Alveolar macrophage activation and an emphysema-like phenotype in adiponectin-deficient mice

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 294, Issue 6, 2008, Pages

  Summer, R ^a   Little, F F ^a   Ouchi, N ^a   Takemura, Y ^a   Aprahamian, T ^a   Dwyer, D ^a   Fitzsimmons, K ^a   Suki, B ^b   Parameswaran, H ^b   Fine, A ^a   Walsh, K ^a  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Boston University   (United States)

Author keywords

Collectin; Lung; Matrix metalloproteinases

Indexed keywords

ADIPONECTIN; GELATINASE A; GELATINASE B; MACROPHAGE ELASTASE; TUMOR NECROSIS FACTOR ALPHA; MATRIX METALLOPROTEINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME ACTIVITY; INFLAMMATION; LUNG ALVEOLUS MACROPHAGE; LUNG EMPHYSEMA; LUNG FLUID; MACROPHAGE ACTIVATION; MEDIATOR RELEASE; MOUSE; NONHUMAN; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; ANIMAL; C57BL MOUSE; CHEMISTRY; DRUG EFFECT; EMPHYSEMA; LUNG; LUNG LAVAGE; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; SECRETION;

ADIPONECTIN; ANIMALS; BRONCHOALVEOLAR LAVAGE FLUID; EMPHYSEMA; LUNG; MACROPHAGES, ALVEOLAR; MATRIX METALLOPROTEINASES; MICE; MICE, INBRED C57BL; PHENOTYPE; TUMOR NECROSIS FACTOR-ALPHA;

EID: 48949119345     PISSN: 10400605     EISSN: 15221504     Source Type: Journal    
DOI: 10.1152/ajplung.00397.2007     Document Type: Article

References (60)

1. Berg AH, Combs TP, Du X, Brownlee M, Scherer PE. The adipocyte-secreted protein Acrp30 enhances hepatic insulin action. Nat Med 7: 947-953, 2001.
2. Bergen HT, Cherlet TC, Manuel P, Scott JE. Identification of leptin receptors in lung and isolated fetal type II cells. Am J Respir Cell Mol Biol 27: 71-77, 2002.
3. Botas C, Poulain F, Akiyama J, Brown C, Allen L, Goerke J, Clements J, Carlson E, Gillespie AM, Epstein C, Hawgood S. Altered surfactant homeostasis and alveolar type II cell morphology in mice lacking surfactant protein D. Proc Natl Acad Sci USA 95: 11869-11874, 1998.
4. Chen Y, Dales R, Jiang Y. The association between obesity and asthma is stronger in nonallergic than allergic adults. Chest 130: 890-895, 2006.
5. Chen Y, Dales R, Tang M, Krewski D. Obesity may increase the incidence of asthma in women but not in men: longitudinal observations from the Canadian National Population Health Surveys. Am J Epidemiol 155: 191-197, 2002.
6. Chinard FP. Quantitative assessment of epithelial lining fluid in the lung. Am J Physiol Lung Cell Mol Physiol 263: L617-L618, 1992.
7. Chinetti G, Zawadski C, Fruchart JC, Staels B. Expression of adiponectin receptors in human macrophages and regulation by agonists of the nuclear receptors PPARalpha, PPARgamma, and LXR. Biochem Biophys Res Commun 314: 151-158, 2004.
8. Churg A, Dai J, Tai H, Xie C, Wright JL. Tumor necrosis factor-alpha is central to acute cigarette smoke-induced inflammation and connective tissue breakdown. Am J Respir Crit Care Med 166: 849-854, 2002.
9. Churg A, Wang RD, Tai H, Wang X, Xie C, Wright JL. Tumor necrosis factor-alpha drives 70% of cigarette smoke-induced emphysema in the mouse. Am J Respir Crit Care Med 170: 492-498, 2004.
10. Coxson HO, Chan IH, Mayo JR, Hlynsky J, Nakano Y, Birmingham CL. Early emphysema in patients with anorexia nervosa. Am J Respir Crit Care Med 170: 748-752, 2004.
11. Demedts IK, Demoor T, Bracke KR, Joos GF, Brusselle GG. Role of apoptosis in the pathogenesis of COPD and pulmonary emphysema. Respir Res 7: 53, 2006.
12. Greenlee KJ, Werb Z, Kheradmand F. Matrix metalloproteinases in lung: multiple, multifarious, and multifaceted. Physiol Rev 87: 69-98, 2007.
13. Gueders MM, Foidart JM, Noel A, Cataldo DD. Matrix metalloproteinases (MMPs) and tissue inhibitors of MMPs in the respiratory tract: potential implications in asthma and other lung diseases. Eur J Pharmacol 533: 133-144, 2006.
14. Gultekin FA, Kerem M, Tatlicioglu E, Aricioglu A, Unsal C, Bukan N. Leptin treatment ameliorates acute lung injury in rats with ceruleininduced acute pancreatitis. World J Gastroenterol 13: 2932-2938, 2007.
15. Hautamaki RD, Kobayashi DK, Senior RM, Shapiro SD. Requirement for macrophage elastase for cigarette smoke-induced emphysema in mice. Science 277: 2002-2004, 1997.
16. Hu E, Liang P, Spiegelman BM. AdipoQ is a novel adipose-specific gene dysregulated in obesity. J Biol Chem 271: 10697-10703, 1996.
17. Inselma LS, Milanese A, Deurloo A. Effect of obesity on pulmonary function in children. Pediatr Pulmonol 16: 130-137, 1993.
18. Inselman LS, Padilla-Burgos LB, Teichberg S, Spencer H. Alveolar enlargement in obesity-induced hyperplastic lung growth. J Appl Physiol 65: 2291-2296, 1988.
19. Inselman LS, Wapnir RA, Spencer H. Obesity-induced hyperplastic lung growth. Am Rev Respir Dis 135: 613-616, 1987.
20. Kadowaki T, Yamauchi T, Kubota N, Hara K, Ueki K, Tobe K. Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome. J Clin Invest 116: 1784-1792, 2006.
21. Karlinsky JB, Goldstein RH, Ojserkis B, Snider GL. Lung mechanics and connective tissue levels in starvation-induced emphysema in hamsters. Am J Physiol Regul Integr Comp Physiol 251: R282-R288, 1986.
22. Katagiri H, Yamada T, Oka Y. Adiposity and cardiovascular disorders: disturbance of the regulatory system consisting of humoral and neuronal signals. Circ Res 101: 27-39, 2007.
23. Kononov S, Brewer K, Sakai H, Cavalcante FS, Sabayanagam CR, Ingenito EP, Suki B. Roles of mechanical forces and collagen failure in the development of elastase-induced emphysema. Am J Respir Crit Care Med 164: 1920-1926, 2001.
24. Lau DC, Dhillon B, Yan H, Szmitko PE, Verma S. Adipokines: molecular links between obesity and atherosclerosis. Am J Physiol Heart Circ Physiol 288: H2031-H2041, 2005.
25. Lohmann-Matthes ML, Steinmuller C, Franke-Ullmann G. Pulmonary macrophages. Eur Respir J 7: 1678-1689, 1994.
26. Lomas DA, Evans DL, Finch JT, Carrell RW. The mechanism of Z. alpha 1-antitrypsin accumulation in the liver. Nature 357: 605-607, 1992.
27. Maeda K, Okubo K, Shimomura I, Funahashi T, Matsuzawa Y, Matsubara K. cDNA cloning and expression of a novel adipose specific collagen-like factor, apM1 (adipose most abundant gene transcript 1). Biochem Biophys Res Commun 221: 286-289, 1996.
28. Maeda N, Shimomura I, Kishida K, Nishizawa H, Matsuda M, Nagaretani H, Furuyama N, Kondo H, Takahashi M, Arita Y, Komuro R, Ouchi N, Kihara S, Tochino Y, Okutomi K, Horie M, Takeda S, Aoyama T, Funahashi T, Matsuzawa Y. Diet-induced insulin resistance in mice lacking adiponectin/ACRP30. Nat Med 8: 731-737, 2002.
29. Ouchi N, Kihara S, Funahashi T, Matsuzawa Y, Walsh K. Obesity, adiponectin and vascular inflammatory disease. Curr Opin Lipidol 14: 561-566, 2003.
30. Ouchi N, Walsh K. Adiponectin as an anti-inflammatory factor. Clin Chim Acta 380: 24-30, 2007.
31. Parameswaran H, Majumdar A, Ito S, Alencar AM, Suki B. Quantitative characterization of air space enlargement in emphysema. J Appl Physiol 100: 186-193, 2006.
32. Park PH, McMullen MR, Huang H, Thakur V, Nagy LE. Short-term treatment of RAW264.7 macrophages with adiponectin increases TNF-alpha expression via ERK1/2 activation and Egr-1 expression: role of TNF-alpha in adiponectin-stimulated IL-10 production. J Biol Chem 282: 21695-21703, 2007.
33. Rajala MW, Scherer PE. Minireview: the adipocyte-at the crossroads of energy homeostasis, inflammation, and atherosclerosis. Endocrinology 144: 3765-3773, 2003.
34. Ray CS, Sue DY, Bray G, Hansen JE, Wasserman K. Effects of obesity on respiratory function. Am Rev Respir Dis 128: 501-506, 1983.
35. Ruan H, Lodish HF. Regulation of insulin sensitivity by adipose tissue-derived hormones and inflammatory cytokines. Curr Opin Lipidol 15: 297-302, 2004.
36. Sahebjami H, Vassallo CL, Wirman JA. Lung mechanics and ultrastructure in prolonged starvation. Am Rev Respir Dis 117: 77-83, 1978.
37. Sahebjami H, Wirman JA. Emphysema-like changes in the lungs of starved rats. Am Rev Respir Dis 124: 619-624, 1981.
38. Shapiro SD. The macrophage in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 160: S29-S32, 1999.
39. Shibata R, Ouchi N, Kihara S, Sato K, Funahashi T, Walsh K. Adiponectin stimulates angiogenesis in response to tissue ischemia through stimulation of amp-activated protein kinase signaling. J Biol Chem 279: 28670-28674, 2004.
40. Shibata R, Sato K, Kumada M, Izumiya Y, Sonoda M, Kihara S, Ouchi N, Walsh K. Adiponectin accumulates in myocardial tissue that has been damaged by ischemia-reperfusion injury via leakage from the vascular compartment. Cardiovasc Res 74: 471-479, 2007.
41. Shibata R, Sato K, Pimentel DR, Takemura Y, Kihara S, Ohashi K, Funahashi T, Ouchi N, Walsh K. Adiponectin protects against myocardial ischemia-reperfusion injury through AMPK- and COX-2-dependent mechanisms. Nat Med 11: 1096-1103, 2005.
42. Shore SA, Terry RD, Flynt L, Xu A, Hug C. Adiponectin attenuates allergen-induced airway inflammation and hyperresponsiveness in mice. J Allergy Clin Immunol 118: 389-395, 2006.
43. Spiegelman BM, Choy L, Hotamisligil GS, Graves RA, Tontonoz P. Regulation of adipocyte gene expression in differentiation and syndromes of obesity/diabetes. J Biol Chem 268: 6823-6826, 1993.
44. Stoller JK, Aboussouan LS. Alpha1-antitrypsin deficiency. Lancet 365: 2225-2236, 2005.
45. Suga T, Kurabayashi M, Sando Y, Ohyama Y, Maeno T, Maeno Y, Aizawa H, Matsumura Y, Kuwaki T, Kuro O, Nabeshima Y, Nagai R. Disruption of the klotho gene causes pulmonary emphysema in mice. Defect in maintenance of pulmonary integrity during postnatal life. Am J Respir Cell Mol Biol 22: 26-33, 2000.
46. Suki B, Lutchen KR, Ingenito EP. On the progressive nature of emphysema: roles of proteases, inflammation, and mechanical forces. Am J Respir Crit Care Med 168: 516-521, 2003.
47. Summer R, Kotton DN, Sun X, Ma B, Fitzsimmons K, Fine A. Side population cells and Bcrp1 expression in lung. Am J Physiol Lung Cell Mol Physiol 285: L97-L104, 2003.
48. Takefuji S, Yatsuya H, Tamakoshi K, Otsuka R, Wada K, Matsushita K, Sugiura K, Hotta Y, Mitsuhashi H, Oiso Y, Toyoshima H. Smoking status and adiponectin in healthy Japanese men and women. Prev Med 45: 471-475, 2007.
49. Takemura Y, Ouchi N, Shibata R, Aprahamian T, Kirber MT, Summer RS, Kihara S, Walsh K. Adiponectin modulates inflammatory reactions via calreticulin receptor-dependent clearance of early apoptotic bodies. J Clin Invest 117: 375-386, 2007.
50. Thakur V, Pritchard MT, McMullen MR, Nagy LE. Adiponectin normalizes LPS-stimulated TNFalpha production by rat Kupffer cells after chronic ethanol feeding. Am J Physiol Gastrointest Liver Physiol 290: G998-G1007, 2006.
51. Thurlbeck WM. Internal surface area of normal and emphysematous lungs. Aspen Emphysema Conf 10: 379-393, 1967.
52. Thurlbeck WM. The internal surface area of nonemphysematous lungs. Am Rev Respir Dis 95: 765-773, 1967.
53. Trayhurn P. Adipocyte biology. Obes Rev 8, Suppl 1: 41-44, 2007.
54. Trayhurn P, Wood IS. Adipokines: inflammation and the pleiotropic role of white adipose tissue. Br J Nutr 92: 347-355, 2004.
55. Von WP, Joseph K, Muller B, Franck WM. Bronchoalveolar lavage. Quantitation of intraalveolar fluid? Am Rev Respir Dis 147: 148-152, 1993.
56. Wert SE, Yoshida M, LeVine AM, Ikegami M, Jones T, Ross GF, Fisher JH, Korfhagen TR, Whitsett JA. Increased metalloproteinase activity, oxidant production, and emphysema in surfactant protein D gene-inactivated mice. Proc Natl Acad Sci USA 97: 5972-5977, 2000.
57. Yamaguchi N, Argueta JG, Masuhiro Y, Kagishita M, Nonaka K, Saito T, Hanazawa S, Yamashita Y. Adiponectin inhibits Toll-like receptor family-induced signaling. FEBS Lett 579: 6821-6826, 2005.
58. Zhang L, Ikegami M, Crouch EC, Korfhagen TR, Whitsett JA. Activity of pulmonary surfactant protein-D (SP-D) in vivo is dependent on oligomeric structure. J Biol Chem 276: 19214-19219, 2001.
59. Zhang X, Shan P, Jiang G, Cohn L, Lee PJ. Toll-like receptor 4 deficiency causes pulmonary emphysema. J Clin Invest 116: 3050-3059, 2006.
60. Zhou Y, Sun X, Jin L, Stringfield T, Lin L, Chen Y. Expression profiles of adiponectin receptors in mouse embryos. Gene Expr Patterns 5: 711-715, 2005.