Trioxsalen in the presence of UVA is able to induce nuclear factor kappa B binding activity in HaCaT keratinocytes

Skin Pharmacology and Applied Skin Physiology

Volumn 15, Issue 5, 2002, Pages 335-341

  Sanchez Ruderisch H ^a   Schwarz, C ^a   Shang, J ^a   Tebbe, B ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

HaCaT; Nuclear factor kappa B; Trioxsalen; UVA

Indexed keywords

3 (4 METHYLPHENYLSULFONYL) 2 PROPENENITRILE; COMPLEMENTARY DNA; CYTOKINE; CYTOKINE RECEPTOR; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1 RECEPTOR; INTERLEUKIN 12; INTERLEUKIN 2 RECEPTOR; PLATELET DERIVED GROWTH FACTOR; TRIOXYSALEN; TUMOR NECROSIS FACTOR ALPHA;

CELL PROLIFERATION; CELL STRAIN; CONFERENCE PAPER; CONTROLLED STUDY; CULTURE MEDIUM; CYTOTOXICITY; ELECTROPHORETIC MOBILITY; GENE EXPRESSION; HUMAN; HUMAN CELL; KERATINOCYTE; PRIORITY JOURNAL; PROTEIN BINDING; REGULATORY MECHANISM; ULTRAVIOLET A RADIATION;

CELL DIVISION; CELLS, CULTURED; GENE EXPRESSION; HUMANS; KERATINOCYTES; NF-KAPPA B; PROTEIN BINDING; TRIOXSALEN; ULTRAVIOLET RAYS;

EID: 0036379069     PISSN: 14222868     EISSN: None     Source Type: Journal    
DOI: 10.1159/000064538     Document Type: Conference Paper

References (14)

1. Beijersbergen van Henegouwen GM, Wijn ET, Schoonderwoerd SA, Dall'Acqua F: A method for the determination of PUVA-induced in vivo irreversible binding of 8-methoxypsoralen (8-MOP) to epidermal lipids, proteins and DNA/RNA. J Photochem Photobiol B 1989;3:631-635.
2. Moor AC, Gasparro FP: Biochemical aspects of psoralen photochemotherapy. Clin Dermatol 1996;14:353-365.
3. Wlaschek M, Hommel C, Wenk J, Brenneisen P, Ma W, Herrmann G, Scharffetter-Kochanek K: Isolation and identification of psoralen plus ultraviolet A (PUVA)-induced genes in human dermal fibroblast by polymerase chain reaction-based subtractive hybridization. J Invest Dermatol 2000;115:909-913.
4. Nivsarkar M, Kumar GP, Laloraya M: Photophysical alterations of erythrocyte membrane by 4,5′,8-trimethyl psoralen: Membrane response towards psoralen phototherapy. Biochem Biophys Res Commun 1994;199:1413-1421.
5. Pathak MA: Molecular aspects of drug photosensitivity with special emphasis on psoralen photosensitization reaction. J Natl Cancer Inst 1982;69:163-170.
6. Karin M: The beginning of the end: IkappaB kinase (IKK) and NF-kappaB activation. J Biol Chem 1999;274:27339-27342.
7. Kaufman CK, Fuchs E: It's got you covered. NF-kappaB in the epidermis. J Cell Biol 2000;149:999-1004.
8. Boukamp P, Petrussevska RT, Breitkreutz D, Hornung J, Markham A, Fusenig NE: Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line. J Cell Biol 1988;106:761-771.
9. Gillies RJ, Didier N, Denton M: Determination of cell number in monolayer cultures. Anal Biochem 1986;159:1089-1113.
10. Corsini E, Terzoli A, Bruccoleri A, Marinovich M, Galli CL: Induction of tumor necrosis factor-α in vivo by a skin irritant, tributyltin, through activation of transcription factors: Its pharmacological modulation by anti-inflammatory drugs. J Invest Dermatol 1997;108:892-896.
11. Hirano F, Chung M, Tanaka H, Maruyama N, Makino I, Moore D, Scheidereit C: Alternative splicing variants of IκBβ establish differential NF-κB signal responsiveness in human cells. Mol Cell Biol 1998;18:2596-2607.
12. Tebbe B, Schwarz C, Sánchez Ruderisch H, Treudler R, Orfanos CE: L-ascorbic acid increases NFκB activation in UVA-irradiated HaCaT keratinocytes. J Invest Dermatol 2001;117:154-156.
13. Liu Z, Lu Y, Lebwohl M, Wei H: PUVA (8-methoxy-psoralen plus ultraviolet A) induces the formation of 8-hydroxy-2′-deoxyguanosine and DNA fragmentation in calf thymus DNA and human epidermoid carcinoma cells. Free Radic Biol Med 1999;27:127-133.
14. Devary Y, Rosette C, DiDonato JA, Karin M: NF-kappa B activation by ultraviolet light is not dependent on a nuclear signal. Science 1993;261:1442-1445.