Leptin promotes osteoblast differentiation and mineralization of primary cultures of vascular smooth muscle cells by inhibiting glycogen synthase kinase (GSK)-3β

Biochemical and Biophysical Research Communications

Volumn 425, Issue 4, 2012, Pages 924-930

  Zeadin, Melec G ^a,b   Butcher, Martin K ^a,b,c   Shaughnessy, Stephen G ^a,b   Werstuck, Geoff H ^a,b  

^a MCMASTER UNIVERSITY   (Canada)

^b MCMASTER UNIVERSITY   (Canada)

^c JURAVINSKI CANCER CENTRE   (Canada)

Author keywords

GSK 3 ; Leptin; Osteoblasts; Vascular calcification; Vascular smooth muscle cells; Wnt signaling

Indexed keywords

ALKALINE PHOSPHATASE; BETA CATENIN; BONE SIALOPROTEIN; GLYCOGEN SYNTHASE KINASE; LEPTIN; MESSENGER RNA; OSTEOPONTIN; WNT PROTEIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL CALCIFICATION; CELL DIFFERENTIATION; ENZYME INHIBITION; MINERALIZATION; NONHUMAN; OSTEOBLAST; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; VASCULAR SMOOTH MUSCLE;

ACTIVE TRANSPORT, CELL NUCLEUS; ANIMALS; BETA CATENIN; CALCIFICATION, PHYSIOLOGIC; CALCIUM-BINDING PROTEINS; CATTLE; CELL DIFFERENTIATION; CELL NUCLEUS; CELLS, CULTURED; EXTRACELLULAR MATRIX PROTEINS; GLYCOGEN SYNTHASE KINASE 3; HUMANS; INTEGRIN-BINDING SIALOPROTEIN; LEPTIN; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; OSTEOBLASTS; OSTEOPONTIN;

ADENOVIRIDAE; BOVINAE;

EID: 84865982612     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2012.08.011     Document Type: Article

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