Structural basis of biological nitrile reduction

Journal of Biological Chemistry

Volumn 287, Issue 36, 2012, Pages 30560-30570

  Chikwana, Vimbai M ^a   Stec, Boguslaw ^b   Lee, Bobby W K ^a   De Crécy Lagard, Valérie ^c   Iwata Reuyl, Dirk ^a   Swairjo, Manal A ^d  

^a PORTLAND STATE UNIVERSITY   (United States)

^b BURNHAM INSTITUTE   (United States)

^c UNIVERSITY OF FLORIDA   (United States)

^d WESTERN UNIVERSITY OF HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; BACILLUS SUBTILIS; CATALYTIC RESIDUE; CONFORMATIONAL CHANGE; COVALENT LINKAGE; HYDRIDE TRANSFERS; INTERSUBUNIT INTERFACE; NITRILE GROUPS; REDUCTION REACTION; STRUCTURAL BASIS; TRANSIENT KINETIC DATA; WILD-TYPE ENZYMES;

CYANIDES; REACTION INTERMEDIATES;

ENZYMES;

7 AMINOMETHYL 7 DEAZAGUANINE; 7 CYANO 7 DEAZAGUANINE; BACTERIAL ENZYME; GUANINE DERIVATIVE; NITRILE; PROTEIN QUEF; THIOIMIDE; UNCLASSIFIED DRUG;

ARTICLE; BACILLUS SUBTILIS; BINDING KINETICS; CATALYSIS; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; CRYSTALLIZATION; FLUORESCENCE; GEL PERMEATION CHROMATOGRAPHY; KINETICS; MUTANT; NONHUMAN; PRIORITY JOURNAL; REDUCTION; ULTRACENTRIFUGATION; WILD TYPE;

AMINO ACID SUBSTITUTION; BACILLUS SUBTILIS; BACTERIAL PROTEINS; MUTATION, MISSENSE; NITRILES; OXIDATION-REDUCTION; OXIDOREDUCTASES;

BACILLUS SUBTILIS;

EID: 84865735120     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.388538     Document Type: Article

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