Determination and differentiation of surface and bound water in drug substances by near infrared spectroscopy

Journal of Pharmaceutical Sciences

Volumn 92, Issue 5, 2003, Pages 1058-1065

  Zhou, George X ^a   Ge, Zhihong ^a   Dorwart, Jason ^a   Izzo, Bill ^a   Kukura, Joseph ^a   Bicker, Gary ^a   Wyvratt, Jean ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Bound water; Free water; Near infrared spectroscopy; On line monitoring; Surface water; Water determination

Indexed keywords

DRUG; M 1; UNCLASSIFIED DRUG;

ARTICLE; CALIBRATION; CRYSTAL STRUCTURE; DIFFERENTIAL SCANNING CALORIMETRY; DRUG ABSORPTION; DRUG MANUFACTURE; DRUG QUALITY; DRUG STRUCTURE; MOISTURE; NEAR INFRARED SPECTROSCOPY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; QUALITY CONTROL; TITRIMETRY; VALIDATION PROCESS; WATER CONTENT; X RAY POWDER DIFFRACTION;

EID: 0037406496     PISSN: 00223549     EISSN: None     Source Type: Journal    
DOI: 10.1002/jps.10375     Document Type: Article

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