Aurora A kinase interacts with and phosphorylates VHL protein

Biologia

Volumn 67, Issue 5, 2012, Pages 1026-1030

  Ferchichi, Imen ^a   Arlot, Yannick ^b   Cremet, Jean Yves ^b   Prigent, Claude ^b   Benammar Elgaaied, Amel ^a  

^a FACULTÉ DES SCIENCES DE TUNIS   (Tunisia)

^b UNIVERSITÉ DE RENNES 1   (France)

Author keywords

Aurora A; cell culture; immunoprecipitation; pVHL; test kinase

Indexed keywords

EID: 84865795791     PISSN: 00063088     EISSN: 13369563     Source Type: Journal    
DOI: 10.2478/s11756-012-0091-0     Document Type: Article

References (21)

1. Ampofo E., Kietzmann T., Zimmer A., Jakupovic M., Montenarh M. & Götz C. 2010. Phosphorylation of the von Hippel-Lindau protein (VHL) by protein kinase CK2 reduces its protein stability and affects p53 and HIF-1α mediated transcription. Int. J. Biochem. Cell. Biol. 42: 1729-1735.
2. Carvajal R., Tse A. & Schwartz G. 2006. Aurora kinases: new targets for cancer therapy. Clin. Cancer Res. 12: 6869-6875.
3. Cowley D. O., Rivera-Perez J. A., Schliekelman M., He Y. J., Oliver T. G., Lu L., O'Quinn R., Salmon E. D., Magnuson T. & van Dyke T. 2009. Aurora A kinase is essential for bipolar spindle formation and early development. Mol. Cell. Biol. 29: 1059-1071.
4. Crosio C., Fimia G. M., Loury R., Kimura M., Okano Y., Zhou H., Sen S., Allis C. D. & Sassone-Corsi P. 2002. Mitotic phosphorylation of histone H3: spatio-temporal regulation by mammalian Aurora kinases. Mol. Cell. Biol. 22: 874-885.
5. Ehara H., Yokoi S., Tamaki M., Nishino Y., Takahashi Y., Deguchi T., Kimura M., Yoshioka T. & Okano Y. 2003. Expression of mitotic Aurora/Ipl1p-related kinases in renal cell carcinomas: an immunohistochemical study. Urol. Res. 31: 382-386.
6. Ferchichi I., Stambouli N., Marrackchi R., Arlot Y., Prigent C., Fadiel A., Odunsi K., Ben Ammar Elgaaied A. & Hamza A. 2010. Experimental and computational studies indicate specific binding of pVHL protein to Aurora A kinase. J. Phys. Chem. B 114: 1486-1497.
7. Fu J., Bian M., Jiang Q. & Zhang C. 2007. Roles of Aurora kinases in mitosis and tumorigenesis. Mol. Cancer Res. 5: 1-10.
8. Giet R., McLean D., Descamps S., Lee M. J., Raff J. W., Prigent C. & Glover D. M. 2002. Drosophila Aurora A kinase is required to localize D-TACC to centrosomes and to regulate astral microtubules. J. Cell. Biol. 156: 437-451.
9. Hergovich A., Lisztwan J., Barry R., Ballschmieter P. & Krek W. 2003. Regulation of microtubule stability by the von Hippel-Lindau tumour suppressor protein pVHL. Nat. Cell Biol. 1: 64-70.
10. Kim W. Y. & Kaelin W. G. 2004. Role of VHL gene mutation in human cancer. J. Clin. Oncol. 22: 4991-5004.
11. Kuehn E. W., Walz G. & Benzing T. 2007. Von Hippel-Lindau: a tumor suppressor links microtubules to ciliogenesis and cancer development. Cancer Res. 67: 4537-4540.
12. Loh J. K., Lieu A. S., Chou C. H., Lin F. Y., Wu C. H., Howng S. L., Chio C. C. & Hong Y. R. 2010. Differential expression of centrosomal proteins at different stages of human glioma. BMC Cancer. 10: 268.
13. Lolkema M. P., Gervais M. L., Snijckers C. M., Hill R. P., Giles R. H., Voest E. E. & Ohh M. 2005. Tumor suppression by the von Hippel-Lindau protein requires phosphorylation of the acidic domain. J. Biol. Chem. 280: 22205-22211.
14. Lolkema M. P., Mehra N., Jorna A. S., van Beest M., Giles R. H. & Voest E. E. 2004. The von Hippel-Lindau tumor suppressor protein influences microtubule dynamics at the cell periphery. Exp. Cell Res. 301: 139-146.
15. Marumoto T., Zhang D. & Saya H. 2005. Aurora A - a guardian of poles. Nat. Rev. Cancer. 5: 42-50.
16. Meraldi P. & Nigg E. A. 2002. The centrosome cycle. FEBS Lett. 521: 9-13.
17. Nadler Y., Camp R. L., Schwartz C., Rimm D. L., Kluger H. M. & Kluger Y. 2008. Expression of Aurora A (but not Aurora B) is predictive of survival in breast cancer. Clin. Cancer Res. 14: 4455-4462.
18. Roe J. S. & Youn H. D. 2006. The positive regulation of p53 by the tumor suppressor VHL. Cell. Cycle 5: 2054-2056.
19. Sinha S., Mondal G., Hwang E. J., Han da W., Dutta S. K., Iyer S., Karumanchi S. A., Kim K. I., Couch F. J. & Mukhopadhyay D. 2011. Von Hippel-Lindau gene product directs cytokinesis: a new tumor suppressor function. J. Cell Sci. 124: 2132-2142.
20. Thoma C. R., Toso A., Gutbrodt K. L., Reggi S. P., Frew I. J., Schraml P., Hergovich A., Moch H., Meraldi P. & Krek W. 2009. VHL loss causes spindle misorientation and chromosome instability. Nat. Cell Biol. 11: 994-1001.
21. Woodward E. R., Buchberger A., Clifford S. C., Hurst L. D., Affara N. A. & Maher E. R. 2000. Comparative sequence analysis of the VHL tumor suppressor gene. Genomics 65: 253-265.