Efficacy against lung metastasis with a tumor-targeting mutant of Salmonella typhimurium in immunocompetent mice

Cell Cycle

Volumn 11, Issue 1, 2012, Pages 187-193

  Zhao, Ming ^a   Suetsugu, Atsushi ^a   Ma, Huaiyu ^a   Zhang, Lei ^a   Liu, Fang ^a   Zhang, Yong ^a   Tran, Benjamin ^a   Hoffman, Robert M ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Amino acid auxotroph; Confocal microscopy; Fluorescence imaging; GFP; Lung; Metastasis; RFP; Salmonella typhimurium; Selective tumor targeting

Indexed keywords

A 1R; ANTINEOPLASTIC AGENT; SALMONELLA TYPHIMURIUM DOUBLE AUXOTROPH; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; AUXOTROPHIC MUTANT; CANCER SURVIVAL; CELL DEATH; DRUG EFFICACY; FEMALE; HUMAN; HUMAN CELL; IMMUNOCOMPETENCE; IN VITRO STUDY; LEWIS CARCINOMA; LUNG METASTASIS; METASTASIS INHIBITION; METRONOMIC DRUG ADMINISTRATION; MOUSE; NONHUMAN; SALMONELLA TYPHIMURIUM;

BACTERIA (MICROORGANISMS); MUS; MUS MUSCULUS; SALMONELLA TYPHIMURIUM;

EID: 84862907750     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.11.1.18667     Document Type: Article

References (29)

1. Zhao M, Yang M, Li XM, Jiang P, Baranov E, Li S, et al. Tumor-targeting bacterial therapy with amino acid auxotrophs of GFP-expressing Salmonella typhimurium. Proc Natl Acad Sci USA 2005; 102:755-60; PMID:15644448; http://dx.doi.org/10.1073/pnas.0408422102.
2. Low KB, Ittensohn M, Le T, Platt J, Sodi S, Amoss M, et al. Lipid A mutant Salmonella with suppressed virulence and TNFα induction retain tumor-targeting in vivo. Nat Biotechnol 1999; 17:37-41; PMID:9920266; http://dx.doi.org/10.1038/5205.
3. Clairmont C, Lee KC, Pike J, Ittensohn M, Low KB, Pawelek J, et al. Biodistribution and genetic stability of the novel antitumor agent VNP20009, a genetically modified strain of Salmonella typhimurium. J Infect Dis 2000; 181:1996-2002; PMID:10837181; http://dx.doi.org/10.1086/315497.
4. Sznol M, Lin SL, Bermudes D, Zheng LM, King I. Use of preferentially replicating bacteria for the treatment of cancer. J Clin Invest 2000; 105:1027-30; PMID:10772643; http://dx.doi.org/10.1172/JCI9818.
5. Yazawa K, Fujimori M, Amano J, Kano Y, Taniguchi S. Bifidobacterium longum as a delivery system for cancer gene therapy: Selective localization and growth in hypoxic tumors. Cancer Gene Ther 2000; 7:269-74; PMID:10770636; http://dx.doi.org/10.1038/sj.cgt.7700122.
6. Yazawa K, Fujimori M, Nakamura T, Sasaki T, Amano J, Kano Y, et al. Bifidobacterium longum as a delivery system for gene therapy of chemically induced rat mammary tumors. Breast Cancer Res Treat 2001; 66:165-70; PMID:11437103; http://dx.doi.org/10.1023/A:1010644217648.
7. Dang LH, Bettegowda C, Huso DL, Kinzler KW, Vogelstein B. Combination bacteriolytic therapy for the treatment of experimental tumors. Proc Natl Acad Sci USA 2001; 98:15155-60; PMID:11724950; http://dx.doi.org/10.1073/pnas. 251543698.
8. Hoiseth SK, Stocker BA. Aromatic-dependent Salmonella typhimurium are non-virulent and effective as live vaccines. Nature 1981; 291:238-9; PMID:7015147; http://dx.doi.org/10.1038/291238a0.
9. Pawelek JM, Low KB, Bermudes D. Tumor-targeted Salmonella as a novel anticancer vector. Cancer Res 1997; 57:4537-44; PMID:9377566.
10. Zhao M, Yang M, Ma H, Li X, Tan X, Li S, et al. Targeted therapy with a Salmonella typhimurium leucine-arginine auxotroph cures orthotopic human breast tumors in nude mice. Cancer Res 2006; 66:7647-52; PMID:16885365; http://dx.doi.org/10.1158/0008-5472.CAN-06-0716.
11. Zhao M, Geller J, Ma H, Yang M, Penman S, Hoffman RM. Monotherapy with a tumor-targeting mutant of Salmonella typhimurium cures orthotopic metastatic mouse models of human prostate cancer. Proc Natl Acad Sci USA 2007; 104:10170-4; PMID:17548809; http://dx.doi.org/10.1073/pnas.0703867104.
12. Hayashi K, Zhao M, Yamauchi K, Yamamoto N, Tsuchiya H, Tomita K, et al. Systemic targeting of primary bone tumor and lung metastasis of high-grade osteosarcoma in nude mice with a tumor-selective strain of Salmonella typhimurium. Cell Cycle 2009; 8:870-5; PMID:19221501; http://dx.doi.org/10.4161/ cc.8.6.7891.
13. Nagakura C, Hayashi K, Zhao M, Yamauchi K, Yamamoto N, Tsuchiya H, et al. Efficacy of a genetically modified Salmonella typhimurium in an orthotopic human pancreatic cancer in nude mice. Anticancer Res 2009; 29:1873-8; PMID:19528442.
14. Hayashi K, Zhao M, Yamauchi K, Yamamoto N, Tsuchiya H, Tomita K, et al. Cancer metastasis directly eradicated by targeted therapy with a modified Salmonella typhimurium. J Cell Biochem 2009; 106:992-8; PMID:19199339; http://dx.doi.org/10.1002/jcb.22078.
15. Yam C, Zhao M, Hayashi K, Ma H, Kishimoto H, McElroy M, et al. Monotherapy with a tumor-targeting mutant of S. typhimurium inhibits liver metastasis in a mouse model of pancreatic cancer. J Surg Res 2010; 164:248-55; PMID:19766244; http://dx.doi.org/10.1016/j.jss.2009.02.023.
16. Kimura H, Zhang L, Zhao M, Hayashi K, Tsuchiya H, Tomita K, et al. Targeted therapy of spinal cord glioma with a genetically modified Salmonella typhimurium. Cell Prolif 2010; 43:41-8; PMID:19922490; http://dx.doi.org/10. 1111/j.1365-2184.2009.00652.x.
17. Leschner S, Westphal K, Dietrich N, Viegas N, Jablonska J, Lyszkiewicz M, et al. Tumor invasion of Salmonella enterica serovar Typhimurium is accompanied by strong hemorrhage promoted by TNFα. PLoS ONE 2009; 4:e6692; PMID:19693266; http://dx.doi.org/10.1371/journal.pone.0006692.
18. Liu F, Zhang L, Hoffman RM, Zhao M. Vessel destruction by tumor-targeting Salmonella typhimurium A1-R is enhanced by high tumor vascularity. Cell Cycle 2010; 9:4518-24; PMID:21135579; http://dx.doi. org/10.4161/cc.9.22.13744.
19. Mann AP, Bhavane RC, Somasunderam A, Liz Montalvo-Ortiz B, Ghaghada KB, Volk D, et al. Thioaptamer conjugated liposomes for tumor vasculature targeting. Oncotarget 2011; 2:298-304; PMID:21666286.
20. Qiao Y, Huang X, Nimmagadda S, Bai R, Staedtke V, Foss CA, et al. A robust approach to enhance tumor-selective accumulation of nanoparticles. Oncotarget 2011; 2:59-68; PMID:21378416.
21. Uchugonova A, Hoffman RM, Weinigel M, Koenig K. Watching stem cells in the skin of living mice non-invasively. Cell Cycle 2011; 10:2017-20; PMID:21558804; http://dx.doi.org/10.4161/cc.10.12.15895.
22. Beloueche-Babari M, Workman P, Leach MO. Exploiting tumor metabolism for non-invasive imaging of the therapeutic activity of molecularly targeted anticancer agents. Cell Cycle 2011; 10:2883-93; PMID:21857160; http://dx.doi.org/10.4161/cc.10.17.17192.
23. Dienstmann R, Martinez P, Felip E. Personalizing therapy with targeted agents in non-small cell lung cancer. Oncotarget 2011; 2:165-77; PMID:21444946.
24. Wall DM, Srikanth CV, McCormick BA. Targeting tumors with Salmonella typhimurium - potential for therapy. Oncotarget 2010; 1:721-8; PMID:21321381.
25. Hoffman RM, Yang M. Subcellular imaging in the live mouse. Nat Protoc 2006; 1:775-82; PMID:17406307; http://dx.doi.org/10.1038/nprot.2006.109.
26. Hoffman RM, Yang M. Color-coded fluorescence imaging of tumor-host interactions. Nat Protoc 2006; 1:928-35; PMID:17406326; http://dx.doi.org/10. 1038/nprot.2006.119.
27. Hoffman RM, Yang M. Whole-body imaging with fluorescent proteins. Nat Protoc 2006; 1:1429-38; PMID:17406431; http://dx.doi.org/10.1038/nprot.2006.223.
28. Yamauchi K, Yang M, Jiang P, Xu M, Yamamoto N, Tsuchiya H, et al. Development of real-time subcellular dynamic multicolor imaging of cancer-cell trafficking in live mice with a variable-magnification wholemouse imaging system. Cancer Res 2006; 66:4208-14; PMID:16618743; http://dx.doi.org/10.1158/ 0008-5472.CAN-05-3927.
29. Uchugonova A, Duong J, Zhang N, König K, Hoffman RM. The bulge area is the origin of nestin-expressing pluripotent stem cells of the hair follicle. J Cell Biochem 2011; 112:2046-50; PMID:21465525; http://dx.doi.org/10.1002/jcb. 23122.