Design of group IIA secreted/synovial phospholipase A2 inhibitors: An oxadiazolone derivative suppresses chondrocyte prostaglandin E2 secretion

PLoS ONE

Volumn 5, Issue 6, 2010, Pages

  Ombetta, Jean Edouard ^a   Thelier, Natacha ^b   Dong, Chang Zhi ^c   Plocki, Stéphanie ^c   Tsagris, Lydia ^c   Rannou, François ^b,d   Massicot, France ^e   Djimdé, Atimé ^c   El Hayek, Elissar ^b   Shi, Yiming ^c   Heymans, Françoise ^c   Gresh, Nohad ^f   Chauvet, Caroline ^b  

^a UNIVERSITÉ DE TOURS   (France)

^b INSERM   (France)

^c Laboratoire de Pharmacochimie   (France)

^d Institut Cochin   (France)

^e UNIVERSITÉ PARIS DESCARTES   (France)

^f UNIVERSITÉ PARIS DESCARTES   (France)

Author keywords

[No Author keywords available]

Indexed keywords

3 [[4 [5(INDOL 1 YL)PENTOXY]BENZYL]] 4H 1,2,4 OXADIAZOL 5 ONE; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; OXADIAZOLE DERIVATIVE; PHOSPHOLIPASE A2 GROUP II; PHOSPHOLIPASE A2 GROUP IIA; PROSTAGLANDIN E2; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CARTILAGE CELL; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE RELEASE; CYTOTOXICITY TEST; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYMATIC ASSAY; ENZYME ACTIVITY; FEMALE; GENE EXPRESSION; IC 50; NONHUMAN; PROSTAGLANDIN RELEASE; STRUCTURE ACTIVITY RELATION;

ANIMALS; CELL LINE; CHONDROCYTES; DINOPROSTONE; ENZYME INHIBITORS; INTERLEUKIN-1BETA; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; PHOSPHOLIPASES A2; RABBITS;

ORYCTOLAGUS CUNICULUS;

EID: 77956206306     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0010914     Document Type: Article

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