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Volumn 56, Issue 9, 2012, Pages 1433-1444

Antihyperuricemic and nephroprotective effects of resveratrol and its analogues in hyperuricemic mice

Author keywords

Gout; Hypouricemic effect; Nephroprotection; Stilbenes; Structure activity relationship

Indexed keywords

ABC TRANSPORTER; ABCG2 PROTEIN, MOUSE; ANTIGOUT AGENT; CARRIER PROTEIN; COMBRETASTATIN A4 PHOSPHATE; CREATININE; DISACCHARIDE; GLUCOSE TRANSPORTER; GLUCOSIDE; MEMBRANE PROTEIN; MULBERROSIDE A; OCTAMER TRANSCRIPTION FACTOR 1; ORGANIC ANION TRANSPORTER; ORGANIC ANION TRANSPORTER 1; ORGANIC CATION TRANSPORTER; OTERACIL; OTERACIL POTASSIUM; POLYDATIN; POU2F1 PROTEIN, MOUSE; PTEROSTILBENE; RESVERATROL; SLC22A12 PROTEIN, MOUSE; SLC22A2 PROTEIN, MOUSE; SLC22A4 PROTEIN, MOUSE; SLC22A5 PROTEIN, MOUSE; SLC22A6 PROTEIN, MOUSE; SLC2A9 PROTEIN, MOUSE; STILBENE DERIVATIVE; TRANS 2,3',4,5' TETRAHYDROXYSTILBENE; TRANS 3,4' DIHYDROXY 2',3',5 TRIMETHOXYSTILBENE; TRANS-2,3',4,5'-TETRAHYDROXYSTILBENE; TRANS-3,4'-DIHYDROXY-2',3',5-TRIMETHOXYSTILBENE; URIC ACID;

EID: 84865703695     PISSN: 16134125     EISSN: 16134133     Source Type: Journal    
DOI: 10.1002/mnfr.201100828     Document Type: Article
Times cited : (70)

References (45)
  • 1
    • 34548142983 scopus 로고    scopus 로고
    • Independent impact of gout on mortality and risk for coronary heart disease
    • Choi, H. K., Curhan, G., Independent impact of gout on mortality and risk for coronary heart disease. Circulation 2007, 116, 894-900.
    • (2007) Circulation , vol.116 , pp. 894-900
    • Choi, H.K.1    Curhan, G.2
  • 2
    • 34447617704 scopus 로고    scopus 로고
    • Relationship of uric acid with progression of kidney disease
    • Chonchol, M., Shlipak, M. G., Katz, R., Sarnak, M. J. et al., Relationship of uric acid with progression of kidney disease. Am. J. Kidney Dis. 2007, 50, 239-247.
    • (2007) Am. J. Kidney Dis. , vol.50 , pp. 239-247
    • Chonchol, M.1    Shlipak, M.G.2    Katz, R.3    Sarnak, M.J.4
  • 3
    • 77957804998 scopus 로고    scopus 로고
    • Serum uric acid levels and the risk of type 2 diabetes: a prospective study
    • de
    • Bhole, V., Choi, J. W., Kim, S. W., de Vera, M. et al., Serum uric acid levels and the risk of type 2 diabetes: a prospective study. Am. J. Med. 2010, 123, 957-961.
    • (2010) Am. J. Med. , vol.123 , pp. 957-961
    • Bhole, V.1    Choi, J.W.2    Kim, S.W.3    Vera, M.4
  • 4
    • 70349345913 scopus 로고    scopus 로고
    • Glut9 is a major regulator of urate homeostasis and its genetic inactivation induces hyperuricosuria and urate nephropathy
    • Preitner, F., Bonny, O., Laverriere, A., Rotman, S. et al., Glut9 is a major regulator of urate homeostasis and its genetic inactivation induces hyperuricosuria and urate nephropathy. Proc. Natl. Acad. Sci. USA 2009, 106, 15501-15506.
    • (2009) Proc. Natl. Acad. Sci. USA , vol.106 , pp. 15501-15506
    • Preitner, F.1    Bonny, O.2    Laverriere, A.3    Rotman, S.4
  • 5
    • 26244449838 scopus 로고    scopus 로고
    • Roles of organic anion transporters (OATs) and a urate transporter (URAT1) in the pathophysiology of human disease
    • Enomoto, A., Endou, H., Roles of organic anion transporters (OATs) and a urate transporter (URAT1) in the pathophysiology of human disease. Clin. Exp. Nephrol. 2005, 9, 195-205.
    • (2005) Clin. Exp. Nephrol. , vol.9 , pp. 195-205
    • Enomoto, A.1    Endou, H.2
  • 6
    • 67649886415 scopus 로고    scopus 로고
    • Identification of a urate transporter, ABCG2, with a common functional polymorphism causing gout
    • Woodward, O. M., Kottgen, A., Coresh, J., Boerwinkle, E. et al., Identification of a urate transporter, ABCG2, with a common functional polymorphism causing gout. Proc. Natl. Acad. Sci. USA 2009, 106, 10338-10342.
    • (2009) Proc. Natl. Acad. Sci. USA , vol.106 , pp. 10338-10342
    • Woodward, O.M.1    Kottgen, A.2    Coresh, J.3    Boerwinkle, E.4
  • 7
    • 76249119000 scopus 로고    scopus 로고
    • Genetic analysis of ABCG2 gene C421A polymorphism with gout disease in Chinese Han male population
    • Wang, B., Miao, Z., Liu, S., Wang, J. et al., Genetic analysis of ABCG2 gene C421A polymorphism with gout disease in Chinese Han male population. Hum. Genet. 2010, 127, 245-246.
    • (2010) Hum. Genet. , vol.127 , pp. 245-246
    • Wang, B.1    Miao, Z.2    Liu, S.3    Wang, J.4
  • 9
    • 72049089059 scopus 로고    scopus 로고
    • Pathophysiological regulation of renal SLC22A organic ion transporters in acute kidney injury: pharmacological and toxicological implications
    • Saito, H., Pathophysiological regulation of renal SLC22A organic ion transporters in acute kidney injury: pharmacological and toxicological implications. Pharmacol. Therapeut. 2010, 125, 79-91.
    • (2010) Pharmacol. Therapeut. , vol.125 , pp. 79-91
    • Saito, H.1
  • 10
    • 33847213858 scopus 로고    scopus 로고
    • OCTN2-mediated carnitine uptake in a newly discovered human proximal tubule cell line (Caki-1)
    • Glube, N., Closs, E., Langguth, P., OCTN2-mediated carnitine uptake in a newly discovered human proximal tubule cell line (Caki-1). Mol. Pharm. 2007, 4, 160-168.
    • (2007) Mol. Pharm. , vol.4 , pp. 160-168
    • Glube, N.1    Closs, E.2    Langguth, P.3
  • 11
    • 1342302111 scopus 로고    scopus 로고
    • Reduced expression of organic cation transporters rOCT1 and rOCT2 in experimental diabetes
    • Grover, B., Buckley, D., Buckley, A. R., Cacini, W., Reduced expression of organic cation transporters rOCT1 and rOCT2 in experimental diabetes. J. Pharmacol. Exp. Ther. 2004, 308, 949-956.
    • (2004) J. Pharmacol. Exp. Ther. , vol.308 , pp. 949-956
    • Grover, B.1    Buckley, D.2    Buckley, A.R.3    Cacini, W.4
  • 12
    • 79957460481 scopus 로고    scopus 로고
    • Mulberroside A possesses potent uricosuric and nephroprotective effects in hyperuricemic mice
    • Wang, C. P., Wang, Y., Wang, X., Zhang, X. et al., Mulberroside A possesses potent uricosuric and nephroprotective effects in hyperuricemic mice. Planta Med. 2011, 77, 786-794.
    • (2011) Planta Med. , vol.77 , pp. 786-794
    • Wang, C.P.1    Wang, Y.2    Wang, X.3    Zhang, X.4
  • 13
    • 10744226387 scopus 로고    scopus 로고
    • A cluster of mutations in the UMOD gene causes familial juvenile hyperuricemic nephropathy with abnormal expression of uromodulin
    • Dahan, K., Devuyst, O., Smaers, M., Vertommen, D. et al., A cluster of mutations in the UMOD gene causes familial juvenile hyperuricemic nephropathy with abnormal expression of uromodulin. J. Am. Soc. Nephrol. 2003, 14, 2883-2893.
    • (2003) J. Am. Soc. Nephrol. , vol.14 , pp. 2883-2893
    • Dahan, K.1    Devuyst, O.2    Smaers, M.3    Vertommen, D.4
  • 14
    • 20044368467 scopus 로고    scopus 로고
    • Renal effects of Tamm-Horsfall protein (uromodulin) deficiency in mice
    • Bachmann, S., Mutig, K., Bates, J., Welker, P. et al., Renal effects of Tamm-Horsfall protein (uromodulin) deficiency in mice. Am. J. Physiol. Renal Physiol. 2005, 288, F559-F567.
    • (2005) Am. J. Physiol. Renal Physiol. , vol.288
    • Bachmann, S.1    Mutig, K.2    Bates, J.3    Welker, P.4
  • 15
    • 4644275038 scopus 로고    scopus 로고
    • Serum uric acid-lowering therapies: where are we heading in management of hyperuricemia and the potential role of uricase
    • Bomalaski, J. S., Clark, M. A., Serum uric acid-lowering therapies: where are we heading in management of hyperuricemia and the potential role of uricase. Curr. Rheumatol. Rep. 2004, 6, 240-247.
    • (2004) Curr. Rheumatol. Rep. , vol.6 , pp. 240-247
    • Bomalaski, J.S.1    Clark, M.A.2
  • 16
    • 10344228746 scopus 로고    scopus 로고
    • Current management of gout in patients unresponsive or allergic to allopurinol
    • Bardin, T., Current management of gout in patients unresponsive or allergic to allopurinol. Joint Bone Spine 2004, 71, 481-485.
    • (2004) Joint Bone Spine , vol.71 , pp. 481-485
    • Bardin, T.1
  • 17
    • 84855334376 scopus 로고    scopus 로고
    • Resveratrol in human cancer chemoprevention-choosing the 'right' dose
    • Scott, E., Steward, W. P., Gescher, A. J., Brown, K., Resveratrol in human cancer chemoprevention-choosing the 'right' dose. Mol. Nutr. Food Res. 2012, 56, 7-13.
    • (2012) Mol. Nutr. Food Res. , vol.56 , pp. 7-13
    • Scott, E.1    Steward, W.P.2    Gescher, A.J.3    Brown, K.4
  • 19
    • 79961047423 scopus 로고    scopus 로고
    • Resveratrol and health-a comprehensive review of human clinical trials
    • Smoliga, J. M., Baur, J. A., Hausenblas, H. A., Resveratrol and health-a comprehensive review of human clinical trials. Mol. Nutr. Food Res. 2011, 55, 1129-1141.
    • (2011) Mol. Nutr. Food Res. , vol.55 , pp. 1129-1141
    • Smoliga, J.M.1    Baur, J.A.2    Hausenblas, H.A.3
  • 20
    • 78851469143 scopus 로고    scopus 로고
    • Transport, stability, and biological activity of resveratrol
    • Delmas, D., Aires, V., Limagne, E., Dutartre, P. et al., Transport, stability, and biological activity of resveratrol. Ann. NY Acad. Sci. 2011, 1215, 48-59.
    • (2011) Ann. NY Acad. Sci. , vol.1215 , pp. 48-59
    • Delmas, D.1    Aires, V.2    Limagne, E.3    Dutartre, P.4
  • 21
    • 80455143206 scopus 로고    scopus 로고
    • Calorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans
    • Timmers, S., Konings, E., Bilet, L., Houtkooper, R. H. et al., Calorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans. Cell Metab. 2011, 14, 612-622.
    • (2011) Cell Metab. , vol.14 , pp. 612-622
    • Timmers, S.1    Konings, E.2    Bilet, L.3    Houtkooper, R.H.4
  • 22
    • 80052910300 scopus 로고    scopus 로고
    • Resveratrol improves insulin sensitivity, reduces oxidative stress and activates the Akt pathway in type 2 diabetic patients
    • Brasnyó, P., Molnár, G. A., Mohás, M., Markó, L. et al., Resveratrol improves insulin sensitivity, reduces oxidative stress and activates the Akt pathway in type 2 diabetic patients. Br. J. Nutr. 2011, 106, 383-389.
    • (2011) Br. J. Nutr. , vol.106 , pp. 383-389
    • Brasnyó, P.1    Molnár, G.A.2    Mohás, M.3    Markó, L.4
  • 23
    • 84860558348 scopus 로고    scopus 로고
    • Cardioprotection by resveratrol: a human clinical trial in patients with stable coronary artery disease
    • Magyar, K., Halmosi, R., Palfi, A., Feher, G. et al., Cardioprotection by resveratrol: a human clinical trial in patients with stable coronary artery disease. Clin. Hemorheol. Microcirc. 2012, 50, 179-187.
    • (2012) Clin. Hemorheol. Microcirc. , vol.50 , pp. 179-187
    • Magyar, K.1    Halmosi, R.2    Palfi, A.3    Feher, G.4
  • 24
    • 79961090100 scopus 로고    scopus 로고
    • Resveratrol derivatives as promising chemopreventive agents with improved potency and selectivity
    • Kondratyuk, T. P., Park, E. J., Marler, L. E., Ahn, S. Y. et al., Resveratrol derivatives as promising chemopreventive agents with improved potency and selectivity. Mol. Nutr. Food Res. 2011, 55, 1249-1265.
    • (2011) Mol. Nutr. Food Res. , vol.55 , pp. 1249-1265
    • Kondratyuk, T.P.1    Park, E.J.2    Marler, L.E.3    Ahn, S.Y.4
  • 25
    • 38649091351 scopus 로고    scopus 로고
    • A pilot study of evaluation of the antioxidative activity of resveratrol and its analogue in a 6-month feeding test in young adult mice
    • Matsuoka, A., Kodama, Y., Fukuhara, K., Honda, S. et al., A pilot study of evaluation of the antioxidative activity of resveratrol and its analogue in a 6-month feeding test in young adult mice. Food Chem. Toxicol. 2008, 46, 1125-1130.
    • (2008) Food Chem. Toxicol. , vol.46 , pp. 1125-1130
    • Matsuoka, A.1    Kodama, Y.2    Fukuhara, K.3    Honda, S.4
  • 26
    • 57149146175 scopus 로고    scopus 로고
    • Structure-efficiency relationship in derivatives of stilbene. Comparison of resveratrol, pinosylvin and pterostilbene
    • Perecko, T., Jancinova, V., Drabikova, K., Nosal, R. et al., Structure-efficiency relationship in derivatives of stilbene. Comparison of resveratrol, pinosylvin and pterostilbene. Neuro. Endocrinol. Lett. 2008, 29, 802-805.
    • (2008) Neuro. Endocrinol. Lett. , vol.29 , pp. 802-805
    • Perecko, T.1    Jancinova, V.2    Drabikova, K.3    Nosal, R.4
  • 27
    • 69249180127 scopus 로고    scopus 로고
    • Anti-inflammatory action of pterostilbene is mediated through the p38 mitogen-activated protein kinase pathway in colon cancer cells
    • Paul, S., Rimando, A. M., Lee, H. J., Ji, Y. et al., Anti-inflammatory action of pterostilbene is mediated through the p38 mitogen-activated protein kinase pathway in colon cancer cells. Cancer Prev. Res. 2009, 2, 650-657.
    • (2009) Cancer Prev. Res. , vol.2 , pp. 650-657
    • Paul, S.1    Rimando, A.M.2    Lee, H.J.3    Ji, Y.4
  • 28
    • 67349165065 scopus 로고    scopus 로고
    • Lipid-lowering effects of polydatin from Polygonum cuspidatum in hyperlipidemic hamsters
    • Du, J., Sun, L. N., Xing, W. W., Huang, B. K. et al., Lipid-lowering effects of polydatin from Polygonum cuspidatum in hyperlipidemic hamsters. Phytomedicine 2009, 16, 652-658.
    • (2009) Phytomedicine , vol.16 , pp. 652-658
    • Du, J.1    Sun, L.N.2    Xing, W.W.3    Huang, B.K.4
  • 29
    • 54049155669 scopus 로고    scopus 로고
    • Resveratrol, a natural phytoalexin, normalizes hyperglycemia in streptozotocin-nicotinamide induced experimental diabetic rats
    • Palsamy, P., Subramanian, S., Resveratrol, a natural phytoalexin, normalizes hyperglycemia in streptozotocin-nicotinamide induced experimental diabetic rats. Biomed. Pharmacother. 2008, 62, 598-605.
    • (2008) Biomed. Pharmacother. , vol.62 , pp. 598-605
    • Palsamy, P.1    Subramanian, S.2
  • 30
    • 79955697792 scopus 로고    scopus 로고
    • Anti-hyperuricemic and nephroprotective effects of Smilax china L
    • Chen, L., Yin, H., Lan, Z., Ma, S. et al., Anti-hyperuricemic and nephroprotective effects of Smilax china L. J. Ethnopharmacol. 2011, 135, 399-405.
    • (2011) J. Ethnopharmacol. , vol.135 , pp. 399-405
    • Chen, L.1    Yin, H.2    Lan, Z.3    Ma, S.4
  • 31
    • 78549288940 scopus 로고    scopus 로고
    • Repeat dose study of the cancer chemopreventive agent resveratrol in healthy volunteers: safety, pharmacokinetics, and effect on the insulin-like growth factor axis
    • Brown, V. A., Patel, K. R., Viskaduraki, M., Crowell, J. A. et al., Repeat dose study of the cancer chemopreventive agent resveratrol in healthy volunteers: safety, pharmacokinetics, and effect on the insulin-like growth factor axis. Cancer Res. 2010, 70, 9003-9011.
    • (2010) Cancer Res. , vol.70 , pp. 9003-9011
    • Brown, V.A.1    Patel, K.R.2    Viskaduraki, M.3    Crowell, J.A.4
  • 32
    • 65349173645 scopus 로고    scopus 로고
    • Dietary administration of high doses of pterostilbene and quercetin to mice is not toxic
    • Ruiz, M. J., Fernandez, M., Pico, Y., Manes, J. et al., Dietary administration of high doses of pterostilbene and quercetin to mice is not toxic. J. Agric. Food Chem. 2009, 57, 3180-3186.
    • (2009) J. Agric. Food Chem. , vol.57 , pp. 3180-3186
    • Ruiz, M.J.1    Fernandez, M.2    Pico, Y.3    Manes, J.4
  • 33
    • 79953031514 scopus 로고    scopus 로고
    • Polydatin ameliorates DSS-induced colitis in mice through inhibition of nuclear factor-kappaB activation
    • Yao, J., Wang, J. Y., Liu, L., Zeng, W. S. et al., Polydatin ameliorates DSS-induced colitis in mice through inhibition of nuclear factor-kappaB activation. Planta Med. 2011, 77, 421-427.
    • (2011) Planta Med. , vol.77 , pp. 421-427
    • Yao, J.1    Wang, J.Y.2    Liu, L.3    Zeng, W.S.4
  • 34
    • 84856171338 scopus 로고    scopus 로고
    • Challenges of translating basic research into therapeutics: resveratrol as an example
    • Smoliga, J. M., Vang, O., Baur, J. A., Challenges of translating basic research into therapeutics: resveratrol as an example. J. Gerontol. A Biol. Sci. Med. Sci. 2012, 67, 158-167.
    • (2012) J. Gerontol. A Biol. Sci. Med. Sci. , vol.67 , pp. 158-167
    • Smoliga, J.M.1    Vang, O.2    Baur, J.A.3
  • 35
    • 79959261445 scopus 로고    scopus 로고
    • What is new for an old molecule? Systematic review and recommendations on the use of resveratrol
    • Vang, O., Ahmad, N., Baile, C. A., Baur, J. A. et al., What is new for an old molecule? Systematic review and recommendations on the use of resveratrol. PLoS One 2011, 6, e19881.
    • (2011) PLoS One , vol.6
    • Vang, O.1    Ahmad, N.2    Baile, C.A.3    Baur, J.A.4
  • 36
    • 40449086665 scopus 로고    scopus 로고
    • Dose translation from animal to human studies revisited
    • Reagan-Shaw, S., Nihal, M., Ahmad, N., Dose translation from animal to human studies revisited. FASEB J. 2008, 22, 659-661.
    • (2008) FASEB J. , vol.22 , pp. 659-661
    • Reagan-Shaw, S.1    Nihal, M.2    Ahmad, N.3
  • 37
    • 85054012724 scopus 로고    scopus 로고
    • Center for Drug Evaluation and Research, Estimating the maximum safe starting dose in initial clinical trials for therapeutics in adult healthy volunteers
    • U.S. Department of Health and Human Services, U.S. FDA, Available from
    • U.S. Department of Health and Human Services, Center for Drug Evaluation and Research, Estimating the maximum safe starting dose in initial clinical trials for therapeutics in adult healthy volunteers. U.S. FDA 2005, 6-7. Available from http://www.fda.gov/downloads/Drugs/GuidanceComplianceRegulatoryInformation/Guidances/UCM078932.pdf.
    • (2005) , pp. 6-7
  • 38
    • 68049147267 scopus 로고    scopus 로고
    • Safety studies conducted on high-purity trans-resveratrol in experimental animals
    • Williams, L. D., Burdock, G. A., Edwards, J. A., Beck, M. et al., Safety studies conducted on high-purity trans-resveratrol in experimental animals. Food Chem. Toxicol. 2009, 47, 2170-2182.
    • (2009) Food Chem. Toxicol. , vol.47 , pp. 2170-2182
    • Williams, L.D.1    Burdock, G.A.2    Edwards, J.A.3    Beck, M.4
  • 39
    • 20344364428 scopus 로고    scopus 로고
    • Metabolism and bioavailability of trans-resveratrol
    • Wenzel, E., Somoza, V., Metabolism and bioavailability of trans-resveratrol. Mol. Nutr. Food Res. 2005, 49, 472-481.
    • (2005) Mol. Nutr. Food Res. , vol.49 , pp. 472-481
    • Wenzel, E.1    Somoza, V.2
  • 41
    • 77749343695 scopus 로고    scopus 로고
    • Three major metabolites of mulberroside A in rat intestinal contents and feces
    • Zhaxi, M., Chen, L., Li, X., Komatsu, K. et al., Three major metabolites of mulberroside A in rat intestinal contents and feces. Planta Med. 2010, 76, 362-364.
    • (2010) Planta Med. , vol.76 , pp. 362-364
    • Zhaxi, M.1    Chen, L.2    Li, X.3    Komatsu, K.4
  • 42
    • 0034901818 scopus 로고    scopus 로고
    • Grape extract, resveratrol, and its analogs: a review
    • Sovak, M., Grape extract, resveratrol, and its analogs: a review. J. Med. Food 2001, 4, 93-105.
    • (2001) J. Med. Food , vol.4 , pp. 93-105
    • Sovak, M.1
  • 43
    • 3242803476 scopus 로고    scopus 로고
    • Resveratrol, pterostilbene, and piceatannol in vaccinium berries
    • Rimando, A. M., Kalt, W., Magee, J. B., Dewey, J. et al., Resveratrol, pterostilbene, and piceatannol in vaccinium berries. J. Agric. Food Chem. 2004, 52, 4713-4719.
    • (2004) J. Agric. Food Chem. , vol.52 , pp. 4713-4719
    • Rimando, A.M.1    Kalt, W.2    Magee, J.B.3    Dewey, J.4
  • 44
    • 77954690029 scopus 로고    scopus 로고
    • Biotransformation of mulberroside A from Morus alba results in enhancement of tyrosinase inhibition
    • Kim, J. K., Kim, M., Cho, S. G., Kim, M. K. et al., Biotransformation of mulberroside A from Morus alba results in enhancement of tyrosinase inhibition. J. Ind. Microbiol. Biotechnol. 2010, 37, 631-637.
    • (2010) J. Ind. Microbiol. Biotechnol. , vol.37 , pp. 631-637
    • Kim, J.K.1    Kim, M.2    Cho, S.G.3    Kim, M.K.4
  • 45
    • 79952146166 scopus 로고    scopus 로고
    • Biological activity of peanut (Arachis hypogaea) phytoalexins and selected natural and synthetic stilbenoids
    • Sobolev, V. S., Khan, S. I., Tabanca, N., Wedge, D. E. et al., Biological activity of peanut (Arachis hypogaea) phytoalexins and selected natural and synthetic stilbenoids. J. Agric. Food Chem. 2011, 59, 1673-1682.
    • (2011) J. Agric. Food Chem. , vol.59 , pp. 1673-1682
    • Sobolev, V.S.1    Khan, S.I.2    Tabanca, N.3    Wedge, D.E.4


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