SCOPUS 정보 검색 플랫폼

Green Processing and Synthesis

Volumn 1, Issue 2, 2012, Pages 149-167

Micro reactor and flow chemistry for industrial applications in drug discovery and development

(2) Baraldi, Patricia T a Hessel, Volker b

a Institute Vita Nova (Brazil)

b EINDHOVEN UNIVERSITY OF TECHNOLOGY (Netherlands)

Author keywords

Active pharmaceutical ingredients; Continuous flow; Flow systems; Micro reactors

Indexed keywords

BATCH REACTORS; CHEMICAL INDUSTRY; DRUG PRODUCTS;

ACTIVE PHARMACEUTICALS INGREDIENTS; CASE-STUDIES; CONTINUOUS-FLOW; DRUG DEVELOPMENT; DRUG DISCOVERY; FINE CHEMICAL INDUSTRY; FLOW CHEMISTRY; FLOW SYSTEMS; MICRO-FLOW; MICRO-REACTOR;

LEAD COMPOUNDS;

EID: 84866012269 PISSN: 21919542 EISSN: 21919550 Source Type: Journal
DOI: 10.1515/gps-2012-0008 Document Type: Review

Times cited : (63)

References (65)

1
- 27944438117
- Dawood KM, Kirschning A. Tetrahedron 2005, 61, 12121-12130.
- (2005) Tetrahedron , vol.61 , pp. 12121-12130
- Dawood, K.M.¹ Kirschning, A.²

2
- 33645999986
- Desai B, Dallinger D, Kappe CO. Tetrahedron 2006, 62, 4651-4664.
- (2006) Tetrahedron , vol.62 , pp. 4651-4664
- Desai, B.¹ Dallinger, D.² Kappe, C.O.³

3
- 48149109607
- Colombo M, Peretto I. Drug Discov. Today 2008, 13, 677-684.
- (2008) Drug Discov. Today , vol.13 , pp. 677-684
- Colombo, M.¹ Peretto, I.²

4
- 58149129347
- Moseley JD, Woodman EK. Org. Proc. Res. Dev. 2008, 12, 967-981.
- (2008) Org. Proc. Res. Dev. , vol.12 , pp. 967-981
- Moseley, J.D.¹ Woodman, E.K.²

5
- 79251526861
- Andrews I, Dunn P, Hayler J, Hinkley B, Hughes D, Kaptein B, Lorenz K, Mathew S, Rammeloo T, Wang L, Wells A, White TD. Org. Proc. Res. Dev. 2011, 15, 22-30.
- (2011) Org. Proc. Res. Dev. , vol.15 , pp. 22-30
- Andrews, I.¹ Dunn, P.² Hayler, J.³ Hinkley, B.⁴ Hughes, D.⁵ Kaptein, B.⁶ Lorenz, K.⁷ Mathew, S.⁸ Rammeloo, T.⁹ Wang, L.¹⁰ Wells, A.¹¹ White, T.D.¹²

6
- 0003428180
- Wiley-VCH: Weinheim
- Ehrfeld W, Hessel V, Löwe H. Microreactors: New Technology for Modern Chemistry, Wiley-VCH: Weinheim, 2000.
- (2000) Microreactors: New Technology for Modern Chemistry
- Ehrfeld, W.¹ Hessel, V.² Löwe, H.³

7
- 0033153003
- DeWitt SH. Curr. Opin. Chem. Biol. 1999, 3, 350-356.
- (1999) Curr. Opin. Chem. Biol. , vol.3 , pp. 350-356
- DeWitt, S.H.¹

8
- 0037704669
- Watts P, Haswell SJ. Drug Discov. Today 2003, 9, 586-593.
- (2003) Drug Discov. Today , vol.9 , pp. 586-593
- Watts, P.¹ Haswell, S.J.²

9
- 37649010665
- Kang L, Chung BG, Langer R, Khademhosseini A. Drug Discov. Today 2008, 13, 1-13.
- (2008) Drug Discov. Today , vol.13 , pp. 1-13
- Kang, L.¹ Chung, B.G.² Langer, R.³ Khademhosseini, A.⁴

10
- 77958151627
- Buchholz S. Chem. Eng. Process. 2010, 49, 993-995.
- (2010) Chem. Eng. Process. , vol.49 , pp. 993-995
- Buchholz, S.¹

11
- 70350650698
- Kockmann N, Roberge DM. Chem. Eng. Technol. 2009, 32, 1682-1694.
- (2009) Chem. Eng. Technol. , vol.32 , pp. 1682-1694
- Kockmann, N.¹ Roberge, D.M.²

12
- 0037054163
- Fletcher PDI, Haswell SJ, Pombo-Villar E, Warrington BH, Watts P, Wong SYF, Zhang X. Tetrahedron 2002, 58, 4735-4757.
- (2002) Tetrahedron , vol.58 , pp. 4735-4757
- Fletcher, P.D.I.¹ Haswell, S.J.² Pombo-Villar, E.³ Warrington, B.H.⁴ Watts, P.⁵ Wong, S.Y.F.⁶ Zhang, X.⁷

13
- 84945175445
- in press
- Vural-Gursel I, Wang Q, Hessel V, Noel T, Lang J. Chem. Eng. Technol. in press.
- Chem. Eng. Technol
- Vural-Gursel, I.¹ Wang, Q.² Hessel, V.³ Noel, T.⁴ Lang, J.⁵

14
- 33846558913
- Watts P, Wiles C. Chem. Commun. 2007, 443-467. 10.1039/B609428G.
- (2007) Chem. Commun. , pp. 443-467
- Watts, P.¹ Wiles, C.²

15
- 33751345115
- Geyer K, Cod é e JDC, Seeberger PH. Chem. Eur. J. 2006, 12, 8434-8442.
- (2006) Chem. Eur. J. , vol.12 , pp. 8434-8442
- Geyer, K.¹ Codée, J.D.C.² Seeberger, P.H.³

16
- 42349099366
- Ley SV, Baxendale R. Chimia 2008, 62, 162-168.
- (2008) Chimia , vol.62 , pp. 162-168
- Ley, S.V.¹ Baxendale, R.²

17
- 80051507748
- Kirschning A. Beilstein J. Org. Chem. 2011, 7, 1046-1047.
- (2011) Beilstein J. Org. Chem. , vol.7 , pp. 1046-1047
- Kirschning, A.¹

18
- 77953138778
- Illg T, Löb P, Hessel V. Bioorg. Med. Chem. 2010, 18, 3707-3719.
- (2010) Bioorg. Med. Chem. , vol.18 , pp. 3707-3719
- Illg, T.¹ Löb, P.² Hessel, V.³

19
- 79960484739
- Viviano M, Glasnov TN, Reichart B, Tekautz G, Kappe CO. Org. Proc. Res. Dev. 2011, 15, 858-870.
- (2011) Org. Proc. Res. Dev. , vol.15 , pp. 858-870
- Viviano, M.¹ Glasnov, T.N.² Reichart, B.³ Tekautz, G.⁴ Kappe, C.O.⁵

20
- 79958003609
- 1st ed., Taylor and Francis Group CRC Press: Boca Raton
- Wiles CP. Micro Reaction Technology in Organic Synthesis, 1st ed., Taylor and Francis Group CRC Press: Boca Raton, 2011.
- (2011) Micro Reaction Technology in Organic Synthesis
- Wiles, C.P.¹

21
- 34250757296
- 1st ed., Wiley-VCH: Weinheim
- Hessel V, Löwe H, M ü ller A, Kolb G. Chemical Micro Process Engineering-Processing and Plants, 1st ed., Wiley-VCH: Weinheim, 2005.
- (2005) Chemical Micro Process Engineering-Processing and Plants
- Hessel, V.¹ Löwe, H.² Müller, A.³ Kolb, G.⁴

22
- 0842320834
- 1st ed., Wiley-VCH: Weinheim
- Hessel V, Hardt S, Löwe H. Chemical Micro Process Engineering-Fundamentals, Modelling and Reactions, 1st ed., Wiley-VCH: Weinheim, 2004.
- (2004) Chemical Micro Process Engineering-Fundamentals, Modelling and Reactions
- Hessel, V.¹ Hardt, S.² Löwe, H.³

23
- 78650493525
- 3rd ed., Wiley-VCH: Weinheim
- Hessel V, Renken A, Schouten JC, Yoshida J-I. Handbook of Micro Process Technology, 3rd ed., Wiley-VCH: Weinheim, 2009.
- (2009) Handbook of Micro Process Technology
- Hessel, V.¹ Renken, A.² Schouten, J.C.³ Yoshida, J.-I.⁴

24
- 84858680256
- Kralisch D, Streckmann I, Krtschi U, Santacesaria E, Di Serio M, Russo V, De Carlo L, Linhart W, Christian E, Cortese B, de Croon MHJM, Hessel V. Chem. Sus. Chem. 2012, 5, 300-311.
- (2012) Chem. Sus. Chem. , vol.5 , pp. 300-311
- Kralisch, D.¹ Streckmann, I.² Krtschi, U.³ Santacesaria, E.⁴ Di Serio, M.⁵ Russo, V.⁶ De Carlo, L.⁷ Linhart, W.⁸ Christian, E.⁹ Cortese, B.¹⁰ De Croon, M.H.J.M.¹¹ Hessel, V.¹²

25
- 57549107015
- Becht S, Franke R, Geisselmann A, Hahn H. Chem. Eng. Process. 2009, 48, 329-332.
- (2009) Chem. Eng. Process. , vol.48 , pp. 329-332
- Becht, S.¹ Franke, R.² Geisselmann, A.³ Hahn, H.⁴

26
- 34547684656
- Harmsen GJ. Chem. Eng. Process. 2007, 46, 774-780.
- (2007) Chem. Eng. Process. , vol.46 , pp. 774-780
- Harmsen, G.J.¹

27
- 0037332334
- Stankiewicz A. Chem. Eng. Process. 2003, 42, 137-144.
- (2003) Chem. Eng. Process. , vol.42 , pp. 137-144
- Stankiewicz, A.¹

28
- 78049234468
- 1st ed., The Royal Society of Chemistry: Cambrigde
- Lapkin AA, Plucinski PK. Engineering Factors for Effi cient Flow Processes in Chemical Industries, 1st ed., The Royal Society of Chemistry: Cambrigde, 2010.
- (2010) Engineering Factors for Effi cient Flow Processes in Chemical Industries
- Lapkin, A.A.¹ Plucinski, P.K.²

29
- 70350650700
- Hessel V. Chem. Eng. Technol. 2009, 32, 1655-1681.
- (2009) Chem. Eng. Technol. , vol.32 , pp. 1655-1681
- Hessel, V.¹

30
- 79952316164
- Hessel V, Cortese B, de Croon MHJM. Chem. Eng. Sci. 2011, 66, 1426-1448.
- (2011) Chem. Eng. Sci. , vol.66 , pp. 1426-1448
- Hessel, V.¹ Cortese, B.² De Croon, M.H.J.M.³

31
- 33749864616
- Müller G, Gaupp T, Wahl F, Wille G. Chimia 2006, 60, 618-622.
- (2006) Chimia , vol.60 , pp. 618-622
- Müller, G.¹ Gaupp, T.² Wahl, F.³ Wille, G.⁴

32
- 84945199660
- Jimenez-Gonzalez C, Ponder CS, Broxterman QB, Manley JB. Org. Proc. Res. Dev. 2011, 15, 22-30.
- (2011) Org. Proc. Res. Dev. , vol.15 , pp. 22-30
- Jimenez-Gonzalez, C.¹ Ponder, C.S.² Broxterman, Q.B.³ Manley, J.B.⁴

33
- 77949853471
- Hopkin MD, Baxendale IR, Ley SV. Chem. Commun. 2010, 46, 2450-2452.
- (2010) Chem. Commun. , vol.46 , pp. 2450-2452
- Hopkin, M.D.¹ Baxendale, I.R.² Ley, S.V.³

34
- 78649782930
- Lamb GW, Al Badran FA, Willians JMJ, Kolaczkowski ST. Chem. Eng. Res. Des. 2010, 88, 1533-1540.
- (2010) Chem. Eng. Res. Des. , vol.88 , pp. 1533-1540
- Lamb, G.W.¹ Al Badran, F.A.² Willians, J.M.J.³ Kolaczkowski, S.T.⁴

35
- 58149127519
- LaPorte TL, Hamedi M, DePue JS, Shen L, Watson D, Hseih D. Org. Proc. Res. Dev. 2008, 12, 956-966.
- (2008) Org. Proc. Res. Dev. , vol.12 , pp. 956-966
- LaPorte, T.L.¹ Hamedi, M.² DePue, J.S.³ Shen, L.⁴ Watson, D.⁵ Hseih, D.⁶

36
- 77957093966
- Successful1 st symposium on continuous flow reactor technology for industrial applications
- De Maria G. Successful 1 st Symposium on " Continuous Flow Reactor Technology for Industrial Applications ". Chimica Oggi/ Chemistry Today 2010, 28, 26-32.
- (2010) Chimica Oggi/Chemistry Today , vol.28 , pp. 26-32
- De Maria, G.¹

37
- 84856840761
- Wegner J, Ceylan S, Kirschning A. Adv. Synth. Catal. 2012, 354, 17-57.
- (2012) Adv. Synth. Catal. , vol.354 , pp. 17-57
- Wegner, J.¹ Ceylan, S.² Kirschning, A.³

38
- 58149123661
- Gross TD, Chou S, Bonneville D, Gross RS, Wang P, Campopiano O, Ouellette MA, Zook EZ, Reddy JP, Moree WJ, Jovic F, Chopade S. Org. Proc. Res. Dev. 2008, 12, 929-939.
- (2008) Org. Proc. Res. Dev. , vol.12 , pp. 929-939
- Gross, T.D.¹ Chou, S.² Bonneville, D.³ Gross, R.S.⁴ Wang, P.⁵ Campopiano, O.⁶ Ouellette, M.A.⁷ Zook, E.Z.⁸ Reddy, J.P.⁹ Moree, W.J.¹⁰ Jovic, F.¹¹ Chopade, S.¹²

39
- 77950319440
- Venturoni F, Nikbin N, Ley SV, Baxendale IR. Org. Biomol. Chem. 2010, 8, 1798-1806.
- (2010) Org. Biomol. Chem. , vol.8 , pp. 1798-1806
- Venturoni, F.¹ Nikbin, N.² Ley, S.V.³ Baxendale, I.R.⁴

40
- 78549237444
- Fuse S, Tanabe N, Yoshida M, Yoshida H, Doi T, Takahashi T. Chem. Commun. 2010, 46, 8722-8724.
- (2010) Chem. Commun. , vol.46 , pp. 8722-8724
- Fuse, S.¹ Tanabe, N.² Yoshida, M.³ Yoshida, H.⁴ Doi, T.⁵ Takahashi, T.⁶

41
- 77953420776
- Thayer AM. Chem. Eng. News 2009, 87, 17-19.
- (2009) Chem. Eng. News , vol.87 , pp. 17-19
- Thayer, A.M.¹

42
- 44649171164
- Tietze LF, Liu D. ARKIVOC 2008, viii, 193-210.
- (2008) ARKIVOC , vol.8 , pp. 193-210
- Tietze, L.F.¹ Liu, D.²

43
- 33746284567
- Sugimoto A, Sumino Y, Takagi M, Fukuyama T, Ryu I. Tetrahedron Lett. 2006, 47, 6197-6200.
- (2006) Tetrahedron Lett. , vol.47 , pp. 6197-6200
- Sugimoto, A.¹ Sumino, Y.² Takagi, M.³ Fukuyama, T.⁴ Ryu, I.⁵

44
- 84857029523
- L é vesque F, Seeberger PH. Angew. Chem. Int. Ed. 2012, 51, 1706-1709.
- (2012) Angew. Chem. Int. Ed. , vol.51 , pp. 1706-1709
- Lévesque, F.¹ Seeberger, P.H.²

45
- 77949808653
- Qian Z, Baxendale IR, Ley SV. Synlett 2010, 505-508.
- (2010) Synlett , pp. 505-508
- Qian, Z.¹ Baxendale, I.R.² Ley, S.V.³

46
- 0035567224
- Bogaert-Alvarez RJ, Demena P, Kodersha G, Polomski RE, Soundararajan N, Wang SSY. Org. Proc. Res. Dev. 2001, 5, 636-645.
- (2001) Org. Proc. Res. Dev. , vol.5 , pp. 636-645
- Bogaert-Alvarez, R.J.¹ Demena, P.² Kodersha, G.³ Polomski, R.E.⁴ Soundararajan, N.⁵ Wang, S.S.Y.⁶

47
- 79952845636
- Lv Y, Yu Z, Su W. Org. Proc. Res. Dev. 2011, 15, 471-475.
- (2011) Org. Proc. Res. Dev. , vol.15 , pp. 471-475
- Lv, Y.¹ Yu, Z.² Su, W.³

48
- 77955566494
- Vaske YSM, Mahoney ME, Konopelski JP, Rogow DL, McDonald WJ. J. Am. Chem. Soc. 2010, 132, 11379-11385.
- (2010) J. Am. Chem. Soc. , vol.132 , pp. 11379-11385
- Vaske, Y.S.M.¹ Mahoney, M.E.² Konopelski, J.P.³ Rogow, D.L.⁴ McDonald, W.J.⁵

49
- 84858852481
- Pagano N, Herath A, Cosford NDP. J. Flow Chem. 2011, 1, 28-31.
- (2011) J. Flow Chem. , vol.1 , pp. 28-31
- Pagano, N.¹ Herath, A.² Cosford, N.D.P.³

50
- 0037358078
- Choe J, Kim Y, Song KH. Org. Proc. Res. Dev. 2003, 7, 187-190.
- (2003) Org. Proc. Res. Dev. , vol.7 , pp. 187-190
- Choe, J.¹ Kim, Y.² Song, K.H.³

51
- 34547203591
- Wong H, Dockens RC, Pajor L, Yeola S, Grace JE, Jr, Stark AD, Taub RA, Yocca FD, Zaczek RC, Li Y-W. Drug Metab. Dispos. 2007, 35, 1387-1392.
- (2007) Drug Metab. Dispos. , vol.35 , pp. 1387-1392
- Wong, H.¹ Dockens, R.C.² Pajor, L.³ Yeola, S.⁴ Grace, J.E.⁵ Stark, A.D.⁶ Taub, R.A.⁷ Yocca, F.D.⁸ Zaczek, R.C.⁹ Li, Y.-W.¹⁰

52
- 23944474122
- Schwalbe T, Kadzimirsz D, Jas G. QSAR Comb. Sci. 2005, 24, 758-768.
- (2005) QSAR Comb. Sci. , vol.24 , pp. 758-768
- Schwalbe, T.¹ Kadzimirsz, D.² Jas, G.³

53
- 77950143910
- Bedore MW, Zaborenko N, Jensen KF, Jamison TF. Org. Proc. Res. Dev. 2010, 14, 432-440.
- (2010) Org. Proc. Res. Dev. , vol.14 , pp. 432-440
- Bedore, M.W.¹ Zaborenko, N.² Jensen, K.F.³ Jamison, T.F.⁴

54
- 75749106169
- Herath A, Dahl R, Cosford NDP. Org. Lett. 2010, 12, 412-415.
- (2010) Org. Lett. , vol.12 , pp. 412-415
- Herath, A.¹ Dahl, R.² Cosford, N.D.P.³

55
- 70350348246
- Bogdan R, Poe SL, Kubis DC, Broadwater SJ, McQuade DT. Angew. Chem. 2009, 48, 8547-8550.
- (2009) Angew. Chem. , vol.48 , pp. 8547-8550
- Bogdan, R.¹ Poe, S.L.² Kubis, D.C.³ Broadwater, S.J.⁴ McQuade, D.T.⁵

56
- 39749134078
- Gustafsson T, Ponten F, Seeberger PH. Chem. Commun. 2008, 1100-1102. 10.1039/B719603B.
- (2008) Chem. Commun. , pp. 1100-1102
- Gustafsson, T.¹ Ponten, F.² Seeberger, P.H.³

57
- 78249258386
- Zizheng Qian Z, Baxendale IR, Ley SV. Chem. Eur. J. 2010, 16, 12342-12348.
- (2010) Chem. Eur. J. , vol.16 , pp. 12342-12348
- Zizheng Qian, Z.¹ Baxendale, I.R.² Ley, S.V.³

58
- 84856215505
- Estrada GOD, Blanco ALP, da Silva JFM, Alonso CG, Fernandes-Machado NRC, Cardozo-Filho L, de Souza ROMA, Miranda LSM, Tetrahedron Lett. 2012, 53, 1089-1093.
- (2012) Tetrahedron Lett. , vol.53 , pp. 1089-1093
- Estrada, G.O.D.¹ Blanco, A.L.P.² Da Silva, J.F.M.³ Alonso, C.G.⁴ Fernandes-Machado, N.R.C.⁵ Cardozo-Filho, L.⁶ De Souza, R.O.M.A.⁷ Miranda, L.S.M.⁸

59
- 84856324842
- Junior II, Flores MC, Sutili FK, Leite SGF, Miranda LSM, Leal ICR, de Souza ROMA. J. Mol. Catal. B Enzym., 2012, 77, 53-58.
- (2012) J. Mol. Catal. B Enzym. , vol.77 , pp. 53-58
- Junior, I.I.¹ Flores, M.C.² Sutili, F.K.³ Leite, S.G.F.⁴ Miranda, L.S.M.⁵ Leal, I.C.R.⁶ De Souza, R.O.M.A.⁷

60
- 84945188383
- Junior II, Florest MC, Sutili FK, Leite SGF, Miranda LSM, Leal ICR, de Souza, ROMA. Org. Proc. Res. Dev. 10.1021/ op200132y.
- Org. Proc. Res. Dev
- Junior, I.I.¹ Florest, M.C.² Sutili, F.K.³ Leite, S.G.F.⁴ Miranda, L.S.M.⁵ Leal, I.C.R.⁶ De Souza, R.O.M.A.⁷

61
- 0031693885
- Gordeev MF, Patel DV, England BP, Jonnalagadda S, Combs JD, Gordon EM. Bioorg. Med. Chem. 1998, 883-889.
- (1998) Bioorg. Med. Chem. , pp. 883-889
- Gordeev, M.F.¹ Patel, D.V.² England, B.P.³ Jonnalagadda, S.⁴ Combs, J.D.⁵ Gordon, E.M.⁶

62
- 0344063592
- Lai SM, Ng C, Martin-Aranda R, Yeung KL. Micropor. Mesopor. Mater. 2003, 239-252.
- (2003) Micropor. Mesopor. Mater. , pp. 239-252
- Lai, S.M.¹ Ng, C.² Martin-Aranda, R.³ Yeung, K.L.⁴

63
- 0037245229
- Lai SM, Martin-Aranda R, Yeung KL. Chem. Commun. 2003, 218-219. 10.1039/B209297B.
- (2003) Chem. Commun. , pp. 218-219
- Lai, S.M.¹ Martin-Aranda, R.² Yeung, K.L.³

64
- 77949414343
- Jovanovic J, Rebrov EV, Nijhuis TAX, Hessel V, Schouten JC. Ind. Eng. Chem. Res. 2010, 49, 2681-2687.
- (2010) Ind. Eng. Chem. Res. , vol.49 , pp. 2681-2687
- Jovanovic, J.¹ Rebrov, E.V.² Nijhuis, T.A.X.³ Hessel, V.⁴ Schouten, J.C.⁵

65
- 10044290795
- Nikbin N, Watts P. Org. Proc. Res. Dev. 2004, 8, 942-944.
- (2004) Org. Proc. Res. Dev. , vol.8 , pp. 942-944
- Nikbin, N.¹ Watts, P.²

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