Development of brucine-loaded microsphere/thermally responsive hydrogel combination system for intra-articular administration

Journal of Controlled Release

Volumn 162, Issue 3, 2012, Pages 628-635

  Chen, Zhi Peng ^a   Liu, Wen ^b   Liu, Dan ^c   Xiao, Yan Yu ^c   Chen, Hong Xuan ^b   Chen, Jun ^a   Li, Weidong ^a   Cai, Hao ^a   La, Wei ^a   Cai, Bao Chang ^a   Pan, Jinhuo ^a  

^a NANJING UNIVERSITY OF CHINESE MEDICINE   (China)

^b HENAN UNIVERSITY   (China)

^c CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Brucine; Chitosan; Microsphere; Thermally responsive hydrogel

Indexed keywords

ACTIVE COMPOUNDS; AVERAGE SIZE; BRUCINE; BURST RELEASE; COMBINATION SYSTEMS; DRUG CONCENTRATION; DRUG DELIVERY SYSTEM; DRUG DELIVERY VEHICLES; DRUG RELEASE; DRUG-POLYMER INTERACTION; IN-VITRO; INTRA-ARTICULAR INJECTION; RELEASE BEHAVIORS; SPRAY-DRYING METHOD; SYNOVIUM; THERMALLY RESPONSIVE; TIME-PERIODS;

BEHAVIORAL RESEARCH; BIOCOMPATIBILITY; BORATE MINERALS; CHITOSAN; COMBINATORIAL SWITCHING; DEGRADATION; DRUG DELIVERY; FOURIER TRANSFORMS; GLYCEROL; MICROSPHERES; PHOTOGRAPHY; SCANNING ELECTRON MICROSCOPY; X RAY DIFFRACTION;

HYDROGELS;

BIOPOLYMER; BORATE SODIUM; BRUCINE; CHITOSAN; GLYCEROL; INTERLEUKIN 1BETA; MICROSPHERE; SODIUM CHLORIDE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOCOMPATIBILITY; CONTROLLED STUDY; DRUG METABOLISM; DRUG RELEASE; HISTOPATHOLOGY; HYDROGEL; IN VITRO STUDY; INFRARED SPECTROSCOPY; MALE; MOLECULAR INTERACTION; NONHUMAN; OSTEOARTHRITIS; PRIORITY JOURNAL; RABBIT; RAT; SCANNING ELECTRON MICROSCOPY; SPRAY DRYING; SYNOVIUM; X RAY DIFFRACTION;

ANALGESICS; ANIMALS; CHITOSAN; HYDROGELS; INJECTIONS, INTRA-ARTICULAR; INTERLEUKIN-1BETA; MALE; MICROSPHERES; OSTEOARTHRITIS; PARTICLE SIZE; RABBITS; RATS; RATS, SPRAGUE-DAWLEY; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; STRYCHNINE; SURFACE PROPERTIES; SYNOVIAL FLUID; TEMPERATURE; TUMOR NECROSIS FACTOR-ALPHA; X-RAY DIFFRACTION;

EID: 84865810937     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2012.07.037     Document Type: Article

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