Longitudinal changes in serum ferritin levels correlate with measures of hepatic stiffness in transfusion-independent patients with β-thalassemia intermedia

Blood Cells, Molecules, and Diseases

Volumn 49, Issue 3-4, 2012, Pages 136-139

  Musallam, Khaled M ^a   Motta, Irene ^a   Salvatori, Marta ^a   Fraquelli, Mirella ^a   Marcon, Alessia ^a   Taher, Ali T ^b   Cappellini, Maria Domenica ^a  

^a UNIVERSITY OF MILAN   (Italy)

^b AMERICAN UNIVERSITY OF BEIRUT   (Lebanon)

Author keywords

Chelation; Fibrosis; Iron; Liver; Thalassemia intermedia

Indexed keywords

FERRITIN; IRON CHELATING AGENT;

ADULT; ARTICLE; BETA THALASSEMIA; BLOOD TRANSFUSION; CHELATION; CLINICAL ARTICLE; COHORT ANALYSIS; CONTROLLED STUDY; DIAGNOSTIC TEST ACCURACY STUDY; DIAGNOSTIC VALUE; DISEASE ASSOCIATION; DISEASE COURSE; ELASTOGRAPHY; FERRITIN BLOOD LEVEL; HEALTH STATUS; HUMAN; HUMAN TISSUE; INTERMETHOD COMPARISON; IRON OVERLOAD; LIVER BIOPSY; LIVER FIBROSIS; LIVER STIFFNESS; LONGITUDINAL STUDY; PREDICTION; PRIORITY JOURNAL; REPRODUCIBILITY; RETROSPECTIVE STUDY; SENSITIVITY AND SPECIFICITY;

ADULT; BETA-THALASSEMIA; BLOOD TRANSFUSION; CASE-CONTROL STUDIES; ELASTICITY IMAGING TECHNIQUES; FEMALE; FERRITINS; FIBROSIS; HUMANS; IRON; IRON CHELATING AGENTS; IRON OVERLOAD; LIVER; LONGITUDINAL STUDIES; MALE; MIDDLE AGED;

EID: 84865977512     PISSN: 10799796     EISSN: 10960961     Source Type: Journal    
DOI: 10.1016/j.bcmd.2012.06.001     Document Type: Article

References (24)

1. Ginzburg Y., Rivella S. beta-Thalassemia: a model for elucidating the dynamic regulation of ineffective erythropoiesis and iron metabolism. Blood 2011, 118:4321-4330.
2. Nai A., Pagani A., Mandelli G., et al. Deletion of Tmprss6 attenuates the phenotype in a mouse model of beta-thalassemia. Blood 2012, (Published online before print April 6, 2012). 10.1182/blood-2012-01-401885.
3. Parrow N.L., Gardenghi S., Ramos P., et al. Decreased hepcidin expression in murine beta-thalassemia is associated with suppression of Bmp/Smad signaling. Blood 2012, 119:3187-3189.
4. Origa R., Galanello R., Ganz T., et al. Liver iron concentrations and urinary hepcidin in beta-thalassemia. Haematologica 2007, 92:583-588.
5. Pakbaz Z., Fischer R., Fung E., et al. Serum ferritin underestimates liver iron concentration in transfusion independent thalassemia patients as compared to regularly transfused thalassemia and sickle cell patients. Pediatr. Blood Cancer 2007, 49:329-332.
6. Taher A., Musallam K.M., El Rassi F., et al. Levels of non-transferrin-bound iron as an index of iron overload in patients with thalassaemia intermedia. Br. J. Haematol. 2009, 146:569-572.
7. Taher A., El Rassi F., Isma'eel H., et al. Correlation of liver iron concentration determined by R2 magnetic resonance imaging with serum ferritin in patients with thalassemia intermedia. Haematologica 2008, 93:1584-1586.
8. Taher A.T., Musallam K.M., El-Beshlawy A., et al. Age-related complications in treatment-naive patients with thalassaemia intermedia. Br. J. Haematol. 2010, 150:486-489.
9. Roghi A., Cappellini M.D., Wood J.C., et al. Absence of cardiac siderosis despite hepatic iron overload in Italian patients with thalassemia intermedia: an MRI T2* study. Ann. Hematol. 2010, 89:585-589.
10. Taher A.T., Musallam K.M., Wood J.C., Cappellini M.D. Magnetic resonance evaluation of hepatic and myocardial iron deposition in transfusion-independent thalassemia intermedia compared to regularly transfused thalassemia major patients. Am. J. Hematol. 2010, 85:288-290.
11. Origa R., Barella S., Argiolas G.M., et al. No evidence of cardiac iron in 20 never- or minimally-transfused patients with thalassemia intermedia. Haematologica 2008, 93:1095-1096.
12. Musallam K.M., Cappellini M.D., Wood J.C., et al. Elevated liver iron concentration is a marker of increased morbidity in patients with beta thalassemia intermedia. Haematologica 2011, 96:1605-1612.
13. Musallam K.M., Beydoun A., Hourani R., et al. Brain magnetic resonance angiography in splenectomized adults with beta-thalassemia intermedia. Eur. J. Haematol. 2011, 87:539-546.
14. Musallam K.M., Nasreddine W., Beydoun A., et al. Brain positron emission tomography in splenectomized adults with beta-thalassemia intermedia: uncovering yet another covert abnormality. Ann. Hematol. 2012, 91:235-241.
15. Fraquelli M., Cassinerio E., Roghi A., et al. Transient elastography in the assessment of liver fibrosis in adult thalassemia patients. Am. J. Hematol. 2010, 85:564-568.
16. Restivo Pantalone G., Renda D., Valenza F., et al. Hepatocellular carcinoma in patients with thalassaemia syndromes: clinical characteristics and outcome in a long term single centre experience. Br. J. Haematol. 2010, 150:245-247.
17. Borgna-Pignatti C., Vergine G., Lombardo T., et al. Hepatocellular carcinoma in the thalassaemia syndromes. Br. J. Haematol. 2004, 124:114-117.
18. Mancuso A. Hepatocellular carcinoma in thalassemia: a critical review. World J. Hepatol. 2010, 2:171-174.
19. Cossu P., Toccafondi C., Vardeu F., et al. Iron overload and desferrioxamine chelation therapy in beta-thalassemia intermedia. Eur. J. Pediatr. 1981, 137:267-271.
20. Ladis V., Berdousi H., Gotsis E., Kattamis A. Deferasirox administration for the treatment of non-transfusional iron overload in patients with thalassaemia intermedia. Br. J. Haematol. 2010, 151:504-508.
21. Voskaridou E., Plata E., Douskou M., et al. Treatment with deferasirox (Exjade) effectively decreases iron burden in patients with thalassaemia intermedia: results of a pilot study. Br. J. Haematol. 2010, 148:332-334.
22. Olivieri N.F., Koren G., Matsui D., et al. Reduction of tissue iron stores and normalization of serum ferritin during treatment with the oral iron chelator L1 in thalassemia intermedia. Blood 1992, 79:2741-2748.
23. Pippard M.J., Weatherall D.J. Iron balance and the management of iron overload in beta-thalassemia intermedia. Birth Defects Orig. Artic. Ser. 1988, 23:29-33.
24. Angelucci E., Muretto P., Nicolucci A., et al. Effects of iron overload and hepatitis C virus positivity in determining progression of liver fibrosis in thalassemia following bone marrow transplantation. Blood 2002, 100:17-21.