Purification of naringin and neohesperidin from Huyou (Citrus changshanensis) fruit and their effects on glucose consumption in human HepG2 cells

Food Chemistry

Volumn 135, Issue 3, 2012, Pages 1471-1478

  Zhang, Jiukai ^a   Sun, Chongde ^a   Yan, Youyou ^b   Chen, Qingjun ^c   Luo, Fenglei ^a   Zhu, Xiaoyan ^a   Li, Xian ^a   Chen, Kunsong ^a  

^a ZHEJIANG UNIVERSITY   (China)

^b ZHEJIANG UNIVERSITY   (China)

^c National Light Industry Food Quality Inspection Hangzhou Station   (China)

Author keywords

AMPK; Citrus changshanensis; Glucose consumption; Naringin; Neohesperidin; Purification

Indexed keywords

AMPK; CITRUS CHANGSHANENSIS; GLUCOSE CONSUMPTION; NARINGIN; NEOHESPERIDIN;

CHROMATOGRAPHY; GLUCOSE; PHOSPHORYLATION; PURIFICATION; SOLAR RADIATION;

CITRUS FRUITS;

ANTIDIABETIC AGENT; AURANTIIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; NEOHESPERIDIN;

ANTIDIABETIC ACTIVITY; ARTICLE; CELL STRAIN HEPG2; CHROMATOGRAPHY; CITRUS; CITRUS CHANGSHANENSIS; DRUG PURIFICATION; GLUCOSE INTAKE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIGH SPEED COUNTER CURRENT CHROMATOGRAPHY; HUMAN; HUMAN CELL; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PROTEIN PHOSPHORYLATION;

CITRUS; FLAVANONES; FRUIT; GLUCOSE; HEP G2 CELLS; HESPERIDIN; HUMANS; PLANT EXTRACTS;

CITRUS;

EID: 84865711481     PISSN: 03088146     EISSN: 18737072     Source Type: Journal    
DOI: 10.1016/j.foodchem.2012.06.004     Document Type: Article

References (30)

1. D.C. Abeysinghe, X. Li, C.D. Sun, W.S. Zhang, C.H. Zhou, and K.S. Chen Bioactive compounds and antioxidant capacities in different edible tissues of citrus fruit of four species Food Chemistry 104 2007 1338 1344 (Pubitemid 46783251)
2. A.F. Amos, D.J. McCarty, and P. Zimmet The rising global burden of diabetes and its complications: Estimates and projections to the year 2010 Diabetic Medicine 14 1997 S7 S85
3. E. Bellocco, D. Barreca, G. Laganà, U. Leuzzi, E. Tellone, S. Ficarra, A. Kotyk, and A. Galtieri Influence of l-rhamnosyl-d-glucosyl derivatives on properties and biological interaction of flavonoids Molecular and Cellular Biochemistry 321 2009 165 171
4. Y. Cai, Q. Luo, M. Sun, and H. Corke Antioxidant activity and phenolic compounds of 112 traditional Chinese medicinal plants associated with anticancer Life Sciences 74 2004 2157 2184 (Pubitemid 38210440)
5. J. Del Rio, M. Fuster, F. Sabater, I. Porras, A. Garcia-Lidon, and A. Ortuno Selection of citrus varieties highly productive for the neohesperidin dihydrochalcone precursor Food Chemistry 59 1997 433 437 (Pubitemid 27193101)
6. R.S. Hundal, M. Krssak, S. Dufour, D. Laurent, V. Lebon, V. Chandramouli, S.E. Inzucchi, W.C. Schumann, K.F. Petersen, and B.R. Landau Mechanism by which metformin reduces glucose production in type 2 diabetes Diabetes 49 2000 2063 2069
7. 2-induced cytotoxicity in PC12 cells Journal of Agricultural and Food Chemistry 56 2008 859 864
8. M. Inês Amaro, J. Rocha, H. Vila-Real, M. Eduardo-Figueira, H. Mota-Filipe, B. Sepodes, and M.H. Ribeiro Anti-inflammatory activity of naringin and the biosynthesised naringenin by naringinase immobilized in microstructured materials in a model of DSS-induced colitis in mice Food Research International 42 2009 1010 1017
9. U. Jung, H. Kim, J. Lee, M. Lee, H. Kim, E. Park, H. Kim, T. Jeong, and M. Choi Naringin supplementation lowers plasma lipids and enhances erythrocyte antioxidant enzyme activities in hypercholesterolemic subjects Clinical Nutrition 22 2003 561 568 (Pubitemid 37455724)
10. U.J. Jung, M.K. Lee, K.S. Jeong, and M.S. Choi The hypoglycemic effects of hesperidin and naringin are partly mediated by hepatic glucose-regulating enzymes in C57BL/KsJ-db/db mice The Journal of Nutrition 134 2004 2499
11. U.J. Jung, M.K. Lee, Y.B. Park, M. Kang, and M.S. Choi Effect of citrus flavonoids on lipid metabolism and glucose-regulating enzyme mRNA levels in type-2 diabetic mice The International Journal of Biochemistry & Cell Biology 38 2006 1134 1145
12. S. Kawaii, Y. Tomono, E. Katase, K. Ogawa, and M. Yano Quantitation of flavonoid constituents in citrus fruits Journal of Agricultural and Food Chemistry 47 1999 3565 3571 (Pubitemid 29449470)
13. G.N. Kim, J.G. Shin, and H.D. Jang Antioxidant and antidiabetic activity of Dangyuja (Citrus grandis Osbeck) extract treated with Aspergillus saitoi Food Chemistry 117 2009 35 41
14. +-glucose cotransporter by naringenin International Journal of Biochemistry & Cell Biology 38 2006 985 995 (Pubitemid 43363427)
15. S. Li, C.Y. Lo, and C.T. Ho Hydroxylated polymethoxyflavones and methylated flavonoids in sweet orange (Citrus sinensis) peel Journal of Agricultural and Food Chemistry 54 2006 4176 4185 (Pubitemid 44013319)
16. Y.Y. Li, H.S. Wu, L. Tang, C.R. Feng, J.H. Yu, Y. Li, Y.S. Yang, B. Yang, and Q.J. He The potential insulin sensitizing and glucose lowering effects of a novel indole derivative in vitro and in vivo Pharmacological Research 56 2007 335 343 (Pubitemid 47496225)
17. F. Menichini, R. Tundis, M.R. Loizzo, M. Bonesi, B. Liu, P. Jones, S.J. Persaud, V. Mastellone, P. Lombardi, and P.J. Houghton C. medica cv Diamante peel chemical composition and influence on glucose homeostasis and metabolic parameters Food Chemistry 124 2010 1083 1089
18. P.P. Mouly, C.R. Arzouyan, E.M. Gaydou, and J.M. Estienne Differentiation of citrus juices by factorial discriminant analysis using liquid chromatography of flavanone glycosides Journal of Agricultural and Food Chemistry 42 1994 70 79
19. M. Nishiura, S. Kamiya, and S. Esaki Flavonoids in Citrus and related genera: III. Flavonoid pattern and Citrus taxonomy Agricultural and Biological Chemistry 35 1971 1691 1706
20. Y. Nogata, K. Sakamoto, H. Shiratsuchi, T. Ishii, M. Yano, and H. Ohta Flavonoid composition of fruit tissues of citrus species Bioscience, Biotechnology, and Biochemistry 70 2006 178 192 (Pubitemid 43150976)
21. A. Purushotham, M. Tian, and M. Belury The citrus fruit flavonoid naringenin suppresses hepatic glucose production from Fao hepatoma cells Molecular Nutrition & Food Research 53 2009 300 307
22. R.L. Rouseff, S.F. Martin, and C.O. Youtsey Quantitative survey of narirutin, naringin, hesperidin, and neohesperidin in citrus Journal of Agricultural and Food Chemistry 35 1987 1027 1030
23. M. Sugiura, M. Ohshima, K. Ogawa, and M. Yano Chronic administration of Satsuma mandarin fruit (Citrus unshiu Marc.) improves oxidative stress in streptozotocin-induced diabetic rat liver Biological and Pharmaceutical Bulletin 29 2006 588 591
24. C.D. Sun, B. Zhang, J.K. Zhang, C.J. Xu, Y.L. Wu, X. Li, and K.S. Chen Cyanidin-3-glucoside-rich extract from Chinese bayberry fruit protects pancreatic β cells and ameliorates hyperglycemia in streptozotocin-induced diabetic mice Journal of Medicinal Food 15 2012 288 298
25. E. Tripoli, M.L. Guardia, S. Giammanco, D.D. Majo, and M. Giammanco Citrus flavonoids: Molecular structure, biological activity and nutritional properties: A review Food Chemistry 104 2007 466 479 (Pubitemid 46661050)
26. B. Viollet, B. Guigas, N.S. Garcia, J. Leclerc, M. Foretz, and F. Andreelli Cellular and molecular mechanisms of metformin: An overview Clinical Science 122 2012 253 270
27. C.J. Xu, L. Bao, B. Zhang, Z.M. Bei, X.Y. Ye, S.L. Zhang, and K.S. Chen Parentage analysis of huyou (Citrus changshanensis) based on internal transcribed spacer sequences Plant Breeding 125 2006 519 522 (Pubitemid 44392695)
28. T. Yoshida, A. Okuno, J. Tanaka, K. Takahashi, R. Nakashima, S. Kanda, J. Ogawa, Y. Hagisawa, and T. Fujiwara Metformin primarily decreases plasma glucose not by gluconeogenesis suppression but by activating glucose utilization in a non-obese type 2 diabetes Goto-Kakizaki rats European Journal of Pharmacology 623 2009 141 147
29. J.K. Zhang, X.Y. Zhu, F.L. Luo, C.D. Sun, J.Z. Huang, X. Li, and K.S. Chen Separation and purification of neohesperidin from the albedo of Citrus reticulata cv. Suavissima by combination of macroporous resin and high-speed counter-current chromatography Journal of Separation Science 35 2012 128 136
30. J. Zhishen, T. Mengcheng, and W. Jianming The determination of flavonoid contents in mulberry and their scavenging effects on superoxide radicals Food Chemistry 64 1999 555 559 (Pubitemid 29060787)