Increased HoxB4 inhibits apoptotic cell death in pro-B cells

Korean Journal of Physiology and Pharmacology

Volumn 16, Issue 4, 2012, Pages 265-271

  Park, Sung Won ^a   Won, Kyung Jong ^b   Lee, Yong Soo ^c   Kim, Hye Sun ^d   Kim, Yu Kyung ^a   Lee, Hyeon Woo ^d   Kim, Bokyung ^b   Lee, Byeong Han ^e   Kim, Jin Hoi ^f   Kim, Dong Ku ^f  

^a CHA University   (South Korea)

^b Konkuk University School of Medicine   (South Korea)

^c Samsung Medical Center   (South Korea)

^d Kyung Hee University   (South Korea)

^e Asan Medical Center   (South Korea)

^f Konkuk University   (South Korea)

Author keywords

Apoptosis; Ba F3; Cell cycle arrest; Cell proliferation; HoxB4

Indexed keywords

DOXORUBICIN; HOMEODOMAIN PROTEIN; INTERLEUKIN 3; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR HOXB4; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DEATH; CELL PROLIFERATION; CELL SIZE; CELL SURVIVAL; CONTROLLED STUDY; G2 PHASE CELL CYCLE CHECKPOINT; GENE OVEREXPRESSION; IN VITRO STUDY; M PHASE CELL CYCLE CHECKPOINT; MOUSE; NONHUMAN; PRE B LYMPHOCYTE; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

EID: 84865808849     PISSN: 12264512     EISSN: None     Source Type: Journal    
DOI: 10.4196/kjpp.2012.16.4.265     Document Type: Article

References (30)

1. Deneault E, Cellot S, Faubert A, Laverdure JP, Fréchette M, Chagraoui J, Mayotte N, Sauvageau M, Ting SB, Sauvageau G. A functional screen to identify novel effectors of hematopoietic stem cell activity. Cell. 2009;137:369-379.
2. Opferman JT. Life and death during hematopoietic differentiation. Curr Opin Immunol. 2007;19:497-502.
3. Chen CZ, Lodish HF. MicroRNAs as regulators of mammalian hematopoiesis. Semin Immunol. 2005;17:155-165.
4. Duncan AW, Rattis FM, DiMascio LN, Congdon KL, Pazianos G, Zhao C, Yoon K, Cook JM, Willert K, Gaiano N, Reya T. Integration of Notch and Wnt signaling in hematopoietic stem cell maintenance. Nat Immunol. 2005;6:314-322.
5. Blank U, Karlsson G, Karlsson S. Signaling pathways governing stem-cell fate. Blood. 2008;111:492-503.
6. Sauvageau G, Lansdorp PM, Eaves CJ, Hogge DE, Dragowska WH, Reid DS, Largman C, Lawrence HJ, Humphries RK. Differential expression of homeobox genes in functionally distinct CD34+ subpopulations of human bone marrow cells. Proc Natl Acad Sci USA. 1994;91:12223-12227.
7. Daley GQ, Baltimore D. Transformation of an interleukin 3-dependent hematopoietic cell Une by the chronic myelogenous leukemia-specific P210bcr/abl protein. Proc Natl Acad Sci USA. 1988;85:9312-9316.
8. Ajjappala BS, Kim YS, Kim MS, Lee MY, Lee KY, Ki HY, Cha DH, Baek KH. 14-3-3 gamma is stimulated by IL-3 and promotes cell proliferation. J Immunol. 2009;182:1050-1060.
9. Magli MC, Barba P, Celetti A, De Vita G, Cilio C, Boncinelli E. Coordinate regulation of HOX genes in human hematopoietic cells. Proc Natl Acad Sci USA. 1991;88:6348-6352.
10. Krumlauf R. Hox genes in vertebrate development. Cell. 1994;78:191-201.
11. Martinez P, Amemiya CT. Genomics of the HOX gene cluster. Comp Biochem Physiol B Biochem Mol Biol. 2002;133:571-580.
12. Svingen T, Tonissen KF. Hox transcription factors and their elusive mammalian gene targets. Heredity (Edinb). 2006;97:88-96.
13. Buske C, Feuring-Buske M, Abramovich C, Spiekermann K, Eaves CJ, Coulombel L, Sauvageau G, Hogge DE, Humphries RK. Deregulated expression of HOXB4 enhances the primitive growth activity of human hematopoietic cells. Blood. 2002;100:862-868.
14. Will E, Speidel D, Wang Z, Ghiaur G, Rimek A, Schiedlmeier B, Williams DA, Baum C, Ostertag W, Klump H. HOXB4 inhibits cell growth in a dose-dependent manner and sensitizes cells towards extrinsic cues. Cell Cycle. 2006;5:14-22.
15. Antonchuk J, Sauvageau G, Humphries RK. HOXB4-induced expansion of adult hematopoietic stem cells ex vivo. Cell. 2002;109:39-45.
16. Milsom MD, Schiedlmeier B, Bailey J, Kim MO, Li D, Jansen M, Ali AM, Kirby M, Baum C, Fairbairn LJ, Williams DA. Ectopic HOXB4 overcomes the inhibitory effect of tumor necrosis factor-{alpha} on Fanconi anemia hematopoietic stem and progenitor cells. Blood. 2009;113:5111-5120.
17. Schiedlmeier B, Santos AC, Ribeiro A, Moncaut N, Lesinski D, Auer H, Kornacker K, Ostertag W, Baum C, Mallo M, Klump H. HOXB4's road map to stem cell expansion. Proc Natl Acad Sci USA. 2007;104:16952-16957.
18. Gamen S, Anel A, Lasierra P, Alava MA, Martinez-Lorenzo MJ, Piñeiro A, Naval J. Doxorubicin-induced apoptosis in human T-cell leukemia is mediated by caspase-3 activation in a Fas-independent way. FEBS Lett. 1997;417:360-364.
19. Kim HS, Lee YS, Kim DK. Doxorubicin exerts cytotoxic effects through cell cycle arrest and Fas-mediated cell death. Pharmacology. 2009;84:300-309.
20. Haddad R, Pflumio F, Vigon I, Visentin G, Auvray C, Fichelson S, Amsellem S. The HOXB4 homeoprotein differentially promotes ex vivo expansion of early human lymphoid progenitors. Stem Cells. 2008;26:312-322.
21. Scatizzi JC, Mavers M, Hutcheson J, Young B, Shi B, Pope RM, Ruderman EM, Samways DS, Corbett JA, Egan TM, Perlman H. The CDK domain of p21 is a suppressor of IL-1beta-mediated inflammation in activated macrophages. Eur J Immunol. 2009;39:820-825.
22. See WA, Zhang G, Chen F, Cao Y. p21 Expression by human urothelial carcinoma cells modulates the phenotypic response to BCG. Urol Oncol. 2010;28:526-533.
23. Kim CH, Yoo YM. Melatonin induces apoptotic cell death via p53 in LNCaP cells. Korean J Physiol Pharmacol. 2010;14:365-369.
24. Chung JS, Lee SB, Park SH, Kang ST, Na AR, Chang TS, Kim HJ, Yoo YD. Mitochondrial reactive oxygen species originating from Romo1 exert an important role in normal cell cycle progression by regulating p27(Kip1) expression. Free Radic Res. 2009;43:729-737.
25. Kim KC, Lee C. Curcumin induces downregulation of E2F4 expression and apoptotic cell death in HCT116 human colon cancer cells; Involvement of reactive oxygen species. Korean J Physiol Pharmacol. 2010;14:391-397.
26. Aaltonen K, Amini RM, Landberg G, Eerola H, Aittomäki K, Heikkilä P, Nevanlinna H, Blomqvist C. Cyclin D1 expression is associated with poor prognostic features in estrogen receptor positive breast cancer. Breast Cancer Res Treat. 2009;113:75-82.
27. Krosl J, Sauvageau G. AP-1 complex is effector of Hox-induced cellular proliferation and transformation. Oncogene. 2000;19:5134-5141.
28. Zhu N, Shao Y, Xu L, Yu L, Sun L. Gadd45-alpha and Gadd45-gamma utilize p38 and JNK signaling pathways to induce cell cycle G2/M arrest in Hep-G2 hepatoma cells. Mol Biol Rep. 2009;36:2075-2085.
29. Jin S, Tong T, Fan W, Fan F, Antinore MJ, Zhu X, Mazzacurati L, Li X, Petrik KL, Rajasekaran B, Wu M, Zhan Q. GADD45-induced cell cycle G2-M arrest associates with altered subcellular distribution of cyclin B1 and is independent of p38 kinase activity. Oncogene. 2002;21:8696-8704.
30. Li Q, Ching AK, Chan BC, Chow SK, Lim PL, Ho TC, Ip WK, Wong CK, Lam CW, Lee KK, Chan JY, Chui YL. A death receptor-associated anti-apoptotic protein, BRE, inhibits mitochondrial apoptotic pathway. J Biol Chem. 2004;279:52106- 52116.