Phosphorylation of the von Hippel-Lindau protein (VHL) by protein kinase CK2 reduces its protein stability and affects p53 and HIF-1α mediated transcription

International Journal of Biochemistry and Cell Biology

Volumn 42, Issue 10, 2010, Pages 1729-1735

  Ampofo, Emmanuel ^a   Kietzmann, Thomas ^b,c   Zimmer, Andreas ^a   Jakupovic, Mirza ^c   Montenarh, Mathias ^a   Götz, Claudia ^a  

^a SAARLAND UNIVERSITY   (Germany)

^b UNIVERSITY OF OULU   (Finland)

^c University of Koblenz Landau   (Germany)

Author keywords

Degradation; HIF 1 ; P53; Protein kinase CK2; VHL tumour suppressor

Indexed keywords

4,5,6,7 TETRABROMOBENZOTRIAZOLE; CASEIN KINASE II; HYPOXIA INDUCIBLE FACTOR 1ALPHA; PROTEIN KINASE INHIBITOR; PROTEIN P53; UNCLASSIFIED DRUG; VON HIPPEL LINDAU PROTEIN;

ARTICLE; CELL HYPOXIA; CELL SURVIVAL; DOWN REGULATION; DRUG INHIBITION; HUMAN; HUMAN CELL; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN STABILITY;

CASEIN KINASE II; DOWN-REGULATION; HEK293 CELLS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MUTAGENESIS, SITE-DIRECTED; MUTANT PROTEINS; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN STABILITY; TRANSCRIPTIONAL ACTIVATION; TRANSGENES; TRIAZOLES; TUMOR SUPPRESSOR PROTEIN P53; VON HIPPEL-LINDAU TUMOR SUPPRESSOR PROTEIN;

EID: 77956187680     PISSN: 13572725     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biocel.2010.07.008     Document Type: Article

References (27)

1. Ahmad K.A., Wang G., Unger G., Slaton J., Ahmed K. Protein kinase CK2-a key suppressor of apoptosis. Adv Enzyme Regul 2008, 48:179-187.
2. Appel K., Wagner P., Boldyreff B., Issinger O.-G., Montenarh M. Mapping of the interaction sites of the growth suppressor protein p53 with the regulatory β-subunit of protein kinase CK2. Oncogene 1995, 11:1971-1978.
3. Channavajhala P., Seldin D.C. Functional interaction of protein kinase CK2 and c-Myc in lymphomagenesis. Oncogene 2002, 21:5280-5288.
4. Desagher S., Osen-Sand A., Montessuit S., Magnenat E., Vilbois F., Hochmann A., et al. Phosphorylation of Bid by casein kinases I and II regulates its cleavage by caspase 8. Mol Cell 2001, 8:601-611.
5. Faust R.A., Niehans G., Gapany M., Hoistad D., Knapp D., Cherwitz D., et al. Subcellular immunolocalization of protein kinase CK2 in normal and carcinoma cells. Int J Biochem Cell Biol 1999, 31:941-949.
6. Götz C., Scholtes P., Schuster N., Prowald A., Nastainczyk W., Montenarh M. Protein kinase CK2 binds to a multi-protein binding domain of the growth suppressor protein p53. Mol Cell Biochem 1999, 191:111-120.
7. Hergovich A., Lisztwan J., Thoma C.R., Wirbelauer C., Barry R.E., Krek W. Priming-dependent phosphorylation and regulation of the tumor suppressor pVHL by glycogen synthase kinase 3. Mol Cell Biol 2006, 26:5784-5796.
8. Hubert A., Paris S., Piret J.P., Ninane N., Raes M., Michiels C. Casein kinase 2 inhibition decreases hypoxia-inducible factor-1 activity under hypoxia through elevated p53 protein level. J Cell Sci 2006, 119:3351-3362.
9. Kaelin W.G. Molecular basis of the VHL hereditary cancer syndrome. Nat Rev Cancer 2002, 2:673-682.
10. Kietzmann T., Cornesse Y., Brechtel K., Modaressi S., Jungermann K. Perivenous expression of the mRNA of the three hypoxia-inducible factor alpha-subunits, HIF1alpha, HIF2alpha and HIF3alpha, in rat liver. Biochem J 2001, 354:531-537.
11. Kim W.Y., Kaelin W.G. Role of VHL gene mutation in human cancer. J Clin Oncol 2004, 22:4991-5004.
12. Krippner-Heidenreich A., Talanian R.V., Sekul R., Kraft R., Thole H., Ottleben H., et al. Targeting of the transcription factor Max during apoptosis: phosphorylation-regulated cleavage by caspase-5 at an unusual glutamic acid residue in position P1. Biochem J 2001, 358:705-715.
13. Landesman-Bollag E., Romieu-Mourez R., Song D.H., Sonenshein G.E., Cardiff R.D., Seldin D.C. Protein kinase CK2 in mammary gland tumorigenesis. Oncogene 2001, 20:3247-3257.
14. Lane D.P., Gannon J.V. Monoclonal antibody analysis of the SV40 large T antigen-p53 complex. Cancer Cells 1986, 4:387-393.
15. Lohrum M., Scheidtmann K.H. Differential effects of phosphorylation of rat p53 on transactivation of promoters derived from different p53 responsive genes. Oncogene 1996, 13:2527-2539.
16. Lolkema M.P., Gervais M.L., Snijckers C.M., Hill R.P., Giles R.H., Voest E.E., et al. Tumor suppression by the von Hippel-Lindau protein requires phosphorylation of the acidic domain. J Biol Chem 2005, 280:22205-22211.
17. McKendrick L., Milne D., Meek D. Protein kinase CK2-dependent regulation of p53 function: evidence that the phosphorylation status of the serine 386 (CK2) site of p53 is constitutive and stable. Mol Cell Biochem 1999, 191:187-199.
18. Münstermann U., Fritz G., Seitz G., Yiping L., Schneider H.R., Issinger O.-G. Casein kinase II is elevated in human tumours and rapidly proliferating non-neoplastic tissue. Eur J Biochem 1990, 189:251-257.
19. Prowald A., Schuster N., Montenarh M. Regulation of the DNA binding of p53 by its interaction with protein kinase CK2. FEBS Lett 1997, 408:99-104.
20. Roe J.S., Kim H., Lee S.M., Kim S.T., Cho E.J., Youn H.D. p53 stabilization and transactivation by a von Hippel-Lindau protein. Mol Cell 2006, 22:395-405.
21. Roe J.S., Youn H.D. The positive regulation of p53 by the tumor suppressor VHL. Cell Cycle 2006, 5:2054-2056.
22. Sarno S., Reddy H., Meggio F., Ruzzene M., Davies S.P., Donella-Deana A., et al. Selectivity of 4,5,6,7-tetrabromobenzotriazole, an ATP site-directed inhibitor of protein kinase CK2 ('casein kinase-2'). FEBS Lett 2001, 496:44-48.
23. Scaglioni P.P., Yung T.M., Cai L.F., Erdjument-Bromage H., Kaufman A.J., Singh B., et al. A CK2-dependent mechanism for degradation of the PML tumor suppressor. Cell 2006, 126:269-283.
24. St-Denis N.A., Litchfield D.W. From birth to death: the role of protein kinase CK2 in the regulation of cell proliferation and survival. Cell Mol Life Sci 2009, 66:1817-1829.
25. Stebbins C.E., Kaelin W.G., Pavletich N.P. Structure of the VHL-ElonginC-ElonginB complex: implications for VHL tumor suppressor function. Science 1999, 284:455-461.
26. Vazquez F., Grossman S.R., Takahashi Y., Rokas M.V., Nakamura N., Sellers W.R. Phosphorylation of the PTEN tail acts as an inhibitory switch by preventing its recruitment into a protein complex. J Biol Chem 2001, 276:48627-48630.
27. Wagner P., Appel K., Issinger O.G., Montenarh M. On the interaction of p53 with casein kinase II. Int J Oncol 1994, 4:491-498.