P21 Expression by human urothelial carcinoma cells modulates the phenotypic response to BCG

Urologic Oncology: Seminars and Original Investigations

Volumn 28, Issue 5, 2010, Pages 526-533

  See, William A ^a   Zhang, Guangjian ^a   Chen, Fanghong ^a   Cao, Yanli ^a  

^a MEDICAL COLLEGE OF WISCONSIN   (United States)

Author keywords

BCG; Bladder cancer; P21

Indexed keywords

BCG VACCINE; CAMPTOTHECIN; CASPASE 3; PROTEIN P21; SHORT HAIRPIN RNA;

APOPTOSIS; ARTICLE; CARCINOMA CELL; CELL CYCLE ARREST; CELL VIABILITY; CONTROLLED STUDY; DRUG CYTOTOXICITY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; UROTHELIUM;

BCG VACCINE; CAMPTOTHECIN; CASPASE 3; CELL CYCLE; CELL LINE, TUMOR; CYCLIN-DEPENDENT KINASE INHIBITOR P21; ECDYSTERONE; HUMANS; PHENOTYPE; URINARY BLADDER NEOPLASMS;

EID: 77956284009     PISSN: 10781439     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.urolonc.2008.12.023     Document Type: Article

References (13)

1. Chen F., Zhang G., Iwamoto Y., et al. Bacillus Calmette-Guerin initiates intracellular signaling in a transitional carcinoma cell line by cross-linking α5β1 integrin. J Urol 2003, 170:605-610.
2. Chen F., Zhang G., Iwamoto Y. BCG directly induces cell cycle arrest in human transitional carcinoma cell lines as a consequence of integrin cross-linking. BMC Urology 2005, 5:8.
3. Chen F., Zhang G., Cao Y., et al. Bacillus Calmette-Guerin inhibits apoptosis in human urothelial carcinoma cell lines in response to cytotoxic injury. J Urol 2007, 178:2166-2170.
4. See W.A., Zhang G., Chen F., et al. BCG induces necrotic cell death in urothelial carcinoma cells associated with the release of the chemokine HMGB1. J Urol 2007, 179(Suppl 4):370.
5. Zhang G., Chen F., Cao Y., et al. Bacillus Calmette-Guerin induces p21 expression in human transitional carcinoma cell lines via an immediate early, p53 independent pathway. Urologic Oncology 2007, 25:221-227.
6. Harper J.W., Adami G.R., Wei N., et al. The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell 1993, 75:805-816.
7. Gartel A.L., Tyner A.L. The role of the cyclin-dependent kinase inhibitor p21 in apoptosis. Mol Cancer Therapeut 2002, 1:639-649.
8. Waf1/Cip1/Sdi1 expression increases gene transduction efficiency in primitive human hematopoietic cells. Gene Ther 2005, 12:1444-1452. ; (Epub 2005 May 5).
9. Kavoussi L.R., Brown E.J., Ritchey J.K., et al. Fibronectin-mediated bacillus Calmette-Guerin attachment to murine bladder mucosa. Requirement for the expression of an antitumor response. J Clin Invest 1990, 85:62-67.
10. Chen F.H., Zhang G.J., Iwamoto Y., et al. BCG initiates intracellular signaling in a transitional carcinoma cell line by cross-linking a5b1 integrin. J Urol 2003, 170:605-610.
11. Chen F.H., Crist S.A., Zhang G.J., et al. Interleukin-6 production by human bladder tumor cell lines is up-regulated by bacillus Calmette-Guerin through nuclear factor-κB and Ap-1 via an immediate early pathway. J Urol 2002, 168:786-797.
12. Gartel A.L., Radhakrishnan S.K. Lost in transcription: p21 repression, mechanisms, and consequences. Cancer Res 2005, 65:3980-3985.
13. Kwon Y.H., Jovanovic A., Serfas M.S., Tyner A.L. The Cdk inhibitor p21 is required for necrosis, but it inhibits apoptosis following toxin-induced liver injury. J Biol Chem 2003, 278:30348-30355.