Nitric oxide donor exisulind is an effective inhibitor of murine photocarcinogenesis

Photochemistry and Photobiology

Volumn 88, Issue 5, 2012, Pages 1141-1148

  Singh, Tripti ^a   Chaudhary, Sandeep C ^a   Kapur, Puneet ^a   Weng, Zhiping ^a   Elmets, Craig A ^a   Kopelovich, Levy ^b   Athar, Mohammad ^a  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CADHERIN; CDH2 PROTEIN, MOUSE; CYCLIN D1; DRUG DERIVATIVE; FIBRONECTIN; NITRIC OXIDE DONOR; NONSTEROID ANTIINFLAMMATORY AGENT; PROTEIN BAD; PROTEIN BAX; SNAIL FAMILY TRANSCRIPTION FACTORS; SULINDAC; SULINDAC SULFONE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR TWIST; TUMOR MARKER;

ANIMAL; CARCINOMA; CONFERENCE PAPER; DRUG EFFECT; EPITHELIAL MESENCHYMAL TRANSITION; GENE EXPRESSION; GENETICS; HAIRLESS MOUSE; METABOLISM; MOUSE; PATHOLOGY; RADIATION EXPOSURE; SIGNAL TRANSDUCTION; SKIN; SKIN TUMOR; SNAIL; TOPICAL DRUG ADMINISTRATION; ULTRAVIOLET RADIATION;

ADMINISTRATION, TOPICAL; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BCL-2-ASSOCIATED X PROTEIN; BCL-ASSOCIATED DEATH PROTEIN; CADHERINS; CARCINOMA; CYCLIN D1; EPITHELIAL-MESENCHYMAL TRANSITION; FIBRONECTINS; GENE EXPRESSION; MICE; MICE, HAIRLESS; NITRIC OXIDE DONORS; SIGNAL TRANSDUCTION; SKIN; SKIN NEOPLASMS; SNAILS; SULINDAC; TRANSCRIPTION FACTORS; TUMOR MARKERS, BIOLOGICAL; TWIST TRANSCRIPTION FACTOR; ULTRAVIOLET RAYS;

ANIMALIA; MURINAE; MUS;

EID: 84865958103     PISSN: 00318655     EISSN: 17511097     Source Type: Journal    
DOI: 10.1111/j.1751-1097.2012.01093.x     Document Type: Conference Paper

References (33)

1. Ciolino, H. P., S. E. Bass, C. J. MacDonald, R. Y. Cheng, and, G. C. Yeh, (2008) Sulindac and its metabolites induce carcinogen metabolizing enzymes in human colon cancer cells. Int. J. Cancer 122 (5), 990-998. (Pubitemid 351213995)
2. Duggan, D. E., K. F. Hooke, and, S. S. Hwang, (1980) Kinetics of the tissue distributions of sulindac and metabolites. Relevance to sites and rates of bioactivation. Drug Metab. Dispos. 8 (4), 241-246. (Pubitemid 10034553)
3. Goluboff, E. T., (2001) Exisulind, a selective apoptotic antineoplastic drug. Expert Opin. Investig. Drugs 10 (10), 1875-1882.
4. Goluboff, E. T., A. Shabsigh, J. A. Saidi, I. B. Weinstein, N. Mitra, D. Heitjan, G. A. Piazza, R. Pamukcu, R. Buttyanand, and, C. A. Olsson, (1999) Exisulind (sulindac sulfone) suppresses growth of human prostate cancer in a nude mouse xenograft model by increasing apoptosis. Urology 53 (2), 440-445. (Pubitemid 29063347)
5. Kozoni, V., T. Rosenberg, and, B. Rigas, (2007) Development of novel agents based on nitric oxide for the control of colon cancer. Acta Pharmacol. Sin. 28 (9), 1429-1433. (Pubitemid 47366693)
6. Williams, J. L., S. Borgo, I. Hasan, E. Castillo, F. Traganos, and, B. Rigas, (2001) Nitric oxide-releasing nonsteroidal anti-inflammatory drugs (NSAIDs) alter the kinetics of human colon cancer cell lines more effectively than traditional NSAIDs: implications for colon cancer chemoprevention. Cancer Res. 61 (8), 3285-3289. (Pubitemid 32695014)
7. Oltvai, Z. N., C. L. Milliman, and, S. J. Korsmeyer, (1993) Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell 74 (4), 609-619. (Pubitemid 23259742)
8. Wölfle, U., P. R. Esser, B. Simon-Haarhaus, S. F. Martin, J. Lademann, and, C. M. Schempp, (2011) UVB-induced DNA damage, generation of reactive oxygen species, and inflammation are effectively attenuated by the flavonoid luteolin in vitro and in vivo. Free Radic. Biol. Med. 50 (9), 1081-1093.
9. Rho, O., D. J. Kim, K. Kiguchiand, and, J. Digiovanni, (2011) Growth factor signaling pathways as targets for prevention of epithelial carcinogenesis. Mol. Carcinog. 50 (4), 264-279.
10. Lee, J. L., H. Mukhtar, D. R. Bickers, L. Kopelovich, and, M. Athar, (2003) Cyclooxygenases in the skin: pharmacological and toxicological implications. Toxicol. Appl. Pharmacol. 192 (3), 294-306. (Pubitemid 37311345)
11. An, K. P., M. Athar, X. Tang X, S. K. Katiyar, J. Russo, J. Beech, M. Aszterbaum, L. Kopelovich, E. H. Epstein Jr, H. Mukhtar, and, D. R. Bickers, (2002) Cyclooxygenase-2 expression in murine and human nonmelanoma skin cancers: implications for therapeutic approaches. Photochem. Photobiol. 76 (1), 73-80.
12. Athar, M., K. P. An, K. D. Morel, A. L. Kim, M. Aszterbaum, J. Longley, E. H. Epstein Jr., and, D. R. Bickers, (2001) Ultraviolet B(UVB)-induced cox-2 expression in murine skin: an immunohistochemical study. Biochem. Biophys. Res. Commun. 280 (4), 1042-1047. (Pubitemid 32924445)
13. Lee, J. L., A. L. Kim, L. Kopelovich, D. R. Bickers, and, M. Athar, (2005) Differential expression of E prostanoid receptors in murine and human non-melanoma skin cancer. J. Invest. Dermatol. 125 (4), 818-825.
14. Kim, A. L., J. M. Labasi, Y. Zhu, X. Tang, K. McClure, C. A. Gabel, M. Athar, and, D. R. Bickers, (2005) Role of p38 MAPK in UVB-induced inflammatory responses in the skin of SKH-1 hairless mice. J. Invest. Dermatol. 124 (6), 1318-1325. Erratum in: J. Invest. Dermatol. (2005). 125(6), 1320. (Pubitemid 40847422)
15. Athar, M., K. P. An, X. Tang, K. D. Morel, A. L. Kim, L. Kopelovich, and, D. R. Bickers, (2004) Photoprotective effects of sulindac against ultraviolet B-induced phototoxicity in the skin of SKH-1 hairless mice. Toxicol. Appl. Pharmacol. 195 (3), 370-378. (Pubitemid 38338658)
16. Tang, X., A. L. Kim, L. Kopelovich, D. R. Bickers, and, M. Athar, (2008) Cyclooxygenase-2 inhibitor nimesulide blocks ultraviolet B-induced photocarcinogenesis in SKH-1 hairless mice. Photochem. Photobiol. 84 (2), 522-527. (Pubitemid 351421406)
17. Trikha, P., N. Sharma, and, M. Athar, (2001) Nitroglycerin: a NO donor inhibits TPA-mediated tumor promotion in murine skin. Carcinogenesis 22 (8), 1207-1211. (Pubitemid 32737337)
18. Efimova, T., (2010) p38delta mitogen-activated protein kinase regulates skin homeostasis and tumorigenesis. Cell Cycle 9 (3), 498-505.
19. Kim, E. K., and, E. J. Choi, (2010) Pathological roles of MAPK signaling pathways in human diseases. Biochim. Biophys. Acta 1802 (4), 396-405.
20. Huang, P., J. Han, and, L. Hui, (2010) MAPK signaling in inflammation-associated cancer development. Protein Cell 1 (3), 218-226.
21. Joe, A. K., H. Liu, D. Xiao, J. W. Soh, J. T. Pinto, D. G. Beer, G. A. Piazza, W. J. Thompson, and, I. B. Weinstein, (2003) Exisulind and CP248 induce growth inhibition and apoptosis in human esophageal adenocarcinoma and squamous carcinoma cells. J. Exp. Ther. Oncol. 3 (2), 83-94. (Pubitemid 36702521)
22. Rice, P. L., K. S. Beard, L. J. Driggers, and, D. J. Ahnen, (2004) Inhibition of extracellular-signal regulated kinases 1/2 is required for apoptosis of human colon cancer cells in vitro by sulindac metabolites. Cancer Res. 64 (22), 8148-8151. (Pubitemid 39491748)
23. Chang, E. J., J. K. Kundu, L. Liu, J. W. Shin, and, Y. J. Surh, (2011) Ultraviolet B radiation activates NF-κB and induces iNOS expression in HR-1 hairless mouse skin: role of IκB kinase-β. Mol. Carcinog. 50 (4), 310-317.
24. Thiery, J. P., (2002) Epithelial-mesenchymal transitions in tumour progression. Nat. Rev. Cancer 2 (6), 442-454.
25. Hugo, H., M. L. Ackland, T. Blick, M. G. Lawrence, J. Clements, E. D. Williams, and, E. W. Thompson, (2007) Epithelial-mesenchymal and mesenchymal-epithelial transitions in carcinoma progression. J. Cell. Physiol. 213 (2), 374-383. (Pubitemid 47509716)
26. Halbleib, J. M., and, W. J. Nelson, (2006) Cadherins in development: cell adhesion, sorting, and tissue morphogenesis. Genes Dev. 20 (23), 3199-3214. (Pubitemid 44904842)
27. Athar, M., S. B. Walsh, L. Kopelovich, and, C. A. Elmets, (2011) Pathogenesis of nonmelanoma skin cancers in organ transplant recipients. Arch. Biochem. Biophys. 508 (2), 159-163.
28. Matsuo, N., H. Shiraha, T. Fujikawa, N. Takaoka, N. Ueda, S. Tanaka, S. Nishina, Y. Nakanishi, M. Uemura, A. Takaki, S. Nakamura, Y. Kobayashi, K. Nouso, T. Yagi, and, K. Yamamoto, (2009) Twist expression promotes migration and invasion in hepatocellular carcinoma. BMC Cancer 9, 240.
29. Suyama, K., I. Shapiro, M. Guttman, and, R. B. Hazan, (2002) A signaling pathway leading to metastasis is controlled by N-cadherin and the FGF receptor. Cancer Cell 2 (4), 301-314. (Pubitemid 41043964)
30. Nieto, M. A., (2002) The snail superfamily of zinc-finger transcription factors. Nat. Rev. Mol. Cell Biol. 3 (3), 155-166.
31. Carver, E. A., R. Jiang, Y. Lan, K. F. Oram, and, T. Gridley, (2001) The mouse snail gene encodes a key regulator of the epithelial-mesenchymal transition. Mol. Cell. Biol. 21 (23), 8184-8188. (Pubitemid 33051806)
32. Peinado, H., D. Olmeda, and, A. Cano, (2007) Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype? Nat. Rev. Cancer 7 (6), 415-428. (Pubitemid 46809165)
33. Olmeda, D., A. Montes, G. Moreno-Bueno, J. M. Flores, F. Portillo, and, A. Cano, (2008) Snai1 and Snai2 collaborate on tumor growth and metastasis properties of mouse skin carcinoma cell lines. Oncogene 27 (34), 4690-4701.