Elevated ferric, calcium and magnesium ions in the brain induce protein aggregation in brain mitochondria

West Indian Medical Journal

Volumn 61, Issue 2, 2012, Pages 122-127

  Alleyne, T ^a   Mohan, N ^a   Adogwa, A ^a  

^a UNIVERSITY OF THE WEST INDIES   (Trinidad and Tobago)

Author keywords

Alzheimer's; Metal ions; Neurodegenerative disorder; Protein aggregation

Indexed keywords

ALUMINUM; ALUMINUM CHLORIDE; CALCIUM CHLORIDE; CALCIUM ION; FERRIC CHLORIDE; FERRIC ION; MAGNESIUM CHLORIDE; MAGNESIUM ION; PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN MITOCHONDRION; CONTROLLED STUDY; HISTOPATHOLOGY; MEDULLA OBLONGATA; MESENCEPHALON; MOLECULAR WEIGHT; NEUROFIBRILLARY TANGLE; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTEIN AGGREGATION;

ALUMINUM COMPOUNDS; ANIMALS; BRAIN; CALCIUM CHLORIDE; CHLORIDES; ELECTROPHORESIS, POLYACRYLAMIDE GEL; FERRIC COMPOUNDS; MAGNESIUM CHLORIDE; MITOCHONDRIAL PROTEINS; RABBITS;

EID: 84866004531     PISSN: 00433144     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. Kochanek KD, Murphy SL, Anderson RN, Scott C. Deaths: Final data for 2002. National Vital Statistics Report 2004; 53: 1-116.
2. McConnel C, Turner L. Medicine, ageing and human longevity: The economics and ethics of anti-ageing interventions. EMBO Reports 2005; 6 (S1): S59-S62.
3. Hampel H, Mitchell A, Blennow K, Frank RA, Brettschneider S, Weller L et al. Core biological marker candidates of Alzheimer's disease-perspectives for diagnosis, prediction of outcome and reflection of biological activity. J Neural Transm 2004; 111: 247-72.
4. Maccioni RB, Lavados M, Maccioni CB, Mendoza-Naranjo A. Biological markers of Alzheimer's disease and mild cognitive impairment. Curr Alz Res 2004; 1: 307-14.
5. Kish SJ, Bergeron C, RajputA, Dozie S, Mastrogiacomo F, Chang LJ et al. Brain cytochrome oxidase in Alzheimer's disease. J Neurochem 1992; 59: 776-9.
6. Parker WD, Mahr N, Filley C, Parks J, Hughes D, Young D et al. Reduced platelet cytochrome c oxidase activity in Alzheimer's disease. Neurology 1994; 44: 1086-90.
7. Parker WDJ, Parks J. Cytochrome c oxidase in Alzheimer's disease brain: Purification and characterization. Neurology 1995; 45: 482-6.
8. Suzuki H, Takeda M, Nishimura T. Enzymatic characterization of cathepsin D in rabbit brains with experimental neurofibrillary changes. Biochem Mol Biol Int 1994; 32: 1033-9.
9. Glick JL. Dementias; the role of magnesium deficiency and an hypothesis concerning the pathogenesis of Alzheimer's disease. Med Hypothesis 1990; 31: 211-25.
10. Good PF, Perl DP, Bierer LM, Schmeidler J. Selective accumulation of aluminium and iron in the neurofibrillary tangles of Alzheimer's disease: a laser microprobe (LAMMA). Ann Neurol 1992; 31: 286-92.
11. Huang X, Moir R, Tanzi R, Bush A, Rogers J. Redox-active metals, oxidative stress and Alzheimer's disease pathology. Ann NY Acad Sci 2006; 1012: 153-63.
12. 2+ mobilization is altered in fibroblasts from patients with Alzheimer disease. Proc Natl Acad Sci USA 1994; 91: 534-8.
13. Ke Y, Qian ZM. Iron misregulation in the brain: a primary cause of neurodegenerative disorders. Lancet Neurol 2003; 2: 246-53.
14. Querfurth HW, Selkoe DJ. Calcium ionophore increases amyloid beta peptide production by cultured cells. Biochemistry 1994; 33: 4550-61.
15. Emilsson L, Saetre P, Jazin E. Alzheimer's disease: mRNA expression profiles of multiple patients show alterations of genes involved with calcium signalling. Neurobiol Dis 2006; 21: 618-25.
16. Murayama H, Shin RW, Higuchi J, Shibuya S, Muramoto T, Kitamoto T. Interaction of aluminum with PHFtau in Alzheimer's disease neurofibrillary degeneration evidenced by desferrioxamine-assisted chelating autoclave method. Am J Pathol 1999; 155: 877-85.
17. Forno LS. Neuropathology of Parkinson's disease. J Neuropathol Exp Neurol 1996; 55: 259-72.
18. Hughes AJ, Daniel SE, Lees AJ. Improved accuracy of clinical diagnosis of Lewy body Parkinson's disease. Neurology 2001; 57: 1497-9.
19. OakleyAE, Collingwood JF, Dobson J, Love G, Perrott HR, Edwardson JA et al. Individual dopaminergic neurons show raised iron levels in Parkinson's disease. Neurology 2007; 68: 1820-5.
20. Rybick BA, Johnson CC, Uman J, Gorell JM. Parkinson's disease mortality and the industrial use of heavy metals in Michigan. Mov Disord 1993; 8: 87-92.
21. Uversky VN, Li J, Fink AL. Metal-triggered structural transformations, aggregation, and fibrillation of human alpha-synuclein. A possible molecular link between Parkinson's disease and heavy metal exposure. J Biol Chem 2001; 276: 44284-96.
22. Büeler H. Impaired mitochondrial dynamics and function in the pathogenesis of Parkinson's disease. Exp Neurol 2009; 218: 235-46.
23. Farber S, Slack B, Blusztajn J. Acceleration of phosphatidylcholine synthesis and breakdown by inhibitors of mitochondrial function in neuronal cells: a model of the membrane defect of Alzheimer's disease. FASEB J 2000; 14: 2198-206.
24. Klatzo I,Wisniewski H, Streicher E. Experimental production of neurofibrillary degeneration: Light microscopic observations. J Neuropathol Exp Neurol 1965; 24: 187-99.
25. Luna LG, ed. Manual of histologic staining methods of the Armed Forces Institute of Pathology. 3rd Ed. New York: McGraw-Hill Book Company; 1968: 12-20.
26. Kiernan JA. Histological and Histochemical Methods: Theory and Practice. 3rd ed. Oxford: Butterworth Heinemann; 1999: 368-9.
27. Yonetani T. Studies on cytochrome oxidase. Improved preparation and some properties. J Biol Chem 1961; 236: 1680-8.
28. Alleyne T, Joseph J, Lalla A, Sampson V, Adogwa A. Cytochrome c oxidase isolated from the brain of Swayback-Diseased sheep displays unusual structure and uncharacteristic kinetics. Mol Chem Neuropathol 1998; 3: 233-47.
29. Sampson V, Alleyne T. Cytochrome c/cytochrome c oxidase interaction. Direct structural evidence for conformational changes during enzyme turnover. Eur J Biochem 2001; 268: 6534-44.
30. Mohan N, Alleyne T, Joseph J, Adogwa A. Low activity and poor membrane tethering for brain cytochrome c oxidase in cholesterolcopper Alzheimer's model. J Mol Neurosci 2009; 38: 273-9.
31. Alleyne T, Mohan N, Joseph J, Adogwa A. Unraveling the role of metal ions and low catalytic activity of cytochrome c oxidase in Azheimer's disease. J Mol Neurosci 2011; 43: 284-9.
32. Terry R, Gonatas NK, Weiss M. Ultra-structural studies in Alzheimer's presenile dementia. Am J Pathol 1964; 44: 269-97.
33. Wisniewski HM, Terry RD. Morphology of the aging brain, human and animal. Prog Brain Res 1973; 40: 167-86.
34. KrigmanMR, Feldman RG, Bensch K. Alzheimer's presenile dementia. A histochemical and electron microscopic study. Lab Invest 1965; 14: 381-96.
35. Hensley K, Carney JM, Mattson MP, Aksenova M, Harris M, Wu JF et al. A model for beta-amyloid aggregation and neurotoxicity based on free radical generation by the peptide: relevance to Alzheimer disease. Proc Natl Acad Sci USA. 1994; 91: 3270-4.
36. Huang X, Atwood CS, Hartshorn MA, Multhaup G, Goldstein LE, Scarpa RC et al. The A beta peptide of Alzheimer's disease directly produces hydrogen peroxide through metal ion reduction. Biochemistry 1999; 38: 7609-16.
37. Allinson TM, Parkin ET, Turner AJ, Hooper NM. ADAMs family members as amyloid precursor protein alpha-secretases. J Neurosci Res 2003; 74: 342-52.
38. Vassar R, Bennett BD, Babu-Khan S, Kahn S, Mendiaz EA, Denis P et al. Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE. Science 1999; 286: 735-41.
39. Wolfe MS, Xia W, Ostaszewski BL, Diehl TS, Kimberly WT, Selkoe DJ. Two transmembrane aspartates in presenilin-l required for presenilin endoproteolysis and gamma secretase activity. Nature 1999; 398: 513-17.
40. Andrasi E, Igaz S, Molnar Z, Mako S. Disturbances of magnesium concentrations in various brain areas in Alzheimer's disease. Magnes Res 2000; 13: 189-96.