메뉴 건너뛰기




Volumn 103, Issue 9, 2012, Pages 1617-1624

Cancer-testis antigen BORIS is a novel prognostic marker for patients with esophageal cancer

Author keywords

[No Author keywords available]

Indexed keywords

BORIS ANTIGEN; CANCER TESTIS ANTIGEN; COMPLEMENTARY DNA; IMMUNOGLOBULIN G; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

EID: 84865778255     PISSN: 13479032     EISSN: 13497006     Source Type: Journal    
DOI: 10.1111/j.1349-7006.2012.02355.x     Document Type: Article
Times cited : (31)

References (44)
  • 1
    • 33745726677 scopus 로고    scopus 로고
    • Perioperative chemotherapy versus surgery alone for resectable gastroesophageal cancer
    • Cunningham D, Allum WH, Stenning SP et al. Perioperative chemotherapy versus surgery alone for resectable gastroesophageal cancer. N Engl J Med 2006; 355: 11-20.
    • (2006) N Engl J Med , vol.355 , pp. 11-20
    • Cunningham, D.1    Allum, W.H.2    Stenning, S.P.3
  • 2
    • 41949119177 scopus 로고    scopus 로고
    • Phase III trial of trimodality therapy with cisplatin, fluorouracil, radiotherapy, and surgery compared with surgery alone for esophageal cancer: CALGB 9781
    • Tepper J, Krasna MJ, Niedzwiecki D et al. Phase III trial of trimodality therapy with cisplatin, fluorouracil, radiotherapy, and surgery compared with surgery alone for esophageal cancer: CALGB 9781. J Clin Oncol 2008; 26: 1086-92.
    • (2008) J Clin Oncol , vol.26 , pp. 1086-1092
    • Tepper, J.1    Krasna, M.J.2    Niedzwiecki, D.3
  • 3
    • 0037379730 scopus 로고    scopus 로고
    • CD4+ and CD8+ T cells cooperate to improve prognosis of patients with esophageal squamous cell carcinoma
    • Cho Y, Miyamoto M, Kato K et al. CD4+ and CD8+ T cells cooperate to improve prognosis of patients with esophageal squamous cell carcinoma. Cancer Res 2003; 63: 1555-9.
    • (2003) Cancer Res , vol.63 , pp. 1555-1559
    • Cho, Y.1    Miyamoto, M.2    Kato, K.3
  • 4
    • 12644276375 scopus 로고    scopus 로고
    • A testicular antigen aberrantly expressed in human cancers detected by autologous antibody screening
    • Chen YT, Scanlan MJ, Sahin U et al. A testicular antigen aberrantly expressed in human cancers detected by autologous antibody screening. Proc Nat Acad Sci USA 1997; 94: 1914-8.
    • (1997) Proc Nat Acad Sci USA , vol.94 , pp. 1914-1918
    • Chen, Y.T.1    Scanlan, M.J.2    Sahin, U.3
  • 5
    • 0036075392 scopus 로고    scopus 로고
    • An oncological view on the blood-testis barrier
    • Bart J, Groen HJ, van der Graaf WT et al. An oncological view on the blood-testis barrier. Lancet Oncol 2002; 3: 357-63.
    • (2002) Lancet Oncol , vol.3 , pp. 357-363
    • Bart, J.1    Groen, H.J.2    van der Graaf, W.T.3
  • 6
    • 34247485458 scopus 로고    scopus 로고
    • T cell immunomonitoring and tumor responses in patients immunized with a complex of cholesterol-bearing hydrophobized pullulan (CHP) and NY-ESO-1 protein
    • Uenaka A, Wada H, Isobe M et al. T cell immunomonitoring and tumor responses in patients immunized with a complex of cholesterol-bearing hydrophobized pullulan (CHP) and NY-ESO-1 protein. Cancer Immun 2007; 7: 9.
    • (2007) Cancer Immun , vol.7 , pp. 9
    • Uenaka, A.1    Wada, H.2    Isobe, M.3
  • 7
    • 35649003872 scopus 로고    scopus 로고
    • LUD 00-009: phase 1 study of intensive course immunization with NY-ESO-1 peptides in HLA-A2 positive patients with NY-ESO-1-expressing cancer
    • Bender A, Karbach J, Neumann A et al. LUD 00-009: phase 1 study of intensive course immunization with NY-ESO-1 peptides in HLA-A2 positive patients with NY-ESO-1-expressing cancer. Cancer Immun 2007; 7: 16.
    • (2007) Cancer Immun , vol.7 , pp. 16
    • Bender, A.1    Karbach, J.2    Neumann, A.3
  • 8
    • 45549099784 scopus 로고    scopus 로고
    • Treatment of metastatic melanoma with autologous CD4+ T cells against NY-ESO-1
    • Hunder NN, Wallen H, Cao J et al. Treatment of metastatic melanoma with autologous CD4+ T cells against NY-ESO-1. N Engl J Med 2008; 358: 2698-703.
    • (2008) N Engl J Med , vol.358 , pp. 2698-2703
    • Hunder, N.N.1    Wallen, H.2    Cao, J.3
  • 9
    • 58949091881 scopus 로고    scopus 로고
    • Involvement of epithelial cell transforming sequence-2 oncoantigen in lung and esophageal cancer progression
    • Hirata D, Yamabuki T, Miki D et al. Involvement of epithelial cell transforming sequence-2 oncoantigen in lung and esophageal cancer progression. Clin Cancer Res 2009; 15: 256-66.
    • (2009) Clin Cancer Res , vol.15 , pp. 256-266
    • Hirata, D.1    Yamabuki, T.2    Miki, D.3
  • 10
    • 37549018422 scopus 로고    scopus 로고
    • Cancer-testis antigen lymphocyte antigen 6 complex locus K is a serologic biomarker and a therapeutic target for lung and esophageal carcinomas
    • Ishikawa N, Takano A, Yasui W et al. Cancer-testis antigen lymphocyte antigen 6 complex locus K is a serologic biomarker and a therapeutic target for lung and esophageal carcinomas. Cancer Res 2007; 67: 11601-11.
    • (2007) Cancer Res , vol.67 , pp. 11601-11611
    • Ishikawa, N.1    Takano, A.2    Yasui, W.3
  • 11
    • 17144427710 scopus 로고    scopus 로고
    • Expression of D2-40 in lymphatic endothelium of normal tissues and in vascular tumours
    • Fukunaga M. Expression of D2-40 in lymphatic endothelium of normal tissues and in vascular tumours. Histopathology 2005; 46: 396-402.
    • (2005) Histopathology , vol.46 , pp. 396-402
    • Fukunaga, M.1
  • 12
    • 0036715251 scopus 로고    scopus 로고
    • A new monoclonal antibody, D2-40, for detection of lymphatic invasion in primary tumors
    • Kahn HJ, Marks A. A new monoclonal antibody, D2-40, for detection of lymphatic invasion in primary tumors. Lab Invest 2002; 82: 1255-7.
    • (2002) Lab Invest , vol.82 , pp. 1255-1257
    • Kahn, H.J.1    Marks, A.2
  • 13
    • 31544439410 scopus 로고    scopus 로고
    • A novel cancer testis antigen that is frequently expressed in pancreatic, lung, and endometrial cancers
    • Okada T, Akada M, Fujita T et al. A novel cancer testis antigen that is frequently expressed in pancreatic, lung, and endometrial cancers. Clin Cancer Res 2006; 12: 191-7.
    • (2006) Clin Cancer Res , vol.12 , pp. 191-197
    • Okada, T.1    Akada, M.2    Fujita, T.3
  • 14
    • 23944515703 scopus 로고    scopus 로고
    • Immune responses to DNA mismatch repair enzymes hMSH2 and hPMS1 in patients with pancreatic cancer, dermatomyositis and polymyositis
    • Okada T, Noji S, Goto Y et al. Immune responses to DNA mismatch repair enzymes hMSH2 and hPMS1 in patients with pancreatic cancer, dermatomyositis and polymyositis. Int J Cancer 2005; 116: 925-33.
    • (2005) Int J Cancer , vol.116 , pp. 925-933
    • Okada, T.1    Noji, S.2    Goto, Y.3
  • 15
    • 56449110842 scopus 로고    scopus 로고
    • Identification of the HERV-K gag antigen in prostate cancer by SEREX using autologous patient serum and its immunogenicity
    • Ishida T, Obata Y, Ohara N et al. Identification of the HERV-K gag antigen in prostate cancer by SEREX using autologous patient serum and its immunogenicity. Cancer Immun 2008; 8: 15.
    • (2008) Cancer Immun , vol.8 , pp. 15
    • Ishida, T.1    Obata, Y.2    Ohara, N.3
  • 16
    • 0035909949 scopus 로고    scopus 로고
    • Aberrant expression of homeobox gene HOXA7 is associated with mullerian-like differentiation of epithelial ovarian tumors and the generation of a specific autologous antibody response
    • Naora H, Montz FJ, Chai CY, Roden RB. Aberrant expression of homeobox gene HOXA7 is associated with mullerian-like differentiation of epithelial ovarian tumors and the generation of a specific autologous antibody response. Proc Nat Acad Sci USA 2001; 98: 15209-14.
    • (2001) Proc Nat Acad Sci USA , vol.98 , pp. 15209-15214
    • Naora, H.1    Montz, F.J.2    Chai, C.Y.3    Roden, R.B.4
  • 17
    • 57049126143 scopus 로고    scopus 로고
    • Human protein factory for converting the transcriptome into an in vitro-expressed proteome
    • Goshima N, Kawamura Y, Fukumoto A et al. Human protein factory for converting the transcriptome into an in vitro-expressed proteome. Nat Methods 2008; 5: 1011-7.
    • (2008) Nat Methods , vol.5 , pp. 1011-1017
    • Goshima, N.1    Kawamura, Y.2    Fukumoto, A.3
  • 18
    • 0037076432 scopus 로고    scopus 로고
    • BORIS, a novel male germ-line-specific protein associated with epigenetic reprogramming events, shares the same 11-zinc-finger domain with CTCF, the insulator protein involved in reading imprinting marks in the soma
    • Loukinov DI, Pugacheva E, Vatolin S et al. BORIS, a novel male germ-line-specific protein associated with epigenetic reprogramming events, shares the same 11-zinc-finger domain with CTCF, the insulator protein involved in reading imprinting marks in the soma. Proc Nat Acad Sci USA 2002; 99: 6806-11.
    • (2002) Proc Nat Acad Sci USA , vol.99 , pp. 6806-6811
    • Loukinov, D.I.1    Pugacheva, E.2    Vatolin, S.3
  • 19
    • 0033542479 scopus 로고    scopus 로고
    • A serologic marker of paraneoplastic limbic and brain-stem encephalitis in patients with testicular cancer
    • Voltz R, Gultekin SH, Rosenfeld MR et al. A serologic marker of paraneoplastic limbic and brain-stem encephalitis in patients with testicular cancer. N Engl J Med 1999; 340: 1788-95.
    • (1999) N Engl J Med , vol.340 , pp. 1788-1795
    • Voltz, R.1    Gultekin, S.H.2    Rosenfeld, M.R.3
  • 20
    • 41849143759 scopus 로고    scopus 로고
    • Risk factors of lymph node metastasis in T1 esophageal squamous cell carcinoma
    • Kim DU, Lee JH, Min BH et al. Risk factors of lymph node metastasis in T1 esophageal squamous cell carcinoma. J Gastroenterol Hepatol 2008; 23: 619-25.
    • (2008) J Gastroenterol Hepatol , vol.23 , pp. 619-625
    • Kim, D.U.1    Lee, J.H.2    Min, B.H.3
  • 21
    • 0033868028 scopus 로고    scopus 로고
    • Improvement in the results of surgical treatment of advanced squamous esophageal carcinoma during 15 consecutive years
    • Ando N, Ozawa S, Kitagawa Y, Shinozawa Y, Kitajima M. Improvement in the results of surgical treatment of advanced squamous esophageal carcinoma during 15 consecutive years. Ann Surg 2000; 232: 225-32.
    • (2000) Ann Surg , vol.232 , pp. 225-232
    • Ando, N.1    Ozawa, S.2    Kitagawa, Y.3    Shinozawa, Y.4    Kitajima, M.5
  • 22
    • 33746421457 scopus 로고    scopus 로고
    • Antitumor efficacy of DNA vaccination to the epigenetically acting tumor promoting transcription factor BORIS and CD80 molecular adjuvant
    • Loukinov D, Ghochikyan A, Mkrtichyan M et al. Antitumor efficacy of DNA vaccination to the epigenetically acting tumor promoting transcription factor BORIS and CD80 molecular adjuvant. J Cell Biochem 2006; 98: 1037-43.
    • (2006) J Cell Biochem , vol.98 , pp. 1037-1043
    • Loukinov, D.1    Ghochikyan, A.2    Mkrtichyan, M.3
  • 23
    • 33846003817 scopus 로고    scopus 로고
    • Elicitation of T cell responses to histologically unrelated tumors by immunization with the novel cancer-testis antigen, brother of the regulator of imprinted sites
    • Ghochikyan A, Mkrtichyan M, Loukinov D et al. Elicitation of T cell responses to histologically unrelated tumors by immunization with the novel cancer-testis antigen, brother of the regulator of imprinted sites. J Immunol 2007; 178: 566-73.
    • (2007) J Immunol , vol.178 , pp. 566-573
    • Ghochikyan, A.1    Mkrtichyan, M.2    Loukinov, D.3
  • 24
    • 80051667961 scopus 로고    scopus 로고
    • Cancer-testis antigen, BORIS based vaccine delivered by dendritic cells is extremely effective against a very aggressive and highly metastatic mouse mammary carcinoma
    • Mkrtichyan M, Ghochikyan A, Davtyan H et al. Cancer-testis antigen, BORIS based vaccine delivered by dendritic cells is extremely effective against a very aggressive and highly metastatic mouse mammary carcinoma. Cell Immunol 2011; 270: 188-97.
    • (2011) Cell Immunol , vol.270 , pp. 188-197
    • Mkrtichyan, M.1    Ghochikyan, A.2    Davtyan, H.3
  • 25
    • 38949136330 scopus 로고    scopus 로고
    • BORIS, a paralogue of the transcription factor, CTCF, is aberrantly expressed in breast tumours
    • D'Arcy V, Pore N, Docquier F et al. BORIS, a paralogue of the transcription factor, CTCF, is aberrantly expressed in breast tumours. Br J Cancer 2008; 98: 571-9.
    • (2008) Br J Cancer , vol.98 , pp. 571-579
    • D'Arcy, V.1    Pore, N.2    Docquier, F.3
  • 27
    • 34250207709 scopus 로고    scopus 로고
    • Global expression analysis of cancer/testis genes in uterine cancers reveals a high incidence of BORIS expression
    • Risinger JI, Chandramouli GV, Maxwell GL et al. Global expression analysis of cancer/testis genes in uterine cancers reveals a high incidence of BORIS expression. Clin Cancer Res 2007; 13: 1713-9.
    • (2007) Clin Cancer Res , vol.13 , pp. 1713-1719
    • Risinger, J.I.1    Chandramouli, G.V.2    Maxwell, G.L.3
  • 28
    • 37549004361 scopus 로고    scopus 로고
    • Expression of the CTCF-paralogous cancer-testis gene, brother of the regulator of imprinted sites (BORIS), is regulated by three alternative promoters modulated by CpG methylation and by CTCF and p53 transcription factors
    • Renaud S, Pugacheva EM, Delgado MD et al. Expression of the CTCF-paralogous cancer-testis gene, brother of the regulator of imprinted sites (BORIS), is regulated by three alternative promoters modulated by CpG methylation and by CTCF and p53 transcription factors. Nucleic Acids Res 2007; 35: 7372-88.
    • (2007) Nucleic Acids Res , vol.35 , pp. 7372-7388
    • Renaud, S.1    Pugacheva, E.M.2    Delgado, M.D.3
  • 29
    • 0036781505 scopus 로고    scopus 로고
    • The novel BORIS + CTCF gene family is uniquely involved in the epigenetics of normal biology and cancer
    • Klenova EM, Morse HC 3rd, Ohlsson R, Lobanenkov VV. The novel BORIS + CTCF gene family is uniquely involved in the epigenetics of normal biology and cancer. Semin Cancer Biol 2002; 12: 399-414.
    • (2002) Semin Cancer Biol , vol.12 , pp. 399-414
    • Klenova, E.M.1    Morse 3rd, H.C.2    Ohlsson, R.3    Lobanenkov, V.V.4
  • 30
    • 79954582740 scopus 로고    scopus 로고
    • Coordinated cancer germline antigen promoter and global DNA hypomethylation in ovarian cancer: association with the BORIS/CTCF expression ratio and advanced stage
    • Woloszynska-Read A, Zhang W, Yu J et al. Coordinated cancer germline antigen promoter and global DNA hypomethylation in ovarian cancer: association with the BORIS/CTCF expression ratio and advanced stage. Clin Cancer Res 2011; 17: 2170-80.
    • (2011) Clin Cancer Res , vol.17 , pp. 2170-2180
    • Woloszynska-Read, A.1    Zhang, W.2    Yu, J.3
  • 31
    • 34347344986 scopus 로고    scopus 로고
    • Dynamic transcriptional regulatory complexes including BORIS, CTCF and Sp1 modulate NY-ESO-1 expression in lung cancer cells
    • Kang Y, Hong JA, Chen GA, Nguyen DM, Schrump DS. Dynamic transcriptional regulatory complexes including BORIS, CTCF and Sp1 modulate NY-ESO-1 expression in lung cancer cells. Oncogene 2007; 26: 4394-403.
    • (2007) Oncogene , vol.26 , pp. 4394-4403
    • Kang, Y.1    Hong, J.A.2    Chen, G.A.3    Nguyen, D.M.4    Schrump, D.S.5
  • 32
    • 24744448032 scopus 로고    scopus 로고
    • Reciprocal binding of CTCF and BORIS to the NY-ESO-1 promoter coincides with derepression of this cancer-testis gene in lung cancer cells
    • Hong JA, Kang Y, Abdullaev Z et al. Reciprocal binding of CTCF and BORIS to the NY-ESO-1 promoter coincides with derepression of this cancer-testis gene in lung cancer cells. Cancer Res 2005; 65: 7763-74.
    • (2005) Cancer Res , vol.65 , pp. 7763-7774
    • Hong, J.A.1    Kang, Y.2    Abdullaev, Z.3
  • 33
    • 24744440159 scopus 로고    scopus 로고
    • Conditional expression of the CTCF-paralogous transcriptional factor BORIS in normal cells results in demethylation and derepression of MAGE-A1 and reactivation of other cancer-testis genes
    • Vatolin S, Abdullaev Z, Pack SD et al. Conditional expression of the CTCF-paralogous transcriptional factor BORIS in normal cells results in demethylation and derepression of MAGE-A1 and reactivation of other cancer-testis genes. Cancer Res 2005; 65: 7751-62.
    • (2005) Cancer Res , vol.65 , pp. 7751-7762
    • Vatolin, S.1    Abdullaev, Z.2    Pack, S.D.3
  • 34
    • 27944486675 scopus 로고    scopus 로고
    • Heterogeneous expression of GAGE, NY-ESO-1, MAGE-A and SSX proteins in esophageal cancer: Implications for immunotherapy
    • Akcakanat A, Kanda T, Tanabe T et al. Heterogeneous expression of GAGE, NY-ESO-1, MAGE-A and SSX proteins in esophageal cancer: Implications for immunotherapy. Int J Cancer 2006; 118: 123-8.
    • (2006) Int J Cancer , vol.118 , pp. 123-128
    • Akcakanat, A.1    Kanda, T.2    Tanabe, T.3
  • 35
    • 5144230934 scopus 로고    scopus 로고
    • NY-ESO-1 expression and immunogenicity in esophageal cancer
    • Fujita S, Wada H, Jungbluth AA et al. NY-ESO-1 expression and immunogenicity in esophageal cancer. Clin Cancer Res 2004; 10: 6551-8.
    • (2004) Clin Cancer Res , vol.10 , pp. 6551-6558
    • Fujita, S.1    Wada, H.2    Jungbluth, A.A.3
  • 36
    • 3042767922 scopus 로고    scopus 로고
    • NY-ESO-1 expression and its serum immunoreactivity in esophageal cancer
    • Akcakanat A, Kanda T, Koyama Y et al. NY-ESO-1 expression and its serum immunoreactivity in esophageal cancer. Cancer Chemother Pharmacol 2004; 54: 95-100.
    • (2004) Cancer Chemother Pharmacol , vol.54 , pp. 95-100
    • Akcakanat, A.1    Kanda, T.2    Koyama, Y.3
  • 37
    • 63349100797 scopus 로고    scopus 로고
    • Coordinated activation of candidate proto-oncogenes and cancer testes antigens via promoter demethylation in head and neck cancer and lung cancer
    • Smith IM, Glazer CA, Mithani SK et al. Coordinated activation of candidate proto-oncogenes and cancer testes antigens via promoter demethylation in head and neck cancer and lung cancer. PLoS ONE 2009; 4: e4961.
    • (2009) PLoS ONE , vol.4
    • Smith, I.M.1    Glazer, C.A.2    Mithani, S.K.3
  • 38
    • 48649092902 scopus 로고    scopus 로고
    • CTCFL/BORIS is a methylation-independent DNA-binding protein that preferentially binds to the paternal H19 differentially methylated region
    • Nguyen P, Cui H, Bisht KS et al. CTCFL/BORIS is a methylation-independent DNA-binding protein that preferentially binds to the paternal H19 differentially methylated region. Cancer Res 2008; 68: 5546-51.
    • (2008) Cancer Res , vol.68 , pp. 5546-5551
    • Nguyen, P.1    Cui, H.2    Bisht, K.S.3
  • 39
    • 0030950759 scopus 로고    scopus 로고
    • An imprinting element from the mouse H19 locus functions as a silencer in Drosophila
    • Lyko F, Brenton JD, Surani MA, Paro R. An imprinting element from the mouse H19 locus functions as a silencer in Drosophila. Nat Genet 1997; 16: 171-3.
    • (1997) Nat Genet , vol.16 , pp. 171-173
    • Lyko, F.1    Brenton, J.D.2    Surani, M.A.3    Paro, R.4
  • 40
    • 0347986844 scopus 로고    scopus 로고
    • Transgenic RNAi reveals essential function for CTCF in H19 gene imprinting
    • Fedoriw AM, Stein P, Svoboda P, Schultz RM, Bartolomei MS. Transgenic RNAi reveals essential function for CTCF in H19 gene imprinting. Science 2004; 303: 238-40.
    • (2004) Science , vol.303 , pp. 238-240
    • Fedoriw, A.M.1    Stein, P.2    Svoboda, P.3    Schultz, R.M.4    Bartolomei, M.S.5
  • 41
    • 33746063711 scopus 로고    scopus 로고
    • CTCF binding at the H19 imprinting control region mediates maternally inherited higher-order chromatin conformation to restrict enhancer access to Igf2
    • Kurukuti S, Tiwari VK, Tavoosidana G et al. CTCF binding at the H19 imprinting control region mediates maternally inherited higher-order chromatin conformation to restrict enhancer access to Igf2. Proc Nat Acad Sci USA 2006; 103: 10684-9.
    • (2006) Proc Nat Acad Sci USA , vol.103 , pp. 10684-10689
    • Kurukuti, S.1    Tiwari, V.K.2    Tavoosidana, G.3
  • 42
    • 0037339969 scopus 로고    scopus 로고
    • Loss of imprinting of IGF2 and H19 in osteosarcoma is accompanied by reciprocal methylation changes of a CTCF-binding site
    • Ulaner GA, Vu TH, Li T et al. Loss of imprinting of IGF2 and H19 in osteosarcoma is accompanied by reciprocal methylation changes of a CTCF-binding site. Hum Mol Genet 2003; 12: 535-49.
    • (2003) Hum Mol Genet , vol.12 , pp. 535-549
    • Ulaner, G.A.1    Vu, T.H.2    Li, T.3
  • 43
    • 37149033830 scopus 로고    scopus 로고
    • The H19 non-coding RNA is essential for human tumor growth
    • Matouk IJ, DeGroot N, Mezan S et al. The H19 non-coding RNA is essential for human tumor growth. PLoS ONE 2007; 2: e845.
    • (2007) PLoS ONE , vol.2
    • Matouk, I.J.1    DeGroot, N.2    Mezan, S.3
  • 44
    • 0030031360 scopus 로고    scopus 로고
    • Loss of H19 imprinting in esophageal cancer
    • Hibi K, Nakamura H, Hirai A et al. Loss of H19 imprinting in esophageal cancer. Cancer Res 1996; 56: 480-2.
    • (1996) Cancer Res , vol.56 , pp. 480-482
    • Hibi, K.1    Nakamura, H.2    Hirai, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.