Micro-CT for anatomic referencing in PET and SPECT: Radiation dose, biologic damage, and image quality

Journal of Nuclear Medicine

Volumn 52, Issue 11, 2011, Pages 1827-1833

  Kersemans, Veerle ^a   Thompson, James ^a   Cornelissen, Bart ^a   Woodcock, Michael ^a   Allen, Philip D ^a   Buls, Nico ^b   Muschel, Ruth J ^a   Hill, Mark A ^a   Smart, Sean C ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY HOSPITAL BRUSSELS   (Belgium)

Author keywords

Biologic damage; Micro CT; Radiation dose

Indexed keywords

CELL DNA; HISTONE H2AX;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTRAST TO NOISE RATIO; CONTROLLED STUDY; DNA DAMAGE; DOSIMETRY; DOUBLE STRANDED DNA BREAK; EBT2 GAFCHROMIC FILM; FILM; HISTOPATHOLOGY; IMAGE ANALYSIS; IMAGE DISPLAY; IMAGE QUALITY; JEJUNUM DISEASE; LEUKOCYTE DISORDER; LINEAR SYSTEM; LIVER INJURY; MICRO-COMPUTED TOMOGRAPHY; MOUSE; MOUSE STRAIN; NANOIMAGING; NONHUMAN; PATHOLOGICAL ANATOMY; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; PROTEIN SYNTHESIS; RADIATION ABSORPTION; RADIATION DOSE; RADIATION INJURY; RADIATION RESPONSE; RADIOLOGICAL PARAMETERS; RADIOSENSITIVITY; SIGNAL NOISE RATIO; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; STRAIN DIFFERENCE;

ANIMALS; DNA BREAKS, DOUBLE-STRANDED; HISTONES; JEJUNUM; LIVER; MICE; POSITRON-EMISSION TOMOGRAPHY; QUALITY CONTROL; RADIATION DOSAGE; RADIATION INJURIES, EXPERIMENTAL; REFERENCE STANDARDS; TIME FACTORS; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON; X-RAY MICROTOMOGRAPHY;

EID: 80455127081     PISSN: 01615505     EISSN: None     Source Type: Journal    
DOI: 10.2967/jnumed.111.089151     Document Type: Article

References (18)

1. Boone JM, Velazquez O, Cherry SR. Small-animal x-ray dose from micro-CT. Mol Imaging. 2004;3:149-158.
2. Butson MJ, Yua PKN, Cheunga T, Alnawaf H. Energy response of the new EBT2 radiochromic film to x-ray radiation. Radiat Meas. 2010;45:836-839.
3. Rothkamm K, Balroop S, Shekhdar J, Fernie P, Goh V. Leukocyte DNA damage after multi-detector row CT: a quantitative biomarker of low-level radiation exposure. Radiology. 2007;242:244-251. (Pubitemid 44956030)
4. Rubin P, Casarett GW. Clinical radiation pathology as applied to curative radiotherapy. Cancer. 1968;22:767-778.
5. Eloot L, Buls N, Covens P, Willekens I, Lahoutte T, de Mey J. Quality control of micro-computed tomography systems. Radiat Prot Dosimetry. 2010;139:463-467.
6. Abramoff MD, Magelhaes PJ, Ram SJ. Image processing with ImageJ. Biophotonics Int. 2004;11:36-42.
7. Willekens I, Buls N, Lahoutte T, et al. Evaluation of the radiation dose in micro-CT with optimization of the scan protocol. Contrast Media Mol Imaging. 2010;5:201-207.
8. Foster WK, Ford NL. Investigating the effect of longitudinal micro-CT imaging on tumour growth in mice. Physics Med Biol. 2011;56:315-326.
9. Laforest R, Waterson CE, Broski SM, Lewis JS. Radiation dose considerations in tumour growth monitoring with CT. Mol Imaging. 2004;3:288.
10. Carlson SK, Classic KL, Bender CE, Russell SJ. Small animal absorbed radiation dose from serial micro-computed tomography imaging. Mol Imaging Biol. 2007;9:78-82. (Pubitemid 46336222)
11. Prise KM, Schettino G, Folkard M, Held KD. New insights on cell death from radiation exposure. Lancet Oncol. 2005;6:520-528. (Pubitemid 40903633)
12. Helleday T, Petermann E, Lundin C, Hodgson B, Sharma RA. DNA repair pathways as targets for cancer therapy. Natl Rev. 2008;8:193-204. (Pubitemid 351301852)
13. Banath JP, Olive PL. Expression of phosphorylated histone H2AX as a surrogate of cell killing by drugs that create DNA double-strand breaks. Cancer Res. 2003;63:4347-4350. (Pubitemid 36951002)
14. Bonner WM, Redon CE, Dickey JS, et al. GammaH2AX and cancer. Natl Rev. 2008;8:957-967.
15. Joiner MC, Marples B, Lambin P, Short SC, Turesson I. Low-dose hypersensitivity: current status and possible mechanisms. Int J Radiat Oncol Biol Phys. 2001;49:379-389. (Pubitemid 32123610)
16. Longo JA, Nevaldine B, Longo SL, Winfield JA, Hahn PJ. An assay for quantifying DNA double-strand break repair that is suitable for small numbers of unlabeled cells. Radiat Res. 1997;147:35-40. (Pubitemid 27014445)
17. Prise KM. New advances in radiation biology. Occup Med (Lond). 2006;56: 156-161.
18. Bushberg J, Seibert J, Leidthold E, Boone J. The Essential Physics of Medical Imaging. 2nd ed. Baltimore, MD: Lippincott, Williams & Wilkins; 2002.