Adoptive transfer of naïve dendritic cells in resolving post-sepsis long-term immunosuppression

Medical Hypotheses

Volumn 79, Issue 4, 2012, Pages 478-480

  Laudanski, Krzysztof ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; HISTONE H3; INTERLEUKIN 12; PROSTACYCLIN; TUMOR NECROSIS FACTOR ALPHA;

ADAPTIVE IMMUNITY; ADOPTIVE TRANSFER; ARTICLE; DENDRITIC CELL; EPIGENETICS; HEMATOPOIETIC STEM CELL; HUMAN; IMMUNE DEFICIENCY; IMMUNOMODULATION; INNATE IMMUNITY; LIFE EXPECTANCY; LUNG ASPERGILLOSIS; MESENCHYMAL STEM CELL; MONOCYTE; MYELOID DENDRITIC CELL; NEOPLASM; NONHUMAN; OPPORTUNISTIC INFECTION; SEPSIS; STEM CELL; SURVIVOR;

ADAPTIVE IMMUNITY; DENDRITIC CELLS; HUMANS; IMMUNE TOLERANCE; IMMUNITY, INNATE; IMMUNOTHERAPY, ADOPTIVE; MODELS, IMMUNOLOGICAL; SEPSIS;

EID: 84865980962     PISSN: 03069877     EISSN: 15322777     Source Type: Journal    
DOI: 10.1016/j.mehy.2012.06.028     Document Type: Article

References (34)

1. Siner J.M. Sepsis: definitions, epidemiology, etiology and pathogenesis, PCCSU 2009, American College of Chest Physician, Chicago, IL, pp. 0-3.
2. Stearns-Kurosawa D.J., Osuchowski M.F., Valentine C., Kurosawa S., Remick D.G. The pathogenesis of sepsis. Annu Rev Pathol 2010.
3. Quartin A.A., Schein R.M., Kett D.H., Peduzzi P.N. Magnitude and duration of the effect of sepsis on survival. Department of Veterans Affairs Systemic Sepsis Cooperative Studies Group. JAMA 1997, 277:1058-1063.
4. Delano M.J., Thayer T., Gabrilovich S., Kelly-Scumpia K.M., Winfield R.D., Scumpia P.O., et al. Sepsis induces early alterations in innate immunity that impact mortality to secondary infection. J Immunol 2011, 186:195-202.
5. Benjamim C.F., Hogaboam C.M., Kunkel S.L. The chronic consequences of severe sepsis. J Leukoc Biol 2004, 75:408-412.
6. Osawa R., Singh N. Cytomegalovirus infection in critically ill patients: a systematic review. Crit Care 2009, 13:R68.
7. Pastille E., Didovic S., Brauckmann D., Rani M., Agrawal H., Schade F.U., et al. Modulation of dendritic cell differentiation in the bone marrow mediates sustained immunosuppression after polymicrobial sepsis. J Immunol 2011, 186:977-986.
8. Marshall J.C. Sepsis: rethinking the approach to clinical research. J Leukoc Biol 2008, 83:471-482.
9. Beutler B., Poltorak A. Sepsis and evolution of the innate immune response. Crit Care Med 2001, 29:S2-S6. [discussion S6-S7].
10. Sriskandan S., Altmann D.M. The immunology of sepsis. J Pathol 2008, 214:211-223.
11. Travis J. Origins. On the origin of the immune system. Science 2009, 324:580-582.
12. Wen H., Schaller M.A., Dou Y., Hogaboam C.M., Kunkel S.L. Dendritic cells at the interface of innate and acquired immunity: the role for epigenetic changes. J Leukoc Biol 2008, 83:439-446.
13. Adema G.J. Dendritic cells from bench to bedside and back. Immunol Lett 2009, 122:128-130.
14. Auffray C., Sieweke M.H., Geissmann F. Blood monocytes: development, heterogeneity, and relationship with dendritic cells. Annu Rev Immunol 2009, 27:669-692.
15. Merad M., Manz M.G. Dendritic cell homeostasis. Blood 2009, 113:3418-3427.
16. Toapanta F.R., Ross T.M. Impaired immune responses in the lungs of aged mice following influenza infection. Respir Res 2009, 10:112.
17. Geissmann F., Manz M.G., Jung S., Sieweke M.H., Merad M., Ley K. Development of monocytes, macrophages, and dendritic cells. Science 2010, 327:656-661.
18. Hoebe K., Janssen E., Beutler B. The interface between innate and adaptive immunity. Nat Immunol 2004, 5:971-974.
19. Palucka K.A., Taquet N., Sanchez-Chapuis F., Gluckman J.C. Dendritic cells as the terminal stage of monocyte differentiation. J Immunol 1998, 160:4587-4595.
20. Venet F., Huang X., Chung C.S., Chen Y., Ayala A. Plasmacytoid dendritic cells control lung inflammation and monocyte recruitment in indirect acute lung injury in mice. Am J Pathol 2010, 176:764-773.
21. Naik S.H., Metcalf D., van Nieuwenhuijze A., Wicks I., Wu L., O'Keeffe M., et al. Intrasplenic steady-state dendritic cell precursors that are distinct from monocytes. Nat Immunol 2006, 7:663-671.
22. Chomarat P., Banchereau J., Davoust J., Palucka A.K. IL-6 switches the differentiation of monocytes from dendritic cells to macrophages. Nat Immunol 2000, 1:510-514.
23. Suckale J., Sim R.B., Dodds A.W. Evolution of innate immune systems. Biochem Mol Biol Educ 2005, 33:177-183.
24. Danilova N. Evolution of the Human Immune System 2008, Encyclopedia of Life Sciences, John Wiley and Sons, Chichester.
25. Hotchkiss R.S., Karl I.E. The pathophysiology and treatment of sepsis. N Engl J Med 2003, 348:138-150.
26. Carson W.F., Cavassani K.A., Dou Y., Kunkel S.L. Epigenetic regulation of immune cell functions during post-septic immunosuppression. Epigenetics 2011, 6:273-283.
27. Wen H., Dou Y., Hogaboam C.M., Kunkel S.L. Epigenetic regulation of dendritic cell-derived interleukin-12 facilitates immunosuppression after a severe innate immune response. Blood 2008, 111:1797-1804.
28. Grimaldi D., Louis S., Pene F., Sirgo G., Rousseau C., Claessens Y.E., et al. Profound and persistent decrease of circulating dendritic cells is associated with ICU-acquired infection in patients with septic shock. Intensive Care Med 2011, 37:1438-1446.
29. Benjamim C.F., Hogaboam C.M., Lukacs N.W., Kunkel S.L. Septic mice are susceptible to pulmonary aspergillosis. Am J Pathol 2003, 163:2605-2617.
30. Pene F., Zuber B., Courtine E., Rousseau C., Ouaaz F., Toubiana J., et al. Dendritic cells modulate lung response to Pseudomonas aeruginosa in a murine model of sepsis-induced immune dysfunction. J Immunol 2008, 181:8513-8520.
31. Kuo C.H., Lin C.H., Yang S.N., Huang M.Y., Chen H.L., Kuo P.L., et al. Effect of PGI(2) analogs on cytokine expression in human myeloid dendritic cells via epigenetic regulation. Mol Med 2011.
32. Foster S.L., Hargreaves D.C., Medzhitov R. Gene-specific control of inflammation by TLR induced chromatin modifications. Nature 2007, 447:972-978.
33. Ghannam S., Bouffi C., Djouad F., Jorgensen C., Noel D. Immunosuppression by mesenchymal stem cells: mechanisms and clinical applications. Stem Cell Res Therapy 2010, 1:2.
34. Delano M.J., Kelly-Scumpia K.M., Thayer T.C., Winfield R.D., Scumpia P.O., Cuenca A.G., et al. Neutrophil mobilization from the bone marrow during polymicrobial sepsis is dependent on CXCL12 signaling. J Immunol 2011, 187:911-918.