BDNF polymorphism-dependent OFC and DLPFC plasticity differentially moderates implicit and explicit bias

Cerebral Cortex

Volumn 22, Issue 11, 2012, Pages 2602-2609

  Forbes, Chad E ^a,b,c   Poore, Joshua C ^b   Barbey, Aron K ^d   Krueger, Frank ^b,e   Solomon, Jeffrey ^f   Lipsky, Robert H ^g   Hodgkinson, Colin A ^h   Goldman, David ^h   Grafman, Jordan ^b  

^a NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING   (United States)

^b NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

^c UNIVERSITY OF DELAWARE   (United States)

^d UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^e GEORGE MASON UNIVERSITY   (United States)

^f Medical Numerics Inc   (United States)

^g INOVA FAIRFAX HOSPITAL   (United States)

^h NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM   (United States)

Author keywords

BDNF; implicit and explicit bias; PFC plasticity; social neuroscience; TBI

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; METHIONINE; VALINE;

ADULT; ARTICLE; ATTITUDE; BRAIN CORTEX; CLINICAL ARTICLE; COGNITION; CONTROLLED STUDY; HUMAN; MALE; NERVE CELL NETWORK; NERVE CELL PLASTICITY; PREFRONTAL CORTEX; PRIORITY JOURNAL; RATING SCALE; SINGLE NUCLEOTIDE POLYMORPHISM; SOCIAL BEHAVIOR; TASK PERFORMANCE; TRAUMATIC BRAIN INJURY;

ADULT; ATTITUDE; BRAIN INJURIES; BRAIN-DERIVED NEUROTROPHIC FACTOR; DNA; FEMALE; FRONTAL LOBE; HUMANS; MALE; NERVOUS SYSTEM DISEASES; NEURONAL PLASTICITY; POLYMORPHISM, GENETIC; PREFRONTAL CORTEX; REGRESSION ANALYSIS; SEXISM; STEREOTYPING; TOMOGRAPHY, X-RAY COMPUTED; VETERANS; WOMEN; WORD ASSOCIATION TESTS;

EID: 84866042588     PISSN: 10473211     EISSN: 14602199     Source Type: Journal    
DOI: 10.1093/cercor/bhr337     Document Type: Article

References (56)

1. Aiken LS, West SG. 1991. Multiple regression: testing and interpreting interactions: thousand oaks. California (CA): Sage Publications Inc. xi. p. 212.
2. Beste C, Baune BT, Domschke K, Falkenstein M, Konrad C. 2010. Paradoxical association of the brain-derived-neurotrophic-factor val66met genotype with response inhibition. Neuroscience. 166:178-184.
3. Binder DK, Scharfman HE. 2004. Brain-derived neurotrophic factor. Growth Factors. 22:123-131. (Pubitemid 39377904)
4. Bouchard C. 2008. Gene-environment interactions in the etiology of obesity: defining the fundamentals. Obesity (Silver Spring). (Suppl 16) 3: S5-S10.
5. Cunningham WA, Johnson MK, Raye CL, Chris Gatenby J, Gore JC, Banaji MR. 2004. Separable neural components in the processing of black and white faces. Psychol Sci. 15:806-813. (Pubitemid 40004392)
6. Cunningham WA, Zelazo PD. 2007. Attitudes and evaluations: a social cognitive neuroscience perspective. Trends Cogn Sci. 11:97-104. (Pubitemid 46282523)
7. Dasgupta N, McGhee DE, Greenwald AG, Banaji MR. 2000. Automatic preference for white Americans: eliminating the familiarity explanation. J Exp Soc Psychol. 36:316-328.
8. Dempster E, Toulopoulou T, McDonald C, Bramon E, Walshe M, Filbey F, Wickham H, Sham PC, Murray RM, Collier DA. 2005. Association between BDNF val66 met genotype and episodic memory. Am J Med Genet B Neuropsychiatr Genet. 134B:73-75. (Pubitemid 40411113)
9. Devine PG. 1989. Stereotypes and prejudice: their automatic and controlled components. J Pers Soc Psychol. 56:5-18.
10. Dovidio JF, Kawakami K, Gaertner SL. 2002. Implicit and explicit prejudice and interracial interaction. J Pers Soc Psychol. 82:62-68.
11. Egan MF, Kojima M, Callicott JH, Goldberg TE, Kolachana BS, Bertolino A, Zaitsev E, Gold B, Goldman D, Dean M, et al. 2003. The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function. Cell. 112:257-269. (Pubitemid 36144114)
12. Fazio RH, Olson MA. 2003. Implicit measures in social cognition research: their meaning and use. Annu Rev Psychol. 54:297-327. (Pubitemid 37417496)
13. First MB, Spitzer RL, Gibbon M, Williams JBW. 2001. Structured clinical interview for DSM-IV-TR axis I disorders, non-patient edition (SCIDI/NP). New York (NY): Biometrics Research New York State Psychiatric Institute.
14. Forbes CE, Grafman J. 2010. The role of the human prefrontal cortex in social cognition and moral judgment. Annu Rev Neurosci. 33:299-324.
15. Fuster JM. 1997. The prefrontal cortex: anatomy, physiology, and neuropsychology of the frontal lobe. New York (NY): Raven.
16. Gajewski PD, Hengstler JG, Golka K, Falkenstein M, Beste C. 2011. The met-allele of the BDNF Val66Met polymorphism enhances task switching in elderly. Neurobiol Aging. 32:7-19.
17. Glaser J, Knowles ED. 2008. Implicit motivation to control prejudice. J Exp Soc Psychol. 44:164-172.
18. Gozzi M, Raymont V, Solomon J, Koenigs M, Grafman J. 2009. Dissociable effects of prefrontal and anterior temporal cortical lesions on stereotypical gender attitudes. Neuropsychologia. 47:2125-2132.
19. Grafman J, Jonas BS, Martin A, Salazar AM, Weingartner H, Ludlow C, Smutok MA, Vance SC. 1988. Intellectual function following penetrating head injury in Vietnam veterans. Brain. 111(Pt 1):169-184.
20. Greenwald AG, Nosek BA, Banaji MR. 2003. Understanding and using the Implicit Association Test: I. An improved scoring algorithm. J Pers Soc Psychol. 85:197-216. (Pubitemid 37394958)
21. Greenwald AG, Poehlman TA, Uhlmann EL, Banaji MR. 2009. Understanding and using the Implicit Association Test: III. Metaanalysis of predictive validity. J Pers Soc Psychol. 97:17-41.
22. Hariri AR, Goldberg TE, Mattay VS, Kolachana BS, Callicott JH, Egan MF, Weinberger DR. 2003. Brain-derived neurotrophic factor val66met polymorphism affects human memory-related hippocampal activity and predicts memory performance. J Neurosci. 23:6690-6694. (Pubitemid 36951196)
23. Ho BC, Andreasen NC, Dawson JD, Wassink TH. 2007. Association between brain-derived neurotrophic factor Val66Met gene polymorphism and progressive brain volume changes in schizophrenia. Am J Psychiatry. 164:1890-1899. (Pubitemid 351739243)
24. Ho BC, Milev P, O'Leary DS, Librant A, Andreasen NC, Wassink TH. 2006. Cognitive and magnetic resonance imaging brain morphometric correlates of brain-derived neurotrophic factor Val66Met gene polymorphism in patients with schizophrenia and healthy volunteers. Arch Gen Psychiatry. 63:731-740.
25. Huang EJ, Reichardt LF. 2001. Neurotrophins: roles in neuronal development and function. Annu Rev Neurosci. 24:677-736. (Pubitemid 32695243)
26. Juhasz G, Dunham JS, McKie S, Thomas E, Downey D, Chase D, Lloyd-Williams K, Toth ZG, Platt H, Mekli K, et al. 2011. The CREB1-BDNF-NTRK2 pathway in depression: multiple gene-cognitionenvironment interactions. Biol Psychiatry. 69:762-771.
27. Kaufman J, Yang BZ, Douglas-Palumberi H, Grasso D, Lipschitz D, Houshyar S, Krystal JH, Gelernter J. 2006. Brain-derived neurotrophic factor-5-HTTLPR gene interactions and environmental modifiers of depression in children. Biol Psychiatry. 15:673-680.
28. Knutson KM, Mah L, Manly CF, Grafman J. 2007. Neural correlates of automatic beliefs about gender and race. Hum Brain Mapp. 28:915-930. (Pubitemid 47549697)
29. Krueger F, Pardini M, Huey ED, Raymont V, Solomon J, Lipsky RH, Hodgkinson CA, Goldman D, Grafman J. 2011. The role of the met66 BDNF allele in the recovery of executive functioning following combat-related traumatic brain injury. J Neurosci. 31:598-606.
30. Lancaster JL, Woldorff MG, Parsons LM, Liotti M, Freitas CS, Rainey L, Kochunov PV, Nickerson D, Mikiten SA, Fox PT. 2000. Automated Talairach atlas labels for functional brain mapping. Hum Brain Mapp. 10:120-131. (Pubitemid 30456920)
31. Leibrock J, Lottspeich F, Hohn A, Hofer M, Hengerer B, Masiakowski P, Thoenen H, Barde YA. 1989. Molecular cloning and expression of brain-derived neurotrophic factor. Nature. 341:149-152. (Pubitemid 19222776)
32. Lepore L, Brown R. 1997. Category and stereotype activation: is prejudice inevitable? J Pers Soc Psychol. 72:275-287.
33. Lu B. 2003. Pro-region of neurotrophins: role in synaptic modulation. Neuron. 39:735-738. (Pubitemid 37088086)
34. Maisonpierre PC, Belluscio L, Squinto S, Ip NY, Furth ME, Lindsay RM, Yancopoulos GD. 1990. Neurotrophin-3: a neurotrophic factor related to NGF and BDNF. Science. 247:1446-1451.
35. Makale M, Solomon J, Patronas NJ, Danek A, Butman JA, Grafman J. 2002. Quantification of brain lesions using interactive automated software. Behav Res Methods Instrum Comput. 34:6-18.
36. Maldjian JA, Laurienti PJ, Kraft RA, Burdette JH. 2003. An automated method for neuroanatomic and cytoarchitectonic atlas-based interrogation of fMRI data sets. Neuroimage. 19:1233-1239. (Pubitemid 36918259)
37. McAllister AK, Lo DC, Katz LC. 1995. Neurotrophins regulate dendritic growth in developing visual cortex. Neuron. 15:791-803.
38. McKinney K. 1987. Age and gender differences in college students' attitudes towards women: a replication and extension. Sex Roles. 17:353-358.
39. Milne E, Grafman J. 2001. Ventromedial prefrontal cortex lesions in humans eliminate implicit gender stereotyping. J Neurosci. 21:RC150.
40. Montag C, Weber B, Fliessbach K, Elger C, Reuter M. 2009. The BDNF Val66Met polymorphism impacts parahippocampal and amygdala volume in healthy humans: incremental support for a genetic risk factor for depression. Psychol Med. 39:1831-1839.
41. Nosek BA, Banaji M, Greenwald AG. 2002. Harvesting implicit group attitudes and beliefs from a demonstration web site. Group Dyn. 6:101-115. (Pubitemid 34232588)
42. Pezawas L, Verchinski BA, Mattay VS, Callicott JH, Kolachana BS, Straub RE, Egan MF, Meyer-Lindenberg A, Weinberger DR. 2004. The brain-derived neurotrophic factor val66met polymorphism and variation in human cortical morphology. J Neurosci. 24:10099-10102. (Pubitemid 39492034)
43. Raymont V, Greathouse A, Reding K, Lipsky R, Salazar A, Grafman J. 2008. Demographic, structural and genetic predictors of late cognitive decline after penetrating head injury. Brain. 131:543-558. (Pubitemid 351197611)
44. Rolls ET. 2000. The orbitofrontal cortex and reward. Cereb Cortex. 10:284-294. (Pubitemid 30159295)
45. Rudman LA, Greenwald AG, McGhee DE. 2001. Implicit self-concept and evaluative implicit gender stereotypes: self and ingroup share desirable traits. Pers Soc Psychol Bull. 27:1164-1178.
46. Rudman LA, Lee MR. 2002. Implicit and explicit consequences of exposure to violent and misogynous rap music. Group Processes Intergroup Relat. 5:133-150.
47. Rybakowski JK, Borkowska A, Czerski PM, Skibinska M, Hauser J. 2003. Polymorphism of the brain-derived neurotrophic factor gene and performance on a cognitive prefrontal test in bipolar patients. Bipolar Disord. 5:468-472. (Pubitemid 38072252)
48. Rybakowski JK, Borkowska A, Skibinska M, Hauser J. 2006. Illnessspecific association of val66met BDNF polymorphism with performance on Wisconsin Card Sorting Test in bipolar mood disorder. Mol Psychiatry. 11:122-124. (Pubitemid 43164612)
49. Sambataro F, Murty VP, Lemaitre HS, Reed JD, Das S, Goldberg TE, Callicott JH, Weinberger DR, Mattay VS. 2010. BDNF modulates normal human hippocampal ageing [corrected]. Mol Psychiatry. 15:116-118.
50. Solomon J, Raymont V, Braun A, Butman JA, Grafman J. 2007. Userfriendly software for the analysis of brain lesions (ABLe). Comput Methods Programs Biomed. 86:245-254. (Pubitemid 46661017)
51. Spence JT, Hahn ED. 1997. The attitudes toward women scale and attitude change in college students. Psychol Women Q. 21:17-34.
52. Spence JT, Helmreich R, Stapp J. 1973. A short version of the Attitudes toward Women Scale (AWS). Bulletin Psychon Soc. 2:219-220.
53. Tan YL, Zhou DF, Cao LY, Zou YZ, Wu GY, Zhang XY. 2005. Effect of the BDNF Val66Met genotype on episodic memory in schizophrenia. Schizophr Res. 77:355-356.
54. Twenge JM. 1997. Attitudes toward women, 1970-1995. Psychol Women Q. 21:35-51.
55. United States Department of Defense. 1960. Armed Forces Qualification Test (AFQT-7A). Form 1293. Washington, DC: United States Department of Defense.
56. Wechsler DA. 1997. Wechsler memory scale-III. New York (NY): Psychological Corporation.