Structural basis for the activity and substrate specificity of fluoroacetyl-CoA thioesterase FIK

Journal of Biological Chemistry

Volumn 285, Issue 29, 2010, Pages 22495-22504

  Dias, Marcio V B ^a   Huang, Fanglu ^a   Chirgadze, Dimitri Y ^a   Tosin, Manuela ^a   Spiteller, Dieter ^a,b   Dry, Emily F V ^a   Leadlay, Peter F ^a   Spencer, Jonathan B ^a   Blundell, Tom L ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b MAX PLANCK INSTITUTE FOR CHEMICAL ECOLOGY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; ASPARTATES; CATALYTIC BASE; CATALYTIC TRIAD; COENZYME A; CRYSTAL STRUCTURE ANALYSIS; DEFENSE MECHANISM; FLUOROACETATE; SIDE CHAINS; SITE DIRECTED MUTAGENESIS; STRUCTURAL BASIS; STRUCTURAL COMPARISON; SUBSTRATE SPECIFICITY; THIOESTERASES; TRICARBOXYLIC ACID CYCLE; TYPE II; VARIOUS SUBSTRATES; WATER MOLECULE;

ACIDS; CRYSTAL STRUCTURE; CRYSTALLOGRAPHY; ENZYME ACTIVITY; FLUORINE; PLANTS (BOTANY);

SUBSTRATES;

ACONITIC ACID; ASPARTIC ACID; COENZYME A; CYSTEINE; DIMER; FLUORINE; FLUOROACETIC ACID; FLUOROACETYL COENZYME A; GLUTAMIC ACID; HISTIDINE; PROTEIN FLK; SERINE; THIOL ESTER HYDROLASE; THREONINE; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CITRIC ACID CYCLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; CRYSTALLOGRAPHY; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME SPECIFICITY; ENZYME STRUCTURE; HYDROLYSIS; NONHUMAN; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS;

ACETYL COENZYME A; BIOCATALYSIS; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; HYDROPHOBICITY; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; MUTANT PROTEINS; MUTATION; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, SECONDARY; STREPTOMYCES; SUBSTRATE SPECIFICITY; THIOLESTER HYDROLASES; THREONINE;

CANIS FAMILIARIS; STREPTOMYCES CATTLEYA;

EID: 77954575257     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.107177     Document Type: Article

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