The catalytic mechanism of the hotdog-fold enzyme superfamily 4-hydroxybenzoyl-coa thioesterase from arthrobacter sp. Strain SU

Biochemistry

Volumn 51, Issue 35, 2012, Pages 7000-7016

  Song, Feng ^a   Thoden, James B ^b   Zhuang, Zhihao ^a   Latham, John ^a   Trujillo, Michael ^c   Holden, Hazel M ^b   Dunaway Mariano, Debra ^a  

^a UNIVERSITY OF NEW MEXICO   (United States)

^b UNIVERSITY OF WISCONSIN MADISON   (United States)

^c NEW MEXICO DEPARTMENT OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; ACTIVE SITE RESIDUES; ARTHROBACTER SP; BASE CATALYSIS; CATALYTIC EFFICIENCIES; CATALYTIC MECHANISMS; COENZYME A; COVALENT ENZYME INTERMEDIATES; DOUBLE MUTANTS; ENZYME SUPERFAMILIES; HYDROGEN-BOND FORMATION; HYDROLYSIS REACTION; KINETIC ANALYSIS; NUCLEOPHILIC CATALYSIS; SINGLE MUTANT; SINGLE-STEP; STEADY-STATE KINETICS; SUBSTRATE BINDING; THIOESTERASES; THIOESTERS; TRANSITION-STATE; TWO-STEP PROCESS; WILD TYPES; X-RAY STRUCTURE;

CARBOXYLATION; CATALYSIS; HYDROGEN BONDS; HYDROLYSIS; KINETICS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; NUCLEOTIDES; QUANTUM CHEMISTRY; REACTION INTERMEDIATES; X RAY ANALYSIS; X RAYS;

ENZYMES;

4 HYDROXYBENZOYL COENZYME A THIOESTERASE; AMINO ACID; BACTERIAL ENZYME; THIOL ESTER HYDROLASE; UNCLASSIFIED DRUG;

ARTHROBACTER; ARTICLE; BACTERIAL STRAIN; CATALYSIS; ENZYME STRUCTURE; ENZYME SUBSTRATE COMPLEX; HYDROLYSIS KINETICS; NONHUMAN; PHOSPHORUS NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; PROTEIN FOLDING; SITE DIRECTED MUTAGENESIS; STEADY STATE; X RAY ANALYSIS;

ACYL COENZYME A; ARTHROBACTER; BINDING SITES; CATALYTIC DOMAIN; COENZYME A; CRYSTALLOGRAPHY, X-RAY; KINETICS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; MUTATION; THIOLESTER HYDROLASES;

ARTHROBACTER SP.;

EID: 84865756646     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi301059m     Document Type: Article

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