A Novel Mutation in the RYR2 Gene Leading to Catecholaminergic Polymorphic Ventricular Tachycardia and Paroxysmal Atrial Fibrillation: Dose-Dependent Arrhythmia-Event Suppression by β-Blocker Therapy

Canadian Journal of Cardiology

Volumn 27, Issue 6, 2011, Pages 870.e7-870.e10

  Kazemian, Pedram ^a   Gollob, Michael H ^b,c   Pantano, Alfredo ^a   Oudit, Gavin Y ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

^b UNIVERSITY OF OTTAWA HEART INSTITUTE   (Canada)

^c UNIVERSITY OF OTTAWA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; AMPHETAMINE; ARGININE; BARBITURIC ACID DERIVATIVE; CANNABIS; COCAINE; GADOLINIUM; METOPROLOL; ORAL CONTRACEPTIVE AGENT; POTASSIUM CHANNEL KCNE1; POTASSIUM CHANNEL KCNE2; POTASSIUM CHANNEL KCNQ1; RYANODINE RECEPTOR 2; SERINE; SODIUM CHANNEL NAV1.5;

ACCIDENT; ADULT; ANGIOCARDIOGRAPHY; ARTICLE; CARDIAC IMAGING; CARDIOGENIC SHOCK; CARDIOVASCULAR MAGNETIC RESONANCE; CASE REPORT; CATECHOLAMINERGIC POLYMORPHIC VENTRICULAR TACHYCARDIA; CORONARY ARTERY OBSTRUCTION; DEFIBRILLATOR; DROWNING; DRUG DOSE INCREASE; ELECTROCARDIOGRAM; ELECTROLYTE BLOOD LEVEL; ELECTROPHYSIOLOGY; EMOTIONAL STRESS; EXERCISE TEST; EXON; FEMALE; FOLLOW UP; GENE REPRESSION; GENETIC ANALYSIS; HEART ARREST; HEART ATRIUM FIBRILLATION; HEART VENTRICLE ARRHYTHMIA; HEART VENTRICLE FIBRILLATION; HUMAN; INTRAUTERINE CONTRACEPTIVE DEVICE; LONG QT SYNDROME; MITRAL VALVE DISEASE; MUTATION; POLYMORPHIC VENTRICULAR TACHYCARDIA; PULMONARY HYPERTENSION; SINUS RHYTHM; SUDDEN DEATH; SUDDEN INFANT DEATH SYNDROME; SYNCOPE; TOXICOLOGY;

EID: 82155192337     PISSN: 0828282X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cjca.2011.02.003     Document Type: Article

References (5)

1. Priori S.G., Napolitano C., Memmi M., et al. A clinical and molecular characterization of patients with catecholaminergic polymorphic ventricular tachycardia. Circulation 2002, 106:69-74.
2. Zipes D.P., Camm A.J., Borggrefe M., et al. ACC/AHA/ESC 2006 Guidelines for Management of Patients With Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death: a report of the American College of Cardiology/American Heart Association Task Force and the European Society of Cardiology Committee for Practice Guidelines. Circulation 2006, 114:e385-e484.
3. Medeiros-Domingo A., Bhuiyan Z.A., Tester D.J., et al. The RYR2-encoded ryanodine receptor/calcium release channel in patients diagnosed previously with either catecholaminergic polymorphic ventricular tachycardia or genotype negative, exercise-induced long QT syndrome: a comprehensive open reading frame mutational analysis. J Am Coll Cardiol 2009, 54:2065-2074.
4. Jiang D., Xiao B., Yang D., et al. RyR2 mutations linked to ventricular tachycardia and sudden death reduce the threshold for store-overload-induced Ca2+ release (SOICR). Proc Natl Acad Sci USA 2004, 101:13062-13067.
5. Sumitomo N., Sakurada H., Taniguchi K., et al. Association of atrial arrhythmia and sinus node dysfunction in patients with catecholaminergic polymorphic ventricular tachycardia. Circ J 2007, 71:1606-1609.