Nuclear HSP90 regulates the glucocorticoid responsiveness of PBMCs in patients with idiopathic nephrotic syndrome

International Immunopharmacology

Volumn 14, Issue 3, 2012, Pages 334-340

  Ouyang, Juan ^a   Chen, Peisong ^a   Jiang, Tang ^a   Chen, Yili ^a   Li, Junxun ^a  

^a THE FIRST AFFILIATED HOSPITAL OF SUN YAT SEN UNIVERSITY   (China)

Author keywords

Glucocorticoid receptor; Glucocorticoid resistance; Heat shock protein 90; Idiopathic nephrotic syndrome

Indexed keywords

DNA; GLUCOCORTICOID; HEAT SHOCK PROTEIN 90; INTERLEUKIN 6; PREDNISONE;

ADULT; ARTICLE; BLOOD SAMPLING; CELL NUCLEUS; CLINICAL ARTICLE; DNA BINDING; DRUG DOSE REDUCTION; FEMALE; FLOW CYTOMETRY; GEL MOBILITY SHIFT ASSAY; HUMAN; IMMUNOPRECIPITATION; IN VITRO STUDY; MALE; MOLECULAR INTERACTION; MORNING DOSAGE; NEPHROTIC SYNDROME; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA EXTRACTION; TRANSACTIVATION; UPREGULATION; WESTERN BLOTTING;

ADULT; CELL NUCLEUS; CELLS, CULTURED; DNA; DRUG RESISTANCE; FEMALE; GLUCOCORTICOIDS; HSP90 HEAT-SHOCK PROTEINS; HUMANS; INTERLEUKIN-6; LEUKOCYTES, MONONUCLEAR; MALE; NEPHROTIC SYNDROME; RNA, MESSENGER; YOUNG ADULT;

EID: 84866105906     PISSN: 15675769     EISSN: 18781705     Source Type: Journal    
DOI: 10.1016/j.intimp.2012.08.012     Document Type: Article

References (29)

1. P.J. Barnes, and I.M. Adcock Glucocorticoid resistance in inflammatory diseases Lancet 373 2009 1905 1917
2. E.F. van Rossum, and E.L. van den Akker Glucocorticoid resistance Endocr Dev 20 2011 127 136
3. T. Kino, E. Charmandari, and G.P. Chrousos Glucocorticoid receptor: implications for rheumatic diseases Clin Exp Rheumatol 29 2011 S32 S41
4. S.D. Hearing, M. Norman, C. Smyth, C. Foy, and C.M. Dayan Wide variation in lymphocyte steroid sensitivity among healthy human volunteers J Clin Endocrinol Metab 84 1999 4149
5. K.N. Priftis, A. Papadimitriou, M.B. Anthracopoulos, A. Fretzayas, and G.P. Chrousos Endocrine-immune interactions in adrenal function of asthmatic children on inhaled corticosteroids Neuroimmunomodulation 16 2009 333 339
6. P. Chen, T. Jiang, J. Ouyang, Y. Cui, and Y. Chen Epigenetic programming of diverse glucocorticoid response and inflammatory/immune-mediated disease Med Hypotheses 73 2009 657 658
7. M.N. Silverman, and E.M. Sternberg Neuroendocrine-immune interactions in rheumatoid arthritis: mechanisms of glucocorticoid resistance Neuroimmunomodulation 15 2008 19 28
8. E. Charmandari, T. Kino, T. Ichijo, and G.P. Chrousos Generalized glucocorticoid resistance: clinical aspects, molecular mechanisms, and implications of a rare genetic disorder J Clin Endocrinol Metab 93 2008 1563 1572
9. I. Grad, and D. Picard The glucocorticoid responses are shaped by molecular chaperones Mol Cell Endocrinol 275 2007 2 12
10. J. Ouyang, T. Jiang, M. Tan, Y. Cui, and X. Li Abnormal expression and distribution of heat shock protein 90: potential etiologic immunoendocrine mechanism of glucocorticoid resistance in idiopathic nephrotic syndrome Clin Vaccine Immunol 13 2006 496 500
11. I.M. Adcock, S.J. Lane, C.R. Brown, M.J. Peters, T.H. Lee, and P.J. Barnes Differences in binding of glucocorticoid receptor to DNA in steroid-resistant asthma J Immunol 154 1995 3500 3505
12. Z. Fan, G. Tardif, D. Hum, N. Duval, J.P. Pelletier, and J. Martel-Pelletier Hsp90{beta} and p130(cas): novel regulatory factors of MMP-13 expression in human osteoarthritic chondrocytes Ann Rheum Dis 6 2009 976 982
13. T.D. Schmittgen, and K.J. Livak Analyzing real-time PCR data by the comparative C(T) method Nat Protoc 6 2008 1101 1108
14. M. Motojima, T. Ando, and T. Yoshioka Sp1-like activity mediates angiotensin-II-induced plasminogen-activator inhibitor type-1 (PAI-1) gene expression in mesangial cells Biochem J 349 2000 435
15. H. Tanaka, Y. Dong, Q.I.A. Li, S. Okret, and J.A. Gustafsson Identification and characterization of a cis-acting element that interferes with glucocorticoid-inducible activation of the mouse mammary tumor virus promoter Proc Natl Acad Sci 88 1991 5393
16. A. Stephanou, V. Amin, D.A. Isenberg, S. Akira, T. Kishimoto, and D.S. Latchman Interleukin 6 activates heat-shock protein 90 beta gene expression Biochem J 321 Pt 1 1997 103 106
17. F. Ramirez, and D. Mason Induction of resistance to active experimental allergic encephalomyelitis by myelin basic protein-specific Th2 cell lines generated in the presence of glucocorticoids and IL-4 Eur J Immunol 30 2000 747 758
18. D. Haack, K. Schärer, A. Asam-Tauscher, and P. Vecsei Glucocorticoid receptors in idiopathic nephrotic syndrome Pediatr Nephrol 13 1999 653 656
19. B.C. Freeman, and K.R. Yamamoto Disassembly of transcriptional regulatory complexes by molecular chaperones Science 296 2002 2232 2235
20. M. Bronnegard, J. Boos, C. Marcus, J. McGuire, S. Werner, and J.A. Gustafsson Expression of hsp90 beta messenger ribonucleic acid in patients with familial glucocorticoid resistance - correlation to receptor status J Steroid Biochem Mol Biol 52 1995 345 349
21. M. Matysiak, B. Makosa, A. Walczak, and K. Selmaj Patients with multiple sclerosis resisted to glucocorticoid therapy: abnormal expression of heat-shock protein 90 in glucocorticoid receptor complex Mult Scler 14 2008 919 926
22. R.N. Liu, and Z. Huang Expression of heat shock protein 90 in peripheral blood mononuclear cells of children with myasthenia gravis Zhongguo Dang Dai Er Ke Za Zhi 11 2009 453 455
23. M. Lauten, C. Beger, K. Gerdes, G. Asgedom, C. Kardinal, and K. Welte Expression of heat-shock protein 90 in glucocorticoid-sensitive and -resistant childhood acute lymphoblastic leukaemia Leukemia 17 2003 1551 1556
24. D.A. Stavreva, W.G. Müller, G.L. Hager, C.L. Smith, and J.G. McNally Rapid glucocorticoid receptor exchange at a promoter is coupled to transcription and regulated by chaperones and proteasomes Mol Cell Biol 24 2004 2682 2697
25. W.B. Pratt, M.D. Galigniana, J.M. Harrell, and D.B. DeFranco Role of hsp90 and the hsp90-binding immunophilins in signalling protein movement Cell Signal 16 2004 857 872
26. L.I. Gallo, A.A. Ghini, G.P. Pilipuk, and M.D. Galigniana Differential recruitment of tetratricorpeptide repeat domain immunophilins to the mineralocorticoid receptor influences both heat-shock protein 90-dependent retrotransport and hormone-dependent transcriptional activity Biochemistry 46 2007 14044 14057
27. M.D. Galigniana, P.C. Echeverría, A.G. Erlejman, and G. Piwien-Pilipuk Role of molecular chaperones and TPR-domain proteins in the cytoplasmic transport of steroid receptors and their passage through the nuclear pore Nucleus (Austin, Tex) 1 2010 299
28. B.L. Conway-Campbell, C.L. George, J.R. Pooley, D.M. Knight, M.R. Norman, and G.L. Hager The HSP90 molecular chaperone cycle regulates cyclical transcriptional dynamics of the glucocorticoid receptor and its coregulatory molecules CBP/p300 during ultradian ligand treatment Mol Endocrinol 25 2011 944 954
29. K.I. Kang, X. Meng, J. Devin-Leclerc, I. Bouhouche, A. Chadli, and F. Cadepond The molecular chaperone Hsp90 can negatively regulate the activity of a glucocorticosteroid-dependent promoter Proc Natl Acad Sci U S A 96 1999 1439 1444