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77950186580
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We are aware of one report of epoxide aminolysis in a continuous flow manner: Tachibana, S.; Yoshiyama, R., Oishi, T.; Sakurai, M.; Ishida, K.; Tsujiuchi, T.; Hidehisa, M.; Araki, R.; Saito K. WO/2007/ JP65354, 2007
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We are aware of one report of epoxide aminolysis in a continuous flow manner: Tachibana, S.; Yoshiyama, R., Oishi, T.; Sakurai, M.; Ishida, K.; Tsujiuchi, T.; Hidehisa, M.; Araki, R.; Saito K. WO/2007/ JP65354, 2007;
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77950109484
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The Biotage Initiator used for the batch reactions has a pressure limitation of 20 bar
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The Biotage Initiator used for the batch reactions has a pressure limitation of 20 bar.
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38
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77950162106
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For examples of poor selectivity in the aminolysis of styrene oxide see ref 5
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For examples of poor selectivity in the aminolysis of styrene oxide see ref 5.
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39
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77950111297
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40
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77950127625
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Metoprolol is isolated as the succinate or tartrate salt and is sold under a variety of names including: Lopressor (Novartis), Toprol-XL (AstraZeneca, Novartis), Metrol (Arrow Pharmaceuticals), Betaloc (AstraZeneca), Neobloc (Trima Pharmaceuticals), and Corvitol (Berlin-Chemie AG) among others
-
Metoprolol is isolated as the succinate or tartrate salt and is sold under a variety of names including: Lopressor (Novartis), Toprol-XL (AstraZeneca, Novartis), Metrol (Arrow Pharmaceuticals), Betaloc (AstraZeneca), Neobloc (Trima Pharmaceuticals), and Corvitol (Berlin-Chemie AG) among others.
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77950164436
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Approximately 3% conversion to 4 was obtained in the syringe after 12 h at rt
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Approximately 3% conversion to 4 was obtained in the syringe after 12 h at rt.
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77950179170
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