Photoprotective effects of sulindac against ultraviolet B-induced phototoxicity in the skin of SKH-1 hairless mice

Toxicology and Applied Pharmacology

Volumn 195, Issue 3, 2004, Pages 370-378

  Athar, Mohammad ^a   An, Kathy P ^a   Tang, Xiuwei ^a   Morel, Kimberly D ^a   Kim, Arianna L ^a   Kopelovich, Levy ^b   Bickers, David R ^a  

^a Columbia University ^*  (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

12 O tetradecanoylphorbol 13 acetate; Anti inflammatory activity; COX; Cyclooxygenase; PG; Phototoxicity; Prostaglandin; Sulindac; Surrogate markers; TPA; UVB

Indexed keywords

ACETONE; CYCLIN A; CYCLIN D1; DRINKING WATER; SULINDAC;

ARTICLE; CARCINOGENESIS; CHEMOPROPHYLAXIS; CONTROLLED STUDY; DRUG EFFECT; EDEMA; EPIDERMIS HYPERPLASIA; ERYTHEMA; FEMALE; INFLAMMATION; MOUSE; NONHUMAN; NUDE MOUSE; PHOTOTOXICITY; POLYMORPHONUCLEAR CELL; PROTEIN EXPRESSION; RADIATION ATTENUATION; RADIATION INJURY; STIMULUS RESPONSE; ULTRAVIOLET B RADIATION; ULTRAVIOLET IRRADIATION;

ADMINISTRATION, CUTANEOUS; ADMINISTRATION, ORAL; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CYCLINS; DERMATITIS, PHOTOTOXIC; DINOPROSTONE; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; MICE; MICE, INBRED HRS; SKIN; SULINDAC; TIME FACTORS; TUMOR SUPPRESSOR PROTEIN P53; ULTRAVIOLET RAYS;

ANIMALIA;

EID: 1542722125     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.taap.2003.09.030     Document Type: Article

References (32)

1. Abd-El-Aleem S.A., Ferguson M.W., Appleton I., Bhowmick A., McCollum C.N., Ireland G.W. Expression of cyclooxygenase isoforms in normal human skin and chronic venous ulcers. J. Pathol. 195:2001;616-623.
2. An K.P., Athar M., Tang X., Katiyar S.K., Russo J., Beech J., Aszterbaum M., Kopelovich L., Epstein E.H. Jr., Mukhtar H., Bickers D.R. Cyclooxygenase-2 expression in murine and human nonmelanoma skin cancers: implications for therapeutic approaches. Photochem. Photobiol. 76:2002;73-80.
3. Athar M., An K.P., Morel K.D., Kim A.L., Aszterbaum M., Longley J., Epstein E.H. Jr., Bickers D.R. Ultraviolet B (UVB)-induced cox-2 expression in murine skin: an immunohistochemical study. Biochem. Biophys. Res. Commun. 280:2001;1042-1047.
4. Balansky R.M., Izzotti A., D'Agostini F., Camoirano A., Bagnasco M., Lubet R.A., De Flora S. Systemic genotoxic effects produced by light, and synergism with cigarette smoke in the respiratory tract of hairless mice. Carcinogenesis. 24:2003;1525-1532.
5. Bickers D.R., Athar M. Novel approaches to chemoprevention of skin cancer. J. Dermatol. 27:2000;691-695.
6. Buckman S.Y., Gresham A., Hale P., Hruza G., Anast J., Masferrer J., Pentland A.P. COX-2 expression is induced by UVB exposure in human skin: implications for the development of skin cancer. Carcinogenesis. 19:1998;723-729.
7. Eriksson L.O., Sturfelt G., Thysell H., Wollheim F.A. Effects of sulindac and naproxen on prostaglandin excretion in patients with impaired renal function and rheumatoid arthritis. Am. J. Med. 89:1990;313-321.
8. Fischer S.M. Is cyclooxygenase-2 important in skin carcinogenesis? J. Environ. Pathol. Toxicol. Oncol. 21:2002;183-191.
9. Fischer S.M., Lo H.H., Gordon G.B., Seibert K., Kelloff G., Lubet R.A., Conti C.J. Chemopreventive activity of celecoxib, a specific cyclooxygenase-2 inhibitor, and indomethacin against ultraviolet light-induced skin carcinogenesis. Mol. Carcinog. 25:1999;231-240.
10. Fosslien E. Molecular pathology of cyclooxygenase-2 in neoplasia. Ann. Clin. Lab. Sci. 30:2000;3-21.
11. Furstenberger G., Gross M., Marks F. Eicosanoids and multistage carcinogenesis in NMRI mouse skin: role of prostaglandins E and F in conversion (first stage of tumor promotion) and promotion (second stage of tumor promotion). Carcinogenesis. 10:1989;91-96.
12. Futagami A., Ishizaki M., Fukuda Y., Kawana S., Yamanaka N. Wound healing involves induction of cyclooxygenase-2 expression in rat skin. Lab. Invest. 82:2002;1503-1513.
13. Gupta S.K., Bansal P., Bhardwaj R.K., Jaiswal J., Velpandian T. Comparison of analgesic and anti-inflammatory activity of meloxicam gel with diclofenac and piroxicam gels in animal models: pharmacokinetic parameters after topical application. Skin Pharmacol. Appl. Skin Physiol. 15:2002;105-111.
14. Kim A.L., Athar M., Bickers D.R., Gautier J. Ultraviolet-B-induced G1 arrest is mediated by downregulation of cyclin-dependent kinase 4 in transformed keratinocytes lacking functional p53. J. Invest. Dermatol. 118:2002;818-824.
15. Lee J.L., Mukhtar H., Bicker D.R., Kopelovich L. Cyclooxygenases in the skin: pharmacological and toxicological implications. Toxicol. Appl. Pharmacol. 192:2003;294-306.
16. Liu S.F., Ye X., Malik A.B. Inhibition of NF-kappaB activation by pyrrolidine dithiocarbamate prevents in vivo expression of proinflammatory genes. Circulation. 100:1999;1330-1337.
17. Muller-Decker K., Reinerth G., Krieg P., Zimmermann R., Heise H., Bayerl C., Marks F., Furstenberger G. Prostaglandin-H-synthase isozyme expression in normal and neoplastic human skin. Int. J. Cancer. 82:1999;648-656.
18. Muller-Decker K., Neufang G., Berger I., Neumann M., Marks F., Furstenberger G. Transgenic cyclooxygenase-2 overexpression sensitizes mouse skin for carcinogenesis. Proc. Natl. Acad. Sci. U.S.A. 99:2002;12483-12488.
19. Neufang G., Furstenberger G., Heidt M., Marks F., Muller-Decker K. Abnormal differentiation of epidermis in transgenic mice constitutively expressing cyclooxygenase-2 in skin. Proc. Natl. Acad. Sci. U.S.A. 98:2001;7629-7634.
20. Orengo I.F., Gerguis J., Phillips R., Guevara A., Lewis A.T., Black H.S. Celecoxib, a cyclooxygenase 2 inhibitor as a potential chemopreventive to UV-induced skin cancer: a study in the hairless mouse model. Arch. Dermatol. 138:2002;751-755.
21. Pentland A.P., Schoggins J.W., Scott G.A., Khan K.N., Han R. Reduction of UV-induced skin tumors in hairless mice by selective COX-2 inhibition. Carcinogenesis. 20:1999;1939-1944.
22. Sanchez T., Moreno J.J. Role of leukocyte influx in tissue prostaglandin H synthase-2 overexpression induced by phorbol ester and arachidonic acid in skin. Biochem. Pharmacol. 58:1999;877-879.
23. Sanchez T., Moreno J.J. Role of prostaglandin H synthase isoforms in murine ear edema induced by phorbol ester application on skin. Prostaglandins Other Lipid Mediat. 57:1999;119-131.
24. Sengupta S., Velpandian T., Sapra P., Mathur P., Gupta S.K. Comparative analgesic efficacy of nimesulide and diclofenac gels after topical application on the skin. Skin Pharmacol. Appl. Skin Physiol. 11:1998;273-278.
25. Soriani M., Luscher P., Tyrrell R.M. Direct and indirect modulation of ornithine decarboxylase and cyclooxygenase by UVB radiation in human skin cells. Carcinogenesis. 20:1999;727-732.
26. Tegeder I., Pfeilschifter J., Geisslinger G. Cyclooxygenase-independent actions of cyclooxygenase inhibitors. FASEB J. 15:2001;2057-2072.
27. Tiano H.F., Loftin C.D., Akunda J., Lee C.A., Spalding J., Sessoms A., Dunson D.B., Rogan E.G., Morham S.G., Smart R.C., Langenbach R. Deficiency of either cyclooxygenase (COX)-1 or COX-2 alters epidermal differentiation and reduces mouse skin tumorigenesis. Cancer Res. 62:2002;3395-3401.
28. Wada K., Fujii E., Ishida H., Yoshioka T., Muraki T. Effect of lipoteichoic acid on dermal vascular permeability in mice. J. Pharmacol. Exp. Ther. 294:2000;280-286.
29. Wang H.Q., Smart R.C. Overexpression of protein kinase C-alpha in the epidermis of transgenic mice results in striking alterations in phorbol ester-induced inflammation and COX-2, MIP-2 and TNF-alpha expression but not tumor promotion. J. Cell Sci. 112(Pt. 20):1999;3497-3506.
30. Wilgus T.A., Ross M.S., Parrett M.L., Oberyszyn T.M. Topical application of a selective cyclooxygenase inhibitor suppresses UVB mediated cutaneous inflammation. Prostaglandins Other Lipid Mediat. 62:2000;367-384.
31. Wilgus T.A., Parrett M.L., Ross M.S., Tober K.L., Robertson F.M., Oberyszyn T.M. Inhibition of ultraviolet light B-induced cutaneous inflammation by a specific cyclooxygenase-2 inhibitor. Adv. Exp. Med. Biol. 507:2002;85-92.
32. Zhao J., Sharma Y., Agarwal R. Significant inhibition by the flavonoid antioxidant silymarin against 12-O-tetradecanoylphorbol 13-acetate-caused modulation of antioxidant and inflammatory enzymes, and cyclooxygenase 2 and interleukin-1alpha expression in SENCAR mouse epidermis: implications in the prevention of stage I tumor promotion. Mol. Carcinog. 26:1999;321-333.