Polymeric delivery of therapeutic RAE-1 plasmid to the pancreatic islets for the prevention of type 1 diabetes

Journal of Controlled Release

Volumn 162, Issue 3, 2012, Pages 606-611

  Joo, Wan Seok ^a   Jeong, Ji Hoon ^b   Nam, Kihoon ^a   Blevins, Katherine S ^a   Salama, Mohamed E ^c   Kim, Sung Wan ^a  

^a UNIVERSITY OF UTAH   (United States)

^b Sungkyunkwan University   (South Korea)

^c ARUP LABORATORIES   (United States)

Author keywords

Drug delivery; Gene therapy; Retinoic acid early inducible gene 1 (RAE 1); Type 1 diabetes

Indexed keywords

BLOOD GLUCOSE LEVEL; CATIONIC POLYMERS; CYSTAMINE; EXPRESSION SYSTEM; GENE DELIVERY SYSTEMS; NATURAL PHENOMENA; NOD MOUSE; PANCREATIC ISLET; PLASMID DNA; POLYMERIC DELIVERY; POLYPLEXES; RETINOIC ACIDS; T CELLS; TYPE 1 DIABETES;

DNA; DRUG DELIVERY; GENE THERAPY; GENE TRANSFER; GLUCOSE; HEXANE; MAMMALS; POLYETHYLENE GLYCOLS;

FUNCTIONAL POLYMERS;

CYSTEINYLHISTIDYLVALYLLEUCYLTRYPTOPHANYLSERYLTHREONYLARGINYLCYSTEINE; EPHRIN RECEPTOR A2; EPHRIN RECEPTOR A4; GLUCOSE; MACROGOL; PEPTIDE DERIVATIVE; PLASMID DNA; POLY(CYSTAMIN BISACRYLAMIDE DIAMINO HEXANE); POLYMER; RETINOIC ACID INDUCIBLE PROTEIN I; RNA HELICASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; FEMALE; GENE EXPRESSION SYSTEM; GLUCOSE BLOOD LEVEL; HYPERGLYCEMIA; INSULIN DEPENDENT DIABETES MELLITUS; INSULITIS; LYMPHOCYTIC INFILTRATION; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS ISLET; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL;

ANIMALS; DIABETES MELLITUS, TYPE 1; FEMALE; GENE TRANSFER TECHNIQUES; ISLETS OF LANGERHANS; MEMBRANE PROTEINS; MICE; MICE, INBRED NOD; OLIGOPEPTIDES; PLASMIDS; POLYMERS; RECEPTORS, EPH FAMILY; TISSUE DISTRIBUTION;

EID: 84865807490     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2012.08.008     Document Type: Article

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