Epigenetic programming of diverse glucocorticoid response and inflammatory/immune-mediated disease

Medical Hypotheses

Volumn 73, Issue 5, 2009, Pages 657-658

  Chen, Peisong ^a   Jiang, Tang ^a   Ouyang, Juan ^a   Cui, Yingpeng ^a   Chen, Yili ^a  

^a SUN YAT SEN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

AUTACOID; CELL ADHESION MOLECULE; CYTOKINE; GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR;

ARTICLE; ENVIRONMENTAL FACTOR; EPIGENETICS; HOMEOSTASIS; HUMAN; IMMUNE SYSTEM; IMMUNOCOMPETENT CELL; IMMUNOPATHOLOGY; INFLAMMATION; LIFE EVENT; METHYLATION; PATHOGENESIS; PATHOPHYSIOLOGY; PREVALENCE; PRIORITY JOURNAL; PROMOTER REGION; STRESS;

DNA METHYLATION; EPIGENESIS, GENETIC; HUMANS; IMMUNE SYSTEM DISEASES; INFLAMMATION; MODELS, THEORETICAL; PROMOTER REGIONS, GENETIC; RECEPTORS, GLUCOCORTICOID;

EID: 70349755367     PISSN: 03069877     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mehy.2009.08.013     Document Type: Article

References (18)

1. Barnes P.J., and Adcock I.M. Glucocorticoid resistance in inflammatory diseases. Lancet 373 9678 (2009) 1905-1917
2. Silverman M.N., and Sternberg E.M. Neuroendocrine-immune interactions in rheumatoid arthritis: mechanisms of glucocorticoid resistance. Neuroimmunomodulation 15 1 (2008) 19-28
3. Webster J.I., Tonelli L., and Sternberg E.M. Neuroendocrine regulation of immunity. Annu Rev Immunol 20 (2002) 125-163
4. Hearing S.D., et al. Wide variation in lymphocyte steroid sensitivity among healthy human volunteers. J Clin Endocrinol Metab 84 11 (1999) 4149-4154
5. Ouyang J., et al. Abnormal expression and distribution of heat shock protein 90: potential etiologic immunoendocrine mechanism of glucocorticoid resistance in idiopathic nephrotic syndrome. Clin Vaccine Immunol 13 4 (2006) 496-500
6. Jiang T., et al. The phase-shift mutation in the glucocorticoid receptor gene: potential etiologic significance of neuroendocrine mechanisms in lupus nephritis. Clin Chim Acta 313 1-2 (2001) 113-117
7. Turner J.D., and Muller C.P. Structure of the glucocorticoid receptor (NR3C1) gene 5′ untranslated region: identification, and tissue distribution of multiple new human exon 1. J Mol Endocrinol 35 2 (2005) 283-292
8. Presul E., et al. Identification, tissue expression, and glucocorticoid responsiveness of alternative first exons of the human glucocorticoid receptor. J Mol Endocrinol 38 1-2 (2007) 79-90
9. Geng C.D., and Vedeckis W.V. Steroid-responsive sequences in the human glucocorticoid receptor gene 1A promoter. Mol Endocrinol 18 4 (2004) 912-924
10. Purton J.F., et al. Expression of the glucocorticoid receptor from the 1A promoter correlates with T lymphocyte sensitivity to glucocorticoid-induced cell death. J Immunol 173 6 (2004) 3816-3824
11. Pedersen K.B., Geng C.D., and Vedeckis W.V. Three mechanisms are involved in glucocorticoid receptor autoregulation in a human T-lymphoblast cell line. Biochemistry 43 34 (2004) 10851-10858
12. Russcher H., et al. Associations between promoter usage and alternative splicing of the glucocorticoid receptor gene. J Mol Endocrinol 38 1-2 (2007) 91-98
13. Turner J.D., et al. Highly individual methylation patterns of alternative glucocorticoid receptor promoters suggest individualized epigenetic regulatory mechanisms. Nucleic Acids Res 36 22 (2008) 7207-7218
14. Oberlander T.F., et al. Prenatal exposure to maternal depression, neonatal methylation of human glucocorticoid receptor gene (NR3C1) and infant cortisol stress responses. Epigenetics 3 2 (2008) 97-106
15. Wilber A.A., Southwood C.J., and Wellman C.L. Brief neonatal maternal separation alters extinction of conditioned fear and corticolimbic glucocorticoid and NMDA receptor expression in adult rats. Dev Neurobiol 69 2-3 (2009) 73-87
16. van Bel F., and Heijnen C.J. Perinatal programming and reprogramming by glucocorticoid therapy and perinatal stress. Semin Fetal Neonatal Med 14 3 (2009) 127-129
17. McGowan P.O., et al. Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse. Nat Neurosci 12 3 (2009) 342-348
18. Lillycrop K.A., et al. Induction of altered epigenetic regulation of the hepatic glucocorticoid receptor in the offspring of rats fed a protein-restricted diet during pregnancy suggests that reduced DNA methyltransferase-1 expression is involved in impaired DNA methylation and changes in histone modifications. Br J Nutr 97 6 (2007) 1064-1073