Epidermal growth factor receptor pathway mitigates UVA-induced G2/M arrest in keratinocyte cells

Journal of Investigative Dermatology

Volumn 127, Issue 10, 2007, Pages 2418-2424

  Jean, Christine ^a   Hernandez Pigeon, Hélène ^a,b   Blanc, Amandine ^a   Charveron, Marie ^b   Laurent, Guy ^a  

^a CHU PURPAN   (France)

^b INSTITUT DE RECHERCHE PIERRE FABRE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CHECKPOINT KINASE 1; EPIDERMAL GROWTH FACTOR RECEPTOR; PROTEIN KINASE B; SERINE; HER1 PROTEIN, HUMAN; MITOGEN ACTIVATED PROTEIN KINASE KINASE; ONCOPROTEIN; PROTEIN KINASE; UNCLASSIFIED DRUG;

ARTICLE; CELL CULTURE; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL TRANSFORMATION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; KERATINOCYTE; PRIORITY JOURNAL; ULTRAVIOLET A RADIATION; CELL DIVISION; CELL LINE; CELL SURVIVAL; METABOLISM; PATHOLOGY; PHOSPHORYLATION; PHYSIOLOGY; RADIATION EXPOSURE; RADIATION RESPONSE; SIGNAL TRANSDUCTION; ULTRAVIOLET RADIATION;

CELL DIVISION; CELL LINE; CELL SURVIVAL; CELL TRANSFORMATION, NEOPLASTIC; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, RADIATION; G2 PHASE; HUMANS; KERATINOCYTES; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; ONCOGENE PROTEIN V-AKT; PHOSPHORYLATION; PROTEIN KINASES; RECEPTOR, EPIDERMAL GROWTH FACTOR; SIGNAL TRANSDUCTION; ULTRAVIOLET RAYS;

EID: 34848927147     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/sj.jid.5700863     Document Type: Article

References (24)

1. Agar NS, Halliday GM, Barnetson RS, Ananthaswamy HN, Wheeler M, Jones AM (2004) The basal layer in human squamous tumors harbors more UVA than UVB fingerprint mutations: a role for UVA in human skin carcinogenesis. Proc Natl Acad Sci USA 101:4954-9
2. Bartek J, Lukas J (2003) Chk1 and Chk2 kinases in checkpoint control and cancer. Cancer Cell 3:421-9
3. Durocher F, Labrie Y, Soucy P, Sinilnikova O, Labuda D, Bessette P et al. (2006) Mutation analysis and characterization of ATR sequence variants in breast cancer cases from high-risk French Canadian breast/ovarian cancer families. BMC Cancer 6:230
4. El-Abaseri TB, Fuhrman J, Trempus C, Shendrik I, Tennant RW, Hansen LA (2005) Chemoprevention of UV light-induced skin tumorigenesis by inhibition of the epidermal growth factor receptor. Cancer Res 65:3958-65
5. El-Abaseri TB, Putta S, Hansen LA (2006) Ultraviolet irradiation induces keratinocyte proliferation and epidermal hyperplasia through the activation of the epidermal growth factor receptor. Carcinogenesis 27:225-31
6. He YY, Huang JL, Chignell CF (2004) Delayed and sustained activation of extracellular signal-regulated kinase in human keratinocytes by UVA: implications in carcinogenesis. J Biol Chem 279:53867-74
7. He YY, Pi J, Huang JL, Diwan BA, Waalkes MP, Chignell CF (2006) Chronic UVA irradiation of human HaCaT keratinocytes induces malignant transformation associated with acquired apoptotic resistance. Oncogene 26:3680-8
8. Hernandez-Pigeon H, Jean C, Charruyer A, Haure MJ, Baudouin C, Charveron M et al. (2007) UVA induces granzyme B in human keratinocytes through MIF: Implication in extracellular matrix remodelling. J Biol Chem 282:8157-64
9. Hirose Y, Katayama M, Mirzoeva OK, Berger MS, Pieper RO (2005) Akt activation suppresses Chk2-mediated, methylating agent-induced G2 arrest and protects from temozolomide-induced mitotic catastrophe and cellular senescence. Cancer Res 65:4861-9
10. Jessus C, Ozon R (1995) Function and regulation of cdc25 protein phosphate through mitosis and meiosis. Prog Cell Cycle Res 1:215-28
11. Kamata N, Chida K, Rikimaru K, Horikoshi M, Enomoto S, Kuroki T. (1986) Growth-inhibitory effects of epidermal growth factor and overexpression of its receptors on human squamous cell carcinomas in culture. Cancer Res 46:1648-53
12. Kappes UP, Luo D, Potter M, Schulmeister K, Runger TM. (2006) Short- and long-wave UV light (UVB and UVA) induce similar mutations in human skin cells. J Invest Dermatol 126:667-75
13. King FW, Skeen J, Hay N, Shtivelman E (2004) Inhibition of Chk1 by activated PKB/Akt. Cell Cycle 3:634-7
14. Nyberg KA, Michelson RJ, Putnam CW, Weinert TA (2002) Toward maintaining the genome: DNA damage and replication checkpoints. Annu Rev Genet 36:617-56
15. Manke IA, Nguyen A, Lim D, Stewart MQ, Elia AE, Yaffe MB. (2005) MAPKAP kinase-2 is a cell cycle checkpoint kinase that regulates the G2/M transition and S phase progression in response to UV irradiation. Mol Cell 17:37-48
16. Peng CY, Graves PR, Thoma RS, Wu Z, Shaw AS, Piwnica-Worms H (1997) Mitotic and G2 checkpoint control: regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216. Science 277:1501-5
17. Phillipson RP, Tobi SE, Morris JA, McMillan TJ (2002) UV-A induces persistent genomic instability in human keratinocytes through an oxidative stress mechanism. Free Radic Biol Med 32:474-80
18. Puc J, Parsons R (2005) PTEN loss inhibits CHK1 to cause double stranded-DNA breaks in cells. Cell Cycle 4:927-9
19. Rochette PJ, Therrien JP, Drouin R, Perdiz D, Bastien N, Drobetsky EA et al. (2003) UVA-induced cyclobutane pyrimidine dimers form predominantly at thymine-thymine dipyrimidines and correlate with the mutation spectrum in rodent cells. Nucleic Acids Res 31:2786-94
20. Sancar A, Lindsey-Boltz LA, Unsal-Kacmaz K, Linn S (2004) Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints. Annu Rev Biochem 73:39-85
21. Shimizu T, Izumi H, Oga A, Furumoto H, Murakami T, Ojuji R et al. (2001) Epidermal growth factor receptor overexpression and genetic aberrations in metastatic squamous-cell carcinoma of the skin. Dermatology 202:203-6
22. Stiff T, Walker SA, Cerosaletti K, Goodarzi AA, Petermann E, Concannon P et al. (2006) ATR-dependent phosphorylation and activation of ATM in response to UV treatment or replication fork stalling. EMBO J 25:5775-82
23. Toussaint O, Remacle J, Dierick JF, Pascal T, Frippiat C, Zdanov S et al. (2002) From the Hayflick mosaic to the mosaics of ageing. Role of stress-induced premature senescence in human ageing. Int J Biochem Cell Biol 34:1415-29
24. Zhang Y, Dong Z, Bode AM, Ma WY, Chen N, Dong Z (2001) Induction of EGFR-dependent and EGFR-independent signaling pathways by ultraviolet A irradiation. DNA Cell Biol 20:769-79