N-glycosylation at two sites critically alters thiazide binding and activity of the rat thiazide-sensitive Na+:Cl- cotransporter

Journal of the American Society of Nephrology

Volumn 14, Issue 2, 2003, Pages 271-282

  Hoover, Robert S ^b   Poch, Esteban ^d   Monroy, Adriana ^a   Vázquez, Norma ^a   Nishio, Toshiyuki ^c   Gamba, Gerardo ^a   Hebert, Steven C ^b  

^a UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO   (Mexico)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c TOHOKU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^d UNIVERSITY OF BARCELONA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIHYPERTENSIVE AGENT; COTRANSPORTER; GREEN FLUORESCENT PROTEIN; MUTANT PROTEIN; THIAZIDE DIURETIC AGENT; TUNICAMYCIN;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CHLORIDE TRANSPORT; CONTROLLED STUDY; DEGLYCOSYLATION; DRUG ACTIVITY; DRUG BINDING; DRUG BINDING SITE; GLYCOSYLATION; KIDNEY DISTAL TUBULE; MOLECULAR WEIGHT; NONHUMAN; OOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SODIUM TRANSPORT; WILD TYPE; XENOPUS LAEVIS;

EID: 0037304650     PISSN: 10466673     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.ASN.0000043903.93452.D0     Document Type: Article

References (44)

1. Ellison DH, Velazquez H, Wright FS: Thiazide-sensitive sodium chloride cotransport in early distal tubule. Am J Physiol (Renal Fluid Electrolyte Physiol) 253: F546-F554, 1987
2. Gamba G, Saltzberg SN, Lombardi M, Miyanoshita A, Lytto J, Hediger MA, Brenner BM, Hebert SC: Primary structure and functional expression of a cDNA encoding the thiazide-sensitive electroneutral sodium-chloride cotransporter. Proc Natl Acad Sci USA 90: 2749-2753, 1993
3. Gamba G, Miyanoshita A, Lombardi M, Lytton J, Lee W-S, Hediger MA, Hebert SC: Molecular cloning, primary structure and characterization of two members of the mammalian electroneutral sodium-(potassium)-chloride cotransporter family expressed in kidney. J Biol Chem 269: 17713-17722, 1994
4. Simon DB, Nelson-Williams C, Bia MJ, Ellison D, Karet FE, Molina AM, Vaara I, Iwata F, Cushner HM, Koolen M, Gainza FJ, Gitleman HJ, Lifton RP: Gitelman's variant of Bartter's syndrome, inherited hypokalaemic alkalosis, is caused by mutations in the thiazide-sensitive Na-Cl cotransporter. Nat Genet 12: 24-30, 1996
5. Kunchaparty S, Palcso M, Berkman J, Velazquez H, Desir GV, Bernstein P, Reilly RF, Ellison DH: Defective processing and expression of thiazide-sensitive Na-Cl cotransporter as a cause of Gitelman's syndrome. Am J Physiol 277: F643-F649, 1999
6. Xu J-C, Lytle C, Zhu TT, Payne JA, Benz E, Jr., Forbush B, III: Molecular cloning and functional expression of the bumetanidesensitive Na-K-Cl cotransporter. Proc Natl Acad Sci USA 91: 2201-2205, 1994
7. - cotransporter from mouse inner medullary collecting duct (mIMCD-3) cells, J Biol Chem 269: 25677-25683, 1994
8. Payne JA, Stevenson TJ, Donaldson LF: Molecular characterization of a putative K-Cl cotransporter in rat brain. A neuronal-specific isoform. J Biol Chem 271: 16245-16252, 1996
9. Gillen CM, Brill S, Payne JA, Forbush B, III: Molecular cloning and functional expression of the K-Cl cotransporter from rabbit, rat, and human. A new member of the cation-chloride cotransporter family. J Biol Chem 271: 16237-16244, 1996
10. - cotransporter. J Biol Chem 274: 10661-10667, 1999
11. Mount DB, Mercado A, Song L, Xu J, George AL, Jr., Delpire E, Gamba G: Cloning and characterization of KCC3 and KCC4, new members of the cation-chloride cotransporter gene family. J Biol Chem 274: 16355-16362, 1999
12. - cotransporter: A new model for ions and diuretics interaction. Am J Physiol Renal Physiol 279: F161-F169, 2000
13. Plotkin MD, Kaplan MR, Verlander JW, Lee W-S, Brown D, Poch E, Gullans SR, Hebert SC: Localization of the thiazide sensitive Na-Cl cotransporter, rTSC1, in the rat kidney. Kidney Int 50: 174-183, 1996
14. - cotransporter NKCC1 studied by in vitro translation. J Biol Chem 275: 40471-40477, 2000
15. Landolt-Marticorena C, Reithmeier RA: Asparagine-linked oligosaccharides are localized to single extracytosolic segments in multi-span membrane glycoproteins. Biochem J 302(Pt 1): 253-260, 1994
16. Paulson JC: Glycoproteins: What are the sugar chains for? Trends Biochem Sci 14: 272-276, 1989
17. Takacs Z, Wilhelmsen KC, Sorota S: Snake alpha-neurotoxin binding site on the Egyptian cobra (Naja haje) nicotinic acetylcholine receptor is conserved. Mol Biol Evol. 18: 1800-1809, 2001
18. Bulleid NJ, Bassel-Duby RS, Freedman RB, Sambrook JF, Gething MJ: Cell-free synthesis of enzymatically active tissue-type plasminogen activator. Protein folding determines the extent of N-linked glycosylation. Biochem J 286: 275-280, 1992
19. Kunkel TA: Rapid and efficient site-specific mutagenesis without phenotype selection. Proc Natl Acad Sci USA 82: 488-492, 1985
20. Cormack BP, Valdivia RH, Falkow S: FACS-optimized mutants of the green fluorescent protein (GFP). Gene 173: 33-38, 1996
21. Laemmli UK: Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227: 680-685, 1970
22. Elbein AD, Sanford BA, Ramsay MA, Pan YT: Effect of inhibitors on glycoprotein biosynthesis and bacterial adhesion. Ciba Found Symp 80: 270-287, 1981
23. ATP channels. Neuron 22: 537-548, 1999
24. Konstas AA, Bielfeld-Ackermann A, Korbmacher C: Sulfonyl-urea receptors inhibit the epithelial sodium channel (ENaC) by reducing surface expression. Pflugers Arch 442: 752-761, 2001
25. Flagg TP, Tate M, Merot J, Welling PA: A mutation linked with Bartter's syndrome locks Kir 1.1a (ROMK1) channels in a closed state. J Gen Physiol 114: 685-700, 1999
26. + channel activity. J Biol Chem 272: 6548-6555, 1997
27. Chapell R, Bueno OF, Alvarez-Hernandez X, Robinson LC, Leidenheimer NJ: Activation of protein kinase C induces gamma-aminobutyric acid type A receptor internalization in Xenopus oocytes. J Biol Chem 273: 32595-32601, 1998
28. Ji HL, Chalfant ML, Jovov B, Lockhart JP, Parker SB, Fuller CM, Stanton BA, Benos DJ: The cytosolic termini of the beta- and gamma-ENaC subunits are involved in the functional interactions between cystic fibrosis transmembrane conductance regulator and epithelial sodium channel J Biol Chem 275: 27947-27956, 2000
29. Petrecca K, Atanasiu R, Akhavan A, Shrier A: N-linked glycosylation sites determine HERG channel surface membrane expression. J Physiol 515: 41-48, 1999
30. Ma D, Zerangue N, Lin YF, Collins A, Yu M, Jan YN, Jan LY: Role of ER export signals in controlling surface potassium channel numbers. Science 291: 316-319, 2001
31. Janecki AJ, Janecki M, Akhter S, Donowitz M: Quantitation of plasma membrane expression of a fusion protein of Na/H exchanger NHE3 and green fluorescence protein (GFP) in living PS 120 fibroblasts. J Histochem Cytochem 48: 1479-1492, 2000
32. Janecki AJ, Janecki M, Akhter S, Donowitz M: Basic fibroblast growth factor stimulates surface expression and activity of Na(+)/H(+) exchanger NHE3 via mechanism involving phosphatidylinositol 3-kinase J Biol Chem 275: 8133-8142, 2000
33. Peacock SL, Bates MP, Russell DW, Brown MS, Goldstein JL: Human low density lipoprotein receptor expressed in Xenopus oocytes. Conserved signals for O-linked glycosylation and receptor-mediated endocytosis. J Biol Chem 263: 7838-7845, 1988
34. Tran JM, Farrell MA, Fanestil DD: Effect of ions on binding of the thiazide-type diuretic metolazone to kidney membrane. Am J Physiol (Renal Fluid Electrolyte Physiol) 258: F908-F915, 1990
35. Fishburn CS, Elazar Z, Fuchs S: Differential glycosylation and intracellular trafficking for the long and short isoforms of the D2 dopamine receptor. J Biol Chem 270: 29819-29824, 1995
36. Asano T, Takata K, Katagiri H, Ishihara H, Inukai K, Anai M, Hirano H, Yazaki Y, Oka Y: The role of N-glycosylation in the targeting and stability of GLUT1 glucose transporter. FEBS Lett 324: 258-261, 1993
37. Asano T, Katagiri H, Takata K, Lin JL, Ishihara H, Inukai K, Tsukuda K, Kikuchi M, Hirano H, Yazaki Y: The role of N-glycosylation of GLUT1 for glucose transport activity. J Biol Chem 266: 24632-24636, 1991
38. Ott RJ, Hui AC, Giacomini KM: Inhibition of N-linked glycosylation affects organic cation transport across the brush border membrane of opossum kidney (OK) cells. J Biol Chem 267: 133-139, 1992
39. Olivares L, Aragon C, Gimenez C, Zafra F: The role of N-glycosylation in the targeting and activity of the GLUT1 glycine transporter. J Biol Chem 270: 9437-9442, 1995
40. + anti-porter in rat renal brush-border membrane. J Biol Chem 263: 13683-13691, 1988
41. Hayes G, Busch A, Lotscher M, Waldegger S, Lang F, Verrey F, Biber J, Murer H: Role of N-linked glycosylation in rat renal Na/Pi-cotransport. J Biol Chem 269: 24143-24149, 1994
42. -dependent serotonin transporter expressed using recombinant baculovirus in insect cells. J Biol Chem 269: 26303-26310, 1994
43. Vazquez N, Monroy A, Dorantes E, Munoz-Clares RA, and Gamba, G: Functional differences between the flounder and rat thiazide-sensitive Na-Cl cotransporter. Am J Physiol Renal Physiol 282: F599-F607, 2002
44. Beggah AT, Jaunin P, Geering K: Role of glycosylation and disulfide bond formation in the beta subunit in the folding and functional expression of Na, K-ATPase. J Biol Chem 272: 10318-10326, 1997