Serum ferritin underestimates liver iron concentration in transfusion independent thalassemia patients as compared to regularly transfused thalassemia and sickle cell patients

Pediatric Blood and Cancer

Volumn 49, Issue 3, 2007, Pages 329-332

  Pakbaz, Zahra ^a   Fischer, Roland ^a,b   Fung, Ellen ^a   Nielsen, Peter ^b   Harmatz, Paul ^a   Vichinsky, Elliott ^a  

^a CHILDREN S HOSPITAL OAKLAND   (United States)

^b UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

Author keywords

Ferritin; Liver iron concentration; Sickle cell; Thalassemia

Indexed keywords

ASCORBIC ACID; BIOLOGICAL MARKER; DEFEROXAMINE; FERRITIN; IRON;

ADOLESCENT; ADULT; ARTICLE; CHELATION THERAPY; CHILD; CORRELATION ANALYSIS; DISEASE SEVERITY; ERYTHROCYTE TRANSFUSION; FEMALE; FERRITIN BLOOD LEVEL; HUMAN; IRON LIVER LEVEL; IRON OVERLOAD; LIVER LEVEL; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; SICKLE CELL ANEMIA; THALASSEMIA;

ADOLESCENT; ADULT; ANEMIA, SICKLE CELL; BLOOD TRANSFUSION; CHILD; CHILD, PRESCHOOL; FEMALE; FERRITINS; HUMANS; IRON OVERLOAD; LIVER; MALE; MIDDLE AGED; PREDICTIVE VALUE OF TESTS; THALASSEMIA;

EID: 34547799156     PISSN: 15455009     EISSN: 15455017     Source Type: Journal    
DOI: 10.1002/pbc.21275     Document Type: Article

References (20)

1. Bannerman RM, Keusch G, Kreimer-Birnbaum M, et al. Thalassemia intermedia, with iron overload, cardiac failure, diabetes mellitus, hypopituitarism and porphyrinuria. Am J Med 1967;42: 476-486.
2. Celada A. Iron overload in a non-transfused patient with thalassaemia intermedia. Scand J Haematol 1982;28:169-174.
3. Finch CA, Bellotti V, Stray S, et al. Plasma ferritin determination as a diagnostic tool. West J Med 1986;145:657-663.
4. Brittenham GM, Cohen AR, McLaren CE, et al. Hepatic iron stores and plasma ferritin concentration in patients with sickle cell anemia and thalassemia major. Am J Hematol 1993;42:81-85.
5. Telfer PT, Prestcott E, Holden S, et al. Hepatic iron concentration combined with long-term monitoring of serum ferritin to predict complications of iron overload in thalassaemia major. Br J Haematol 2000;110:971-977.
6. Fischer R. Liver iron susceptometry. In: Andrae W, Nowak H, editors. Magnetism in medicine - A handbook. Berlin: Wiley-VCH; 1998. pp 286-301.
7. Fung E, Fischer R, Pakbaz Z, et al. The New SQUID Biosusceptometer at Oakland: First year of experience. Neurol Clin Neurophysiol 2004; 5.
8. Brittenham GM, Farrell DE, Harris JW, et al. Magnetic-susceptibility measurement of human iron stores. N Engl J Med 1982;307: 1671-1675.
9. Olivieri NF, Brittenham GM. Iron-chelating therapy and the treatment of thalassemia. Blood 1997;89:739-761.
10. Fischer R, Harmatz P, Nielsen P. Does liver biopsy overestimate liver iron concentration? Blood 2006;108: letter, 1775-1776; author reply 1776.
11. Fischer R, Tiemann CD, Engelhardt R, et al. Assessment of iron stores in children with transfusion siderosis by biomagnetic liver susceptometry. Am J Hematol 1999;60:289-299.
12. Nielsen P, Engelhardt R, Duerken M, et al. Using SQUID biomagnetic liver susceptometry in the treatment of thalassemia and other iron loading diseases. Transfus Sci 2000;23:257-258.
13. Brittenham GM. Disorders of iron metabolism: Iron deficiency and overload. In: Hoffman R, Benz EJ, Shattil S, et al., editors. Hematology: Basic principals and practice. Philadelphia, PA: Churchill Livingstone; 2000. pp 397-428.
14. Adamsky K, Weizer O, Amariglio N, et al. Decreased hepcidin mRNA expression in thalassemic mice. Br J Haematol 2004;124: 123-124.
15. Papanikolaou G, Tzilianos M, Christakis JI, et al. Hepcidin in iron overload disorders. Blood 2005;105:4103-4105.
16. Nemeth E, Rivera S, Gabayan V, et al. IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin. J Clin Invest 2004;113:1271-1276.
17. Muller RA, Morris DE. Geomagnetic reversals driven by sudden climate changes. Eos 1989;70:276.
18. Fukao S, McClure JP, Ito A, et al. 1st VHF radar observation of midlatitude F-region field-aligned irregularities. Geophys Res Lett 1999;15:768.
19. Buonanno G, Valente A, Gonnella F, et al. Serum ferritin in beta-thalassaemia intermedia. Scand J Haematol 1984;32:83-87.
20. Fiorelli G, Fargion S, Piperno A, et al. Iron metabolism in thalassemia intermedia. Haematologica 1990;75:89-95.