Biology and function of the aryl hydrocarbon receptor: Report of an international and interdisciplinary conference

Archives of Toxicology

Volumn 86, Issue 8, 2012, Pages 1323-1329

  Esser, Charlotte ^a  

^a IUF LEIBNIZ RESEARCH INSTITUTE FOR ENVIRONMENTAL MEDICINE   (Germany)

Author keywords

Diet; Dioxin; FICZ; Immune system; Mast cells; Neurotoxicology; Retrotransposons; Signalling crosstalk; TDO

Indexed keywords

AROMATIC HYDROCARBON RECEPTOR; DIOXIN; LIGAND; XENOBIOTIC AGENT;

ADAPTIVE IMMUNITY; ALLERGY; BRAIN DEVELOPMENT; BRAIN TUMOR; CIRCADIAN RHYTHM; CONFERENCE PAPER; DENDRITIC CELL; EVIDENCE BASED MEDICINE; GENE STRUCTURE; GENOME; HEMATOPOIETIC STEM CELL; HUMAN; INNATE IMMUNITY; LIGAND BINDING; MAST CELL; MOLECULAR BIOLOGY; MOLECULAR INTERACTION; NERVOUS TISSUE; NEUROTOXICOLOGY; NONHUMAN; POLLUTANT; PRIORITY JOURNAL; PROTEIN FUNCTION; RETROPOSON; SIGNAL TRANSDUCTION; T LYMPHOCYTE; TRANSLATIONAL RESEARCH; VEGETARIAN DIET;

ANIMALS; BRAIN NEOPLASMS; DIOXINS; ENVIRONMENTAL POLLUTANTS; GENE EXPRESSION REGULATION; HUMANS; IMMUNE SYSTEM; LIGANDS; NEURONS; RECEPTORS, ARYL HYDROCARBON; RETROELEMENTS; SIGNAL TRANSDUCTION; TRANSLATIONAL MEDICAL RESEARCH;

EID: 84866029143     PISSN: 03405761     EISSN: 14320738     Source Type: Journal    
DOI: 10.1007/s00204-012-0818-2     Document Type: Conference Paper

References (50)

1. Apetoh L, Quintana FJ, Pot C, Joller N, Xiao S, Kumar D, Burns EJ, Sherr DH, Weiner HL, Kuchroo VK (2010) The aryl hydrocarbon receptor interacts with c-Maf to promote the diVerentiation of type 1 regulatory T cells induced by IL-27. Nat Immunol 11:854- 861
2. Arsenescu V, Arsenescu R, Parulkar M, Karounos M, Zhang X, Baker N, Cassis LA (2011) Polychlorinated biphenyl 77 augments angiotensin II-induced atherosclerosis and abdominal aortic aneurysms in male apolipoprotein E deWcient mice. Toxicol Appl Pharmacol 257:148-154
3. Baccarelli A, Pesatori AC, Consonni D, Mocarelli P, Patterson DG Jr, Caporaso NE, Bertazzi PA, Landi MT (2005) Health status and plasma dioxin levels in chloracne cases 20 years after the Seveso, Italy accident. Br J Dermatol 152:459-465 (Pubitemid 40547119)
4. Bernshausen T, Jux B, Esser C, Abel J, Fritsche E (2006) Tissue distribution and function of the Aryl hydrocarbon receptor repressor (AhRR) in C57BL/6 and Aryl hydrocarbon receptor deWcient mice. Arch Toxicol 80:206-211
5. Bolt HM, Degen GH (2002) Comparative assessment of endocrine modulators with oestrogenic activity. II. Persistent organochlorine pollutants. Arch Toxicol 76:187-193 (Pubitemid 34591653)
6. Braeuning A, Kohle C, Buchmann A, Schwarz M (2011) Coordinate regulation of cytochrome P450 1a1 expression in mouse liver by the aryl hydrocarbon receptor and the beta-catenin pathway. Toxicol Sci 122:16-25
7. Casado FL, Singh KP, Gasiewicz TA (2011) Aryl hydrocarbon receptor activation in hematopoietic stem/progenitor cells alters cell function and pathway-speciWc gene modulation reXecting changes in cellular traYcking and migration. Mol Pharmacol 80:673- 682
8. Esser C, Rannug A, Stockinger B (2009) The aryl hydrocarbon receptor and immunity. Trends Immunol 9:447-454
9. Funatake CJ, Marshall NB, Kerkvliet NI (2008) 2,3,7,8-Tetrachlorodibenzo- p-dioxin alters the diVerentiation of alloreactive CD8+ T cells toward a regulatory T cell phenotype by a mechanism that is dependent on aryl hydrocarbon receptor in CD4+ T cells. J Immunotoxicol 5:81-91 (Pubitemid 351431256)
10. Gandhi R, Kumar D, Burns EJ, Nadeau M, Dake B, Laroni A, Kozoriz D, Weiner HL, Quintana FJ (2010) Activation of the aryl hydrocarbon receptor induces human type 1 regulatory T cell-like and Foxp3(+) regulatory T cells. Nat Immunol 11:846-853
11. Gassmann K, Abel J, Bothe H, Haarmann-Stemmann T, Merk HF, QuasthoV KN, Rockel TD, Schreiber T, Fritsche E (2010) Species- speciWc diVerential AhR expression protects human neural progenitor cells against developmental neurotoxicity of PAHs. Environ Health Perspect 118:1571-1577
12. Girardi M, Lewis JM, Filler RB, Hayday AC, Tigelaar RE (2006) Environmentally responsive and reversible regulation of epidermal barrier function by gammadelta T cells. J Invest Dermatol 126:808-814
13. Jin GB, Moore AJ, Head JL, Neumiller JJ, Lawrence BP (2010) Aryl hydrocarbon receptor activation reduces dendritic cell function during inXuenza virus infection. Toxicol Sci 116:514-522
14. Kadow S, Jux B, Zahner SP, Wingerath B, Chmill S, Clausen BE, Hengstler J, Esser C (2011) Aryl hydrocarbon receptor is critical for homeostasis of invariant {gamma}{delta} T cells in the murine epidermis. J Immunol 187:3104-3110
15. Kerkvliet NI, Baecher-Steppan L, Smith BB, Youngberg JA, Henderson MC, Buhler DR (1990) Role of the Ah locus in suppression of cytotoxic T lymphocyte activity by halogenated aromatic hydrocarbons (PCBs and TCDD): structure-activity relationships and eVects in C57Bl/6 mice congenic at the Ah locus. Fundam Appl Toxicol 14:532-541 (Pubitemid 20273791)
16. Kiss EA, Vonarbourg C, Kopfmann S, Hobeika E, Finke D, Esser C, Diefenbach A (2011) Natural aryl hydrocarbon receptor ligands control organogenesis of intestinal lymphoid follicles. Science. doi:10.1126/science. 1214914
17. Kulkarni PS, Crespo JG, Afonso CA (2008) Dioxins sources and current remediation technologies-a review. Environ Int 34:139-153 (Pubitemid 350235606)
18. Lensu S, Tuomisto JT, Tuomisto J, Pohjanvirta R (2011) Characterization of the 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-provoked strong and rapid aversion to unfamiliar foodstuVs in rats. Toxicology 283:140-150
19. Li Y, Innocentin S, Withers DR, Roberts NA, Gallagher AR, Grigorieva EF, Wilhelm C, Veldhoen M (2011) Exogenous stimuli maintain intraepithelial lymphocytes via aryl hydrocarbon receptor activation. Cell. doi:10.1016/j.cell. 2011.09.025
20. Luecke S, Wincent E, Backlund M, Rannug U, Rannug A (2010) Cytochrome P450 1A1 gene regulation by UVB involves crosstalk between the aryl hydrocarbon receptor and nuclear factor kappaB. Chem Biol Interact 184:466-473
21. Marshall NB, Kerkvliet NI (2010) Dioxin and immune regulation: emerging role of aryl hydrocarbon receptor in the generation of regulatory T cells. Ann NY Acad Sci 1183:25-37
22. Mezrich JD, Fechner JH, Zhang X, Johnson BP, Burlingham WJ, BradWeld CA (2010) An interaction between kynurenine and the aryl hydrocarbon receptor can generate regulatory T cells. J Immunol 185:3190-3198
23. Mukai M, Lin TM, Peterson RE, Cooke PS, Tischkau SA (2008) Behavioral rhythmicity of mice lacking AhR and attenuation of light-induced phase shift by 2,3,7,8-tetrachlorodibenzo-p-dioxin. J Biol Rhythms 23:200-210 (Pubitemid 351652366)
24. Nagayama J, Kuroki H, Masuda Y, Handa S, Kuratsune M (1985) Genetically mediated induction of aryl hydrocarbon hydroxylase activity in mice by polychlorinated dibenzofuran isomers and 2,3,7,8-tetrachlorodibenzo-p-dioxin. Arch Toxicol 56:226-229 (Pubitemid 15104914)
25. Neubert R, Jacob-Muller U, Stahlmann R, Helge H, Neubert D (1990) Polyhalogenated dibenzo-p-dioxins and dibenzofurans and the immune system. 1. EVects on peripheral lymphocyte subpopulations of a non-human primate (Callithrix jacchus) after treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Arch Toxicol 64:345-359
26. Nguyen NT, Kimura A, Nakahama T, Chinen I, Masuda K, Nohara K, Fujii-Kuriyama Y, Kishimoto T (2010) Aryl hydrocarbon receptor negatively regulates dendritic cell immunogenicity via a kynurenine-dependent mechanism. Proc Natl Acad Sci USA 107:19961-19966
27. Opitz CA, Litzenburger UM, Sahm F, Ott M, Tritschler I, Trump S, Schumacher T, Jestaedt L, Schrenk D, Weller M, Jugold M, Guillemin GJ, Miller CL, Lutz C, Radlwimmer B, Lehmann I, von Deimling A, Wick W, Platten M (2011) An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor. Nature 478:197-203
28. Platzer B, Richter S, Kneidinger D, Waltenberger D, Woisetschlager M, Strobl H (2009) Aryl hydrocarbon receptor activation inhibits in vitro diVerentiation of human monocytes and Langerhans dendritic cells. J Immunol 183:66-74
29. Prochazkova J, Kabatkova M, Bryja V, Umannova L, Bernatik O, Kozubik A, Machala M, Vondracek J (2011) The interplay of the aryl hydrocarbon receptor and beta-catenin alters both AhRdependent transcription and Wnt/beta-catenin signaling in liver progenitors. Toxicol Sci 122:349-360
30. Reggiani G (1978) Medical problems raised by the TCDD contamination in Seveso, Italy. Arch Toxicol 40:161-188 (Pubitemid 8360159)
31. Rico de SA, Zago M, Pollock SJ, Sime PJ, Phipps RP, Baglole CJ (2011) Genetic ablation of the aryl hydrocarbon receptor causes cigarette smoke-induced mitochondrial dysfunction and apoptosis. J Biol Chem 286:43214-43228
32. Roman AC, Gonzalez-Rico FJ, Fernandez-Salguero PM (2011a) B1-SINE retrotransposons: establishing genomic insulatory networks. Mob Genet Elements 1:66-70
33. Roman AC, Gonzalez-Rico FJ, Molto E, Hernando H, Neto A, Vicente-Garcia C, Ballestar E, Gomez-Skarmeta JL, Vavrova- Anderson J, White RJ, Montoliu L, Fernandez-Salguero PM (2011b) Dioxin receptor and SLUG transcription factors regulate the insulator activity of B1 SINE retrotransposons via an RNA polymerase switch. Genome Res 21:422-432
34. Schmidt JV, BradWeld CA (1996) Ah receptor signaling pathways. Annu Rev Cell Dev Biol 12:55-89 (Pubitemid 26422709)
35. Schrenk D, Lipp HP, Wiesmuller T, Hagenmaier H, Bock KW (1991) Assessment of biological activities of mixtures of polychlorinated dibenzo-p-dioxins: comparison between deWned mixtures and their constituents. Arch Toxicol 65:114-118
36. Schulz VJ, Smit JJ, Willemsen KJ, Fiechter D, Hassing I, Bleumink R, Boon L, Van den BM, van Duursen MB, Pieters RH (2011) Activation of the aryl hydrocarbon receptor suppresses sensitization in a mouse peanut allergy model. Toxicol Sci 123:491-500
37. Singh KP, Garrett RW, Casado FL, Gasiewicz TA (2011) Aryl hydrocarbon receptor-null allele mice have hematopoietic stem/progenitor cells with abnormal characteristics and functions. Stem Cells Dev 20:769-784
38. Stockinger B, Hirota K, Duarte J, Veldhoen M (2011) External inXuences on the immune system via activation of the aryl hydrocarbon receptor. Semin Immunol 23:99-105
39. Sutter CH, Bodreddigari S, Campion C, Wible RS, Sutter TR (2011) 2(3), pp. 7,8-Tetrachlorodibenzo-p-dioxin increases the expression of genes in the human epidermal diVerentiation complex and accelerates epidermal barrier formation. Toxicol Sci 124:128- 137
40. Takemoto K, Nakajima M, Fujiki Y, Katoh M, Gonzalez FJ, Yokoi T (2004) Role of the aryl hydrocarbon receptor and Cyp1b1 in the antiestrogenic activity of 2,3,7,8-tetrachlorodibenzo-p-dioxin. Arch Toxicol 78:309-315 (Pubitemid 38916329)
41. Thiel R, Koch E, Ulbrich B, Chahoud I (1994) Peri- and postnatal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin: eVects on physiological development, reXexes, locomotor activity and learning behaviour in Wistar rats. Arch Toxicol 69:79-86 (Pubitemid 24365847)
42. Vogel CF, Matsumura F (2009) A new cross-talk between the aryl hydrocarbon receptor and RelB, a member of the NF-kappaB family. Biochem Pharmacol 77:734-745
43. Vogel C, Donat S, Dohr O, Kremer J, Esser C, Roller M, Abel J (1997) EVect of subchronic 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure on immune system and target gene responses in mice: calculation of benchmark doses for CYP1A1 and CYP1A2 related enzyme activities. Arch Toxicol 71:372-382 (Pubitemid 27214470)
44. Vogel CF, Goth SR, Dong B, Pessah IN, Matsumura F (2008) Aryl hydrocarbon receptor signaling mediates expression of indoleamine 2,3-dioxygenase. Biochem Biophys Res Commun 375: 331-335
45. Vos JG (1977) Immune suppression as related to toxicology. CRC Crit Rev Toxicol 5:67-101
46. Wang Y, Fan Y, Puga A (2010) Dioxin exposure disrupts the diVerentiation of mouse embryonic stem cells into cardiomyocytes. Toxicol Sci 115:225-237
47. Wu D, Li W, Lok P, Matsumura F, Adam Vogel CF (2011a) AhR deWciency impairs expression of LPS-induced inXammatory genes in mice. Biochem Biophys Res Commun 410:358-363
48. Wu HY, Quintana FJ, da Cunha AP, Dake BT, Koeglsperger T, Starossom SC, Weiner HL (2011b) In vivo induction of Tr1 cells via mucosal dendritic cells and AHR signaling. PLoS One 6:e23618
49. Yaktine AL, Harrison GG, Lawrence RS (2006) Reducing exposure to dioxins and related compounds through foods in the next generation. Nutr Rev 64:403-409 (Pubitemid 44525199)
50. Zhang S, Kim K, Jin UH, Pfent C, Cao H, Amendt B, Liu X, Wilson- Robles H, Safe S (2012) Aryl Hydrocarbon Receptor Agonists Induce MicroRNA-335 Expression and Inhibit Lung Metastasis of Estrogen Receptor Negative Breast Cancer Cells. Mol Cancer Ther 11:108-118