxide for vascular health. Can J Cardiol 2004 20 (Suppl. B 7B 15B.
4. Teerlink T. ADMA metabolism and clearance. Vasc Med 2005 10 : S73 81.
5. Fliser D. Asymmetric dimethylarginine (ADMA): the silent transition from an 'uraemic toxin' to a global cardiovascular risk molecule. Eur J Clin Invest 2005 35 : 71 9.
6. Böger RH. Asymmetric dimethylarginine (ADMA) and cardiovascular disease: insights from prospective clinical trials. Vasc Med 2005 10 : S19 25.
7. Nijveldt RJ, Teerlink T, van der Hoven B, Siroen MPC, Kuik DJ, Rauwerda JA et al. Asymmetrical dimethylarginine (ADMA) in critically ill patients: high plasma ADMA is an independent risk factor of ICU mortality. Clin Nutr 2003 22 : 23 30.
8. Schwedhelm E. Quantification of ADMA: analytical approaches. Vasc Med 2005 10 : S89 95.
9. Teerlink T. Determination of the endogenous nitric oxide synthase inhibitor asymmetric dimethylarginine in biological samples by HPLC. Meth Mol Med 2005 108 : 263 74.
10. Zhang W, Kaye DM. Simultaneous determination of arginine and seven metabolites in plasma by reversed-phase liquid chromatography with a time controlled ortho-phthaldialdehyde precolumn derivatization. Anal Biochem 2004 326 : 87 92.
11. Heresztyn T, Worthley MI, Horowitz JD. Determination of 1-arginine and NG,NG and NG,NG′ dimethyl-l-arginine in plasma by liquid chromatography as AccQ-FluorTM fluorescent derivatives. J Chromatogr B 2004 805 : 325 9.
12. Schwedhelm E, Tan-Andresen J, Maas R, Riederer U, Schulze F, Böger RH. Liquid chromatography-tandem mass spectrometry method for the analysis of asymmetric dimethylarginine in human plasma. Clin Chem 2005 51 : 1268 71.
13. Albsmeier J, Schwedhelm E, Schulze F, Kastner M, Böger RH. Determination of NG NG dimethyl-l-arginine, an endogenous NO synthase inhibitor, by gas chromatography-mass spectrometry. J Chromatogr B 2004 809 : 59 65.
14. Trapp G, Sydow K, Dulay MT, Chou T, Cooke JP, Zare RN. Capillary electrophoretic and micellar electrokinetic separations of asymmetric dimethyl-l-arginine and structurally related amino acids: quantitation in human plasma. J Sep Sci 2004 27 : 1483 90.
15. Schulze F, Wesemann R, Schwedhelm E, Sydow K, Albsmeier J, Cooke JP et al. Determination of asymmetric dimethylarginine (ADMA) using a novel ELISA assay. Clin Chem Lab Med 2004 42 : 1377 83.
16. Hyltoft Petersen P, Fraser CG, Jorgensen L, Brandslund I, Stahl M, Gowans E et al. Combination of analytical quality specifications based on biological within- and between-subject variation. Ann Clin Biochem 2002 39 : 543 50.
17. Fraser CG, Hyltoft Petersen P. Analytical performance characteristics should be judged against objective quality specifications. Clin Chem 1999 45 : 321 3.
18. Fraser CG. Inherent biological variation and reference values. Clin Chem Lab Med 2004 42 : 758 64.
19. Fraser CG, Harris EK. Generation and application of data on biological variation in clinical chemistry. Crit Rev Clin Lab Sci 1989 27 : 409 37.
20. Fraser CG, Hyltoft Petersen P. Quality goals in external quality assessment are best based on biology. Scand J Clin Lab Invest 1993 53 (Suppl. 212 8 9.
21. Mendes Riberio AC, Roberts NB, Lane C, Yaqoob M, Ellory JC. Accumulation of the endogenous l-arginine analogue NG monomethyl-l-arginine in human end-stage renal failure patients on regular haemodialysis. Exp Physiol 1996 81 : 475 81.
22. Marescau B, Nagels G, Possemiers I. Guanindino compounds in serum and urine of nondialyzed patients with chronic renal insufficiency. Metabolism 1997 46 : 1024 31.
23. Kielstein JT, Salpeter SR, Bode-Böger SM, Cooke JP, Fliser D. Symmetric dimethylarginine (SDMA) as endogenous marker of renal function - a meta-analysis. Nephrol Dial Transplant 2006 21 : 2446 51.
24. Bode-Böger SM, Scalera F, Kielstein JT, Martens-Lobenhoffer J, Breithardt G, Fobker M et al. Symmetrical dimethylarginine: a new combined parameter for renal function and the extent of coronary artery disease. J Am Soc Nephrol 2006 17 : 1128 34.
25. Martens-Lobenhoffer J, Westphal S, Friedemann A, Bode-Böger SM, Luley C. Determination of asymmetric dimethylarginine: liquid chromatography-mass spectrometry or ELISA? Clin Chem 2005 51 : 2188 9.
26. Bode-Böger SM, Böger RH, Kienke S, Junker W, Frölich JC. Elevated l-arginine/dimethylarginine ratio contributes to enhanced systemic NO production by dietary l-arginine in hypercholesterolaemic rabbits. Biochem Biophys Res Commun 1996 219 : 598 603.
27. Teerlink T. HPLC analysis of ADMA and other methylated l-arginine analogs in biological fluids. J Chromatogr B 2006, doi: 10.1016/J.Jchromb.200607.024. (in press).
28. Teerlink T. Measurement of asymmetric dimethylarginine in plasma: methodological considerations and clinical relevance. Clin Chem Lab Med 2005 43 : 1130 8.
29. Schulze F, Maas R, Freese R, Schwedhelm E, Silberhorn E, Böger RH. Determination of a reference value for NG NG dimethyl-l-arginine in 500 subjects. Eur J Clin Invest 2005 35 : 622 6.
30. Mooy JM, Grootenhuis PA, de Vries H, Valkenburg HA, Bouter LM, Kostense PJ et al. Prevalence and determinants of glucose intolerance in a Dutch caucasian population: the Hoorn study. Diabetes Care 1995 18 : 1270 3.