A novel role for epidermal growth factor receptor tyrosine kinase and its downstream endoplasmic reticulum stress in cardiac damage and microvascular dysfunction in type 1 diabetes mellitus

Hypertension

Volumn 60, Issue 1, 2012, Pages 71-80

  Galán, Maria ^a   Kassan, Modar ^a   Choi, Soo Kyoung ^a   Partyka, Megan ^a   Trebak, Mohamed ^b   Henrion, Daniel ^c,d,e,f   Matrougui, Khalid ^a  

^a TULANE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b ALBANY MEDICAL COLLEGE   (United States)

^c CNRS   (France)

^d INSERM   (France)

^e ANGERS UNIVERSITY HOSPITAL   (France)

^f UNIVERSITÉ D'ANGERS   (France)

Author keywords

Cardiac fibrosis; EGFRtk; Endothelial function; ER stress; Resistance arteries; Tudca; Type 1 diabetes

Indexed keywords

4 (3 CHLOROANILINO) 6,7 DIMETHOXYQUINAZOLINE; ACTIVATING TRANSCRIPTION FACTOR 4; ACTIVATING TRANSCRIPTION FACTOR 6; COLLAGEN TYPE 1; EPIDERMAL GROWTH FACTOR RECEPTOR; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; INITIATION FACTOR 2ALPHA; INSULIN; PLASMINOGEN ACTIVATOR INHIBITOR 1; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 4; STREPTOZOCIN; ANTIDIABETIC AGENT; CHOLAGOGUE; DDIT3 PROTEIN, MOUSE; QUINAZOLINE DERIVATIVE; TAUROCHENODEOXYCHOLIC ACID; TAUROURSODEOXYCHOLIC ACID; TYRPHOSTIN;

ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; HEART MUSCLE FIBROSIS; INSULIN DEPENDENT DIABETES MELLITUS; MICROANGIOPATHY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; STREPTOZOCIN DIABETES; SYNTHESIS; ANIMAL; C57BL MOUSE; CHEMICALLY INDUCED DISORDER; DRUG ANTAGONISM; DRUG EFFECT; FIBROSIS; GENE EXPRESSION; GENETICS; HEART; HEART MUSCLE; MALE; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; PHOSPHORYLATION; PHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; VASODILATATION; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; CHOLAGOGUES AND CHOLERETICS; DIABETES MELLITUS, TYPE 1; ENDOPLASMIC RETICULUM STRESS; FIBROSIS; GENE EXPRESSION; HEART; HYPOGLYCEMIC AGENTS; INSULIN; MALE; MICE; MICE, INBRED C57BL; MYOCARDIUM; PHOSPHORYLATION; QUINAZOLINES; RECEPTOR, EPIDERMAL GROWTH FACTOR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; STREPTOZOCIN; TAUROCHENODEOXYCHOLIC ACID; TRANSCRIPTION FACTOR CHOP; TYRPHOSTINS; VASODILATION;

EID: 84865815564     PISSN: 0194911X     EISSN: 15244563     Source Type: Journal    
DOI: 10.1161/HYPERTENSIONAHA.112.192500     Document Type: Article

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