UVB-induced DNA damage, generation of reactive oxygen species, and inflammation are effectively attenuated by the flavonoid luteolin in vitro and in vivo

Free Radical Biology and Medicine

Volumn 50, Issue 9, 2011, Pages 1081-1093

  Wölfle, Ute ^a   Esser, Philipp R ^a,b   Simon Haarhaus, Birgit ^a   Martin, Stefan F ^a   Lademann, Jürgen ^c   Schempp, Christoph M ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

^b UNIVERSITY OF FREIBURG   (Germany)

^c CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

3 nitrotyrosine; 3 NT; COX 2; CPD; cyclobutane pyrimidine dimer; cyclooxygenase 2; ERK; extracellular signal regulated kinase; green tea polyphenols; GTP; MAPK; MED; minimal erythema dose; mitogen activated protein kinase; N acetylcysteine; NAC; PGE2; prostaglandin E2; reactive oxygen species; ROS; ultraviolet B.; UVB

Indexed keywords

1,1 DIPHENYL 2 PICRYLHYDRAZYL; ACETYLCYSTEINE; CYCLOOXYGENASE 2; FREE RADICAL; HYDROGEN PEROXIDE; LUTEOLIN; MITOGEN ACTIVATED PROTEIN KINASE 1; PLANT EXTRACT; PROSTAGLANDIN E2; PYRIMIDINE DIMER; REACTIVE OXYGEN METABOLITE; RF 40; TROLOX C; UNCLASSIFIED DRUG;

ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DERMIS; DNA DAMAGE; EPIDERMIS; EX VIVO STUDY; FLUORESCENCE; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; KERATINOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SKIN; SPECTROPHOTOMETRY; ULTRAVIOLET B RADIATION;

ACETYLCYSTEINE; ANTIOXIDANTS; CELL LINE; CHROMANS; CYCLOOXYGENASE 2; CYTOPROTECTION; DINOPROSTONE; DNA DAMAGE; ERYTHEMA; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FLUORESCEINS; GENE EXPRESSION; HUMANS; INFLAMMATION; INHIBITORY CONCENTRATION 50; KERATINOCYTES; LUTEOLIN; ORGAN CULTURE TECHNIQUES; OXIDATIVE STRESS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PYRIMIDINE DIMERS; REACTIVE OXYGEN SPECIES; SKIN; SKIN NEOPLASMS; ULTRAVIOLET RAYS;

EID: 79953253800     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2011.01.027     Document Type: Article

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