High levels of β-catenin promote IFNγ-induced apoptosis in hepatocellular carcinoma cells

Oncology Letters

Volumn 4, Issue 5, 2012, Pages 1092-1096

  Li, Wei ^a   Tong, Hongfei ^b   Huang, Xiaojie ^a   Wang, Wen ^a   Wu, Hao ^a   Lin, Shengzhang ^b  

^a CAPITAL MEDICAL UNIVERSITY   (China)

^b WENZHOU MEDICAL UNIVERSITY   (China)

Author keywords

catenin; Apoptosis; Hepatocellular carcinoma; Interferon

Indexed keywords

BETA CATENIN; CASPASE; CASPASE 3; CASPASE 8; CASPASE 9; GAMMA INTERFERON; PROTEIN BCL XL; PROTEIN INHIBITOR; STAT PROTEIN;

ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CELL STRAIN HEPG2; CONTROLLED STUDY; HUMAN; HUMAN CELL; LIVER CELL CARCINOMA;

EID: 84866135141     PISSN: 17921074     EISSN: 17921082     Source Type: Journal    
DOI: 10.3892/ol.2012.844     Document Type: Article

References (28)

1. Parmar S and Platanias LC: Interferons. Cancer Treat Res 126: 45-68, 2005.
2. Kelly C, Klenerman P and Barnes E: Interferon lambdas: the next cytokine storm. Gut 60: 1284-1293, 2011.
3. Schindler C and Plumlee C: Inteferons pen the JAK-STAT pathway. Semin Cell Dev Biol 19: 311-318, 2008.
4. Boehm U, Klamp T, Groot M and Howard JC: Cellular responses to interferon-gamma. Annu Rev Immunol 15: 749-795, 1997.
5. Clemens MJ: Interferons and apoptosis. J Interferon Cytokine Res 23: 277-292, 2003.
6. Thornberry NA: Caspases: key mediators of apoptosis. Chem Biol 5: R97-R103, 1998.
7. Stennicke HR and Salvesen GS: Caspase assays. Methods Enzymol 322: 91-100, 2000.
8. Kalvakolanu DV: The GRIMs: a new interface between cell death regulation and interferon/retinoid induced growth suppression. Cytokine Growth Factor Rev 15: 169-194, 2004.
9. Hengartner MO: The biochemistry of apoptosis. Nature 407: 770-776, 2000.
10. Elmore S: Apoptosis: a review of programmed cell death. Toxicol Pathol 35: 495-516, 2007.
11. Damalas A, Ben-Ze'ev A, Simcha I, et al: Excess beta-catenin promotes accumulation of transcriptionally active p53. EMBOJ18: 3054-3063, 1999.
12. Damalas A, Kahan S, Shtutman M, Ben-Ze'ev A and Oren M: Deregulated beta-catenin induces a p53-and ARF-dependent growth arrest and cooperates with Ras in transformation. EMBOJ20: 4912-4922, 2001.
13. Saegusa M, Hashimura M, Kuwata T, Hamano M and OkayasuI: Beta-catenin simultaneously induces activation of the p53-p21WAF1 pathway and overexpression of cyclin D1 during squamous differentiation of endometrial carcinoma cells. Am J Pathol 164: 1739-1749, 2004.
14. Kim K, Pang KM, Evans M and Hay ED: Overexpression of beta-catenin induces apoptosis independent of its transactivation function with LEF-1 or the involvement of major G1 cell cycle regulators. Mol Biol Cell 11: 3509-3523, 2000.
15. Espada J, Pérez-Moreno M, Braga VM, Rodriguez-Viciana P and Cano A: H-Ras activation promotes cytoplasmic accumulation and phosphoinositide 3-OH kinase association of beta-catenin in epidermal keratinocytes. J Cell Biol 146: 967-980, 1999.
16. Willert K, Shibamoto S and Nusse R: Wnt-induced dephosphorylation of axin releases beta-catenin from the axin complex. Genes Dev 13: 1768-1773, 1999.
17. Moon RT, Brown JD and Torres M: WNTs modulate cell fate and behavior during vertebrate development. Trends Genet 13: 157-162, 1997.
18. Miller JR and Moon RT: Signal transduction through beta-catenin and specification of cell fate during embryogenesis. Genes Dev10: 2527-2539, 1996.
19. Ghosh JC and Altieri DC: Activation of p53-dependent apoptosis by acute ablation of glycogen synthase kinase-3beta in colorectal cancer cells. Clin Cancer Res 11: 4580-4588, 2005.
20. Raab MS, Breitkreutz I, Tonon G, et al: Targeting PKC: a novel role for beta-catenin in ER stress and apoptotic signaling. Blood113: 1513-1521, 2009.
21. Li W, Henderson LJ, Major EO and Al-Harthi L: IFN-gamma mediates enhancement of HIV replication in astrocytes by inducing an antagonist of the beta-catenin pathway (DKK1) in a STAT 3-dependent manner. J Immunol 186: 6771-6778, 2011.
22. Li W, Lewis-Antes A, Huang J, Balan M and Kotenko SV: Regulation of apoptosis by type III interferons. Cell Prolif 41: 960-979, 2008.
23. Li W, Huang X, Liu Z, Wang Y, Zhang H, Tong H, Wu H and LinS: Type III interferon induces apoptosis in human lung cancer cells. Oncol Rep 28: 1117-1125, 2012.
24. Olmeda D, Castel S, Vilaro S and Cano A: Beta-catenin regulation during the cell cycle: implications in G2/M and apoptosis. Mol Biol Cell 14: 2844-2860, 2003.
25. Nava P, Koch S, Laukoetter MG, et al: Interferon-gamma regulates intestinal epithelial homeostasis through converging beta-catenin signaling pathways. Immunity 32: 392-402, 2010.
26. Janardhanan R, Banik NL and Ray SK: N-(4-Hydroxyphenyl)retinamide induced differentiation with repression of telomerase and cell cycle to increase interferon-gamma sensitivity for apoptosis in human glioblastoma cells. Cancer Lett 261: 26-36, 2008.
27. Zhang X, Chen W, De Paiva CS, et al: Interferon-gamma exacerbates dry eye-induced apoptosis in conjunctiva through dual apoptotic pathways. Invest Ophthalmol Vis Sci 52: 6279-6285, 2011.
28. Zhang MC, Liu HP, Demchik LL, Zhai YF and Yang DJ: LIGHT sensitizes IFN-gamma-mediated apoptosis of HT-29 human carcinoma cells through both death receptor and mitochondria pathways. Cell Res 14: 117-124, 2004.