Low melting point amphiphilic microspheres for delivery of bone morphogenetic protein-6 and transforming growth factor-β3 in a hydrogel matrix

Journal of Controlled Release

Volumn 158, Issue 1, 2012, Pages 53-62

  Sukarto, Abby ^a   Amsden, Brian G ^a  

^a QUEEN S UNIVERSITY   (Canada)

Author keywords

Chondrogenesis; Growth factor; Hydrogel; Microspheres; Osmotic pressure

Indexed keywords

AMPHIPHILICS; BOVINE SERUM ALBUMINS; CAPROLACTONE; CHONDROGENESIS; ELECTROSPRAY TECHNIQUES; GLYCOL CHITOSAN; GROWTH FACTOR; GROWTH FACTOR DELIVERY; HYDROGEL MATRIX; IN-VITRO; LOW DEGREE; LOW MELTING POINT; LOW TEMPERATURES; MELTING RANGE; MODEL PROTEINS; POSITIVELY CHARGED PROTEINS; PROTEIN ISOELECTRIC POINTS; PROTEIN RELEASE; RELEASE PROFILES; RELEASE RATE; STABILIZING AGENTS; SUSTAINED RELEASE; TRANSFORMING GROWTH FACTORS;

BIODEGRADATION; BLOCK COPOLYMERS; CARTILAGE; ENZYMES; GLYCOLS; MICROSPHERES; OSMOSIS; PEPTIDES; PHASE TRANSITIONS; POLYETHYLENE GLYCOLS; POLYETHYLENE OXIDES;

HYDROGELS;

AMPHOPHILE; BONE MORPHOGENETIC PROTEIN 6; BOVINE SERUM ALBUMIN; COPOLYMER; LYSOZYME; MACROGOL; MICROSPHERE; TRANSFORMING GROWTH FACTOR BETA3; TREHALOSE;

ARTICLE; CRYSTALLIZATION; DEGRADATION KINETICS; DISPERSION; DRUG DELIVERY SYSTEM; ELECTROSPRAY; HYDROGEL; IN VITRO STUDY; ISOELECTRIC POINT; LIQUID; LOW TEMPERATURE PROCEDURES; LYOPHILISATE; MELTING POINT; MICROENCAPSULATION; MICROTECHNOLOGY; MOLECULAR WEIGHT; PRIORITY JOURNAL; PROTEIN SECRETION; SOLID STATE; SURFACE CHARGE; SUSTAINED DRUG RELEASE; TEMPERATURE;

ANIMALS; BONE MORPHOGENETIC PROTEIN 6; CATTLE; CELL LINE; CELL PROLIFERATION; DELAYED-ACTION PREPARATIONS; DRUG CARRIERS; HYDROGEL; LYMPHOCYTES; MICE; MICROSPHERES; POLYMERS; SERUM ALBUMIN, BOVINE; TRANSFORMING GROWTH FACTOR BETA3; TRANSITION TEMPERATURE;

EID: 84857912638     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2011.10.015     Document Type: Article

References (92)

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22. B.G. Amsden, L. Timbart, D. Marecak, R. Chapanian, M.Y. Tse, and S.C. Pang VEGF-induced angiogenesis following localized delivery via injectable, low viscosity poly(trimethylene carbonate) J. Control. Release 145 2 2010 109 115
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27. B.G. Amsden, A. Sukarto, D.K. Knight, and S.N. Shapka Methacrylated glycol chitosan as a photopolymerizable biomaterial Biomacromolecules 8 12 2007 3758 3766
28. K. Hiltunen, J.V. Seppaelae, and M. Haerkoenen Effect of catalyst and polymerization conditions on the preparation of low molecular weight lactic acid polymers Macromolecules 30 3 1997 373 379 (Pubitemid 127567622)
29. V. Crescenzi, G. Manzini, G. Calzolari, and C. Borri Thermodynamics of fusion of poly-beta-propiolactone and poly-ε-caprolactone. Comparative analysis of the melting of aliphatic polylactone and polyester chains Eur. Polym. J. 8 3 1972 449 463
30. B.G. Amsden, and M.F.A. Goosen An examination of factors affecting the size, distribution and release characteristics of polymer microbeads made using electrostatics J. Control. Release 43 2-3 1997 183 196 (Pubitemid 26390967)
31. M.L.-S. Tsang, L. Zhou, B.-L. Zheng, J. Wenker, G. Fransen, J. Humphrey, J.M. Smith, M. O'Connor-McCourt, R. Lucas, and J.A. Weatherbee Characterization of recombinant soluble human transforming growth factor-beta receptor type II (rhTGF-beta sRII) Cytokine 7 5 1995 389 397
32. J.-D. Yan, S. Yang, S.-J. LÜ, R.-Y. Lei, and T.-H. Zhu Expression of Recombinant Human BMP-6 in CHO Cell by Fusion of a BMP-6 Mature Peptide to the Signal Peptide and Propeptide of Another Homologue Protein Chin. J. Biotechnol. 23 3 2007 414 418
33. R.E. Canfield Amino acid sequence of egg white lysozyme J. Biol. Chem. 238 8 1963 2698 2707
34. A.J. Celeste, J.A. Iannazzi, R.C. Taylor, R.M. Hewick, V. Rosen, E.A. Wang, and J.M. Wozney Identification of transforming growth-factor-beta family members present in bone-inductive protein purified from bovine bone Proc. Natl. Acad. Sci. U. S. A. 87 24 1990 9843 9847 (Pubitemid 120016540)
35. M.B. Sporn, A.B. Roberts, L.M. Wakefield, and R.K. Assoian Transforming growth-factor-beta-biological function and chemical structure Science 233 4763 1986 532 534 (Pubitemid 16019904)
36. B. Amsden Review of osmotic pressure driven release of proteins from monolithic devices J. Pharm. Pharm. Sci. 10 2 2007 129 143 (Pubitemid 46805398)
37. B.G. Amsden, and Y.L. Cheng Enhanced fraction releasable above percolation-threshold from monoliths containing osmotic excipients J. Control. Release 31 1 1994 21 32 (Pubitemid 24248113)
38. R.A. Siegel, and R. Langer Controlled release of polypeptides and other macromolecules Pharm. Res. 1 1984 2 10 (Pubitemid 14123791)
39. A.P. Pego, A.A. Poot, D.W. Grijpma, and J. Feijen In vitro degradation of trimethylene carbonate based (co)polymers Macromol. Biosci. 2 9 2002 411 419 (Pubitemid 44790995)
40. J.T. Chin, S.L. Wheeler, and A.M. Klibanov Communication to the editor on protein solubility in organic-solvents Biotechnol. Bioeng. 44 1 1994 140 145
41. F. Wu, and T. Jin Polymer-Based Sustained-Release Dosage Forms for Protein Drugs, Challenges, and Recent Advances AAPS PharmSciTech 9 4 2008 1218 1229
42. G. Jiang, B.H. Woo, F.R. Kang, J. Singh, and P.P. DeLuca Assessment of protein release kinetics, stability and protein polymer interaction of lysozyme encapsulated poly (d, l-lactide-co-glycolide) microspheres J. Control. Release 79 1-3 2002 137 145 (Pubitemid 34164167)
43. G. Crotts, and T.G. Park Stability and release of bovine serum albumin encapsulated within poly(d, l-lactide-co-glycolide) microparticles J. Control. Release 44 2-3 1997 123 134 (Pubitemid 27039109)
44. L.R. Wetter, and H.F. Deutsch Immunological studies on egg white proteins. 4. Immunochemical and physical studies of lysozyme J. Biol. Chem. 192 1 1951 237 242
45. P.G. Righetti, and T. Caravaggio Isoelectric points and molecular-weights of proteins-Table J. Chromatogr. 127 1 1976 1 28
46. K. Hirayama, S. Akashi, M. Furuya, and K. Fukuhara Rapid confirmation and revision of the primary structure of bovine serum-albumin by ESIMS and frit-FAB LC MS Biochem. Biophys. Res. Commun. 173 2 1990 639 646
47. J.A. Buckwalter, and H.J. Mankin Articular cartilage.2. Degeneration and osteoarthrosis, repair, regeneration, and transplantation J. Bone Joint Surg. Am. 79A 4 1997 612 632 (Pubitemid 27376937)
48. W. Hunter Of the structures and diseases of articulating cartilages, by William Hunter, Surgeon Philos Trans (1683-1775) 42 1742 514 521
49. M. Radice, P. Brun, R. Cortivo, R. Scapinelli, C. Battaliard, and G. Abatangelo Hyaluronan-based biopolymers as delivery vehicles for bone-marrow-derived mesenchymal progenitors J. Biomed. Mater. Res. 50 2 2000 101 109 (Pubitemid 30126952)
50. P.A. Zuk, M. Zhu, H. Mizuno, J. Huang, J.W. Futrell, A.J. Katz, P. Benhaim, H.P. Lorenz, and M.H. Hedrick Multilineage cells from human adipose tissue: implications for cell-based therapies Tissue Eng. 7 2 2001 211 228 (Pubitemid 32295155)
51. R. Vasita, and D.S. Katti Growth factor-delivery systems for tissue engineering: a materials perspective Expert Rev. Med. Devices 3 1 2006 29 47
52. B.O. Diekman, C.R. Rowland, D.P. Lennon, A.I. Caplan, and F. Guilak Chondrogenesis of adult stem cells from adipose tissue and bone marrow: induction by growth factors and cartilage-derived matrix Tissue Eng. Part A 16 2 2010 523 533
53. T. Hennig, H. Lorenz, A. Thiel, K. Goetzke, A. Dickhut, F. Geiger, and W. Richter Reduced chondrogenic potential of adipose tissue derived stromal cells correlates with an altered TGFbeta receptor and BMP profile and is overcome by BMP-6 J. Cell. Physiol. 211 3 2007 682 691 (Pubitemid 46683036)
54. J. Sohier, L. Moroni, C. van Blitterswijk, K. de Groot, and J.M. Bezemer Critical factors in the design of growth factor releasing scaffolds for cartilage tissue engineering Expert Opin. Drug Deliv. 5 5 2008 543 566 (Pubitemid 351877433)
55. C.M. Agrawal, and K.A. Athanasiou Technique to control pH in vicinity of biodegrading PLA-PGA implants J. Biomed. Mater. Res. 38 2 1997 105 114 (Pubitemid 27233098)
56. C. Martin, H. Winet, and J.Y. Bao Acidity near eroding polylactide-polyglycolide in vitro and in vivo in rabbit tibial bone chambers Biomaterials 17 24 1996 2373 2380 (Pubitemid 26421743)
57. J. Suganuma, and H. Alexander Biological response of intramedullary bone to poly-l-lactic acid J. Appl. Biomater. 4 1 1993 13 27
58. E.J. Bergsma, F.R. Rozema, R.R.M. Bos, and W.C. Debruijn Foreign-body reactions to resorbable poly(l-lactidee) bone plates and screws used for the fixation of unstable zygomatic fractures J. Oral Maxillofac. Surg. 51 6 1993 666 670 (Pubitemid 23163448)
59. M. van de Weert, W.E. Hennink, and W. Jiskoot Protein instability in poly(lactic-co-glycolic acid) microparticles Pharm. Res. 17 10 2000 1159 1167
60. M. Sittinger, D. Reitzel, M. Dauner, H. Hierlemann, C. Hammer, E. Kastenbauer, H. Planck, G.R. Burmester, and J. Bujia Resorbable polyesters in cartilage engineering: Affinity and biocompatibility of polymer fiber structures to chondrocytes J. Biomed. Mater. Res. 33 2 1996 57 63 (Pubitemid 26170805)
61. A.P. Pego, M.J.A. Van Luyn, L.A. Brouwer, P.B. van Wachem, A.A. Poot, D.W. Grijpma, and J. Feijen In vivo behavior of poly(1,3-trimethylene carbonate) and copolymers of 1,3-trimethylene carbonate with d, l-lactide or e-caprolactone: Degradation and tissue response J. Biomed. Mater. Res. A 67A 3 2003 1044 1054 (Pubitemid 37521581)
62. C.G. Pitt Poly-e-caprolactone and its copolymers Drugs Pharm. Sci. 45 1990 71 120 (Biodegradable Polymer Drug Delivery System)
63. G.L. Brode, and J.V. Koleske Lactone polymerization and polymer properties J. Macromol. Sci. Chem. 6 6 1972 1109 1144
64. K.J. Zhu, R.W. Hendren, K. Jensen, and C.G. Pitt Synthesis, properties, and biodegradation of poly(1,3-trimethylene carbonate) Macromolecules 24 8 1991 1736 1740
65. B. Amsden, A. Hatefi, D. Knight, and E. Bravo-Grimaldo Development of biodegradable injectable thermoplastic oligomers Biomacromolecules 5 2 2004 637 642 (Pubitemid 38404505)
66. J.A. Kuphal, L.H. Sperling, and L.M. Robeson Miscible blends of styerene acrylic-acid copolymers with alipathic, crystalline polyamides J. Appl. Polym. Sci. 42 6 1991 1525 1535
67. S. Sharifpoor, and B. Amsden In vitro release of a water-soluble agent from low viscosity biodegradable, injectable oligomers Eur. J. Pharm. Biopharm. 65 3 2007 336 345
68. B.G. Amsden, L. Timbart, D. Marecak, R. Chapanian, M.Y. Tse, and S.C. Pang VEGF-induced angiogenesis following localized delivery via injectable, low viscosity poly(trimethylene carbonate) J. Control. Release 145 2 2010 109 115
69. T. Chandy, and C.P. Sharma Chitosan-as a biomaterial Biomater. Artif. Cells Artif. Organs 18 1 1990 1 24
70. Y.W. Cho, Y.N. Cho, S.H. Chung, G. Yoo, and S.W. Ko Water-soluble chitin as a wound healing accelerator Biomaterials 20 22 1999 2139 2145 (Pubitemid 29488662)
71. N. Liu, X.-G. Chen, H.-J. Park, C.-G. Liu, C.-S. Liu, X.-H. Meng, and L.-J. Yu Effect of MW and concentration of chitosan on antibacterial activity of Escherichia coli Carbohydr. Polym. 64 1 2006 60 65 (Pubitemid 43884936)
72. V.F. Sechriest, Y.J. Miao, C. Niyibizi, A. Westerhausen-Larson, H.W. Matthew, C.H. Evans, F.H. Fu, and J.-K. Suh GAG-augmented polysaccharide hydrogel: a novel biocompatible and biodegradable material to support chondrogenesis J. Biomed. Mater. Res. 49 4 2000 534 541 (Pubitemid 30030473)
73. B.G. Amsden, A. Sukarto, D.K. Knight, and S.N. Shapka Methacrylated glycol chitosan as a photopolymerizable biomaterial Biomacromolecules 8 12 2007 3758 3766
74. K. Hiltunen, J.V. Seppaelae, and M. Haerkoenen Effect of catalyst and polymerization conditions on the preparation of low molecular weight lactic acid polymers Macromolecules 30 3 1997 373 379 (Pubitemid 127567622)
75. V. Crescenzi, G. Manzini, G. Calzolari, and C. Borri Thermodynamics of fusion of poly-beta-propiolactone and poly-ε-caprolactone. Comparative analysis of the melting of aliphatic polylactone and polyester chains Eur. Polym. J. 8 3 1972 449 463
76. B.G. Amsden, and M.F.A. Goosen An examination of factors affecting the size, distribution and release characteristics of polymer microbeads made using electrostatics J. Control. Release 43 2-3 1997 183 196 (Pubitemid 26390967)
77. M.L.-S. Tsang, L. Zhou, B.-L. Zheng, J. Wenker, G. Fransen, J. Humphrey, J.M. Smith, M. O'Connor-McCourt, R. Lucas, and J.A. Weatherbee Characterization of recombinant soluble human transforming growth factor-beta receptor type II (rhTGF-beta sRII) Cytokine 7 5 1995 389 397
78. J.-D. Yan, S. Yang, S.-J. LÜ, R.-Y. Lei, and T.-H. Zhu Expression of Recombinant Human BMP-6 in CHO Cell by Fusion of a BMP-6 Mature Peptide to the Signal Peptide and Propeptide of Another Homologue Protein Chin. J. Biotechnol. 23 3 2007 414 418
79. R.E. Canfield Amino acid sequence of egg white lysozyme J. Biol. Chem. 238 8 1963 2698 2707
80. A.J. Celeste, J.A. Iannazzi, R.C. Taylor, R.M. Hewick, V. Rosen, E.A. Wang, and J.M. Wozney Identification of transforming growth-factor-beta family members present in bone-inductive protein purified from bovine bone Proc. Natl. Acad. Sci. U. S. A. 87 24 1990 9843 9847 (Pubitemid 120016540)
81. M.B. Sporn, A.B. Roberts, L.M. Wakefield, and R.K. Assoian Transforming growth-factor-beta-biological function and chemical structure Science 233 4763 1986 532 534 (Pubitemid 16019904)
82. B. Amsden Review of osmotic pressure driven release of proteins from monolithic devices J. Pharm. Pharm. Sci. 10 2 2007 129 143 (Pubitemid 46805398)
83. B.G. Amsden, and Y.L. Cheng Enhanced fraction releasable above percolation-threshold from monoliths containing osmotic excipients J. Control. Release 31 1 1994 21 32 (Pubitemid 24248113)
84. R.A. Siegel, and R. Langer Controlled release of polypeptides and other macromolecules Pharm. Res. 1 1984 2 10 (Pubitemid 14123791)
85. A.P. Pego, A.A. Poot, D.W. Grijpma, and J. Feijen In vitro degradation of trimethylene carbonate based (co)polymers Macromol. Biosci. 2 9 2002 411 419 (Pubitemid 44790995)
86. J.T. Chin, S.L. Wheeler, and A.M. Klibanov Communication to the editor on protein solubility in organic-solvents Biotechnol. Bioeng. 44 1 1994 140 145
87. F. Wu, and T. Jin Polymer-Based Sustained-Release Dosage Forms for Protein Drugs, Challenges, and Recent Advances AAPS PharmSciTech 9 4 2008 1218 1229
88. G. Jiang, B.H. Woo, F.R. Kang, J. Singh, and P.P. DeLuca Assessment of protein release kinetics, stability and protein polymer interaction of lysozyme encapsulated poly (d, l-lactide-co-glycolide) microspheres J. Control. Release 79 1-3 2002 137 145 (Pubitemid 34164167)
89. G. Crotts, and T.G. Park Stability and release of bovine serum albumin encapsulated within poly(d, l-lactide-co-glycolide) microparticles J. Control. Release 44 2-3 1997 123 134 (Pubitemid 27039109)
90. L.R. Wetter, and H.F. Deutsch Immunological studies on egg white proteins. 4. Immunochemical and physical studies of lysozyme J. Biol. Chem. 192 1 1951 237 242
91. P.G. Righetti, and T. Caravaggio Isoelectric points and molecular-weights of proteins-Table J. Chromatogr. 127 1 1976 1 28
92. K. Hirayama, S. Akashi, M. Furuya, and K. Fukuhara Rapid confirmation and revision of the primary structure of bovine serum-albumin by ESIMS and frit-FAB LC MS Biochem. Biophys. Res. Commun. 173 2 1990 639 646