Intra-articular drug delivery systems: Overcoming the shortcomings of joint disease therapy

Expert Opinion on Drug Delivery

Volumn 6, Issue 1, 2009, Pages 17-26

  Burt, Helen M ^a   Tsallas, Antonia ^a   Gilchrist, Samuel ^a   Liang, Linda S ^b  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

Author keywords

Arthritis; Biocompatibility; Biomaterials; Drug delivery; Efficacy; Intra articular; Microspheres; Nanospheres; Targeted delivery; Tolerability

Indexed keywords

3 (3 CYCLOPENTYLOXY 4 METHOXYBENZYL) 6 ETHYLAMINO 8 ISOPROPYL 3H PURINE; ANTIRHEUMATIC AGENT; BETAMETHASONE; CARBOXYMETHYLCELLULOSE; CELECOXIB; CHOLESTEROL; CONTRAST MEDIUM; DEXAMETHASONE; DICETYL PHOSPHATE; DICLOFENAC; DIMYRISTOYLPHOSPHATIDYLCHOLINE; DRUG CARRIER; FLURBIPROFEN; GLYCEROL BEHENATE; HOLMIUM; HYALURONIC ACID; INDOMETACIN; INSULIN; IOHEXOL; LIPOSOME; METHOTREXATE; METHYLPREDNISOLONE; NANOSPHERE; NAPROXEN; PACLITAXEL; POLYESTER; PREDNISOLONE; TRIAMCINOLONE; ULINASTATIN; UNINDEXED DRUG;

ARTHRITIS; BIOCOMPATIBILITY; BIODEGRADABILITY; CONTROLLED RELEASE FORMULATION; DRUG BLOOD LEVEL; DRUG DELIVERY SYSTEM; DRUG EFFICACY; DRUG HALF LIFE; DRUG SAFETY; DRUG TOLERABILITY; HUMAN; ISOTOPE LABELING; JOINT; JOINT SWELLING; MACROPHAGE; NONHUMAN; OSTEOARTHRITIS; PARTICLE SIZE; PHAGOCYTOSIS; PHARMACOKINETICS; PSORIATIC ARTHRITIS; REVIEW; RHEUMATOID ARTHRITIS; ANIMAL; ARTHROPATHY; CHEMISTRY; DELAYED RELEASE FORMULATION; INTRAARTICULAR DRUG ADMINISTRATION; METABOLISM; PATHOPHYSIOLOGY; SYNOVIAL FLUID; SYNOVITIS;

ANIMALS; ANTIRHEUMATIC AGENTS; DELAYED-ACTION PREPARATIONS; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; HUMANS; INJECTIONS, INTRA-ARTICULAR; JOINT DISEASES; SYNOVIAL FLUID; SYNOVITIS;

EID: 64749105978     PISSN: 17425247     EISSN: None     Source Type: Journal    
DOI: 10.1517/17425240802647259     Document Type: Review

References (65)

1. Smolen JS, Steiner G. Therapeutic strategies for rheumatoid arthritis. Nat Rev Drug Discov 2003;2:473-488 (Pubitemid 37361728)
2. Sarzi-puttini P, Cimmino MA, Scarpa R, et al. Osteoarthritis: an overview of the disease and its treatment strategies. Semin Arthritis Rheum 2005;35:1-10 (Pubitemid 41097249)
3. Klemp P, Stansfield SA, Castle B, Robertson MC. Gout is on the increase in New Zealand. Ann Rheum Dis 1997;56:22-26 (Pubitemid 27060568)
4. McCarty DJ. Pathogenesis and treatment of crystal-induced inflammation. In: McCarty DJ, editor, Arthritis and Allied Conditions. Philadelphia: Lea and Febiger; 1995
5. Caldwell JR. Intra-articular corticosteroids. Guide to selection and indications for use. Drugs 1996;52:507-514
6. Gerwin N, Hops C, Lucke A. Intraarticular drug delivery in osteoarthritis. Adv Drug Deliv Rev 2006;58:226-42 •• Review of intra-articular drug treatments in osteoarthritis with an emphasis on glucocorticoids and hyaluronic acid.
7. Larsen C, Ostergaard J, Larsen SW, et al. Intra-articular depot formulation principles: Role in the management of postoperative pain and arthritic disorders. J Pharm Sci 2008 : published online, doi:10.1002/jps.21346 •• Comprehensive review of intra-articular drug transport and controlled release and depot drug delivery systems administered into joints.
8. Levich JR. Microvascular architecture and exchange in synovial joints. Microcirculation , 1995;2:217-233
9. Knight AD, Levick JR. The density and distribution of capillaries around a synovial cavity. Quart J Exp Physiol 1983;68:629-644 (Pubitemid 14247410)
10. Levick JR, McDonald JN. Ultrastructure of transport pathways in stressed synovium of the knee in anaesthetized rabbits. J Physiol 1989;419:493-508 (Pubitemid 20012030)
11. Stevens CR, Blake DR, Merry P, et al. A comparative study by morphometry of the microvasculature in normal and rheumatoid synovium. Arthr Rheum 1991;34:1508-1513
12. Ghadially F. Fine structure of synovial joints. London, Butterworths; 1983
13. Knox P, Levick JR, Mcdonald JN. Synovial fluid - its mass, macromolecular content and pressure in major limb joints of the rabbit. Quart J Exp Physiol 1988;73:33-45 (Pubitemid 18028553)
14. Ghadially F, Yong N, Lalonde J. A transmission electron microscopic comparison of the articular surface of cartilage processed and attached to bone and detached from bone. J Anat 1982;135:685-706 (Pubitemid 13167502)
15. Howe HS. Rheumatoid arthritis - a review [Review] [59 refs]. Ann Acad Med Singapore 1998;27:83-88
16. van den Berg WB, Bresnihan B. Pathogenesis of joint damage in rheumatoid arthritis: evidence of a dominant role for interleukin-I [Review] [84 refs]. Best Practice Res Clin Rheumatol 1999;13:577-597
17. Schuna A, Schmidt M, Pigarelli D. Rheumatoid arthritis and the seronegative spondyloarthropathies. In: Dipiro J, Talbert R, Yee G, et al., editors, Pharmacotherapy: a pathophysiologic approach. Stamford, Connecticut, Appleton and Lange; 1996
18. Burt HM, Jackson JK. Cytosolic Calcium concentration determinations in neutrophils stimulated by monosodium urate and calcium pyrophosphate crystals: effect of protein adsorption. J Rheumatol 1994;21:138-144 (Pubitemid 2038068)
19. Scott D, Bertin K, Levick JR, Miserocchi GA. Interstitial pressure gradients around joints;location of chief resistance to fluid drainage from the rabbit knee. Exp Physiol 2001;86:739-747 (Pubitemid 33107646)
20. Levick JR, Mcdonald JN. Synovial capillary distribution in relation to altered pressure and permeability in knees of anaethetized rabbits. J Physiol 1989;419:477-492 (Pubitemid 20012029)
21. Simkin PA, Nilson K. Trans-synovial exchange of large and small molecules. Clinics Rheum Dis 1981;7:99-129 (Pubitemid 11079663)
22. Wallis WJ, Simkin PA. Antirheumatic drug concentrations in human synovial fluid and synovial tissue. Observations on extravascular pharmacokinetics. Clin Pharmcokin 1983;8:496-522
23. Levick JR. Contributions of the lymphatic and microvascular systems to fluid absorption from the synovial cavity of the rabbit knee. J Physiol 1980;306:445-461 (Pubitemid 10005632)
24. Wallis WJ, Simkin PA, Nelp WB, Foster DM. Intraarticular volume and clearance in human synovial effusions. Arthritis Rheum 1985;28:441-449 (Pubitemid 15075497)
25. Neander G, Eriksson LO, Wallin-boll E, et al. Pharmacokinetics of intra-articular indomethacin in patients with osteoarthritis. Europ J Clin Pharmacol 1992;42:301-305
26. Wigginton S, Chu B, Weisman M, Howell S. Methotrexate pharmacokinetics after intraarticular injection in patients with rheumatoid arthritis. Arthritis Rheum 1980;23:119-122 (Pubitemid 10214781)
27. Iagnocco A, Cerioni A, Coari G, et al. Intra-articular methotrexate in the treatment of rheumatoid arthritis and psoriatic arthritis: a clinical and sonographic study. Clin Rheumatol 2006;25:159-163 (Pubitemid 43372311)
28. Derendorf H, Mollmann H, Gruner A, et al. Pharmacokinetics and pharmacodynamics of glucocorticoid suspensions after intra-articular administration. Clin Pharmacol Ther 1986;39:313-317 (Pubitemid 16113640)
29. Derendorf H, Mollmann H, Voortman G, et al. Pharmacokinetics of rimexolone after intra-articular administration. J Clin Pharmacol 1990;30:476-479 (Pubitemid 20228352)
30. Lindqvist U, Tolmachev V, Kairemo K, et al. Elimination of stabilized hyaluronan from the knee joint in healthy men. Clin Pharmacokinet 2002;41:603-613 (Pubitemid 34848365)
31. Ohzawa N, Takahashi Y, Ogihara T, et al. Metabolic fate of ulinastatin (2);pharmacokinetics in rabbits following intra-articular administration. Biol Pharm Bull 1997;20:732-738
32. Foong WC, Green KL. Retention and distribution of liposome-entrapped [3H] methotrexate injected into normal or arthritic rabbit joints. J Pharm Pharmacol 1988;40:464-468 (Pubitemid 18177196)
33. Foong WC, Green KL. Treatment of antigen-induced arthritis in rabbits with liposome-entrapped methotrexate injected intra-articularly. J Pharm Pharmacol 1993;45:204-209 (Pubitemid 23108161)
34. Williams AS, Camilleri JP, Goodfellow RM, Williams BD. A single intra-articular injection of liposomally conjugated methotrexate suppresses joint inflammation in rat antigen-induced arthritis. Brit J Rheumatol 1996;35:719-724 (Pubitemid 126719529)
35. Turker S, Erdogan S, Ozer AY, et al. Scintigraphic imaging of radiolabelled drug delivery systems in rabbits with arthritis. Int J Pharm 2005;296:34-43 (Pubitemid 40693370)
36. Turker S, Erdogan S, Ozer YA, et al. Enhanced efficacy of diclofenac sodium loaded lipogelosome formulation in intra-articular treatment of rheumatoid arthritis. J Drug Target 2008;16:51-57
37. Edwards SHR, Cake MA, Spoelstra G, Read RA. Biodistribution and clearance of intra-articular liposomes in a large animal model using a radiographic marker. J Liposome Res 2007;17:249-261 (Pubitemid 350133589)
38. Thakkar H, Sharma RK, Murthy RSR. Enhanced retention of celecoxib loaded solid lipid nanoparticles after intra-articular administration. Drugs 2007;8:275-285 (Pubitemid 47403123)
39. Ratcliffe JH, Hunneyball IM, Smith A, et al. Preparation and evaluation of biodegradable polymeric systems for the intra-articular delivery of drugs. J Pharm Pharmacol 1984;36:431-436 (Pubitemid 14076429)
40. Ratcliffe JH, Hunneyball IM, Wilson CG, et al. Albumin microspheres for intra-articular drug delivery: investigation of their retention in normal and arthritis knee joints of rabbits. J Pharm Pharmacol 1987;39:290-295 (Pubitemid 17046856)
41. Horisawa E, Hirota T, Kawazoe S, et al. Prolonged anti-inflammatory action of D,L-lactide/glycolide copolymer nanospheres containing betamethasone sodium phosphate for an intra-articular delivery system in antigen-induced arthritic rabbit. Pharm Res 2002;19:403-10 •• Study of the biocompatibility and efficacy of glucocorticoid loaded controlled release nanospheres in rabbit joints. (Pubitemid 34408936)
42. Tuncay M, Calis S, Kas HS, et al. Diclofenac sodium incorporated PLGA (50:50) microspheres: formulation considerations and in vitro/in vivo evaluation. Int J Pharm 2000;195:179-188 (Pubitemid 30089502)
43. Bragdon B, Bertone AL, Hardy J, et al. Use of an isolated joint model to detect early changes induced by intra-articular injection of paclitaxel-impregnated polymeric microspheres. J Invest Surgery 2001;14:169-82 •• Demonstration of the influence of paclitaxel loaded microspheres on hemodynamic, microvascular and transsynovial flow responses in an isolated joint model.
44. Lu Y, Zhang G, Sun D, Zhong Y. Preparation and evaluation of biodegradable flurbiprofen gelatin microspheres for intra-articular administration. J Microencap 2007;24:515-524 (Pubitemid 47180535)
45. Liang LS, Jackson JK, Min W, et al. Methotrexate loaded poly(L-lactic acid) microspheres for intra-articular delivery of methotrexate to the joint. J Pharm Sci 2004;93:943-956 (Pubitemid 38420405)
46. Liang LS, Wong W, Burt HM. Pharmacokinetic study of methotrexate following intra-articular injection of methotrexate loaded poly(L-lactic acid) microspheres in rabbits. J Pharm Sci 2005;94:1204-1215 (Pubitemid 40904185)
47. Zhang JX, Yan MQ, Li XH, et al. Local delivery of indomethacin to arthritis bearing rats through polymeric micelles based on amphiphilic polyphosphazenes. Pharm Res 2007;24:1944-1953 (Pubitemid 47389251)
48. Zhang JX, Li SH, Li XH, et al. Physicochemical characterization, in vitro, and in vivo evaluation of indomethacin loaded nanocarriers self-assembled by amphiphilic polyphosphazene. J Biomed Mater Res 2008;86A:914-925
49. Horisawa E, Kubota K, Tuboi I, et al. Size dependency of D,L-lactide/glycolide copolymer particulates for intra-articular delivery system on phagocytosis in rat synovium. Pharm Res 2002;19:132-9 • Investigation of size dependency of nanospheres and their localization in the joint.
50. Rothenfluh DA, Bermudez H, O'Neil C, Hubbell JA. Biofunctional polymer nanoparticles for intra-articular targeting and retention in cartilage. Nature Mat 2008;7:248-254 (Pubitemid 351311300)
51. Ramesh DV, Tabata Y, Ikada Y. Biodegradable microspheres for local drug release in the articulus. J Bioactive Compat Polymers 1999;14:137-49 • Drug release from different size range microspheres was compared in vitro and in vivo.
52. Nishide M, Kamei S, Takakura Y, et al. Fate of biodegradable dl-lactic acid oligomer microspheres in the articulus. J Bioactive Compat Polymers 1999;14:385-98 •• One of very few studies in which the joint tissue localization and biodegradation rates of intra-articularly administered microspheres were evaluated.
53. Greis PE, Georgescu HI, Fu FH, Evans CH. Particle-induced synthesis of collagenase by synovial fibroblasts: an immunocytochemical study. J Orthop Res 1994;12:286-293 (Pubitemid 24146895)
54. Liggins RT, Cruz T, Liang L, et al. Intra-articular treatment of arthritis with microsphere formulations of paclitaxel: biocompatibility and efficacy determinations in rabbits. Inflamm Res 2004;53:363-372 (Pubitemid 39141750)
55. Tang L, Lucas AH, Eaton JW. Inflammatory responses to implanted polymeric biomaterials: role of surface adsorbed immunoglobulin G. J Lab Clin Med 1993;122:292-300
56. Jackson JK, Springate CMK, Hunter WL, Burt HM. Neutrophil activation by plasma opsonized polymeric microspheres: inhibitory effect of Pluronic F127. Biomaterials 2000;21:1483-1491 (Pubitemid 30259292)
57. Tabata Y, Ikada Y. Phagocytosis of polymer microspheres by macrophages. Adv Polym Sci 1990;94:107-141
58. Langer RS, Peppas NA. Present and future applications of biomaterials in controlled drug delivery systems. Biomaterials 1981;2:201-214 (Pubitemid 12195193)
59. Kumar N, Ravikumar MNV, Domb AJ. Biodegradable block copolymers. Adv Drug Deliv Rev 2001;53:23-44 (Pubitemid 33152832)
60. Piskin E. Biodegradable polymers as biomaterials. J Biomat Sci Polymer Ed 1994;6:775-795
61. Peluso G, Petillo O, Ranieri M, et al. Chitosan mediated stimulation of macrophage function. Biomaterials 1994;15:1215-1220
62. Maeda M, Inoue Y, Iwase H, Kifune K. Biomedical properties and applications of chitosan and its derivatives. In: Wise DL, Trantolo DJ, Altobelli DE, et al., editors, Encyclopedic Handbook of Biomaterials and Bioengineering, Part A: Materials. New York, Marcel Dekker, Inc.; 1995
63. Thakkar H, Sharma RK, Mishra AK, et al. Efficacy of chitosan microspheres for controlled intra-articular delivery of celecoxib in inflamed joints. J Pharm Pharmacol 2004;56:1091-1099 (Pubitemid 39207189)
64. Anderson JM, Shive MS. Biodegradation and biocompatibility of PLA and PLGA microspheres. Adv Drug Deliv Rev 1997;28:5-24
65. Brown KE, Shao W, Bathon J, Leong KW. Controlled drug delivery to the joints by enzymatically degradable microspheres. Mat Res Soc Symp Proc 1994;331:73-78