Identification of a sirtuin 3 inhibitor that displays selectivity over sirtuin 1 and 2

European Journal of Medicinal Chemistry

Volumn 55, Issue , 2012, Pages 58-66

  Galli, Ubaldina ^a   Mesenzani, Ornella ^a   Coppo, Camilla ^a   Sorba, Giovanni ^a   Canonico, Pier Luigi ^a   Tron, Gian Cesare ^a   Genazzani, Armando A ^a  

^a UNIVERSITY OF EASTERN PIEDMONT   (Italy)

Author keywords

Histone deacetylase; Isostere; N Unsubstituted 1,2, 3 triazolyl pyridine; Rigid analogues; Sirtuins

Indexed keywords

1H PYRROLO[3,4 C]PYRIDIN 3 (2H)ONE; 2 METHYLNICOTINAMIDE; 3 (1H 1,2,3 TRIAZOL 1 YL)PYRIDINE; 3 (1H 1,2,3 TRIAZOL 4 YL)PYRIDINE; 3 (PYRIDIN 3 YL)ACRYLAMIDE; 3,4 DIHYDRO 2,7 NAPHTHYRIDIN 1 (2H)ONE; 4 METHYLNICOTINAMIDE; 6,7 DIHYDRO 5H PYRROLO[3,4 B]PYRIDIN 5 ONE; 7,8 DIHYDRO 1,6 NAPHTHYRIDIN 5 (6H)ONE; NICOTINAMIDE; NICOTINAMIDE DERIVATIVE; PYRIDINE 3 SULFONAMIDE; SIRTUIN 1; SIRTUIN 2; SIRTUIN 3; SURAMIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INHIBITION; CONTROLLED STUDY; DRUG EFFECT; DRUG IDENTIFICATION; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; IC 50; MOUSE; NONHUMAN;

CELL LINE, TUMOR; CELL PROLIFERATION; DRUG EVALUATION, PRECLINICAL; HISTONE DEACETYLASE INHIBITORS; HUMANS; NIACINAMIDE; SIRTUIN 1; SIRTUIN 2; SIRTUIN 3; SUBSTRATE SPECIFICITY;

EID: 84865721413     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2012.07.001     Document Type: Article

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