The motivations and methodology for high-throughput PET imaging of small animals in cancer research

European Journal of Nuclear Medicine and Molecular Imaging

Volumn 39, Issue 9, 2012, Pages 1497-1509

  Aide, Nicolas ^a,b   Visser, Eric P ^c   Lheureux, Stéphanie ^a,b   Heutte, Natacha ^a   Szanda, Istvan ^d   Hicks, Rodney J ^e  

^a Haematology Institute   (France)

^b UNIVERSITÉ DE CAEN   (France)

^c RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^d KING'S COLLEGE LONDON   (United Kingdom)

^e PETER MACCALLUM CANCER CENTRE   (Australia)

Author keywords

Animal models; Clinical PET CT; High throughput; NEMA NU 4; Planar positron imaging systems; Sample size; Small animal PET

Indexed keywords

FENESTRA VC; FLUORODEOXYGLUCOSE F 18; IODINATED CONTRAST MEDIUM; TRACER; UNCLASSIFIED DRUG;

CANCER RESEARCH; EXPERIMENTAL DESIGN; HIGH THROUGHPUT SCREENING; IMAGE QUALITY; IMAGING SYSTEM; MOLECULARLY TARGETED THERAPY; NONHUMAN; PHANTOM; POSITRON EMISSION TOMOGRAPHY; RADIATION PHYSICS; REVIEW; STATISTICAL SIGNIFICANCE;

ANIMALS; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; MOTIVATION; NEOPLASMS; NUCLEAR MEDICINE; POSITRON-EMISSION TOMOGRAPHY; RESEARCH DESIGN;

EID: 84865633997     PISSN: 16197070     EISSN: 16197089     Source Type: Journal    
DOI: 10.1007/s00259-012-2177-x     Document Type: Review

References (53)

1. AA Adjei 2006 What is the right dose? The elusive optimal biologic dose in phase I clinical trials J Clin Oncol 24 4054 4055 10.1200/JCO.2006.07.4658 16943522 10.1200/JCO.2006.07.4658 1:CAS:528:DC%2BD28XhtVantbzJ
2. C Le Tourneau JJ Lee LL Siu 2009 Dose escalation methods in phase I cancer clinical trials J Natl Cancer Inst 101 708 720 10.1093/jnci/djp079 19436029 10.1093/jnci/djp079
3. F Rojo A Dalmases JM Corominas J Albanell 2007 Pharmacodynamics: biological activity of targeted therapies in clinical trials Clin Transl Oncol 9 634 644 17974524 10.1007/s12094-007-0116-2 1:CAS:528:DC%2BD1cXlslagsw%3D%3D
4. T Fuereder T Wanek P Pflegerl A Jaeger-Lansky D Hoeflmayer S Strommer, et al. 2011 Gastric cancer growth control by BEZ235 in vivo does not correlate with PI3K/mTOR target inhibition but with [18F]FLT uptake Clin Cancer Res 17 5322 5332 10.1158/1078-0432.CCR-10-1659 21712451 10.1158/1078-0432.CCR-10-1659 1:CAS:528:DC%2BC3MXhtVajs7jJ
5. JK Willmann N van Bruggen LM Dinkelborg SS Gambhir 2008 Molecular imaging in drug development Nat Rev Drug Discov 7 591 607 10.1038/nrd2290 18591980 10.1038/nrd2290 1:CAS:528:DC%2BD1cXnvFShsbs%3D
6. D Cejka C Kuntner M Preusser M Fritzer-Szekeres BJ Fueger S Strommer, et al. 2009 FDG uptake is a surrogate marker for defining the optimal biological dose of the mTOR inhibitor everolimus in vivo Br J Cancer 100 1739 1745 10.1038/sj.bjc.6605076 19436299 10.1038/sj.bjc.6605076 1:CAS:528: DC%2BD1MXmsVChtL4%3D
7. WC Eckelman 2008 Further discussions on choosing the number of animals for an experiment Nucl Med Biol 35 1 2 10.1016/j.nucmedbio.2007.10.002 18158936 10.1016/j.nucmedbio.2007.10.002 1:CAS:528:DC%2BD2sXhsVOlt7%2FL
8. WC Eckelman MR Kilbourn JL Joyal R Labiris JF Valliant 2007 Justifying the number of animals for each experiment Nucl Med Biol 34 229 232 10.1016/j.nucmedbio.2007.01.005 17383571 10.1016/j.nucmedbio.2007.01.005 1:CAS:528:DC%2BD2sXjsVGiurY%3D
9. M Dandekar JR Tseng SS Gambhir 2007 Reproducibility of 18F-FDG microPET studies in mouse tumor xenografts J Nucl Med 48 602 607 17401098 10.2967/jnumed.106.036608
10. JR Tseng M Dandekar M Subbarayan Z Cheng JM Park S Louie, et al. 2005 Reproducibility of 3'-deoxy-3'-(18)F-fluorothymidine microPET studies in tumor xenografts in mice J Nucl Med 46 1851 1857 16269599 1:CAS:528: DC%2BD28XitVGltL0%3D
11. E Chang S Liu G Gowrishankar S Yaghoubi JP Wedgeworth F Chin, et al. 2011 Reproducibility study of [(18)F]FPP(RGD)2 uptake in murine models of human tumor xenografts Eur J Nucl Med Mol Imaging 38 722 730 10.1007/s00259-010-1672-1 21125268 10.1007/s00259-010-1672-1 1:CAS:528:DC%2BC3MXivFyks7c%3D
12. N Aide K Kinross C Cullinane P Roselt K Waldeck O Neels, et al. 2010 18F-FLT PET as a surrogate marker of drug efficacy during mTOR inhibition by everolimus in a preclinical cisplatin-resistant ovarian tumor model J Nucl Med 51 1559 1564 10.2967/jnumed.109.073288 20847160 10.2967/jnumed.109.073288
13. C Cullinane DS Dorow S Jackson B Solomon E Bogatyreva D Binns, et al. 2011 Differential (18)F-FDG and 3'-deoxy-3'-(18)F-fluorothymidine PET responses to pharmacologic inhibition of the c-MET receptor in preclinical tumor models J Nucl Med 52 1261 1267 10.2967/jnumed.110.086967 21764800 10.2967/jnumed.110. 086967 1:CAS:528:DC%2BC3MXhtFKju7vE
14. N Aide C Desmonts JM Beauregard T Beyer K Kinross P Roselt, et al. 2010 High throughput static and dynamic small animal imaging using clinical PET/CT: potential preclinical applications Eur J Nucl Med Mol Imaging 37 991 1001 10.1007/s00259-009-1352-1 20107792 10.1007/s00259-009-1352-1
15. JA Disselhorst M Brom P Laverman CH Slump OC Boerman WJ Oyen, et al. 2010 Image-quality assessment for several positron emitters using the NEMA NU 4-2008 standards in the Siemens Inveon small-animal PET scanner J Nucl Med 51 610 617 10.2967/jnumed.109.068858 20237025 10.2967/jnumed.109.068858
16. X Liu R Laforest 2009 Quantitative small animal PET imaging with nonconventional nuclides Nucl Med Biol 36 551 559 10.1016/j.nucmedbio.2009.01. 019 19520296 10.1016/j.nucmedbio.2009.01.019 1:CAS:528:DC%2BD1MXnt1Gqt7s%3D
17. N Anizan T Carlier C Hindorf J Barbet M Bardies 2012 Acquisition setting optimization and quantitative imaging for 124I studies with the Inveon microPET-CT system EJNMMI Res 2 7 10.1186/2191-219X-2-7 22330760 10.1186/2191-219X-2-7 1:CAS:528:DC%2BC38XhtVykurnK
18. A Ruangma B Bai JS Lewis X Sun MJ Welch R Leahy, et al. 2006 Three-dimensional maximum a posteriori (MAP) imaging with radiopharmaceuticals labeled with three Cu radionuclides Nucl Med Biol 33 217 226 10.1016/j.nucmedbio.2005.11.001 16546676 10.1016/j.nucmedbio.2005.11.001 1:CAS:528:DC%2BD28Xis1ehsb0%3D
19. RA de Kemp FH Epstein C Catana BM Tsui EL Ritman 2010 Small-animal molecular imaging methods J Nucl Med 51 Suppl 1 18S 32S 10.2967/jnumed.109. 068148 20457793 10.2967/jnumed.109.068148
20. M Tatsumi Y Nakamoto B Traughber LT Marshall JF Geschwind RL Wahl 2003 Initial experience in small animal tumor imaging with a clinical positron emission tomography/computed tomography scanner using 2-[F-18]fluoro-2-deoxy-D- glucose Cancer Res 63 6252 6257 14559811 1:CAS:528:DC%2BD3sXotV2jurk%3D
21. MD Seemann R Beck S Ziegler 2006 In vivo tumor imaging in mice using a state-of-the-art clinical PET/CT in comparison with a small animal PET and a small animal CT Technol Cancer Res Treat 5 537 542 16981797
22. G Brix J Doll ME Bellemann H Trojan U Haberkorn P Schmidlin, et al. 1997 Use of scanner characteristics in iterative image reconstruction for high-resolution positron emission tomography studies of small animals Eur J Nucl Med 24 779 786 9211765 1:STN:280:DyaK2szmt1Sgug%3D%3D
23. N Aide K Kinross JM Beauregard O Neels T Potdevin P Roselt, et al. 2011 A dual radiologic contrast agent protocol for 18F-FDG and 18F-FLT PET/CT imaging of mice bearing abdominal tumors Mol Imaging Biol 13 518 525 10.1007/s11307-010-0378-x 20632117 10.1007/s11307-010-0378-x
24. FP DiFilippo S Patel K Asosingh SC Erzurum 2012 Small-animal imaging using clinical positron emission tomography/computed tomography and super-resolution Mol Imaging 11 210 219 10.2310/7290.2011.00041 22554485
25. BW Jakoby Y Bercier M Conti ME Casey B Bendriem DW Townsend 2011 Physical and clinical performance of the mCT time-of-flight PET/CT scanner Phys Med Biol 56 2375 2389 10.1088/0031-9155/56/8/004 21427485 10.1088/0031-9155/56/8/004 1:STN:280:DC%2BC3MzotlGitA%3D%3D
26. Q Bao D Newport M Chen DB Stout AF Chatziioannou 2009 Performance evaluation of the inveon dedicated PET preclinical tomograph based on the NEMA NU-4 standards J Nucl Med 50 401 408 10.2967/jnumed.108.056374 19223424 10.2967/jnumed.108.056374
27. I Szanda J Mackewn G Patay P Major K Sunassee GE Mullen, et al. 2011 National Electrical Manufacturers Association NU-4 performance evaluation of the PET component of the NanoPET/CT preclinical PET/CT scanner J Nucl Med 52 1741 1747 10.2967/jnumed.111.088260 21969357 10.2967/jnumed.111.088260
28. R Prasad O Ratib H Zaidi 2010 Performance evaluation of the FLEX triumph X-PET scanner using the national electrical manufacturers association NU-4 standards J Nucl Med 51 1608 1615 10.2967/jnumed.110.076125 20847182 10.2967/jnumed.110.076125
29. ME Revheim K Roe OS Bruland T Bach-Gansmo A Skretting T Seierstad 2011 Monitoring the effect of targeted therapies in a gastrointestinal stromal tumor xenograft using a clinical PET/CT Mol Imaging Biol 13 1234 1240 10.1007/s11307-010-0464-0 21161686 10.1007/s11307-010-0464-0
30. EP Visser JA Disselhorst M Brom P Laverman M Gotthardt WJ Oyen, et al. 2009 Spatial resolution and sensitivity of the Inveon small-animal PET scanner J Nucl Med 50 139 147 10.2967/jnumed.108.055152 19139188 10.2967/jnumed.108. 055152
31. RJ Paproski M Wuest H Jans K Graham W Gati S McQuarrie, et al. 2010 Biodistribution and uptake of 3'-deoxy-3'-fluorothymidine in ENT1-knockout mice and in an ENT1-knockdown tumor model J Nucl Med 51 1447 1451 20720035 10.2967/jnumed.110.076356 1:CAS:528:DC%2BC3cXht1ejsLvK
32. N Aide C Desmonts M Briand M Meryet-Figuiere L Poulain 2010 High-throughput small animal PET imaging in cancer research: evaluation of the capability of the Inveon scanner to image four mice simultaneously Nucl Med Commun 31 851 858 10.1097/MNM.0b013e32833dc61d 20683363
33. FJ Siepel MG van Lier M Chen JA Disselhorst AP Meeuwis WJ Oyen, et al. 2010 Scanning multiple mice in a small-animal PET scanner: influence on image quality Nucl Instrum Methods Phys Res A 621 605 610 10.1016/j.nima.2010.05.057 10.1016/j.nima.2010.05.057 1:CAS:528:DC%2BC3cXpt1ahu78%3D
34. PL Chow FR Rannou AF Chatziioannou 2005 Attenuation correction for small animal PET tomographs Phys Med Biol 50 1837 1850 10.1088/0031-9155/50/8/014 15815099 10.1088/0031-9155/50/8/014
35. MM Jensen JT Jorgensen T Binderup A Kjaer 2008 Tumor volume in subcutaneous mouse xenografts measured by microCT is more accurate and reproducible than determined by 18F-FDG-microPET or external caliper BMC Med Imaging 8 16 10.1186/1471-2342-8-16 18925932 10.1186/1471-2342-8-16
36. V Kersemans J Thompson B Cornelissen M Woodcock PD Allen N Buls, et al. 2011 Micro-CT for anatomic referencing in PET and SPECT: radiation dose, biologic damage, and image quality J Nucl Med 52 1827 1833 10.2967/jnumed.111. 089151 21984798 10.2967/jnumed.111.089151
37. MC Huisman S Reder AW Weber SI Ziegler M Schwaiger 2007 Performance evaluation of the Philips MOSAIC small animal PET scanner Eur J Nucl Med Mol Imaging 34 532 540 10.1007/s00259-006-0271-7 17119959 10.1007/s00259-006-0271-7
38. R Prasad O Ratib H Zaidi 2011 NEMA NU-04-based performance characteristics of the LabPET-8 small animal PET scanner Phys Med Biol 56 6649 6664 10.1088/0031-9155/56/20/009 21941029 10.1088/0031-9155/56/20/009
39. A Chatziioannou J Qi A Moore A Annala K Nguyen R Leahy, et al. 2000 Comparison of 3-D maximum a posteriori and filtered backprojection algorithms for high-resolution animal imaging with microPET IEEE Trans Med Imaging 19 507 512 10.1109/42.870260 11021693 10.1109/42.870260 1:STN:280: DC%2BD3cvmsFOluw%3D%3D
40. J Qi RM Leahy SR Cherry A Chatziioannou TH Farquhar 1998 High-resolution 3D Bayesian image reconstruction using the microPET small-animal scanner Phys Med Biol 43 1001 1013 9572523 10.1088/0031-9155/43/4/027 1:STN:280: DyaK1c3jt1agtw%3D%3D
41. EP Visser JA Disselhorst MGTB van Lier P Laverman GM de Jong WJ Oyen, et al. 2011 Characterization and optimization of image quality as a function of reconstruction algorithms and parameter settings in a Siemens Inveon small-animal PET scanner using the NEMA NU4-2008 standards Nucl Instrum Methods Phys Res A 629 357 367 10.1016/j.nima.2010.10.089 1:CAS:528:DC%2BC3MXht1Cmsbg%3D
42. H Takamatsu T Kakiuchi A Noda H Uchida S Nishiyama R Ichise, et al. 2004 An application of a new planar positron imaging system (PPIS) in a small animal: MPTP-induced parkinsonism in mouse Ann Nucl Med 18 427 431 15462405 10.1007/BF02984486 1:CAS:528:DC%2BD2cXhtVWksL%2FE
43. H Uchida K Sato T Kakiuchi D Fukumoto H Tsukada 2008 Feasibility study of quantitative radioactivity monitoring of tumor tissues inoculated into mice with a planar positron imaging system (PPIS) Ann Nucl Med 22 57 63 10.1007/s12149-007-0082-3 18250988 10.1007/s12149-007-0082-3
44. H Zhang Q Bao NT Vu RW Silverman R Taschereau BN Berry-Pusey, et al. 2010 Performance evaluation of PETbox: a low cost bench top preclinical PET scanner Mol Imaging Biol 13 949 961 10.1007/s11307-010-0413-y 10.1007/s11307-010-0413-y
45. E Lage JJ Vaquero A Sisniega S Espana G Tapias M Abella, et al. 2009 Design and performance evaluation of a coplanar multimodality scanner for rodent imaging Phys Med Biol 54 5427 5441 10.1088/0031-9155/54/18/005 19700817 10.1088/0031-9155/54/18/005 1:STN:280:DC%2BD1Mrps1ejug%3D%3D
46. CS Levin 2012 Promising new photon detection concepts for high-resolution clinical and preclinical PET J Nucl Med 53 167 170 10.2967/jnumed.110.084343 22302960 10.2967/jnumed.110.084343 1:CAS:528:DC%2BC38XjsVSlt7g%3D
47. BJ Fueger J Czernin I Hildebrandt C Tran BS Halpern DB Stout, et al. 2006 Impact of animal handling on the results of 18F-FDG PET studies in mice J Nucl Med 47 999 1006 16741310 1:CAS:528:DC%2BD28XmtlWmtrk%3D
48. RL Wahl CA Henry SP Ethier 1992 Serum glucose: effects on tumor and normal tissue accumulation of 2-[F-18]-fluoro-2-deoxy-D-glucose in rodents with mammary carcinoma Radiology. 183 643 647 1584912 1:CAS:528:DyaK38XltVOns70%3D
49. JE Flores LM McFarland A Vanderbilt AK Ogasawara SP Williams 2008 The effects of anesthetic agent and carrier gas on blood glucose and tissue uptake in mice undergoing dynamic FDG-PET imaging: sevoflurane and isoflurane compared in air and in oxygen Mol Imaging Biol 10 192 200 10.1007/s11307-008-0137-4 18516648 10.1007/s11307-008-0137-4
50. R Boellaard MJ O'Doherty WA Weber FM Mottaghy MN Lonsdale SG Stroobants, et al. 2010 FDG PET and PET/CT: EANM procedure guidelines for tumour PET imaging: version 1.0 Eur J Nucl Med Mol Imaging 37 181 200 10.1007/s00259-009- 1297-4 19915839 10.1007/s00259-009-1297-4
51. KP Wong W Sha X Zhang SC Huang 2011 Effects of administration route, dietary condition, and blood glucose level on kinetics and uptake of 18F-FDG in mice J Nucl Med 52 800 807 10.2967/jnumed.110.085092 21498533 10.2967/jnumed.110.085092
52. JR Tseng D Stuart K Aardalen A Kaplan N Aziz NP Hughes, et al. 2011 Use of DNA microarray and small animal positron emission tomography in preclinical drug evaluation of RAF265, a novel B-Raf/VEGFR-2 inhibitor Neoplasia 13 266 275 21390189 1:CAS:528:DC%2BC3MXjt1Kht7s%3D
53. GA McArthur I Puzanov R Amaravadi A Ribas P Chapman KB Kim, et al. 2012 Marked, homogeneous and early FDG-PET responses to vemurafenib in BRAF-mutant advanced melanoma J Clin Oncol 30 1628 1634 22454415 10.1200/JCO.2011.39.1938 1:CAS:528:DC%2BC38XpsVKjtr0%3D