Zinc-independent folate biosynthesis: Genetic, biochemical, and structural investigations reveal new metal dependence for GTP cyclohydrolase IB

Journal of Bacteriology

Volumn 191, Issue 22, 2009, Pages 6936-6949

  Sankaran, Banumathi ^a   Bonnett, Shilah A ^b   Shah, Kinjal ^c,h   Gabriel, Scott ^d   Reddy, Robert ^e,i   Schimmel, Paul ^e   Rodionov, Dmitry A ^f   De Crécy Lagard, Valérie ^g   Helmann, John D ^d   Iwata Reuyl, Dirk ^b   Swairjo, Manal A ^c,f  

^a LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

^b PORTLAND STATE UNIVERSITY   (United States)

^c WESTERN UNIVERSITY OF HEALTH SCIENCES   (United States)

^d Department of Obstetrics Gynecology   (United States)

^e SCRIPPS RESEARCH INSTITUTE   (United States)

^f BURNHAM INSTITUTE   (United States)

^g UNIVERSITY OF FLORIDA   (United States)

^h Long Beach Department of Health and Human Services   (United States)

ⁱ HUMAN BIOMOLECULAR RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FOLIC ACID; GUANOSINE TRIPHOSPHATE CYCLOHYDROLASE I; GUANOSINE TRIPHOSPHATE CYCLOHYDROLASE IB; UNCLASSIFIED DRUG; ZINC;

ARTICLE; BACILLUS SUBTILIS; BACTERIAL GROWTH; CATALYSIS; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVITY; ENZYME STRUCTURE; NEISSERIA GONORRHOEAE; NONHUMAN; PRIORITY JOURNAL;

AMINO ACID SEQUENCE; BACILLUS SUBTILIS; BACTERIAL PROTEINS; BINDING SITES; CHROMATOGRAPHY, GEL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COMPUTATIONAL BIOLOGY; CRYSTALLOGRAPHY, X-RAY; FOLIC ACID; GTP CYCLOHYDROLASE; MANGANESE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NEISSERIA GONORRHOEAE; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; SEQUENCE HOMOLOGY, AMINO ACID; ZINC;

BACILLUS SUBTILIS; BACTERIA (MICROORGANISMS); MAMMALIA;

EID: 70350449245     PISSN: 00219193     EISSN: None     Source Type: Journal    
DOI: 10.1128/JB.00287-09     Document Type: Article

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