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European Journal of Medicinal Chemistry

Volumn 56, Issue , 2012, Pages 210-216

Synthesis and biological evaluation of selective and potent cyclin-dependent kinase inhibitors

(5) N'Gompaza Diarra, Joannah a,b Bettayeb, Karima c Gresh, Nohad b Meijer, Laurent c Oumata, Nassima a

a Centre de Perharidy (France)

b UNIVERSITÉ PARIS DESCARTES (France)

c Protein Phosphorylation and Human Disease Group (France)

Author keywords

Cancer; DYRK1A; Kinase; Prodrug; Purine; Roscovitine

Indexed keywords

3 [[9 ISOPROPYL 6 [[4 (2 PYRIDYL)PHENYL]METHYLAMINO]PURIN 2 YL]AMINO]PROPANE 1,2 DIOL; [2 HYDROXY 3 [[9 ISOPROPYL 6 [[4 (2 PYRIDYL)PHENYL]METHYLAMINO]PURIN 2 YL]AMINO]PROPYL]VALYL ESTER; CASEIN KINASE I; CYCLIN A; CYCLIN DEPENDENT KINASE 1; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE 5; CYCLIN DEPENDENT KINASE 7; CYCLIN DEPENDENT KINASE INHIBITOR; CYCLIN H; CYCLIN T; ESTER DERIVATIVE; PHOSPHOTRANSFERASE; PRODRUG; PROTEIN DYRK1A; PROTEIN P25; PURINE DERIVATIVE; ROSCOVITINE; UNCLASSIFIED DRUG; VALINE;

ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; DRUG POTENCY; DRUG SCREENING; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; HYDROPHOBICITY; IC 50; MOLECULAR DOCKING;

ANTINEOPLASTIC AGENTS; CELL PROLIFERATION; CELL SURVIVAL; CYCLIN-DEPENDENT KINASES; CYTOCHROME P-450 ENZYME SYSTEM; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROTEIN KINASE INHIBITORS; PURINES; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 84866032367 PISSN: 02235234 EISSN: 17683254 Source Type: Journal
DOI: 10.1016/j.ejmech.2012.08.033 Document Type: Article

Times cited : (12)

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