메뉴 건너뛰기




Volumn 13, Issue 3, 2012, Pages 772-784

Mechanically induced amorphization of drugs: A study of the thermal behavior of cryomilled compounds

Author keywords

amorphous; cryomilling; crystallization; thermal analysis

Indexed keywords

CARBAMAZEPINE; GRISEOFULVIN; INDOMETACIN; KETOCONAZOLE; PIROXICAM; URSODEOXYCHOLIC ACID;

EID: 84866141766     PISSN: None     EISSN: 15309932     Source Type: Journal    
DOI: 10.1208/s12249-012-9801-8     Document Type: Article
Times cited : (63)

References (45)
  • 1
    • 0014559313 scopus 로고
    • Pharmaceutical applications of polymorphism
    • 4899118 10.1002/jps.2600580802 1:CAS:528:DyaF1MXltVGitrw%3D
    • Haleblian J, McCrone W. Pharmaceutical applications of polymorphism. J Pharm Sci. 1969;58(8):911-29.
    • (1969) J Pharm Sci , vol.58 , Issue.8 , pp. 911-929
    • Haleblian, J.1    McCrone, W.2
  • 2
    • 0035897679 scopus 로고    scopus 로고
    • Theoretical approaches to physical transformations of active pharmaceutical ingredients during manufacturing processes
    • 11325478 10.1016/S0169-409X(01)00100-4 1:CAS:528:DC%2BD3MXivFejsrc%3D
    • Morris KR, Griesser UJ, Eckhardt CJ, Stowell JG. Theoretical approaches to physical transformations of active pharmaceutical ingredients during manufacturing processes. Adv Drug Deliv Rev. 2001;48(1):91-114.
    • (2001) Adv Drug Deliv Rev. , vol.48 , Issue.1 , pp. 91-114
    • Morris, K.R.1    Griesser, U.J.2    Eckhardt, C.J.3    Stowell, J.G.4
  • 3
    • 77955056024 scopus 로고    scopus 로고
    • Solid-state transformation of different gabapentin polymorphs upon milling and co-milling
    • 20561572 10.1016/j.ijpharm.2010.06.014 1:CAS:528:DC%2BC3cXpt1Squr0%3D
    • Lin SY, Hsu CH, Ke WT. Solid-state transformation of different gabapentin polymorphs upon milling and co-milling. Int J Pharm. 2010;396(1-2):83-90.
    • (2010) Int J Pharm , vol.396 , Issue.1-2 , pp. 83-90
    • Lin, S.Y.1    Hsu, C.H.2    Ke, W.T.3
  • 4
    • 0022601812 scopus 로고
    • Effect of environmental temperature on polymorphic solid-state transformation of indomethacin during grinding
    • 3719878 10.1248/cpb.34.1784 1:CAS:528:DyaL28Xkt12qt7w%3D
    • Otsuka M, Matsumoto T, Kaneniwa N. Effect of environmental temperature on polymorphic solid-state transformation of indomethacin during grinding. Chem Pharm Bull. 1986;34(4):1784-93.
    • (1986) Chem Pharm Bull , vol.34 , Issue.4 , pp. 1784-1793
    • Otsuka, M.1    Matsumoto, T.2    Kaneniwa, N.3
  • 5
    • 0035928835 scopus 로고    scopus 로고
    • Direct crystal to glass transformation of trehalose induced by ball milling
    • 10.1016/S0038-1098(01)00283-6 1:CAS:528:DC%2BD3MXlsFynur0%3D
    • Willart JF, De Gusseme A, Hemon S, Odou G, Danede F, Descamps M. Direct crystal to glass transformation of trehalose induced by ball milling. Solid State Commun. 2001;119(8-9):501-5.
    • (2001) Solid State Commun. , vol.119 , Issue.8-9 , pp. 501-505
    • Willart, J.F.1    De Gusseme, A.2    Hemon, S.3    Odou, G.4    Danede, F.5    Descamps, M.6
  • 6
    • 0032144034 scopus 로고    scopus 로고
    • Ground and native crystals: Comparison of compression capacity and dissolution rate
    • 10.1016/S0378-5173(98)00120-3 1:CAS:528:DyaK1cXksF2lsbg%3D
    • Longuemard P, Jbilou M, Guyot-Hermann AM, Guyot JC. Ground and native crystals: comparison of compression capacity and dissolution rate. Int J Pharm. 1998;170(1):51-61.
    • (1998) Int J Pharm , vol.170 , Issue.1 , pp. 51-61
    • Longuemard, P.1    Jbilou, M.2    Guyot-Hermann, A.M.3    Guyot, J.C.4
  • 7
    • 0000847179 scopus 로고
    • The use of thermal-analysis in the assessment of crystal disruption
    • 10.1016/0040-6031(94)01951-C 1:CAS:528:DyaK2MXivVOrtrg%3D
    • Duddu SP, Grant DJW. The use of thermal-analysis in the assessment of crystal disruption. Thermochim Acta. 1995;248:131-45.
    • (1995) Thermochim Acta , vol.248 , pp. 131-145
    • Duddu, S.P.1    Grant, D.J.W.2
  • 8
    • 0029058533 scopus 로고
    • Process-induced crystallinity changes in albuterol sulfate and its effect on powder physical stability
    • 7479567 10.1023/A:1016232230638 1:CAS:528:DyaK2MXlsFKlsLY%3D
    • Ward GH, Schultz RK. Process-induced crystallinity changes in albuterol sulfate and its effect on powder physical stability. Pharm Res. 1995;12(5):773-9.
    • (1995) Pharm Res , vol.12 , Issue.5 , pp. 773-779
    • Ward, G.H.1    Schultz, R.K.2
  • 9
    • 0036173405 scopus 로고    scopus 로고
    • The effect of disorder on the chemical reactivity of an organic solid, tetraglycine methyl ester: Change of the reaction mechanism
    • 11835215 10.1002/jps.10066 1:CAS:528:DC%2BD38XhsVSmsL0%3D
    • Shalaev E, Shalaeva M, Zografi G. The effect of disorder on the chemical reactivity of an organic solid, tetraglycine methyl ester: change of the reaction mechanism. J Pharm Sci. 2002;91(2):584-93.
    • (2002) J Pharm Sci , vol.91 , Issue.2 , pp. 584-593
    • Shalaev, E.1    Shalaeva, M.2    Zografi, G.3
  • 10
    • 33846247122 scopus 로고    scopus 로고
    • Towards an understanding of the structurally based potential for mechanically activated disordering of small molecule organic crystals
    • 16924685 10.1002/jps.20672 1:CAS:528:DC%2BD28XhtlSis7%2FP
    • Wildfong PLD, Hancock BC, Moore MD, Morris KR. Towards an understanding of the structurally based potential for mechanically activated disordering of small molecule organic crystals. J Pharm Sci. 2006;95(12):2645-56.
    • (2006) J Pharm Sci , vol.95 , Issue.12 , pp. 2645-2656
    • Wildfong, P.L.D.1    Hancock, B.C.2    Moore, M.D.3    Morris, K.R.4
  • 11
    • 64649086799 scopus 로고    scopus 로고
    • Solid state amorphization of pharmaceuticals
    • 18954076 10.1021/mp800092t 1:CAS:528:DC%2BD1cXht12qt77L
    • Willart JF, Descamps M. Solid state amorphization of pharmaceuticals. Mol Pharm. 2008;5(6):905-20.
    • (2008) Mol Pharm , vol.5 , Issue.6 , pp. 905-920
    • Willart, J.F.1    Descamps, M.2
  • 12
    • 0023743976 scopus 로고
    • A kinetic study of the crystallization process of noncrystalline indomethacin under isothermal conditions
    • 3245981 10.1248/cpb.36.4026 1:CAS:528:DyaL1MXhtlCktA%3D%3D
    • Otsuka M, Kaneniwa N. A kinetic study of the crystallization process of noncrystalline indomethacin under isothermal conditions. Chem Pharm Bull. 1988;36(10):4026-32.
    • (1988) Chem Pharm Bull , vol.36 , Issue.10 , pp. 4026-4032
    • Otsuka, M.1    Kaneniwa, N.2
  • 13
    • 33749457920 scopus 로고    scopus 로고
    • Analysis of amorphous and nanocrystalline solids from their X-ray diffraction patterns
    • 17021963 10.1007/s11095-006-9086-2 1:CAS:528:DC%2BD28XhtVeqsbnM
    • Bates S, Zografi G, Engers D, Morris K, Crowley K, Newman A. Analysis of amorphous and nanocrystalline solids from their X-ray diffraction patterns. Pharm Res. 2006;23(10):2333-49.
    • (2006) Pharm Res , vol.23 , Issue.10 , pp. 2333-2349
    • Bates, S.1    Zografi, G.2    Engers, D.3    Morris, K.4    Crowley, K.5    Newman, A.6
  • 14
    • 58249106124 scopus 로고    scopus 로고
    • Toward understanding the evolution of griseofulvin crystal structure to a mesophase after cryogenic milling
    • 19013224 10.1016/j.ijpharm.2008.10.011 1:CAS:528:DC%2BD1MXpsF2guw%3D%3D
    • Feng T, Bates S, Carvajal MT. Toward understanding the evolution of griseofulvin crystal structure to a mesophase after cryogenic milling. Int J Pharm. 2009;367(1-2):16-9.
    • (2009) Int J Pharm , vol.367 , Issue.1-2 , pp. 16-19
    • Feng, T.1    Bates, S.2    Carvajal, M.T.3
  • 15
    • 52449117081 scopus 로고    scopus 로고
    • Process induced disorder in crystalline materials: Differentiating defective crystals from the amorphous form of griseofulvin
    • 17990307 10.1002/jps.21219 1:CAS:528:DC%2BD1cXpsVOrsL0%3D
    • Feng T, Pinal R, Carvajal MT. Process induced disorder in crystalline materials: differentiating defective crystals from the amorphous form of griseofulvin. J Pharm Sci. 2008;97(8):3207-21.
    • (2008) J Pharm Sci , vol.97 , Issue.8 , pp. 3207-3221
    • Feng, T.1    Pinal, R.2    Carvajal, M.T.3
  • 16
    • 73949154387 scopus 로고    scopus 로고
    • An investigation into the crystallisation behaviour of an amorphous cryomilled pharmaceutical material above and below the glass transition temperature
    • 19492312 10.1002/jps.21811 1:CAS:528:DC%2BD1MXhsVylsrfI
    • Qi S, Weuts I, De Cort S, Stokbroekx S, Leemans R, Reading M, et al. An investigation into the crystallisation behaviour of an amorphous cryomilled pharmaceutical material above and below the glass transition temperature. J Pharm Sci. 2010;99(1):196-208.
    • (2010) J Pharm Sci , vol.99 , Issue.1 , pp. 196-208
    • Qi, S.1    Weuts, I.2    De Cort, S.3    Stokbroekx, S.4    Leemans, R.5    Reading, M.6
  • 17
    • 77953609579 scopus 로고    scopus 로고
    • Investigation of the milling-induced thermal behavior of crystalline and amorphous griseofulvin
    • 20490628 10.1007/s11095-010-0129-3 1:CAS:528:DC%2BC3cXmtlamt7o%3D
    • Trasi NS, Boerrigter SXM, Byrn SR. Investigation of the milling-induced thermal behavior of crystalline and amorphous griseofulvin. Pharm Res. 2010;27(7):1377-89.
    • (2010) Pharm Res , vol.27 , Issue.7 , pp. 1377-1389
    • Trasi, N.S.1    Boerrigter, S.X.M.2    Byrn, S.R.3
  • 18
    • 16244376470 scopus 로고    scopus 로고
    • Preparation and characterization of poly-e-caprolactone nanoparticles containing griseofulvin
    • 15814249 10.1016/j.ijpharm.2005.01.020 1:CAS:528:DC%2BD2MXjt1agsrg%3D
    • Zili Z, Sfar S, Fessi H. Preparation and characterization of poly-e-caprolactone nanoparticles containing griseofulvin. Int J Pharm. 2005;294(1-2):261-7.
    • (2005) Int J Pharm , vol.294 , Issue.1-2 , pp. 261-267
    • Zili, Z.1    Sfar, S.2    Fessi, H.3
  • 20
    • 78649731280 scopus 로고    scopus 로고
    • Polymorphism and solvation of indomethacin
    • 10.1007/s10973-009-0412-x 1:CAS:528:DC%2BC3cXhtFart7bL
    • Nicolai B, Ceolin R, Rietveld IB. Polymorphism and solvation of indomethacin. J Therm Anal Calorim. 2010;102(1):211-6.
    • (2010) J Therm Anal Calorim. , vol.102 , Issue.1 , pp. 211-216
    • Nicolai, B.1    Ceolin, R.2    Rietveld, I.B.3
  • 21
    • 0036171845 scopus 로고    scopus 로고
    • Cryogenic grinding of indomethacin polymorphs and solvates: Assessment of amorphous phase formation and amorphous phase physical stability
    • 11835208 10.1002/jps.10028 1:CAS:528:DC%2BD38XhsVSms7g%3D
    • Crowley KJ, Zografi G. Cryogenic grinding of indomethacin polymorphs and solvates: assessment of amorphous phase formation and amorphous phase physical stability. J Pharm Sci. 2002;91(2):492-507.
    • (2002) J Pharm Sci , vol.91 , Issue.2 , pp. 492-507
    • Crowley, K.J.1    Zografi, G.2
  • 22
    • 33749426140 scopus 로고    scopus 로고
    • Structure in dehydrated trehalose dihydrateevaluation of the concept of partial crystallinity
    • 16927180 10.1007/s11095-006-9058-6 1:CAS:528:DC%2BD28XhtVeqsbvI
    • Rani M, Govindarajan R, Surana R, Suryanarayanan R. Structure in dehydrated trehalose dihydrateevaluation of the concept of partial crystallinity. Pharm Res. 2006;23(10):2356-67.
    • (2006) Pharm Res , vol.23 , Issue.10 , pp. 2356-2367
    • Rani, M.1    Govindarajan, R.2    Surana, R.3    Suryanarayanan, R.4
  • 23
    • 58149319770 scopus 로고
    • The effect of recrystallization on the crystal growth, melting point and solubility of ketoconazole
    • 10.1016/0040-6031(95)02319-4
    • Viseras C, Salem II, Galan ICR, Galan AC, Galindo AL. The effect of recrystallization on the crystal growth, melting point and solubility of ketoconazole. Thermochim Acta. 1995;268:143-51.
    • (1995) Thermochim Acta , vol.268 , pp. 143-151
    • Viseras, C.1    Salem, I.I.2    Galan, I.C.R.3    Galan, A.C.4    Galindo, A.L.5
  • 24
    • 0030927152 scopus 로고    scopus 로고
    • Evaluation of amorphous ursodeoxycholic acid by thermal methods
    • 9210200 10.1023/A:1012114825513 1:CAS:528:DyaK2sXkt1yitLs%3D
    • Yonemochi E, Ueno Y, Ohmae T, Oguchi T, Nakajima S, Yamamoto K. Evaluation of amorphous ursodeoxycholic acid by thermal methods. Pharm Res. 1997;14(6):798-803.
    • (1997) Pharm Res , vol.14 , Issue.6 , pp. 798-803
    • Yonemochi, E.1    Ueno, Y.2    Ohmae, T.3    Oguchi, T.4    Nakajima, S.5    Yamamoto, K.6
  • 25
    • 0032980269 scopus 로고    scopus 로고
    • Differences in crystallization behavior between quenched and ground amorphous ursodeoxycholic acid
    • 10397602 10.1023/A:1018817801444 1:CAS:528:DyaK1MXktVyqsr4%3D
    • Yonemochi E, Inoue Y, Buckton G, Moffat A, Oguchi T, Yamamoto K. Differences in crystallization behavior between quenched and ground amorphous ursodeoxycholic acid. Pharm Res. 1999;16(6):835-40.
    • (1999) Pharm Res , vol.16 , Issue.6 , pp. 835-840
    • Yonemochi, E.1    Inoue, Y.2    Buckton, G.3    Moffat, A.4    Oguchi, T.5    Yamamoto, K.6
  • 27
    • 0023567027 scopus 로고
    • Relations between several polymorphic forms and the dihydrate of carbamazepine
    • 3423093 1:CAS:528:DyaL2sXmtVGju7w%3D
    • Krahn FU, Mielck JB. Relations between several polymorphic forms and the dihydrate of carbamazepine. Pharmaceutica Acta Helvetiae. 1987;62(9):247-54.
    • (1987) Pharmaceutica Acta Helvetiae. , vol.62 , Issue.9 , pp. 247-254
    • Krahn, F.U.1    Mielck, J.B.2
  • 28
    • 0021238034 scopus 로고
    • Kinetics of the thermal transition of carbamzepine polymorphic forms in the solid state
    • 1:CAS:528:DyaL2cXmtVWqsr8%3D
    • Umeda T, Ohnishi N, Yokoyama T, Kuroda K, Kuroda T, Tatsumi E, et al. Kinetics of the thermal transition of carbamzepine polymorphic forms in the solid state. Yakugaku Zasshi-J Pharm Soc Jpn. 1984;104(7):786-92.
    • (1984) Yakugaku Zasshi-J Pharm Soc Jpn. , vol.104 , Issue.7 , pp. 786-792
    • Umeda, T.1    Ohnishi, N.2    Yokoyama, T.3    Kuroda, K.4    Kuroda, T.5    Tatsumi, E.6
  • 29
    • 0029798063 scopus 로고    scopus 로고
    • Characterization of dihydrates prepared from carbamazepine polymorphs
    • 8897272 10.1021/js960117e 1:CAS:528:DyaK28XlsVynurc%3D
    • McMahon LE, Timmins P, Williams AC, York P. Characterization of dihydrates prepared from carbamazepine polymorphs. J Pharm Sci. 1996;85(10):1064-9.
    • (1996) J Pharm Sci , vol.85 , Issue.10 , pp. 1064-1069
    • McMahon, L.E.1    Timmins, P.2    Williams, A.C.3    York, P.4
  • 30
    • 34249101636 scopus 로고    scopus 로고
    • Sudden rise of crystal growth rate of nifedipine near Tg without and with polyvinylpyrrolidone
    • 17455342 10.1002/jps.20925 1:CAS:528:DC%2BD2sXltVGqsLY%3D
    • Ishida H, Wu TA, Yu LA. Sudden rise of crystal growth rate of nifedipine near Tg without and with polyvinylpyrrolidone. J Pharm Sci. 2007;96(5):1131-8.
    • (2007) J Pharm Sci , vol.96 , Issue.5 , pp. 1131-1138
    • Ishida, H.1    Wu, T.A.2    Yu, L.A.3
  • 31
    • 33748586776 scopus 로고    scopus 로고
    • Origin of enhanced crystal growth kinetics near Tg probed with indomethacin polymorphs
    • 16898713 10.1021/jp062771g 1:CAS:528:DC%2BD28Xnt1Ggtb4%3D
    • Wu T, Yu L. Origin of enhanced crystal growth kinetics near Tg probed with indomethacin polymorphs. J Phys Chem B. 2006;110(32):15694-9.
    • (2006) J Phys Chem B. , vol.110 , Issue.32 , pp. 15694-15699
    • Wu, T.1    Yu, L.2
  • 32
    • 0025401379 scopus 로고
    • Relationship between crystallization temperature and melting temperature in crystalline materials
    • 10.1007/BF01045361 1:CAS:528:DyaK3cXit1Kqtrs%3D
    • Okui N. Relationship between crystallization temperature and melting temperature in crystalline materials. J Mater Sci. 1990;25(3):1623-31.
    • (1990) J Mater Sci , vol.25 , Issue.3 , pp. 1623-1631
    • Okui, N.1
  • 33
    • 77955232982 scopus 로고    scopus 로고
    • A classification system to assess the crystallization tendency of organic molecules from undercooled melts
    • 20623696 1:CAS:528:DC%2BC3cXptlejsL8%3D
    • Baird JA, Van Eerdenbrugh B, Taylor LS. A classification system to assess the crystallization tendency of organic molecules from undercooled melts. J Pharm Sci. 2010;99(9):3787-806.
    • (2010) J Pharm Sci , vol.99 , Issue.9 , pp. 3787-3806
    • Baird, J.A.1    Van Eerdenbrugh, B.2    Taylor, L.S.3
  • 34
    • 0035991640 scopus 로고    scopus 로고
    • Physical stability of amorphous pharmaceuticals: Importance of configurational thermodynamic quantities and molecular mobility
    • 12115813 10.1002/jps.10169 1:CAS:528:DC%2BD38XlvV2ksL4%3D
    • Zhou DL, Zhang GGZ, Law D, Grant DJW, Schmitt EA. Physical stability of amorphous pharmaceuticals: importance of configurational thermodynamic quantities and molecular mobility. J Pharm Sci. 2002;91(8):1863-72.
    • (2002) J Pharm Sci , vol.91 , Issue.8 , pp. 1863-1872
    • Zhou, D.L.1    Zhang, G.G.Z.2    Law, D.3    Grant, D.J.W.4    Schmitt, E.A.5
  • 35
    • 33749432466 scopus 로고    scopus 로고
    • Surface crystallization of indomethacin below Tg
    • 16927184 10.1007/s11095-006-9023-4 1:CAS:528:DC%2BD28XhtVeqsbrF
    • Wu T, Yu L. Surface crystallization of indomethacin below Tg. Pharm Res. 2006;23(10):2350-5.
    • (2006) Pharm Res , vol.23 , Issue.10 , pp. 2350-2355
    • Wu, T.1    Yu, L.2
  • 36
    • 64649105863 scopus 로고    scopus 로고
    • Surface-enhanced crystallization of amorphous nifedipine
    • 19434917 10.1021/mp8000638 1:CAS:528:DC%2BD1cXhtFChsbvE
    • Zhu L, Wong L, Yu L. Surface-enhanced crystallization of amorphous nifedipine. Mol Pharm. 2008;5(6):921-6.
    • (2008) Mol Pharm , vol.5 , Issue.6 , pp. 921-926
    • Zhu, L.1    Wong, L.2    Yu, L.3
  • 37
    • 77955469110 scopus 로고    scopus 로고
    • Fast surface crystallization of amorphous griseofulvin below T (g)
    • 20414704 10.1007/s11095-010-0140-8 1:CAS:528:DC%2BC3cXltV2ksr8%3D
    • Zhu L, Jona J, Nagapudi K, Wu TA. Fast surface crystallization of amorphous griseofulvin below T (g). Pharm Res. 2010;27(8):1558-67.
    • (2010) Pharm Res , vol.27 , Issue.8 , pp. 1558-1567
    • Zhu, L.1    Jona, J.2    Nagapudi, K.3    Wu, T.A.4
  • 38
    • 84857503976 scopus 로고    scopus 로고
    • Solid-state vitrification of crystalline griseofulvin by mechanical milling
    • 22252982 10.1002/jps.23041 1:CAS:528:DC%2BC38XpvVSlsQ%3D%3D
    • Willart JF, Carpentier L, Dannede F, Descamps M. Solid-state vitrification of crystalline griseofulvin by mechanical milling. J Pharm Sci. 2012;101(4):1570-7.
    • (2012) J Pharm Sci , vol.101 , Issue.4 , pp. 1570-1577
    • Willart, J.F.1    Carpentier, L.2    Dannede, F.3    Descamps, M.4
  • 39
    • 84862649085 scopus 로고    scopus 로고
    • Origin of two modes of non-isothermal crystallization of glasses produced by milling
    • 22173781 10.1007/s11095-011-0644-x 1:CAS:528:DC%2BC3MXhs1agt7%2FJ
    • Chattoraj S, Bhugra C, Telang C, Zhong L, Wang ZR, Sun CC. Origin of two modes of non-isothermal crystallization of glasses produced by milling. Pharm Res. 2012;29(4):1020-32.
    • (2012) Pharm Res , vol.29 , Issue.4 , pp. 1020-1032
    • Chattoraj, S.1    Bhugra, C.2    Telang, C.3    Zhong, L.4    Wang, Z.R.5    Sun, C.C.6
  • 40
    • 64649098724 scopus 로고    scopus 로고
    • Thermodynamics, molecular mobility and crystallization kinetics of amorphous griseofulvin
    • 19434849 10.1021/mp800169g 1:CAS:528:DC%2BD1cXhtlemtrvN
    • Zhou D, Zhang GGZ, Law D, Grant DJW, Schmitt EA. Thermodynamics, molecular mobility and crystallization kinetics of amorphous griseofulvin. Mol Pharm. 2008;5(6):927-36.
    • (2008) Mol Pharm , vol.5 , Issue.6 , pp. 927-936
    • Zhou, D.1    Zhang, G.G.Z.2    Law, D.3    Grant, D.J.W.4    Schmitt, E.A.5
  • 41
    • 0037473468 scopus 로고    scopus 로고
    • Characterization of piroxicam crystal modifications
    • 12695006 10.1016/S0378-5173(03)00057-7 1:CAS:528:DC%2BD3sXivVGjsLc%3D
    • Vrecer F, Vrbinc M, Meden A. Characterization of piroxicam crystal modifications. Int J Pharm. 2003;256(1-2):3-15.
    • (2003) Int J Pharm , vol.256 , Issue.1-2 , pp. 3-15
    • Vrecer, F.1    Vrbinc, M.2    Meden, A.3
  • 42
    • 53549126335 scopus 로고    scopus 로고
    • Correlation between molecular mobility and crystal growth of amorphous phenobarbital and phenobarbital with polyvinylpyrrolidone and L-proline
    • 18200526 10.1002/jps.21273 1:CAS:528:DC%2BD1cXhtVyltL%2FO
    • Korhonen O, Bhura C, Pikal MJ. Correlation between molecular mobility and crystal growth of amorphous phenobarbital and phenobarbital with polyvinylpyrrolidone and L-proline. J Pharm Sci. 2008;97(9):3830-41.
    • (2008) J Pharm Sci , vol.97 , Issue.9 , pp. 3830-3841
    • Korhonen, O.1    Bhura, C.2    Pikal, M.J.3
  • 43
    • 0030217476 scopus 로고    scopus 로고
    • Supercooled liquids and glasses
    • 10.1021/jp953538d 1:CAS:528:DyaK28Xkt1amsL8%3D
    • Ediger MD, Angell CA, Nagel SR. Supercooled liquids and glasses. J Phys Chem. 1996;100(31):13200-12.
    • (1996) J Phys Chem , vol.100 , Issue.31 , pp. 13200-13212
    • Ediger, M.D.1    Angell, C.A.2    Nagel, S.R.3
  • 44
    • 0035861411 scopus 로고    scopus 로고
    • The use of thermal methods for predicting glass-former fragility
    • 10.1016/S0040-6031(01)00662-1 1:CAS:528:DC%2BD3MXos1ChsL4%3D
    • Crowley KJ, Zografi G. The use of thermal methods for predicting glass-former fragility. Thermochim Acta. 2001;380(2):79-93.
    • (2001) Thermochim Acta , vol.380 , Issue.2 , pp. 79-93
    • Crowley, K.J.1    Zografi, G.2
  • 45
    • 33750475620 scopus 로고    scopus 로고
    • Transformations of glassy indomethacin induced by ball-milling
    • 10.1016/j.jnoncrysol.2006.02.130 1:CAS:528:DC%2BD28XhtFOrurvP
    • Desprez S, Descamps M. Transformations of glassy indomethacin induced by ball-milling. J Non-Cryst Solids. 2006;352(42-49):4480-5.
    • (2006) J Non-Cryst Solids , vol.352 , Issue.42-49 , pp. 4480-4485
    • Desprez, S.1    Descamps, M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.