Two-stage bottom-up tiered approach combining several alternatives for identification of eye irritation potential of chemicals including insoluble or volatile substances

Toxicology in Vitro

Volumn 26, Issue 7, 2012, Pages 1199-1208

  Hayashi, Kazuhiko ^a   Mori, Taeko ^a   Abo, Takayuki ^a   Ooshima, Kenichi ^b   Hayashi, Takumi ^b   Komano, Tomoko ^b   Takahashi, Yutaka ^a   Sakaguchi, Hitoshi ^a   Takatsu, Akihiko ^b   Nishiyama, Naohiro ^a  

^a KAO CORPORATION   (Japan)

^b KANEBO LTD   (Japan)

Author keywords

BCOP; EpiOcular; Eye irritation; HET CAM; STE; Tiered approach

Indexed keywords

ALCOHOL DERIVATIVE; CHEMICAL COMPOUND; ESTER DERIVATIVE; SURFACTANT; VOLATILE AGENT;

ACCURACY; ARTICLE; BOVINE CORNEAL OPACITY AND PERMEABILITY ASSAY; EPIOCULAR ASSAY; EYE IRRITATION; FALSE NEGATIVE RESULT; FALSE POSITIVE RESULT; HEN EGG TEST CHORIOALLANTOIC MEMBRANE ASSAY; PREDICTIVE VALUE; SENSITIVITY AND SPECIFICITY; SHORT TIME EXPOSURE TEST; TOXICITY TESTING; VAPOR PRESSURE;

ANIMAL TESTING ALTERNATIVES; ANIMALS; CATTLE; CELL LINE; CELL SURVIVAL; CHORIOALLANTOIC MEMBRANE; CORNEA; CORNEAL OPACITY; EYE; IRRITANTS; PREDICTIVE VALUE OF TESTS; REPRODUCIBILITY OF RESULTS; RESEARCH DESIGN; SOLUBILITY; TOXICITY TESTS, ACUTE; VOLATILE ORGANIC COMPOUNDS; VOLATILIZATION;

BOVINAE; ORYCTOLAGUS CUNICULUS;

EID: 84866089501     PISSN: 08872333     EISSN: 18793177     Source Type: Journal    
DOI: 10.1016/j.tiv.2012.06.008     Document Type: Article

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