Renal effects of Tamm-Horsfall protein (uromodulin) deficiency in mice

American Journal of Physiology - Renal Physiology

Volumn 288, Issue 3 57-3, 2005, Pages

  Bachmann, Sebastian ^a,d   Mutig, Kerim ^a   Bates, James ^c   Welker, Pia ^a   Geist, Beate ^a   Gross, Volkmar ^a   Luft, Friedrich C ^a   Alenina, Natalia ^a   Bader, Michael ^a   Thiele, Bernd J ^b   Prasadan, Krishna ^c   Raffi, Hajamohideen S ^c   Kumar, Satish ^c  

^a MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^b Department of Physiology ^*  (Germany)

^c UNIVERSITY OF OKLAHOMA HEALTH SCIENCES CENTER   (United States)

^d CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

Gene disrupted mice; Renal concentrating mechanism; Thick ascending limb

Indexed keywords

CREATININE; CYCLOOXYGENASE 2; MESSENGER RNA; RENIN; SUCROSE; TAMM HORSFALL GLYCOPROTEIN;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CREATININE CLEARANCE; ELECTROLYTE BALANCE; HENLE LOOP; HISTOCHEMISTRY; JUXTAGLOMERULAR APPARATUS; KIDNEY CONCENTRATING CAPACITY; KIDNEY FUNCTION; KIDNEY TUBULE ABSORPTION; MACULA DENSA; MOUSE; NONHUMAN; NORTHERN BLOTTING; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DEFECT; PROTEIN DEFICIENCY; REGULATORY MECHANISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; URINE; URINE VOLUME; WATER DEPRIVATION; WESTERN BLOTTING;

EID: 20044368467     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.00143.2004     Document Type: Article

References (49)

1. Bachmann S, Bostanjoglo M, Schmitt R, and Ellison DH. Sodium transport-related proteins in the mammalian distal nephron-distribution, ontogeny and functional aspects. Anat Embryol (Berl) 200: 447-468, 1999.
2. Bachmann S, Dawnay AB, Bouby N, and Bankir L. Tamm-Horsfall protein excretion during chronic alterations in urinary concentration and protein intake in the rat. Renal Physiol Biochem 14: 236-245, 1991.
3. Bachmann S, Koeppen-Hagemann I, and Kriz W. Ultrastructural localization of Tamm-Horsfall glycoprotein (THP) in rat kidney as revealed by protein A-gold immunocytochemistry. Histochemistry 83: 531-538, 1985.
4. Bachmann S, Metzger R, and Bunnemann B. Tamm-Horsfall protein-mRNA synthesis is localized to the thick ascending limb of Henle's loop in rat kidney. Histochemistry 94: 517-523, 1990.
5. Bates JM, Raffi HM, Prasadan K, Mascarenhas R, Laszik Z, Maeda N, Hultgren SJ, and Kumar S. Tamm-Horsfall protein knockout mice are more prone to urinary tract infection. Kidney Int 65: 791-797, 2004.
6. Bosse HM, Bohm R, Resch S, and Bachmann S. Parallel regulation of constitutive NO synthase and renin at the juxtaglomerular apparatus of rat kidney under various stimuli. Am J Physiol Renal Fluid Electrolyte Physiol 269: F793-F805, 1995.
7. - cotransport and associated gene products in mouse DCT. Am J Physiol Renal Physiol 281: F1028-F1035, 2001.
8. Castrop H, Klar J, Wagner C, Höcherl K, and Kurtz A. General inhibition of renocortical cyclooxygenase-2 expression by the renin-angiotensin system. Am J Physiol Renal Physiol 284: F518-F524, 2003.
9. Dahan K, Devuyst O, Smaers M, Vertommen D, Loute G, Poux JM, Viron B, Jacquot C, Gagnadoux MF, Chauveau D, Büchler M, Cochat P, Cosyns JP, Mougenot B, Rider MH, Antignac C, Verellen-Dumoulin C, and Pirson Y. A cluster of mutations in the UMOD gene causes familial juvenile hyperuricemic nephropathy with abnormal expression of uromodulin. J Am Soc Nephrol 14: 2883-2893, 2003.
10. Ellison DH. Divalent cation transport by the distal nephron: insights from Bartter's and Gitelman's syndromes. Am J Physiol Renal Physiol 279: F616-F625, 2000.
11. Ellison DH, Velazquez H, and Wright FS. Adaptation of distal convoluted tubule of the rat. J Can Invest 83: 113-126, 1989.
12. + secretion. Nature 414: 558-561, 2001.
13. Frühauf JH, Welker P, Mutig K, Jentsch TJ, Kinne-Safran E, and Bachmann S. Lipid raft association of essential proteins of the thick ascending limb. J Am Soc Nephrol 14: 561A, 2003.
14. Harris RC Jr. Cyclooxygenase-2 inhibition and renal physiology. Am J Cardiol 89: 10D-17D, 2002.
15. Hart TC, Gorry MC, Hart PS, Woodard AS, Shihabi Z, Sandhu J, Shirts B, Hy L, Zhu H, Barmada MM, and Bleyer AJ. Mutations in UMOD gene are responsible for medullary cystic kidney disease 2 and familial juvenile hyperuricaemic nephropathy. J Med Genet 39: 882-892, 2002.
16. Hebert SC. Bartter syndrome. Curr Opin Nephrol Hypertens 12: 527-532, 2003.
17. Kelly SJ, Delnomdedieu M, Oliverio MI, Wiluams LD, Saifer MGP, Sherman MR, Coffman TM, Johnson GA, and Hershfield MS. Diabetes insipidus in uricase-deficient mice: a model for evaluating therapy with poly(ethylene glycol)-modified uricase. J Am Soc Nephrol 12: 1001-1009, 2001.
18. Kim GH, Ecelbarger CA, Mitchell C, Packer RK, Wade JB, and Knepper MA. Vasopressin increases Na-K-2Cl cotransporter expression in thick ascending limb of Henle's loop. Am J Physiol Renal Physiol 276: F96-F103, 1999.
19. Knepper MA and Masilamani S. Targeted proteomics in the kidney using ensembles of antibodies. Acta Physiol Scand 173: 11-21, 2001.
20. Kohayashi K, Uchida S, Okamura HO, Marumo F, and Sasaki S. Human CLC-KB gene promoter drives the EGFP expression in the specific distal nephron segments and inner ear. J Am Soc Nephrol 13: 1992-1998, 2002.
21. Lynn KL and Marshall RD. Excretion of Tamm-Horsfall glycoprotein in renal disease. Clin Nephrol 22: 253-257, 1984.
22. Malagolini N, Cavallone D, and Serafini-Cessi F. Intracellular transport, cell-surface exposure and release of recombinant Tamm-Horsfall glycoprotein. Kidney Int 52: 1340-1350, 1997.
23. Masilamani S, Kim GH, Mitchell C, Wade JB, and Knepper MA. Aldosterone-mediated regulation of ENaC α, β, and γ subunit proteins in rat kidney. J Clin Invest 104: R19-R23, 1999.
24. Mo L, Zhu XH, Huang HY, Shapiro E, Hasty DL, and Wu XR. Ablation of the Tamm Horsfall protein gene increases susceptibility of mice to bladder colonization by type 1-fimbriated Escherichia coli. Am J Physiol Renal Physiol 286: F786-F795, 2004.
25. Nielsen J, Kwon TH, Masilamani S, Beutler K, Hager H, Nielsen S, and Knepper MA. Sodium transporter abundance profiling in kidney: effect of spironolactone. Am J Physiol Renal Physiol 283: F923-F933, 2002.
26. Nielsen S, Maunsbach AB, Ecelbarger CA, and Knepper MA. Ultrastructural localization of Na-K-2Cl cotransporter in thick ascending limb and macula densa of rat kidney. Am J Physiol Renal Physiol 275: F885-F893, 1998.
27. Obermüller N, Kunchaparty S, Ellison DH, and Bachmann S. Expression of the Na-K-2Cl cotransporter by macula densa and thick ascending limb cells of rat and rabbit nephron. Rapid publication. J Clin Invest 98: 635-640, 1996.
28. Obermüller N, Moser D, Kunchaparly S, Bernstein PL, Velázquez H, Ellison DH, and Bachmann S. Expression of the thiazide sensitive Na/Cl cotransporter in rat and human kidney. Am J Physiol Renal Fluid Electrolyte Physiol 269: F900-F910, 1995.
29. Pak J, Pu Y, Zhang ZT, Hasty DL, and Wu XR. Tamm-Horsfall protein binds to type 1 fimbriated Escherichia coli and prevents E. coli from binding to uroplakin Ia and Ib receptors. J Biol Chem 276: 9924-9930, 2001.
30. Peters M, Ermert S, Jeck N, Derst C, Pechmann U, Weber S, Schlingmann KP, Seyberth HW, Waldegger S, and Konrad M. Classification and rescue of ROMK mutations underlying hyperprostaglandin E syndrome/antenatal Bartter syndrome. Kidney Int 64: 923-932, 2003.
31. Rampoldi L, Caridi G, Santon D, Boaretto F, Bernascone I, Lamorte G, Tardanico R, Dagnino M, Colussi G, Scolari F, Ghiggeri GM, Amoroso A, and Casari G. Allelism of MCKD, FJHN and GCKD caused by impairment of uromodulin export dynamics. Hum Mol Genet 15: 3369-3384, 2003.
32. Rasch R, Torffvit O, Bachmann S, Jensen PK, and Jacobsen NO. Tamm-Horsfall glycoprotein in streptozotocin diabetic rats: a study of kidney in situ hybridization, immunohistochemistry, and urinary excretion. Diabetologia 38: 525-535, 1995.
33. Rotin D, Kandis V, and Schild L. Trafficking and cell surface stability of ENaC. Am J Physiol Renal Physiol 281: F391-F399, 2001.
34. Sanders PW, Booker BB, Bishop JB, and Cheung HC. Mechanisms of intranephronal proteinaceous cast formation by low molecular weight proteins. J Clin Invest 85: 570-576, 1990.
35. + channels are regulated by flow. Am J Physiol Renal Physiol 280: F1010-F1018, 2001.
36. Sato K, Oguchi H, Yoshie T, and Toshihiko K. Tubulointerstitial nephritis induced by Tamm-Horsfall protein sensitization in guinea pigs. Virchows Arch 58: 357-363, 1990.
37. Schmitt R, Ellison DH, Klussmann E, and Bachmann S. Renal expression of sodium transporters and aquaporin-2 in hypothyroid rats. Am J Physiol Renal Physiol 284: F1097-F1104, 2003.
38. Schmitt R, Kahl T, Mutig K, and Bachmann S. Selectively reduced expression of thick ascending limb Tamm-Horsfall protein in hypothyroid kidneys. Histochem Cell Biol 121: 319-327, 2004.
39. Schnermann J. The juxtaglomerular apparatus: from anatomical peculiarity to physiological relevance. J Am Soc Nephrol 14: 1681-1694, 2003.
40. Schröter J, Timmermans G, Seyberth HJ, Greven J, and Bachmann S. Marked reduction of Tamm-Horsfall protein expression and urinary excretion in hyperprostaglandin E-syndrome. Kidney Int 44: 401-410, 1993.
41. Serafini-Cessi F, Malagolini N, and Cavallone D. Tamm-Horsfall glycoprotein: biology and clinical relevance. Am J Kidney Dis 42: 658-676, 2003.
42. Takahashi N, Chernavvsky DR, Gomez RA, Igarashi P, Gitelman HJ, and Smithies O. Uncompensated polyuria in a mouse model of Bartter's syndrome. Proc Natl Acad Sci USA 97: 5434-5439, 2000.
43. Traynor TR, Smart A, Briggs JP, and Schnermann J. Inhibition of macula densa-stimulated renin secretion by pharmacological blockade of cyclooxygenase-2. Am J Physiol Renal Physiol 277: F706-F710, 1999.
44. Tsai CY, Wu TH, Yu CL, Lu JY, and Tsai YY. Increased excretions of β-microglobulin, IL-6, and IL-8 and decreased excretion of Tamm-Horsfall glycoprotein in urine of patients with active lupus nephritis. Nephron 85: 207-214, 2000.
45. Wolf TF, Mucha BE, Attanasio M, Zalewski I, Karle SM, Neumann HPH, Rahman N, Bader B, Baldamus CA, Otto E, Witzgall R, Fuchshuber A, and Hildebrandt F. Mutations of the Uromodulin gene in MCKD type 2 patients cluster in exon 4, which encodes three EGF-like domains. Kidney Int 64: 1580-1587, 2003.
46. Yang T, Singh I, Pham H, Sun D, Smart A, Schnermann JB, and Briggs JP. Regulation of cyclooxygenase expression in the kidney by dietary salt intake. Am J Physiol Renal Physiol 274: F481-F489, 1998.
47. Ying WZ and Sanders PW. Dietary salt regulates expression of Tamm-Horsfall glycoprotein in rats. Kidney Int 54: 1150-1156, 1998.
48. Ying WZ and Sanders PW. Mapping the binding domain of immunoglobulin light chains for Tamm-Horsfall protein. Am J Pathol 158: 1859-1866, 2001.
49. Zimmerhackl LB. Evaluation of nephrotoxicity with renal antigens in children: role of Tamm-Horsfall protein. Eur J Clin Pharmacol 44, Suppl 1: S39-S42, 1993.