-
1
-
-
65449133147
-
Metformin-the gold standard in type 2 diabetes: What does the evidence tell us?
-
Bosi E: Metformin-the gold standard in type 2 diabetes: what does the evidence tell us? Diabetes Obes Metab 11 Suppl 2: 3-8, 2009.
-
(2009)
Diabetes Obes Metab
, vol.11
, Issue.SUPPL. 2
, pp. 3-8
-
-
Bosi, E.1
-
3
-
-
77956821651
-
Metformin action on AMP-activated protein kinase: A translational research approach to understanding a potential new therapeutic target
-
Boyle JG, Salt IP and McKay GA: Metformin action on AMP-activated protein kinase: a translational research approach to understanding a potential new therapeutic target. Diabet Med 27: 1097-1106, 2010.
-
(2010)
Diabet Med
, vol.27
, pp. 1097-1106
-
-
Boyle, J.G.1
Salt, I.P.2
McKay, G.A.3
-
4
-
-
78650677585
-
Metformin reduces cisplatin-mediated apoptotic death of cancer cells through AMPK-independent activation of Akt
-
Janjetovic K, Vucicevic L, Misirkic M, et al: Metformin reduces cisplatin-mediated apoptotic death of cancer cells through AMPK-independent activation of Akt. Eur J Pharmacol 651: 41-50, 2011.
-
(2011)
Eur J Pharmacol
, vol.651
, pp. 41-50
-
-
Janjetovic, K.1
Vucicevic, L.2
Misirkic, M.3
-
5
-
-
77954964776
-
An energetic tale of AMPK-independent effects of metformin
-
Miller RA and Birnbaum MJ: An energetic tale of AMPK-independent effects of metformin. J Clin Invest 120: 2267-2270, 2010.
-
(2010)
J Clin Invest
, vol.120
, pp. 2267-2270
-
-
Miller, R.A.1
Birnbaum, M.J.2
-
6
-
-
10944247187
-
The AMP-activated protein kinase pathway-new players upstream and downstream
-
Hardie DG: The AMP-activated protein kinase pathway-new players upstream and downstream. J Cell Sci 117: 5479-5487, 2004.
-
(2004)
J Cell Sci
, vol.117
, pp. 5479-5487
-
-
Hardie, D.G.1
-
7
-
-
77955923866
-
Metformin: Taking away the candy for cancer?
-
Jalving M, Gietema JA, Lefrandt JD, et al: Metformin: taking away the candy for cancer? Eur J Cancer 46: 2369-2380, 2010.
-
(2010)
Eur J Cancer
, vol.46
, pp. 2369-2380
-
-
Jalving, M.1
Gietema, J.A.2
Lefrandt, J.D.3
-
8
-
-
78650316639
-
Metformin for aging and cancer prevention
-
Anisimov VN: Metformin for aging and cancer prevention. Aging (Albany NY) 2: 760-774, 2010.
-
(2010)
Aging (Albany NY)
, vol.2
, pp. 760-774
-
-
Anisimov, V.N.1
-
10
-
-
77949703788
-
Metformin: A therapeutic opportunity in breast cancer
-
Gonzalez-Angulo AM and Meric-Bernstam F: Metformin: a therapeutic opportunity in breast cancer. Clin Cancer Res 16: 1695-1700, 2010.
-
(2010)
Clin Cancer Res
, vol.16
, pp. 1695-1700
-
-
Gonzalez-Angulo, A.M.1
Meric-Bernstam, F.2
-
11
-
-
84864371674
-
Metformin and cancer: New applications for an old drug
-
Kourelis TV and Siegel RD: Metformin and cancer: new applications for an old drug. Med Oncol 29: 1314-1327, 2012.
-
(2012)
Med Oncol
, vol.29
, pp. 1314-1327
-
-
Kourelis, T.V.1
Siegel, R.D.2
-
12
-
-
77956401999
-
Metformin and other biguanides in oncology: Advancing the research agenda
-
Pollak M: Metformin and other biguanides in oncology: advancing the research agenda. Cancer Prev Res (Phila) 3: 1060-1065, 2010.
-
(2010)
Cancer Prev Res (Phila)
, vol.3
, pp. 1060-1065
-
-
Pollak, M.1
-
13
-
-
77956411030
-
Metformin suppresses colorectal aberrant crypt foci in a short-term clinical trial
-
Hosono K, Endo H, Takahashi H, et al: Metformin suppresses colorectal aberrant crypt foci in a short-term clinical trial. Cancer Prev Res (Phila) 3: 1077-1083, 2010.
-
(2010)
Cancer Prev Res (Phila)
, vol.3
, pp. 1077-1083
-
-
Hosono, K.1
Endo, H.2
Takahashi, H.3
-
14
-
-
65749100582
-
Drug interactions at the blood-brain barrier: Fact or fantasy?
-
Eyal S, Hsiao P and Unadkat JD: Drug interactions at the blood-brain barrier: fact or fantasy? Pharmacol Ther 123: 80-104, 2009.
-
(2009)
Pharmacol Ther
, vol.123
, pp. 80-104
-
-
Eyal, S.1
Hsiao, P.2
Unadkat, J.D.3
-
15
-
-
74949096470
-
AMPK: A metabolic checkpoint that regulates the growth of EGFR activated glioblastomas
-
Guo D, Cloughesy TF, Radu CG and Mischel PS: AMPK: A metabolic checkpoint that regulates the growth of EGFR activated glioblastomas. Cell Cycle 9: 211-212, 2010.
-
(2010)
Cell Cycle
, vol.9
, pp. 211-212
-
-
Guo, D.1
Cloughesy, T.F.2
Radu, C.G.3
Mischel, P.S.4
-
16
-
-
34249069215
-
Dual antiglioma action of metformin: Cell cycle arrest and mitochondria-dependent apoptosis
-
Isakovic A, Harhaji L, Stevanovic D, et al: Dual antiglioma action of metformin: cell cycle arrest and mitochondria-dependent apoptosis. Cell Mol Life Sci 64: 1290-1302, 2007.
-
(2007)
Cell Mol Life Sci
, vol.64
, pp. 1290-1302
-
-
Isakovic, A.1
Harhaji, L.2
Stevanovic, D.3
-
17
-
-
27944501189
-
Glycolytic glioma cells with active glycogen synthase are sensitive to PTEN and inhibitors of PI3K and gluconeogenesis
-
Beckner ME, Gobbel GT, Abounader R, et al: Glycolytic glioma cells with active glycogen synthase are sensitive to PTEN and inhibitors of PI3K and gluconeogenesis. Lab Invest 85: 1457-1470, 2005.
-
(2005)
Lab Invest
, vol.85
, pp. 1457-1470
-
-
Beckner, M.E.1
Gobbel, G.T.2
Abounader, R.3
-
18
-
-
27744497128
-
Leptin: Structure, function and biology
-
Zhang F, Chen Y, Heiman M and Dimarchi R: Leptin: structure, function and biology. Vitam Horm 71: 345-372, 2005.
-
(2005)
Vitam Horm
, vol.71
, pp. 345-372
-
-
Zhang, F.1
Chen, Y.2
Heiman, M.3
Dimarchi, R.4
-
19
-
-
78649347074
-
Leptin-based therapeutics
-
Scolaro L, Cassone, M, Kolaczynski, JW, Otvos L Jr and SurmaczE: Leptin-based therapeutics. Expert Rev Endocrinol Metab 5: 875-889, 2010.
-
(2010)
Expert Rev Endocrinol Metab
, vol.5
, pp. 875-889
-
-
Scolaro, L.1
Cassone, M.2
Kolaczynski, J.W.3
Otvos Jr., L.4
Surmacz, E.5
-
20
-
-
75949101329
-
Leptin and its receptor are overexpressed in brain tumors and correlate with the degree of malignancy
-
Riolfi M, Ferla R, Del Valle L, et al: Leptin and its receptor are overexpressed in brain tumors and correlate with the degree of malignancy. Brain Pathol 20: 481-489, 2010.
-
(2010)
Brain Pathol
, vol.20
, pp. 481-489
-
-
Riolfi, M.1
Ferla, R.2
Del Valle, L.3
-
22
-
-
66249136720
-
Leptin induces migration and invasion of glioma cells through MMP-13 production
-
Yeh WL, Lu DY, Lee MJ and Fu WM: Leptin induces migration and invasion of glioma cells through MMP-13 production. Glia 57: 454-464, 2009.
-
(2009)
Glia
, vol.57
, pp. 454-464
-
-
Yeh, W.L.1
Lu, D.Y.2
Lee, M.J.3
Fu, W.M.4
-
23
-
-
50049091255
-
AMPK: A key regulator of energy balance in the single cell and the whole organism
-
Hardie DG: AMPK: a key regulator of energy balance in the single cell and the whole organism. Int J Obes (Lond) 32 (Suppl4): S7-S12, 2008.
-
(2008)
Int J Obes (Lond)
, vol.32
, Issue.SUPPL. 4
-
-
Hardie, D.G.1
-
24
-
-
77949462458
-
AMPK as a metabolic tumor suppressor: Control of metabolism and cell growth
-
Luo Z, Zang M and Guo W: AMPK as a metabolic tumor suppressor: control of metabolism and cell growth. Future Oncol 6: 457-470, 2010.
-
(2010)
Future Oncol
, vol.6
, pp. 457-470
-
-
Luo, Z.1
Zang, M.2
Guo, W.3
-
25
-
-
68549128622
-
Insulin-sensitising drugs (metformin, rosiglitazone, pioglitazone, D-chiro-inositol) for women with polycystic ovary syndrome, oligo amenorrhoea and subfertility
-
Tang T, Lord JM, Norman RJ, Yasmin E and Balen AH: Insulin-sensitising drugs (metformin, rosiglitazone, pioglitazone, D-chiro-inositol) for women with polycystic ovary syndrome, oligo amenorrhoea and subfertility. Cochrane Database Syst Rev CD003053, 2009.
-
(2009)
Cochrane Database Syst Rev CD003053
-
-
Tang, T.1
Lord, J.M.2
Norman, R.J.3
Yasmin, E.4
Balen, A.H.5
-
26
-
-
77957867584
-
Effect of additional inhibition of human epidermal growth factor receptor 2 with the bispecific tyrosine kinase inhibitor AEE788 on the resistance to specific EGFR inhibition in glioma cells
-
Berezowska S, Diermeier-Daucher S, Brockhoff G, et al: Effect of additional inhibition of human epidermal growth factor receptor 2 with the bispecific tyrosine kinase inhibitor AEE788 on the resistance to specific EGFR inhibition in glioma cells. Int J Mol Med 26: 713-721, 2010.
-
(2010)
Int J Mol Med
, vol.26
, pp. 713-721
-
-
Berezowska, S.1
Diermeier-Daucher, S.2
Brockhoff, G.3
-
27
-
-
69149097363
-
The AMPK agonist AICAR inhibits the growth of EGFRvIII-expressing glioblastomas by inhibiting lipogenesis
-
Guo D, Hildebrandt IJ, Prins RM, et al: The AMPK agonist AICAR inhibits the growth of EGFRvIII-expressing glioblastomas by inhibiting lipogenesis. Proc Natl Acad Sci USA 106: 12932-12937, 2009.
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 12932-12937
-
-
Guo, D.1
Hildebrandt, I.J.2
Prins, R.M.3
-
28
-
-
77957584391
-
Clinical significance of molecular biomarkers in glioblastoma
-
Ang C, Guiot MC, Ramanakumar AV, Roberge D and Kavan P: Clinical significance of molecular biomarkers in glioblastoma. Can J Neurol Sci 37: 625-630, 2010.
-
(2010)
Can J Neurol Sci
, vol.37
, pp. 625-630
-
-
Ang, C.1
Guiot, M.C.2
Ramanakumar, A.V.3
Roberge, D.4
Kavan, P.5
-
29
-
-
34248136479
-
Inhibition of both focal adhesion kinase and insulin-like growth factor-I receptor kinase suppresses glioma proliferation in vitro and in vivo
-
Liu TJ, LaFortune T, Honda T, et al: Inhibition of both focal adhesion kinase and insulin-like growth factor-I receptor kinase suppresses glioma proliferation in vitro and in vivo. Mol Cancer Ther 6: 1357-1367, 2007.
-
(2007)
Mol Cancer Ther
, vol.6
, pp. 1357-1367
-
-
Liu, T.J.1
LaFortune, T.2
Honda, T.3
-
30
-
-
0034730944
-
The Akt/protein kinase B-dependent anti-apoptotic pathway and the mitogen-activated protein kinase cascade are alternatively activated in human glioblastoma multiforme
-
Schlegel J, Piontek G, Budde B, Neff F and Kraus A: The Akt/protein kinase B-dependent anti-apoptotic pathway and the mitogen-activated protein kinase cascade are alternatively activated in human glioblastoma multiforme. Cancer Lett 158: 103-108, 2000.
-
(2000)
Cancer Lett
, vol.158
, pp. 103-108
-
-
Schlegel, J.1
Piontek, G.2
Budde, B.3
Neff, F.4
Kraus, A.5
-
32
-
-
77955770568
-
Metformin and rapamycin have distinct effects on the AKT pathway and proliferation in breast cancer cells
-
Zakikhani M, Blouin MJ, Piura E and Pollak MN: Metformin and rapamycin have distinct effects on the AKT pathway and proliferation in breast cancer cells. Breast Cancer Res Treat 123: 271-279, 2010.
-
(2010)
Breast Cancer Res Treat
, vol.123
, pp. 271-279
-
-
Zakikhani, M.1
Blouin, M.J.2
Piura, E.3
Pollak, M.N.4
-
33
-
-
65349175605
-
Metformin inhibits breast cancer cell growth, colony formation and induces cell cycle arrest in vitro
-
Alimova IN, Liu B, Fan Z, et al: Metformin inhibits breast cancer cell growth, colony formation and induces cell cycle arrest in vitro. Cell Cycle 8: 909-915, 2009.
-
(2009)
Cell Cycle
, vol.8
, pp. 909-915
-
-
Alimova, I.N.1
Liu, B.2
Fan, Z.3
-
34
-
-
33646812555
-
Long-term metformin treatment stimulates cardiomyocyte glucose transport through an AMP-activated protein kinase-dependent reduction in GLUT4 endocytosis
-
Yang J and Holman GD: Long-term metformin treatment stimulates cardiomyocyte glucose transport through an AMP-activated protein kinase-dependent reduction in GLUT4 endocytosis. Endocrinology 147: 2728-2736, 2006.
-
(2006)
Endocrinology
, vol.147
, pp. 2728-2736
-
-
Yang, J.1
Holman, G.D.2
-
35
-
-
25844487061
-
Metformin alters insulin signaling and viability of human granulosa cells
-
Sonntag B, Gotte M, Wulfing P, Schuring AN, Kiesel L and GrebRR: Metformin alters insulin signaling and viability of human granulosa cells. Fertil Steril 84 Suppl 2: 1173-1179, 2005.
-
(2005)
Fertil Steril
, vol.84
, Issue.SUPPL. 2
, pp. 1173-1179
-
-
Sonntag, B.1
Gotte, M.2
Wulfing, P.3
Schuring, A.N.4
Kiesel, L.5
Greb, R.R.6
|