-
1
-
-
23444445660
-
Potent and persistent in vivo anti-HBV activity of chemically modified siRNAs
-
DOI 10.1038/nbt1122
-
Morrissey, D. V.; Lockridge, J. A.; Shaw, L.; Blanchard, K.; Jensen, K.; Breen, W.; Hartsough, K.; Machemer, L.; Radka, S.; Jadhav, V.; Vaish, N.; Zinnen, S.; Vargeese, C.; Bowman, K.; Shaffer, C. S.; Jeffs, L. B.; Judge, A.; MacLachlan, I.; Polisky, B. Potent and persistent in vivo anti-HBV activity of chemically modified siRNAs Nature Biotechnol. 2005, 23 (8) 1002-1007 (Pubitemid 41114035)
-
(2005)
Nature Biotechnology
, vol.23
, Issue.8
, pp. 1002-1007
-
-
Morrissey, D.V.1
Lockridge, J.A.2
Shaw, L.3
Blanchard, K.4
Jensen, K.5
Breen, W.6
Hartsough, K.7
Machemer, L.8
Radka, S.9
Jadhav, V.10
Vaish, N.11
Zinnen, S.12
Vargeese, C.13
Bowman, K.14
Shaffer, C.S.15
Jeffs, L.B.16
Judge, A.17
MacLachlan, I.18
Polisky, B.19
-
2
-
-
33745625836
-
Therapeutic potential of RNA interference against cancer
-
DOI 10.1111/j.1349-7006.2006.00234.x
-
Takeshita, F.; Ochiya, T. Therapeutic potential of RNA interference against cancer Cancer Sci. 2006, 97 (8) 689-696 (Pubitemid 43983779)
-
(2006)
Cancer Science
, vol.97
, Issue.8
, pp. 689-696
-
-
Takeshita, F.1
Ochiya, T.2
-
3
-
-
23444445660
-
Potent and persistent in vivo anti-HBV activity of chemically modified siRNAs
-
DOI 10.1038/nbt1122
-
Morrissey, D. V.; Lockridge, J. A.; Shaw, L.; Blanchard, K.; Jensen, K.; Breen, W.; Hartsough, K.; Machemer, L.; Radka, S.; Jadhav, V.; Vaish, N.; Zinnen, S.; Vargeese, C.; Bowman, K.; Shaffer, C. S.; Jeffs, L. B.; Judge, A.; MacLachlan, I.; Polisky, B. Potent and persistent in vivo anti-HBV activity of chemically modified siRNAs Nature Biotechnol. 2005, 23 (8) 1002-1007 (Pubitemid 41114035)
-
(2005)
Nature Biotechnology
, vol.23
, Issue.8
, pp. 1002-1007
-
-
Morrissey, D.V.1
Lockridge, J.A.2
Shaw, L.3
Blanchard, K.4
Jensen, K.5
Breen, W.6
Hartsough, K.7
Machemer, L.8
Radka, S.9
Jadhav, V.10
Vaish, N.11
Zinnen, S.12
Vargeese, C.13
Bowman, K.14
Shaffer, C.S.15
Jeffs, L.B.16
Judge, A.17
MacLachlan, I.18
Polisky, B.19
-
4
-
-
59349116903
-
Knocking down barriers: Advances in siRNA delivery
-
Whitehead, K. A.; Langer, R.; Anderson, D. G. Knocking down barriers: advances in siRNA delivery Nature Rev. Drug Discovery 2009, 8 (2) 129-138
-
(2009)
Nature Rev. Drug Discovery
, vol.8
, Issue.2
, pp. 129-138
-
-
Whitehead, K.A.1
Langer, R.2
Anderson, D.G.3
-
5
-
-
33646185371
-
RNAi-mediated gene silencing in non-human primates
-
Zimmermann, T. S.; Lee, A. C. H.; Akinc, A.; Bramlage, B.; Bumcrot, D.; Fedoruk, M. N.; Harborth, J.; Heyes, J. A.; Jeffs, L. B.; John, M.; Judge, A. D.; Lam, K.; McClintock, K.; Nechev, L. V.; Palmer, L. R.; Racie, T.; Rohl, I.; Seiffert, S.; Shanmugam, S.; Sood, V.; Soutschek, J.; Toudjarska, I.; Wheat, A. J.; Yaworski, E.; Zedalis, W.; Koteliansky, V.; Manoharan, M.; Vornlocher, H. P.; MacLachlan, I. RNAi-mediated gene silencing in non-human primates Nature 2006, 441 (7089) 111-114
-
(2006)
Nature
, vol.441
, Issue.7089
, pp. 111-114
-
-
Zimmermann, T.S.1
Lee, A.C.H.2
Akinc, A.3
Bramlage, B.4
Bumcrot, D.5
Fedoruk, M.N.6
Harborth, J.7
Heyes, J.A.8
Jeffs, L.B.9
John, M.10
Judge, A.D.11
Lam, K.12
McClintock, K.13
Nechev, L.V.14
Palmer, L.R.15
Racie, T.16
Rohl, I.17
Seiffert, S.18
Shanmugam, S.19
Sood, V.20
Soutschek, J.21
Toudjarska, I.22
Wheat, A.J.23
Yaworski, E.24
Zedalis, W.25
Koteliansky, V.26
Manoharan, M.27
Vornlocher, H.P.28
MacLachlan, I.29
more..
-
6
-
-
43049176170
-
A combinatorial library of lipid-like materials for delivery of RNAi therapeutics
-
DOI 10.1038/nbt1402, PII NBT1402
-
Akinc, A.; Zumbuehl, A.; Goldberg, M.; Leshchiner, E. S.; Busini, V.; Hossain, N.; Bacallado, S. A.; Nguyen, D. N.; Fuller, J.; Alvarez, R.; Borodovsky, A.; Borland, T.; Constien, R.; de Fougerolles, A.; Dorkin, J. R.; Jayaprakash, K. N.; Jayaraman, M.; John, M.; Koteliansky, V.; Manoharan, M.; Nechev, L.; Qin, J.; Racie, T.; Raitcheva, D.; Rajeev, K. G.; Sah, D. W. Y.; Soutschek, J.; Toudjarska, I.; Vornlocher, H. P.; Zimmermann, T. S.; Langer, R.; Anderson, D. G. A combinatorial library of lipid-like materials for delivery of RNAi therapeutics Nature Biotechnol. 2008, 26 (5) 561-569 (Pubitemid 351668042)
-
(2008)
Nature Biotechnology
, vol.26
, Issue.5
, pp. 561-569
-
-
Akinc, A.1
Zumbuehl, A.2
Goldberg, M.3
Leshchiner, E.S.4
Busini, V.5
Hossain, N.6
Bacallado, S.A.7
Nguyen, D.N.8
Fuller, J.9
Alvarez, R.10
Borodovsky, A.11
Borland, T.12
Constien, R.13
De Fougerolles, A.14
Dorkin, J.R.15
Narayanannair Jayaprakash, K.16
Jayaraman, M.17
John, M.18
Koteliansky, V.19
Manoharan, M.20
Nechev, L.21
Qin, J.22
Racie, T.23
Raitcheva, D.24
Rajeev, K.G.25
Sah, D.W.Y.26
Soutschek, J.27
Toudjarska, I.28
Vornlocher, H.-P.29
Zimmermann, T.S.30
Langer, R.31
Anderson, D.G.32
more..
-
7
-
-
71949099757
-
Lipid-based nanotherapeutics for siRNA delivery
-
Schroeder, A.; Levins, C. G.; Cortez, C.; Langer, R.; Anderson, D. G. Lipid-based nanotherapeutics for siRNA delivery J. Intern. Med. 2010, 267 (1) 9-21
-
(2010)
J. Intern. Med.
, vol.267
, Issue.1
, pp. 9-21
-
-
Schroeder, A.1
Levins, C.G.2
Cortez, C.3
Langer, R.4
Anderson, D.G.5
-
8
-
-
34247504151
-
Structure and gene silencing activities of monovalent and pentavalent cationic lipid vectors complexed with siRNA
-
DOI 10.1021/bi062138l
-
Bouxsein, N. F.; McAllister, C. S.; Ewert, K. K.; Samuel, C. E.; Safinya, C. R. Structure and gene silencing activities of monovalent and pentavalent cationic lipid vectors complexed with siRNA Biochemistry 2007, 46 (16) 4785-4792 (Pubitemid 46651201)
-
(2007)
Biochemistry
, vol.46
, Issue.16
, pp. 4785-4792
-
-
Bouxsein, N.F.1
McAllister, C.S.2
Ewert, K.K.3
Samuel, C.E.4
Safinya, C.R.5
-
9
-
-
67249105434
-
A Novel Mechanism Is Involved in Cationic Lipid-Mediated Functional siRNA Delivery
-
Lu, J. J.; Langer, R.; Chen, J. Z. A Novel Mechanism Is Involved in Cationic Lipid-Mediated Functional siRNA Delivery Mol. Pharmaceutics 2009, 6 (3) 763-771
-
(2009)
Mol. Pharmaceutics
, vol.6
, Issue.3
, pp. 763-771
-
-
Lu, J.J.1
Langer, R.2
Chen, J.Z.3
-
10
-
-
1142274292
-
Surface Functionalized Cationic Lipid-DNA Complexes for Gene Delivery: PEGylated Lamellar Complexes Exhibit Distinct DNA-DNA Interaction Regimes
-
Martin-Herranz, A.; Ahmad, A.; Evans, H. M.; Ewert, K.; Schulze, U.; Safinya, C. R. Surface Functionalized Cationic Lipid-DNA Complexes for Gene Delivery: PEGylated Lamellar Complexes Exhibit Distinct DNA-DNA Interaction Regimes Biophys. J. 2004, 86 (2) 1160-1168 (Pubitemid 38209559)
-
(2004)
Biophysical Journal
, vol.86
, Issue.2
, pp. 1160-1168
-
-
Martin-Herranz, A.1
Ahmad, A.2
Evans, H.M.3
Ewert, K.4
Schulze, U.5
Safinya, C.R.6
-
11
-
-
12244291636
-
New multivalent cationic lipids reveal bell curve for transfection efficiency versus membrane charge density: Lipid - DNA complexes for gene delivery
-
DOI 10.1002/jgm.717
-
Ahmad, A.; Evans, H. M.; Ewert, K.; George, C. X.; Samuel, C. E.; Safinya, C. R. New multivalent cationic lipids reveal bell curve for transfection efficiency versus membrane charge density: lipid-DNA complexes for gene delivery J. Gene Med. 2005, 7, 739-748 (Pubitemid 40872860)
-
(2005)
Journal of Gene Medicine
, vol.7
, Issue.6
, pp. 739-748
-
-
Ahmad, A.1
Evans, H.M.2
Ewert, K.3
George, C.X.4
Samuel, C.E.5
Safinya, C.R.6
-
12
-
-
4143119891
-
DNA release from lipoplexes by anionic lipids: Correlation with lipid mesomorphism, interfacial curvature, and membrane fusion
-
DOI 10.1529/biophysj.104.042895
-
Tarahovsky, Y. S.; Koynova, R.; MacDonald, R. C. DNA release from lipoplexes by anionic lipids: correlation with lipid mesomorphism, interfacial curvature, and membrane fusion Biophys. J. 2004, 87 (2) 1054-1064 (Pubitemid 39095084)
-
(2004)
Biophysical Journal
, vol.87
, Issue.2
, pp. 1054-1064
-
-
Tarahovsky, Y.S.1
Koynova, R.2
MacDonald, R.C.3
-
13
-
-
33749254793
-
An intracellular lamellar-nonlamellar phase transition rationalizes the superior performance of some cationic lipid transfection agents
-
DOI 10.1073/pnas.0603085103
-
Koynova, R.; Wang, L.; MacDonald, R. C. An intracellular lamellar-nonlamellar phase transition rationalizes the superior performance of some cationic lipid transfection agents Proc. Natl. Acad. Sci. U.S.A. 2006, 103 (39) 14373-14378 (Pubitemid 44484757)
-
(2006)
Proceedings of the National Academy of Sciences of the United States of America
, vol.103
, Issue.39
, pp. 14373-14378
-
-
Koynova, R.1
Wang, L.2
MacDonald, R.C.3
-
14
-
-
56049093246
-
Cationic phospholipids forming cubic phases: Lipoplex structure and transfection efficiency
-
Koynova, R.; Wang, L.; MacDonald, R. C. Cationic phospholipids forming cubic phases: lipoplex structure and transfection efficiency Mol. Pharmaceutics 2008, 5 (5) 739-744
-
(2008)
Mol. Pharmaceutics
, vol.5
, Issue.5
, pp. 739-744
-
-
Koynova, R.1
Wang, L.2
MacDonald, R.C.3
-
15
-
-
52249095094
-
Modulation of a membrane lipid lamellar-nonlamellar phase transition by cationic lipids: A measure for transfection efficiency
-
Tenchov, B. G.; Wang, L.; Koynova, R.; MacDonald, R. C. Modulation of a membrane lipid lamellar-nonlamellar phase transition by cationic lipids: a measure for transfection efficiency Biochim. Biophys. Acta, Biomembr. 2008, 1778 (10) 2405-2412
-
(2008)
Biochim. Biophys. Acta, Biomembr.
, vol.1778
, Issue.10
, pp. 2405-2412
-
-
Tenchov, B.G.1
Wang, L.2
Koynova, R.3
MacDonald, R.C.4
-
16
-
-
70349339623
-
Cationic phospholipids: Structure-transfection activity relationships
-
Koynova, R.; Tenchov, B. Cationic phospholipids: structure-transfection activity relationships Soft Matter 2009, 5 (17) 3187-3200
-
(2009)
Soft Matter
, vol.5
, Issue.17
, pp. 3187-3200
-
-
Koynova, R.1
Tenchov, B.2
-
17
-
-
33745238126
-
Cubic membranes: A legend beyond the Flatland of cell membrane organization
-
Almsherqi, Z. A.; Kohlwein, S. D.; Deng, Y. Cubic membranes: a legend beyond the Flatland of cell membrane organization J. Cell Biol. 2006, 173 (6) 839-844
-
(2006)
J. Cell Biol.
, vol.173
, Issue.6
, pp. 839-844
-
-
Almsherqi, Z.A.1
Kohlwein, S.D.2
Deng, Y.3
-
18
-
-
63449100931
-
Cubic Membranes: The Missing Dimension of Cell Membrane Organization
-
Academic Press: New York, Chapter 6
-
Almsherqi, Z. A.; Landh, T.; Kohlwein, S. D.; Deng, Y.; Kwang, W. J., Cubic Membranes: The Missing Dimension of Cell Membrane Organization. In International Review of Cell and Molecular Biology; Academic Press: New York, 2009; Vol. 274, Chapter 6, pp 275-342
-
(2009)
International Review of Cell and Molecular Biology
, vol.274
, pp. 275-342
-
-
Almsherqi, Z.A.1
Landh, T.2
Kohlwein, S.D.3
Deng, Y.4
Kwang, W.J.5
-
19
-
-
47649095628
-
Cubic membranes: A structure-based design for DNA uptake
-
DOI 10.1098/rsif.2007.1351, PII L74556341131N441
-
Almsherqi, Z.; Hyde, S.; Ramachandran, M.; Deng, Y. Cubic membranes: a structure-based design for DNA uptake J. R. Soc. Interface 2008, 5 (26) 1023-1029 (Pubitemid 352020061)
-
(2008)
Journal of the Royal Society Interface
, vol.5
, Issue.26
, pp. 1023-1029
-
-
Almsherqi, Z.1
Hyde, S.2
Ramachandran, M.3
Deng, Y.4
-
20
-
-
78649527137
-
Highly Efficient Gene Silencing Activity of siRNA Embedded in a Nanostructured Gyroid Cubic Lipid Matrix
-
Leal, C.; Bouxsein, N. F.; Ewert, K. K.; Safinya, C. R. Highly Efficient Gene Silencing Activity of siRNA Embedded in a Nanostructured Gyroid Cubic Lipid Matrix J. Am. Chem. Soc. 2010, 132 (47) 16841-16847
-
(2010)
J. Am. Chem. Soc.
, vol.132
, Issue.47
, pp. 16841-16847
-
-
Leal, C.1
Bouxsein, N.F.2
Ewert, K.K.3
Safinya, C.R.4
-
21
-
-
79951665122
-
Self-Assembled Multicompartment Liquid Crystalline Lipid Carriers for Protein, Peptide, and Nucleic Acid Drug Delivery
-
Angelova, A.; Angelov, B.; Mutafchieva, R.; Lesieur, S.; Couvreur, P. Self-Assembled Multicompartment Liquid Crystalline Lipid Carriers for Protein, Peptide, and Nucleic Acid Drug Delivery Acc. Chem. Res. 2011, 44 (2) 147-156
-
(2011)
Acc. Chem. Res.
, vol.44
, Issue.2
, pp. 147-156
-
-
Angelova, A.1
Angelov, B.2
Mutafchieva, R.3
Lesieur, S.4
Couvreur, P.5
-
22
-
-
24344439854
-
Controlling release from the lipidic cubic phase. Amino acids, peptides, proteins and nucleic acids
-
DOI 10.1016/j.jconrel.2005.05.015, PII S0168365905002427
-
Clogston, J.; Caffrey, M. Controlling release from the lipidic cubic phase. Amino acids, peptides, proteins and nucleic acids J. Controlled Release 2005, 107 (1) 97-111 (Pubitemid 41253706)
-
(2005)
Journal of Controlled Release
, vol.107
, Issue.1
, pp. 97-111
-
-
Clogston, J.1
Caffrey, M.2
-
23
-
-
18544366270
-
Proteocubosomes: Nanoporous vehicles with tertiary organized fluid interfaces
-
DOI 10.1021/la047745t
-
Angelova, A.; Angelov, B.; Papahadjopoulos-Sternberg, B.; Ollivon, M.; Bourgaux, C. Proteocubosomes: Nanoporous Vehicles with Tertiary Organized Fluid Interfaces Langmuir 2005, 21 (9) 4138-4143 (Pubitemid 40654623)
-
(2005)
Langmuir
, vol.21
, Issue.9
, pp. 4138-4143
-
-
Angelova, A.1
Angelov, B.2
Papahadjopoulos-Sternberg, B.3
Ollivon, M.4
Bourgaux, C.5
-
24
-
-
0033361183
-
Surfactant self-assembly objects as novel drug delivery vehicles
-
DOI 10.1016/S1359-0294(00)00020-0, PII S1359029400000200
-
Drummond, C. J.; Fong, C. Surfactant self-assembly objects as novel drug delivery vehicles Curr. Opin. Colloid Interface Sci. 1999, 4 (6) 449-456 (Pubitemid 30449773)
-
(1999)
Current Opinion in Colloid and Interface Science
, vol.4
, Issue.6
, pp. 449-456
-
-
Drummond, C.J.1
Fong, C.2
-
25
-
-
4644239049
-
Cubic liquid-crystalline nanoparticles
-
DOI 10.1002/anie.200301683
-
Yang, D.; Armitage, B.; Marder, S. R. Cubic liquid-crystalline nanoparticles Angew. Chem. Int. Ed. 2004, 43 (34) 4402-4409 (Pubitemid 39268845)
-
(2004)
Angewandte Chemie - International Edition
, vol.43
, Issue.34
, pp. 4402-4409
-
-
Yang, D.1
Armitage, B.2
Marder, S.R.3
-
26
-
-
0035946622
-
Cubic phase gels as drug delivery systems
-
DOI 10.1016/S0169-409X(01)00108-9, PII S0169409X01001089
-
Shah, J. C.; Sadhale, Y.; Chilukuri, D. M. Cubic phase gels as drug delivery systems Adv. Drug Delivery Rev. 2001, 47 (2-3) 229-250 (Pubitemid 32324116)
-
(2001)
Advanced Drug Delivery Reviews
, vol.47
, Issue.2-3
, pp. 229-250
-
-
Shah, J.C.1
Sadhale, Y.2
Chilukuri, D.M.3
-
27
-
-
0036897324
-
Cationic charge determines the distribution of liposomes between the vascular and extravascular compartments of tumors
-
Campbell, R. B.; Fukumura, D.; Brown, E. B.; Mazzola, L. M.; Izumi, Y.; Jain, R. K.; Torchilin, V. P.; Munn, L. L. Cationic charge determines the distribution of liposomes between the vascular and extravascular compartments of tumors Cancer Res. 2002, 62 (23) 6831-6836 (Pubitemid 35424069)
-
(2002)
Cancer Research
, vol.62
, Issue.23
, pp. 6831-6836
-
-
Campbell, R.B.1
Fukumura, D.2
Brown, E.B.3
Mazzola, L.M.4
Izumi, Y.5
Jain, R.K.6
Torchilin, V.P.7
Munn, L.L.8
-
28
-
-
56549128631
-
Glycerol monooleate-blood interactions
-
Ericsson, E. M.; Faxälv, L.; Weissenrieder, A.; Askendal, A.; Lindahl, T. L.; Tengvall, P. Glycerol monooleate-blood interactions Colloids Surf., B 2009, 68 (1) 20-26
-
(2009)
Colloids Surf., B
, vol.68
, Issue.1
, pp. 20-26
-
-
Ericsson, E.M.1
Faxälv, L.2
Weissenrieder, A.3
Askendal, A.4
Lindahl, T.L.5
Tengvall, P.6
-
29
-
-
77952884909
-
Interactions of lipid-based liquid crystalline nanoparticles with model and cell membranes
-
Barauskas, J.; Cervin, C.; Jankunec, M.; Spandyreva, M.; Ribokaite, K.; Tiberg, F.; Johnsson, M. Interactions of lipid-based liquid crystalline nanoparticles with model and cell membranes Int. J. Pharm. 2010, 391 (1-2) 284-291
-
(2010)
Int. J. Pharm.
, vol.391
, Issue.1-2
, pp. 284-291
-
-
Barauskas, J.1
Cervin, C.2
Jankunec, M.3
Spandyreva, M.4
Ribokaite, K.5
Tiberg, F.6
Johnsson, M.7
-
30
-
-
27944464099
-
Lipid phase control of DNA delivery
-
DOI 10.1021/bc050226x
-
Koynova, R.; Wang, L.; Tarahovsky, Y.; MacDonald, R. C. Lipid phase control of DNA delivery Bioconjugate Chem. 2005, 16 (6) 1335-1339 (Pubitemid 41681495)
-
(2005)
Bioconjugate Chemistry
, vol.16
, Issue.6
, pp. 1335-1339
-
-
Koynova, R.1
Wang, L.2
Tarahovsky, Y.3
MacDonald, R.C.4
-
31
-
-
0032479572
-
An inverted hexagonal phase of cationic liposome-DNA complexes related to DNA release and delivery
-
DOI 10.1126/science.281.5373.78
-
Koltover, I.; Salditt, T.; Radler, J. O.; Safinya, C. R. An inverted hexagonal phase of cationic liposome-DNA complexes related to DNA release and delivery Science 1998, 281 (5373) 78-81 (Pubitemid 28354046)
-
(1998)
Science
, vol.281
, Issue.5373
, pp. 78-81
-
-
Koltover, I.1
Salditt, T.2
Radler, J.O.3
Safinya, C.R.4
|