Design of experiments-based monitoring of critical quality attributes for the spray-drying process of insulin by NIR spectroscopy

AAPS PharmSciTech

Volumn 13, Issue 3, 2012, Pages 747-755

  Maltesen, Morten Jonas ^a,b   Van De Weert, Marco ^a   Grohganz, Holger ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b NOVOZYMES A S   (Denmark)

Author keywords

moisture content; multivariate analysis; NIR; particle size; spray drying

Indexed keywords

INSULIN; WATER;

ANALYTICAL EQUIPMENT; ARTICLE; CALIBRATION; CONTROLLED STUDY; EXPERIMENTAL DESIGN; MOISTURE; MULTIVARIATE ANALYSIS; NEAR INFRARED SPECTROSCOPY; PARTIAL LEAST SQUARES REGRESSION; PARTICLE SIZE; POWDER; PREDICTIVE VALUE; PRIORITY JOURNAL; QUALITATIVE ANALYSIS; QUALITY CONTROL; REFERENCE DATABASE; SPECTROMETER; SPRAY DRYING; THERMOGRAVIMETRY; TIME OF FLIGHT MASS SPECTROMETRY;

CHEMISTRY, PHARMACEUTICAL; HUMANS; INSULIN; PARTICLE SIZE; QUALITY CONTROL; SPECTROSCOPY, NEAR-INFRARED;

EID: 84866109265     PISSN: None     EISSN: 15309932     Source Type: Journal    
DOI: 10.1208/s12249-012-9796-1     Document Type: Article

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